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Transfusional Medicine

We are dedicated to investigate transfusional activity, the alteration of erythrocytes during the conservation period and extracorporeal photoapheresis. We work on the molecular and serological characterization of blood group variants. In non-invasive fetal genotyping strategies due to blood group incompatibilities. We develop iPSC lines and produce in vitro erythrocytes with rare phenotypes.

We deepen in the knowledge of epidemiology and the detection of infectious agents relevant for safety of the products supplied by the Blood and Tissue Bank.

We investigate in clinical immunology and develop our own HLA and KIR typing protocols. We develop and incorporate new therapeutic applications in cell therapy including hematopoietic transplantation, cellular immunology and regenerative medicine.

We investigate the molecular mechanisms and genotype-phenotype correlation of coagulopathies, haemorrhagic diathesis and other associated congenital pathologies. We develop tools based on the new technologies of parallel massive sequencing with application to the molecular study, genetic counselling and prenatal diagnosis.

Team

Maria Cristina Caparros Felipe

Maria Cristina Caparros Felipe

Research technician
Transfusional Medicine
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Maria Jose Herrero Mata

Maria Jose Herrero Mata

Postdoctoral researcher
Transfusional Medicine
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Maria Madeleine Piron

Maria Madeleine Piron

Postdoctoral researcher
Transfusional Medicine
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Maria Teresa Contijoch Mateos

Maria Teresa Contijoch Mateos

Transfusional Medicine
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Marta Bes Maijo

Marta Bes Maijo

Postdoctoral researcher
Transfusional Medicine
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Mónica Linares Alberich

Mónica Linares Alberich

Research technician
Transfusional Medicine
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Maria Cristina Caparros Felipe

Maria Cristina Caparros Felipe

Research technician
Transfusional Medicine
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Maria Jose Herrero Mata

Maria Jose Herrero Mata

Postdoctoral researcher
Transfusional Medicine
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Maria Madeleine Piron

Maria Madeleine Piron

Postdoctoral researcher
Transfusional Medicine
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Maria Teresa Contijoch Mateos

Maria Teresa Contijoch Mateos

Transfusional Medicine
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Marta Bes Maijo

Marta Bes Maijo

Postdoctoral researcher
Transfusional Medicine
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Mónica Linares Alberich

Mónica Linares Alberich

Research technician
Transfusional Medicine
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Publications

Incidence, diagnosis, and outcome of immune-mediated thrombotic thrombocytopenic purpura: A nationwide survey by the Spanish registry of thrombotic thrombocytopenic purpura.

PMID: 33780553
Journal: JOURNAL OF CLINICAL APHERESIS
Year: 2021
Reference: J Clin Apher. 2021 Aug;36(4):563-573. doi: 10.1002/jca.21894. Epub 2021 Mar 29.
Impact factor: 2.821
Publication type: Paper in international publication
Authors: Salinas, Ramon, Salgado-Barreira, Angel, Fernandez-Docampo, Marta, Pascual-Izquierdo, Cristina, Del Rio-Garma, Julio, de la Rubia, Javier, Viejo, Aurora, Mingot, Eva, Cid, Joan, Solanich, Xavier et al.
DOI: 10.1002/jca.21894

A synthetic mRNA cell reprogramming method using CYCLIN D1 promotes DNA repair generating improved genetically stable human induced pluripotent stem cells.

PMID: 33621399
Journal: STEM CELLS
Year: 2021
Reference: Stem Cells. 2021 Jul;39(7):866-881. doi: 10.1002/stem.3358. Epub 2021 Mar 3.
Impact factor: 6.277
Publication type: Paper in international publication
Authors: Edel, Michael J, Esteller, Manel, Perez, Francisco Vidal, Alvarez-Palomo, Ana Belen, Requena-Osete, Jordi, Delgado-Morales, Raul, Moreno-Manzano, Victoria, Grau-Bove, Carme, Tejera, Agueda M, Otero, Manel Juan et al.
DOI: 10.1002/stem.3358

Simoctocog Alfa (Nuwiq) in Previously Untreated Patients with Severe Haemophilia A: Final Results of the NuProtect Study.

PMID: 33581698
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2021
Reference: Thromb Haemost. 2021 Nov;121(11):1400-1408. doi: 10.1055/s-0040-1722623. Epub 2021 Feb 13.
Impact factor: 5.723
Publication type: Paper in international publication
Authors: Oldenburg, Johannes, Liesner, Ri J, Abraham, Aby, Altisent, Carmen, Belletrutti, Mark J, Carcao, Manuel, Carvalho, Manuela, Chambost, Herve, Chan, Anthony K C, Dubey, Leonid et al.
DOI: 10.1055/s-0040-1722623

Distribution of Human Killer Cell Immunoglobulin-Like Receptors and Ligands Among Blood Donors Of Catalonia.

PMID: 31702113
Journal: HLA
Year: 2020
Reference: HLA. 2020 Mar;95(3):179-188. doi: 10.1111/tan.13754. Epub 2019 Nov 25.
Impact factor:
Publication type: Paper in international publication
Authors: Caro, Jose L; Closa, Laia; Herrero, Maria J; Vidal, Francisco et al.
DOI: 10.1111/tan.13754

Beyond chimerism analysis: methods for tracking a new generation of cell-based medicines.

PMID: 32024991
Journal: BONE MARROW TRANSPLANTATION
Year: 2020
Reference: Bone Marrow Transplant. 2020 Jul;55(7):1229-1239. doi: 10.1038/s41409-020-0822-8. Epub 2020 Feb 5.
Impact factor:
Publication type: Review in international publication
Authors: Casademont-Roca, Aina; Martorell, Lluis; Nogues, Nuria; Vives, Joaquim et al.
DOI: 10.1038/s41409-020-0822-8

Variable readthrough responsiveness of nonsense mutations in hemophilia A.

PMID: 31197069
Journal: HAEMATOLOGICA
Year: 2020
Reference: Haematologica. 2020 Jan 31;105(2):508-518. doi: 10.3324/haematol.2018.212118. Print 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Barquinero, Jordi; Cortina, Vicente; Martorell, Lluis; Parra, Rafael; Vidal, Francisco et al.
DOI: 10.3324/haematol.2018.212118

Multicenter Study on Differential Human Neutrophil Antigen 2 Expression and Underlying Molecular Mechanisms.

PMID: 33173457
Journal: TRANSFUSION MEDICINE AND HEMOTHERAPY
Year: 2020
Reference: Transfus Med Hemother. 2020 Oct;47(5):385-395. doi: 10.1159/000505523. Epub 2020 Jan 22.
Impact factor: 1.937
Publication type: Paper in international publication
Authors: Kellershohn, Josina, Flesch, Brigitte K, Reil, Angelika, Nogues, Nuria, Canals, Carme, Bugert, Peter, Schulze, Torsten J, Huiskes, Elly, Porcelijn, Leendert, Hoglund, Petter et al.
DOI: 10.1159/000505523

Unraveling the effect of silent, intronic and missense mutations on VWF splicing: contribution of next generation sequencing in the study of mRNA.

PMID: 30361419
Journal: HAEMATOLOGICA
Year: 2019
Reference: Haematologica. 2019 Mar;104(3):587-598. doi: 10.3324/haematol.2018.203166. Epub 2018 Oct 25.
Impact factor: 7.57
Publication type: Paper in international publication
Authors: Borras, Nina, Orriols, Gerard, Batlle, Javier, Perez-Rodriguez, Almudena, Fidalgo, Teresa, Martinho, Patricia, Lopez-Fernandez, Maria Fernanda, Rodriguez-Trillo, Angela, Loures, Esther, Castro Quismondo, Nerea et al.
DOI: 10.3324/haematol.2018.203166

Acute liver failure due to immune-mediated hepatitis successfully managed with plasma exchange: New settings call for new treatment strategies?

PMID: 30503040
Journal: JOURNAL OF HEPATOLOGY
Year: 2019
Reference: J Hepatol. 2019 Mar;70(3):564-566. doi: 10.1016/j.jhep.2018.10.020. Epub 2018 Nov 28.
Impact factor: 18.946
Publication type: Letter or abstract
Authors: Riveiro-Barciela, Mar, Munoz-Couselo, Eva, Fernandez-Sojo, Jesus, Diaz-Mejia, Nely, Parra-Lopez, Rafael, Buti, Maria et al.
DOI: 10.1016/j.jhep.2018.10.020

Joint status in Spanish haemophilia B patients assessed using the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD-US) score.

PMID: 30444298
Journal: HAEMOPHILIA
Year: 2019
Reference: Haemophilia. 2019 Jan;25(1):144-153. doi: 10.1111/hae.13628. Epub 2018 Nov 16.
Impact factor: 3.59
Publication type: Paper in international publication
Authors: Martinoli, Carlo, Jimenez-Yuste, Victor, Alvarez-Roman, Maria Teresa, Martin-Salces, Monica, De la Corte-Rodriguez, Hortensia, Altisent, Carmen, Parra, Rafael, Nunez, Ramiro, Perez, Rosario, Garcia-Candel, Faustino et al.
DOI: 10.1111/hae.13628

Recombinant FXIII (rFXIII-A2) Prophylaxis Prevents Bleeding and Allows for Surgery in Patients with Congenital FXIII A-Subunit Deficiency.

PMID: 29448295
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2018
Reference: Thromb Haemost. 2018 Mar;118(3):451-460. doi: 10.1055/s-0038-1624581. Epub 2018 Feb 15.
Impact factor: 4.952
Publication type: Paper in international publication
Authors: Kessler, Craig, Lassila, Riitta, Nugent, Diane, Oldenburg, Johannes, Garly, May-Lill, Rosholm, Anders, Inbal, Aida, Kerlin, Bryce A, Fukutake, Katsuyuki, Altisent, Carmen et al.
DOI: 10.1055/s-0038-1624581

Molecular and clinical profile of von Willebrand disease in Spain (PCM-EVW-ES): Proposal for a new diagnostic paradigm.

PMID: 26245874
Journal: THROMBOSIS AND HAEMOSTASIS
Year: 2016
Reference: Thromb Haemost. 2016 Jan;115(1):40-50. doi: 10.1160/TH15-04-0282. Epub 2015 Aug 6.
Impact factor: 5.255
Publication type: Paper in international publication
Authors: Arribalzaga, Karmele, Cabrera, Noelia, Moret, Andres, Parra, Rafael, Mingot-Castellano, Maria Eva, Balda, Ignacia, Altisent, Carmen, Perez-Montes, Rocio, Fisac, Rosa Maria, Iruin, Gemma et al.
DOI: 10.1160/TH15-04-0282

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News

Over time, wild boars have approached the city of Barcelona and surrounding areas. As carriers of the hepatitis E virus, they are linked to a study identifying them as a potential source of transmission of this disease.