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Transfusional Medicine

We are dedicated to investigate transfusional activity, the alteration of erythrocytes during the conservation period and extracorporeal photoapheresis. We work on the molecular and serological characterization of blood group variants. In non-invasive fetal genotyping strategies due to blood group incompatibilities. We develop iPSC lines and produce in vitro erythrocytes with rare phenotypes.

We deepen in the knowledge of epidemiology and the detection of infectious agents relevant for safety of the products supplied by the Blood and Tissue Bank.

We investigate in clinical immunology and develop our own HLA and KIR typing protocols. We develop and incorporate new therapeutic applications in cell therapy including hematopoietic transplantation, cellular immunology and regenerative medicine.

We investigate the molecular mechanisms and genotype-phenotype correlation of coagulopathies, haemorrhagic diathesis and other associated congenital pathologies. We develop tools based on the new technologies of parallel massive sequencing with application to the molecular study, genetic counselling and prenatal diagnosis.

Team

Laura Martin Fernandez

Laura Martin Fernandez

Postdoctoral researcher
Transfusional Medicine
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Lluis Martorell Cedres

Lluis Martorell Cedres

Postdoctoral researcher
Transfusional Medicine
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Lorena Ramirez Orihuela

Lorena Ramirez Orihuela

Research technician
Transfusional Medicine
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Luciano Rodríguez Gómez

Luciano Rodríguez Gómez

Senior researcher
Transfusional Medicine
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Marc Vilches Martínez

Marc Vilches Martínez

Transfusional Medicine
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Margarita Codinach Creus

Margarita Codinach Creus

Senior researcher
Transfusional Medicine
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Laura Martin Fernandez

Laura Martin Fernandez

Postdoctoral researcher
Transfusional Medicine
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Lluis Martorell Cedres

Lluis Martorell Cedres

Postdoctoral researcher
Transfusional Medicine
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Lorena Ramirez Orihuela

Lorena Ramirez Orihuela

Research technician
Transfusional Medicine
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Luciano Rodríguez Gómez

Luciano Rodríguez Gómez

Senior researcher
Transfusional Medicine
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Marc Vilches Martínez

Marc Vilches Martínez

Transfusional Medicine
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Margarita Codinach Creus

Margarita Codinach Creus

Senior researcher
Transfusional Medicine
Read more

Publications

Integrated GWAS and Gene Expression Suggest ORM1 as a Potential Regulator of Plasma Levels of Cell-Free DNA and Thrombosis Risk.

PMID: 35272364
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2022
Reference: Thromb Haemost. 2022 Mar 10. doi: 10.1055/s-0041-1742169.
Impact factor: 5.723
Publication type: Paper in international publication
Authors: Lopez, Sonia, Martinez-Perez, Angel, Rodriguez-Rius, Alba, Vinuela, Ana, Brown, Andrew A, Martin-Fernandez, Laura, Vilalta, Noelia, Arus, Marc, Panousis, Nikolaos I, Buil, Alfonso et al.
DOI: 10.1055/s-0041-1742169

Cryopreservation of unrelated donor hematopoietic stem cells: the right answer for transplantations during the COVID-19 pandemic?

PMID: 34127808
Journal: BONE MARROW TRANSPLANTATION
Year: 2021
Reference: Bone Marrow Transplant. 2021 Oct;56(10):2489-2496. doi: 10.1038/s41409-021-01367-x. Epub 2021 Jun 14.
Impact factor: 5.483
Publication type: Paper in international publication
Authors: Linares, Monica, Ancochea, Agueda, Garcia-Rey, Enric, Garcia-Munoz, Nadia, Medina, Laura, Castillo, Nerea, Carreras, Enric, Villa, Juliana, Querol, Sergio, Valcarcel, David et al.
DOI: 10.1038/s41409-021-01367-x

Putting the spotlight on donation-related risks and donor safety - are we succeeding in protecting donors?

PMID: 33103801
Journal: VOX SANGUINIS
Year: 2021
Reference: Vox Sang. 2021 Mar;116(3):313-323. doi: 10.1111/vox.13014. Epub 2020 Oct 26.
Impact factor: 2.144
Publication type: Paper in international publication
Authors: Korkalainen, Piia, Wulff, Birgit, Fernandez-Sojo, Jesus, Eguizabal, Cristina, Urbano, Fernando, Vesga, Miguel Angel, Pozenel, Primoz, van Kraaij, Marian, Hansen, Morten Bagge, Slot, Ed et al.
DOI: 10.1111/vox.13014

Diagnostic challenges in von Willebrand disease. Report of two cases with emphasis on multimeric and molecular analysis.

PMID: 32664776
Journal: PLATELETS
Year: 2021
Reference: Platelets. 2021 Jul 4;32(5):697-700. doi: 10.1080/09537104.2020.1784403. Epub 2020 Jul 14.
Impact factor: 3.862
Publication type: Paper in international publication
Authors: Vidal, F, Corrales, I, Borras, N, Torramade-Moix, S, Palomo, M, Escolar, G, Diaz-Ricart, M, Altisent, C, Parra, R, Pino, M et al.
DOI: 10.1080/09537104.2020.1784403

Evaluation of the Spanish population coverage of a prospective HLA haplobank of induced pluripotent stem cells.

PMID: 33849662
Journal: Stem Cell Research & Therapy
Year: 2021
Reference: Stem Cell Res Ther. 2021 Apr 13;12(1):233. doi: 10.1186/s13287-021-02301-0.
Impact factor: 6.832
Publication type: Paper in international publication
Authors: Querol, Sergi, Rudilla, Francesc, Herrero, Maria Jose, Alvarez-Palomo, Belen, Garcia-Martinez, Iris, Gayoso, Jorge, Raya, Angel, Veiga, Anna, Abad, Maria Luisa, Eiras, Adolfo et al.
DOI: 10.1186/s13287-021-02301-0

Shared genetic background between children and adults with attention deficit/hyperactivity disorder.

PMID: 32279069
Journal: NEUROPSYCHOPHARMACOLOGY
Year: 2020
Reference: Neuropsychopharmacology. 2020 Sep;45(10):1617-1626. doi: 10.1038/s41386-020-0664-5. Epub 2020 Apr 12.
Impact factor:
Publication type: Paper in international publication
Authors: Almos, Peter; Arias-Vasquez, Alejandro; Arribas, Lorena; Artigas, Maria Soler; Asherson, Philip; Bau, Claiton Henrique Dotto; Borglum, Anders D; Bosch, Rosa; Buitelaar, Jan K; Casas, Miquel et al.
DOI: 10.1038/s41386-020-0664-5

Characterization of a Cytomegalovirus-Specific T Lymphocyte Product Obtained Through a Rapid and Scalable Production Process for Use in Adoptive Immunotherapy.

PMID: 32161589
Journal: Frontiers in Immunology
Year: 2020
Reference: Front Immunol. 2020 Feb 25;11:271. doi: 10.3389/fimmu.2020.00271. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Barba, Pere; Canto, Ester; Grau-Vorster, Marta; Lopez-Montanes, Maria; Oliver-Vila, Irene; Querol, Sergi; Rudilla, Francesc; Vives, Joaquim et al.
DOI: 10.3389/fimmu.2020.00271

Unraveling the Influence of Common von Willebrand factor variants on von Willebrand Disease Phenotype: An Exploratory Study on the Molecular and Clinical Profile of von Willebrand Disease in Spain Cohort.

PMID: 32135566
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2020
Reference: Thromb Haemost. 2020 Mar;120(3):437-448. doi: 10.1055/s-0040-1702227. Epub 2020 Mar 5.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar, Carlos; Aguinaco, Reyes; Alonso, Nieves; Altisent, Carme; Arribalzaga, Karmele; Batlle, Javier; Batlle-Lopez, Fernando; Bermejo, Nuria; Berrueco, Ruben; Bonanad, Santiago et al.
DOI: 10.1055/s-0040-1702227

Unexpected long-lasting anti-HEV IgM positivity: Is HEV antigen a better serological marker for hepatitis E infection diagnosis?

PMID: 32106351
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2020
Reference: J Viral Hepat. 2020 Jul;27(7):747-753. doi: 10.1111/jvh.13285. Epub 2020 Mar 11.
Impact factor:
Publication type: Paper in international publication
Authors: Barreira-Diaz, Ana; Bes, Marta; Buti, Maria; Esteban, Rafael; Piron, Maria; Quer, Josep; Rando-Segura, Ariadna; Riveiro-Barciela, Mar; Rodriguez-Frias, Francisco; Ruzo, Sofia P et al.
DOI: 10.1111/jvh.13285

Impact of prophylaxis on health-related quality of life of boys with hemophilia: An analysis of pooled data from 9 countries.

PMID: 31294327
Journal: Research and practice in thrombosis and haemostasi
Year: 2019
Reference: Res Pract Thromb Haemost. 2019 Apr 23;3(3):397-404. doi: 10.1002/rth2.12202. eCollection 2019 Jul.
Impact factor: 0
Publication type: Paper in international publication
Authors: Antunes, Sandra V, Usuba, Koyo, Price, Victoria E, Blanchette, Victor, Abad, Audrey, Altisent, Carmen, Buchner-Daley, Loretta, Carneiro, Jorge D A, Feldman, Brian M, Fischer, Kathelijn et al.
DOI: 10.1002/rth2.12202

Compliance with Good Manufacturing Practice in the Assessment of Immunomodulation Potential of Clinical Grade Multipotent Mesenchymal Stromal Cells Derived from Wharton's Jelly.

PMID: 31117301
Journal: Cells
Year: 2019
Reference: Cells. 2019 May 21;8(5). pii: cells8050484. doi: 10.3390/cells8050484.
Impact factor: 5.656
Publication type: Paper in international publication
Authors: Grau-Vorster, Marta, Rodriguez, Luciano, Del Mazo-Barbara, Anna, Mirabel, Clementine, Blanco, Margarita, Codinach, Margarita, Gomez, Susana G, Querol, Sergi, Garcia-Lopez, Joan, Vives, Joaquim et al.
DOI: 10.3390/cells8050484

Archeogenetics of F11 p.Cys38Arg: a 5,400 years old mutation identified in different southwestern European countries.

PMID: 31043424
Journal: BLOOD
Year: 2019
Reference: Blood. 2019 Jun 13;133(24):2618-2622. doi: 10.1182/blood.2019000055. Epub 2019 May 1.
Impact factor: 16.562
Publication type: Paper in international publication
Authors: Vidal, Francisco, Bauduer, Frederic, Carbonell, Pablo, Corral, Javier, Vicente, Vicente, Parra, Rafael, Padilla, Jose, de la Morena-Barrio, Maria Eugenia, Salloum-Asfar, Salam, Esteban, Julio et al.
DOI: 10.1182/blood.2019000055

Adapting Cord Blood Collection and Banking Standard Operating Procedures for HLA-Homozygous Induced Pluripotent Stem Cells Production and Banking for Clinical Application.

PMID: 30965661
Journal: Journal of Clinical Medicine
Year: 2019
Reference: J Clin Med. 2019 Apr 8;8(4). pii: jcm8040476. doi: 10.3390/jcm8040476.
Impact factor: 5.688
Publication type: Review in international publication
Authors: Alvarez-Palomo, Belen, Vives, Joaquim, Casaroli-Marano, Ricardo P P, G Gomez, Susana G, Rodriguez Gomez, Luciano, Edel, Michael J, Querol Giner, Sergi et al.
DOI: 10.3390/jcm8040476

Identification of the novel HLA-B*57:91 allele, by next-generation sequencing in a Spanish individual.

PMID: 29030947
Journal: HLA
Year: 2018
Reference: HLA. 2018 Jan;91(1):69-70. doi: 10.1111/tan.13159. Epub 2017 Nov 13.
Impact factor: 2.558
Publication type: Paper in international publication
Authors: Enrich, E, Campos, E, Caro-Oleas, J L, Herrero-Mata, M J, Rudilla, F et al.
DOI: 10.1111/tan.13159

HLA-DQB1*02:102, a novel allele identified by next-generation sequencing in a Spanish individual.

PMID: 29135082
Journal: HLA
Year: 2018
Reference: HLA. 2018 Feb;91(2):140-141. doi: 10.1111/tan.13174. Epub 2017 Dec 5.
Impact factor: 2.558
Publication type: Paper in international publication
Authors: Enrich, E, Herrero-Mata, M J, Rudilla, F, Caro-Oleas, J L, Mongay, L et al.
DOI: 10.1111/tan.13174

Diagnostic delay in acquired haemophilia: Analysis of causes and consequences in a 20-year Spanish cohort.

PMID: 29732654
Journal: HAEMOPHILIA
Year: 2018
Reference: Haemophilia. 2018 May;24(3):e163-e166. doi: 10.1111/hae.13499. Epub 2018 May 6.
Impact factor: 2.768
Publication type: Review in international publication
Authors: Pardos-Gea, J, Fernandez-Diaz, N, Parra, R, Cortina, V, Altisent, C et al.
DOI: 10.1111/hae.13499

Moderate and severe haemophilia in Spain: An epidemiological update.

PMID: 29578308
Journal: HAEMOPHILIA
Year: 2018
Reference: Haemophilia. 2018 May;24(3):e136-e139. doi: 10.1111/hae.13462. Epub 2018 Mar 26.
Impact factor: 2.768
Publication type: Letter or abstract
Authors: Aznar, J A, Altisent, C, Alvarez-Roman, M T, Bonanad, S, Mingot-Castellano, M E, Lopez, M F et al.
DOI: 10.1111/hae.13462

Risk Factors for the Progression from Low to High Titres in 260 Children with Severe Haemophilia A and Newly Developed Inhibitors.

PMID: 29212115
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2017
Reference: Thromb Haemost. 2017 Dec;117(12):2274-2282. doi: 10.1160/TH17-01-0059. Epub 2017 Dec 6.
Impact factor: 5.627
Publication type: Paper in international publication
Authors: Escuriola-Ettingshausen, Carmen, Mancuso, Maria Elisa, Fischer, Kathelijn, Santagostino, Elena, Oldenburg, Johannes, Platokouki, Helen, Konigs, Cristoph, Carcao, Manuel, Ljung, Rolf, Petrini, Pia et al.
DOI: 10.1160/TH17-01-0059

Advanced cell-based modeling of the royal disease: characterization of the mutated F9 mRNA.

PMID: 28834196
Journal: JOURNAL OF THROMBOSIS AND HAEMOSTASIS
Year: 2017
Reference: J Thromb Haemost. 2017 Nov;15(11):2188-2197. doi: 10.1111/jth.13808. Epub 2017 Sep 25.
Impact factor: 5.287
Publication type: Paper in international publication
Authors: Martorell, L, Luce, E, Vazquez, J L, Richaud-Patin, Y, Jimenez-Delgado, S, Corrales, I, Borras, N, Casacuberta-Serra, S, Weber, A, Parra, R et al.
DOI: 10.1111/jth.13808

Sodium content in products used to treat haemophilia.

PMID: 27228069
Journal: HAEMOPHILIA
Year: 2016
Reference: Haemophilia. 2016 Jul;22(4):e324-7. doi: 10.1111/hae.12948. Epub 2016 May 26.
Impact factor: 2.673
Publication type: Letter or abstract
Authors: Altisent, C, Martorell, M, de la Sierra, A et al.
DOI: 10.1111/hae.12948

Practical aspects of DDAVP use in patients with von Willebrand Disease undergoing invasive procedures: a European survey.

PMID: 26207933
Journal: HAEMOPHILIA
Year: 2016
Reference: Haemophilia. 2016 Jan;22(1):110-20. doi: 10.1111/hae.12763. Epub 2015 Jul 24.
Impact factor: 2.673
Publication type: Paper in international publication
Authors: Zulfikar, B, Windyga, J, Rocino, A, Richards, M, Perez, R, Windyga, J, Dolan, G, Altisent, C, Katsarou, O, Lopez Fernandez, M-F et al.
DOI: 10.1111/hae.12763

Early prophylaxis in children with severe haemophilia A: clinical and ultrasound imaging outcomes.

PMID: 26315845
Journal: HAEMOPHILIA
Year: 2016
Reference: Haemophilia. 2016 Mar;22(2):218-224. doi: 10.1111/hae.12792. Epub 2015 Aug 28.
Impact factor: 2.673
Publication type: Paper in international publication
Authors: Altisent, C, Martorell, M, Crespo, A, Casas, L, Torrents, C, Parra, R et al.
DOI: 10.1111/hae.12792

Practical aspects of factor concentrate use in patients with von Willebrand disease undergoing invasive procedures: a European survey.

PMID: 27292438
Journal: HAEMOPHILIA
Year: 2016
Reference: Haemophilia. 2016 Sep;22(5):739-51. doi: 10.1111/hae.12955. Epub 2016 Jun 13.
Impact factor: 2.673
Publication type: Review in international publication
Authors: Windyga, J, Dolan, G, Altisent, C, Katsarou, O, Lopez Fernandez, M-F, Zulfikar, B et al.
DOI: 10.1111/hae.12955

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Over time, wild boars have approached the city of Barcelona and surrounding areas. As carriers of the hepatitis E virus, they are linked to a study identifying them as a potential source of transmission of this disease.