Skip to main content

Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Team

Javier Hernandez Losa

Javier Hernandez Losa

Predoctoral researcher
Translational Molecular Pathology
Read more
Josep Castellví Vives

Josep Castellví Vives

Translational Molecular Pathology
Read more
Lourdes Elena Salazar Huayna

Lourdes Elena Salazar Huayna

Research technician
Translational Molecular Pathology
Read more
Marta Cano Galietero

Marta Cano Galietero

Research technician
Translational Molecular Pathology
Read more
Marta Sese Faustino

Marta Sese Faustino

Postdoctoral researcher
Translational Molecular Pathology
Read more
Mercedes Martinez Mansilla

Mercedes Martinez Mansilla

Research technician
Translational Molecular Pathology
Read more
Javier Hernandez Losa

Javier Hernandez Losa

Predoctoral researcher
Translational Molecular Pathology
Read more
Josep Castellví Vives

Josep Castellví Vives

Translational Molecular Pathology
Read more
Lourdes Elena Salazar Huayna

Lourdes Elena Salazar Huayna

Research technician
Translational Molecular Pathology
Read more
Marta Cano Galietero

Marta Cano Galietero

Research technician
Translational Molecular Pathology
Read more
Marta Sese Faustino

Marta Sese Faustino

Postdoctoral researcher
Translational Molecular Pathology
Read more
Mercedes Martinez Mansilla

Mercedes Martinez Mansilla

Research technician
Translational Molecular Pathology
Read more

Research lines

Study of PTOV1 modulation in tumor proliferation and progression : Interaction with IGF1 pathways. Notch and Wnt expression in TMAs of tumors.

To evaluate the expression (nuclear and cytoplasmatic) of PTOV1 , Notch and Wnt on TMAs in c different histological types of carcinomas with low and high grades of malignancy  . To correlate the inmunoexpression with classical parameters of  tumor behaviour : tumoral size, grade of malignancy, vascular permeation, lymph nodes metastasis in each histological subtype and demonstrated the role of PTOV1 as predictive molecular marker in carcinomas.

(Research Biomedical Unit)


IP: Inés de Torres Ramirez

Projects

Patologia molecular translacional

IP: Santiago Ramon y Cajal Agüeras
Collaborators: Cleofé Romagosa Pérez-Portabell, Maria Rosa Somoza Lopez de Haro, Jordi Temprana Salvador, Teresa Moline Marimon, Jessica Camacho Soriano, Carmela Iglesias i Felip, Josep Castellví Vives, Elena Muro Blanc, Marta Cano Galietero, Elena Antima Martinez Saez, Javier Hernandez Losa, Marta Sese Faustino, Vicente Peg Camara, Irene Sansano Valero, Trond Aasen, Stefan Hummer
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 40000
Reference: 2021 SGR 01138
Duration: 01/01/2022 - 30/06/2025

Estudio de expresión de antígenos en tejido tumoral de pacientes con Esclerosis Sistémica.

IP: Alfredo Guillen Del Castillo
Collaborators: Carmen Pilar Simeón i Aznar, Vicenç Fonollosa Pla, Maria Roca Herrera, Janire Perurena Prieto, Irene Sansano Valero
Funding agency: Instituto de Salud Carlos III
Funding: 75020
Reference: PI22/01804
Duration: 01/01/2023 - 31/12/2025

Enhancing CD8+ Resident Memory T cell function to control and eliminate viral reservoirs

IP: Meritxell Genesca Ferrer
Collaborators: Vicente Descalzo Jorro, Josep Castellví Vives, Laura Mañalich Barrachina
Funding agency: Instituto de Salud Carlos III
Funding: 171820
Reference: PI20/00160
Duration: 01/01/2021 - 30/06/2025

New therapeutic approaches in head and neck cancer

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea, Jordi Temprana Salvador, Angel García Jiménez, Josep Castellví Vives, Laia Josa Culleré, Marina Bataller Fernández
Funding agency: Instituto de Salud Carlos III
Funding: 183920
Reference: PI20/00556
Duration: 01/01/2021 - 30/06/2025

Publications

OSNA Total Tumor Load for the Prediction of Axillary Involvement in Breast Cancer Patients: Should We use Different Thresholds According to the Intrinsic Molecular Subtype? MOTTO Study.

PMID: 37534372
Journal: Clinical pathology (Thousand Oaks, Ventura County,
Year: 2023
Reference: Clin Pathol. 2023 Jul 31;16:2632010X231183693. doi: 10.1177/2632010X231183693. eCollection 2023 Jan-Dec.
Impact factor:
Publication type: Paper in international publication
Authors: Bernet, L; Cordoba, A; Godey, F; Hardisson, D; Peg, V; Prat, A; Rodrigo, M; Ruiz, I; Sanchez-Mendez, J I; Sancho, M et al.
DOI: 10.1177/2632010X231183693

Matrix Metalloproteinase-9 Expression Is Associated with the Absence of Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Patients.

PMID: 37511057
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2023
Reference: Int J Mol Sci. 2023 Jul 11;24(14):11297. doi: 10.3390/ijms241411297.
Impact factor:
Publication type: Paper in international publication
Authors: Alvaro, Tomas; Arenas, Meritxell; Bosch, Ramon; de la Cruz-Merino, Luis; Galera, Juana; Gallardo, Noelia; Garcia-Fontgivell, Joan; Korzynska, Anna; Lejeune, Marylene; Lopez, Carlos et al.
DOI: 10.3390/ijms241411297

Wall enhancement as a biomarker of intracranial aneurysm instability: a histo-radiological study.

PMID: 37589724
Journal: ACTA NEUROCHIRURGICA
Year: 2023
Reference: Acta Neurochir (Wien). 2023 Aug 17. doi: 10.1007/s00701-023-05739-8.
Impact factor:
Publication type: Paper in international publication
Authors: Arikan, Fuat; Coscojuela, Pilar; De Barros, Andrea; Dinia, Lavinia; Gandara, Dario; Gramegna, Laura Ludovica; Hernandez, David; Luzi, Michele; Martinez-Saez, Elena; Quintana, Manuel et al.
DOI: 10.1007/s00701-023-05739-8

Teaching NeuroImage: Paraneoplastic Cerebellar Degeneration and Antibodies to TRIM 9 and 67 Secondary to Melanoma.

PMID: 37580164
Journal: NEUROLOGY
Year: 2023
Reference: Neurology. 2023 Aug 14:10.1212/WNL.0000000000207702. doi: 10.1212/WNL.0000000000207702.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, Cristina; Gonzalez, Victoria; Martinez-Saez, Elena; Naranjo, Laura; Ruiz-Garcia, Raquel; Vilaseca, Andreu et al.
DOI: 10.1212/WNL.0000000000207702

Characteristics of 24 SARS-CoV-2-Sequenced Reinfection Cases in a Tertiary Hospital in Spain.

PMID: 35722299
Journal: Frontiers in Microbiology
Year: 2022
Reference: Front Microbiol. 2022 May 26;13:876409. doi: 10.3389/fmicb.2022.876409. eCollection 2022.
Impact factor: 5.64
Publication type: Paper in international publication
Authors: Codina, Maria Gema, Martin, Maria Carmen, Castillo, Carla, Garcia-Comunas, Karen, Vasquez-Mercado, Rodrigo, Martins-Martins, Reginald, Colomer-Castell, Sergi, Pumarola, Tomas, Campins, Magda, Quer, Josep et al.
DOI: 10.3389/fmicb.2022.876409

A Nine-Strain Bacterial Consortium Improves Portal Hypertension and Insulin Signaling and Delays NAFLD Progression In Vivo.

PMID: 35625927
Journal: Biomedicines
Year: 2022
Reference: Biomedicines. 2022 May 20;10(5). pii: biomedicines10051191. doi: 10.3390/biomedicines10051191.
Impact factor: 6.081
Publication type: Paper in international publication
Authors: Augustin, Salvador, Martell, Maria, Salcedo, Maria Teresa, Pinheiro, Iris, Barbera, Aurora, Raurell, Imma, Estrella, Federico, de Leeuw, Marcel, Bolca, Selin, Gottardi, Davide et al.
DOI: 10.3390/biomedicines10051191

Non-Invasive Tests of Liver Fibrosis Help in Predicting the Development of Hepatocellular Carcinoma among Patients with NAFLD.

PMID: 35566592
Journal: Journal of Clinical Medicine
Year: 2022
Reference: J Clin Med. 2022 Apr 27;11(9). pii: jcm11092466. doi: 10.3390/jcm11092466.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Banares, Juan, Bermudez, Maria, Vargas, Victor, Salcedo-Allende, Maria Teresa, Castells, Lluis, Augustin, Salvador, Minguez, Beatriz, Pericas, Juan M, Manzano, Ramiro, Rivera-Esteban, Jesus et al.
DOI: 10.3390/jcm11092466

Cost-effectiveness analysis of an active search to retrieve HCV patients lost to follow-up (RELINK-C strategy) and the impact of COVID-19.

PMID: 35555847
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2022
Reference: J Viral Hepat. 2022 Jul;29(7):579-583. doi: 10.1111/jvh.13686. Epub 2022 May 23.
Impact factor: 3.728
Publication type: Paper in international publication
Authors: Vargas-Accarino, Elena, Martinez-Camprecios, Joan, Dominguez-Hernandez, Raquel, Rando-Segura, Ariadna, Riveiro-Barciela, Mar, Rodriguez-Frias, Francisco, Barreira, Ana, Palom, Adriana, Casado, Miguel Angel, Esteban, Rafael et al.
DOI: 10.1111/jvh.13686

Ki-67 immunoexpression and radiological assessment of necrosis improves accuracy of conventional and modified core biopsy systems in predicting the final grade assigned to adult-soft tissue sarcomas. An international collaborative study.

PMID: 34329836
Journal: PATHOLOGY RESEARCH AND PRACTICE
Year: 2021
Reference: Pathol Res Pract. 2021 Sep;225:153562. doi: 10.1016/j.prp.2021.153562. Epub 2021 Jul 22.
Impact factor: 3.25
Publication type: Paper in international publication
Authors: Navarro, Samuel, Cruz, Julia, Righi, Alberto, Gambarotti, Marco, Ferrari, Cristina, Ruengwanichayakun, Poosit, Giner, Francisco, Rausell, Nuria, Lavernia, Javier, Sugita, Shintaro et al.
DOI: 10.1016/j.prp.2021.153562

Partial restoration of immune response in Hepatitis C patients after viral clearance by direct-acting antiviral therapy.

PMID: 34242330
Journal: PLoS One
Year: 2021
Reference: PLoS One. 2021 Jul 9;16(7):e0254243. doi: 10.1371/journal.pone.0254243. eCollection 2021.
Impact factor: 3.24
Publication type: Paper in international publication
Authors: Llorens-Revull, Meritxell, Costafreda, Maria Isabel, Rico, Angie, Guerrero-Murillo, Mercedes, Soria, Maria Eugenia, Piriz-Ruzo, Sofia, Vargas-Accarino, Elena, Gabriel-Medina, Pablo, Rodriguez-Frias, Francisco, Riveiro-Barciela, Mar et al.
DOI: 10.1371/journal.pone.0254243

Acute interstitial nephritis associated with immune checkpoint inhibitors: a single-centre experience.

PMID: 34221369
Journal: Clinical Kidney Journal
Year: 2021
Reference: Clin Kidney J. 2020 Feb 10;14(5):1364-1370. doi: 10.1093/ckj/sfaa008. eCollection 2021 May.
Impact factor: 4.452
Publication type: Paper in international publication
Authors: Oleas, Diana, Bolufer, Monica, Agraz, Irene, Felip, Enriqueta, Munoz, Eva, Gabaldon, Alejandra, Bury, Roxana, Espinel, Eugenia, Seron, Daniel, Garcia-Carro, Clara et al.
DOI: 10.1093/ckj/sfaa008

GEIS-SEHOP clinical practice guidelines for the treatment of rhabdomyosarcoma.

PMID: 34212338
Journal: Clinical & Translational Oncology
Year: 2021
Reference: Clin Transl Oncol. 2021 Dec;23(12):2460-2473. doi: 10.1007/s12094-021-02654-1. Epub 2021 Jul 1.
Impact factor: 3.405
Publication type: Paper in international publication
Authors: Ruano, D, Rubio, P, Verges, R, Valverde, C, Gallego, S, Bernabeu, D, Hindi, N, Mata, C, Marquez, C, Orcajo, J et al.
DOI: 10.1007/s12094-021-02654-1

Steatosis as main determinant of portal hypertension through a restriction of hepatic sinusoidal area in a dietary rat nash model.

PMID: 32770818
Journal: LIVER INTERNATIONAL
Year: 2020
Reference: Liver Int. 2020 Nov;40(11):2732-2743. doi: 10.1111/liv.14632. Epub 2020 Oct 13.
Impact factor: 5.175
Publication type: Paper in international publication
Authors: Barbera, Aurora, Raurell, Imma, Garcia-Lezana, Teresa, Torres-Arauz, Manuel, Bravo, Miren, Hide, Diana, Gil, Mar, Salcedo, Maria Teresa, Genesca, Joan, Martell, Maria et al.
DOI: 10.1111/liv.14632

Sequential immunohistochemistry and virtual image reconstruction using a single slide for quantitative KI67 measurement in breast cancer.

PMID: 32707454
Journal: BREAST
Year: 2020
Reference: Breast. 2020 Oct;53:102-110. doi: 10.1016/j.breast.2020.07.002. Epub 2020 Jul 13.
Impact factor: 3.754
Publication type: Paper in international publication
Authors: Serna, Garazi, Simonetti, Sara, Fasani, Roberta, Pagliuca, Francesca, Guardia, Xavier, Gallego, Paqui, Jimenez, Jose, Peg, Vicente, Saura, Cristina, Eppenberger-Castori, Serenella et al.
DOI: 10.1016/j.breast.2020.07.002

Repolarization of tumor infiltrating macrophages and increased survival in mouse primary CNS lymphomas after XPO1 and BTK inhibition.

PMID: 32691208
Journal: JOURNAL OF NEURO-ONCOLOGY
Year: 2020
Reference: J Neurooncol. 2020 Aug;149(1):13-25. doi: 10.1007/s11060-020-03580-y. Epub 2020 Jul 20.
Impact factor: 3.267
Publication type: Paper in international publication
Authors: Purroy, Noelia, Jimenez, Isabel, Carabia, Julia, Bobillo, Sabela, Palacio, Carles, Abrisqueta, Pau, Pages, Carlota, Nieto, Juan C, Castellvi, Josep, Martinez-Ricarte, Francisco et al.
DOI: 10.1007/s11060-020-03580-y

Lung cancer biomarker testing: perspective from Europe.

PMID: 32676354
Journal: Translational Lung Cancer Research
Year: 2020
Reference: Transl Lung Cancer Res. 2020 Jun;9(3):887-897. doi: 10.21037/tlcr.2020.04.07.
Impact factor: 5.132
Publication type: Review in international publication
Authors: Eri, Zivka, Haragan, Alex, Leonte, Diana, Carvallo, Lina, Prince, Spasenja Savic, Nicholson, Siobhan, Sansano, Irene, Ryska, Ales, Dale, Vibeke G, Perner, Sven et al.
DOI: 10.21037/tlcr.2020.04.07

Impact of delayed and prolonged fixation on the evaluation of immunohistochemical staining on lung carcinoma resection specimen.

PMID: 31264038
Journal: VIRCHOWS ARCHIV
Year: 2019
Reference: Virchows Arch. 2019 Aug;475(2):191-199. doi: 10.1007/s00428-019-02595-9. Epub 2019 Jul 1.
Impact factor: 2.868
Publication type: Paper in international publication
Authors: Thunnissen, Erik, van Seijen, Maartje, Brcic, Luka, Gonzales, Atilio Navarro, Sansano, Irene, Bendek, Matyas, Brcic, Iva, Lissenberg-Witte, Birgit, Korkmaz, H Ibrahim, Geiger, Thomas et al.
DOI: 10.1007/s00428-019-02595-9

Optimization of Transbronchial Cryobiopsy in Lung Transplant Recipients.

PMID: 31229481
Journal: ANNALS OF THORACIC SURGERY
Year: 2019
Reference: Ann Thorac Surg. 2019 Oct;108(4):1052-1058. doi: 10.1016/j.athoracsur.2019.04.096. Epub 2019 Jun 21.
Impact factor: 3.919
Publication type: Paper in international publication
Authors: Loor, Karina, Culebras, Mario, Sansano, Irene, Alvarez, Antonio, Berastegui, Cristina, de Gracia, Javier et al.
DOI: 10.1016/j.athoracsur.2019.04.096

Salvage surgery after definitive chemo-radiotherapy for patients with Non-Small Cell Lung Cancer.

PMID: 31200817
Journal: LUNG CANCER
Year: 2019
Reference: Lung Cancer. 2019 Jul;133:117-122. doi: 10.1016/j.lungcan.2019.05.010. Epub 2019 May 13.
Impact factor: 4.599
Publication type: Paper in international publication
Authors: Romero-Vielva, Laura, Viteri, Santiago, Moya-Horno, Irene, Toscas, Jose Ignacio, Maestre-Alcacer, Jose Antonio, Ramon Y Cajal, Santiago, Rosell, Rafael et al.
DOI: 10.1016/j.lungcan.2019.05.010

Trabectedin and RAdiotherapy in Soft Tissue Sarcoma (TRASTS): Results of a Phase I Study in Myxoid Liposarcoma from Spanish (GEIS), Italian (ISG), French (FSG) Sarcoma Groups.

PMID: 31143880
Journal: EClinicalMedicine
Year: 2019
Reference: EClinicalMedicine. 2019 Mar 11;9:35-43. doi: 10.1016/j.eclinm.2019.03.007. eCollection 2019 Mar.
Impact factor: 0
Publication type: Paper in international publication
Authors: Romagosa, Cleofe, Ranchere-Vince, Dominique, Dei Tos, Angelo P, Casali, Paolo G, Martin-Broto, Javier, Sanfilippo, Roberta, Sunyach, Marie Pierre, Romero, Jesus, Gronchi, Alessandro, Hindi, Nadia et al.
DOI: 10.1016/j.eclinm.2019.03.007

Computer-based intensity measurement assists pathologists in scoring PTEN immunohistochemistry - Clinical associations in NSCLC patients of the ETOP Lungscape cohort.

PMID: 30240851
Journal: Journal of Thoracic Oncology
Year: 2018
Reference: J Thorac Oncol. 2018 Dec;13(12):1851-1863. doi: 10.1016/j.jtho.2018.08.2034. Epub 2018 Sep 18.
Impact factor: 10.336
Publication type: Paper in international publication
Authors: Geiger, Thomas, Tsourti, Zoi, Casanova, Ruben, Deml, Karl-Friedrich, Verbeken, Eric, Thunnissen, Erik, Warth, Arne, Cheney, Richard, Sejda, Aleksandra, Speel, Ernst Jan et al.
DOI: 10.1016/j.jtho.2018.08.2034

Extracellular HMGA1 promotes tumor Invasion and Metastasis in Triple-Negative Breast Cancer.

PMID: 30135148
Journal: CLINICAL CANCER RESEARCH
Year: 2018
Reference: Clin Cancer Res. 2018 Dec 15;24(24):6367-6382. doi: 10.1158/1078-0432.CCR-18-0517. Epub 2018 Aug 22.
Impact factor: 10.199
Publication type: Paper in international publication
Authors: Salvans, Candida, Pujals, Mireia, Fernandez, Yolanda, Abasolo, Ibane, Perez, Jose, Matres, Ana, Valeri, Marta, Gregori, Josep, Villarreal, Laura, Schwartz, Simo et al.
DOI: 10.1158/1078-0432.CCR-18-0517

High Resolution Computed Tomography and Fiberoptic Bronchoscopy in the Study of Severe Asthma.

PMID: 30054117
Journal: ARCHIVOS DE BRONCONEUMOLOGIA
Year: 2018
Reference: Arch Bronconeumol. 2018 Dec;54(12):627. doi: 10.1016/j.arbres.2018.05.018. Epub 2018 Jul 24.
Impact factor: 2.633
Publication type: Paper in national publication
Authors: Clofent, David, Sansano, Irene, Ojanguren, Inigo et al.
DOI: 10.1016/j.arbres.2018.05.018

STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis.

PMID: 29892069
Journal: NATURE MEDICINE
Year: 2018
Reference: Nat Med. 2018 Jul;24(7):1024-1035. doi: 10.1038/s41591-018-0044-4. Epub 2018 Jun 11.
Impact factor: 32.621
Publication type: Paper in international publication
Authors: Priego, Neibla, Zhu, Lucia, Monteiro, Catia, Mulders, Manon, Wasilewski, David, Bindeman, Wendy, Doglio, Laura, Martinez, Liliana, Martinez-Saez, Elena, Cajal, Santiago Ramon Y et al.
DOI: 10.1038/s41591-018-0044-4

Clinical outcomes of patients undergoing antiviral therapy while awaiting liver transplantation.

PMID: 28842296
Journal: JOURNAL OF HEPATOLOGY
Year: 2017
Reference: J Hepatol. 2017 Dec;67(6):1168-1176. doi: 10.1016/j.jhep.2017.08.008. Epub 2017 Aug 24.
Impact factor: 12.486
Publication type: Paper in international publication
Authors: Nogueras, Flor, Giraldez, Alvaro, Prieto, Martin, Forns, Xavier, Londono, Maria-Carlota, Narvaez, Isidoro, Sanchez-Antolin, Gloria, Salcedo, Magdalena, Pascasio, Juan Manuel, Vinaixa, Carmen et al.
DOI: 10.1016/j.jhep.2017.08.008

Absence of Relationship between Mitochondrial DNA Haplogroups and Cisplatin-Induced Hearing Loss.

PMID: 28757873
Journal: International journal of otolaryngology
Year: 2017
Reference: Int J Otolaryngol. 2017;2017:5185268. doi: 10.1155/2017/5185268. Epub 2017 Jul 3.
Impact factor: 0
Publication type: Paper in international publication
Authors: Graterol, D, Mir, C, Garcia-Vaquero, C, Brana, I, Pardo, A N, Rochera-Villach, M I, Lyakhovich, A, LLeonart, M E, Lorente, J et al.
DOI: 10.1155/2017/5185268

A Novel Single-Cell FISH-Flow Assay Identifies Effector Memory CD4+ T cells as a Major Niche for HIV-1 Transcription in HIV-Infected Patients.

PMID: 28698276
Journal: mBio
Year: 2017
Reference: MBio. 2017 Jul 11;8(4). pii: e00876-17. doi: 10.1128/mBio.00876-17.
Impact factor: 6.956
Publication type: Paper in international publication
Authors: Buzon, Maria J, Crespo, Manuel, Falco, Vicenc, Grau-Exposito, Judith, Miguel, Lucia, Navarro, Jordi, Curran, Adria, Burgos, Joaquin, Ocana, Imma, Ribera, Esteban et al.
DOI: 10.1128/mBio.00876-17

Overexpression of Yes Associated Protein 1, an Independent Prognostic Marker in Patients With Pancreatic Ductal Adenocarcinoma, Correlated With Liver Metastasis and Poor Prognosis.

PMID: 28697132
Journal: PANCREAS
Year: 2017
Reference: Pancreas. 2017 Aug;46(7):913-920. doi: 10.1097/MPA.0000000000000867.
Impact factor: 2.967
Publication type: Paper in international publication
Authors: Tabernero, Josep, Salcedo Allende, Maria Teresa, Zeron-Medina, Jorge, Hernandez, Javier, Macarulla, Teresa, Balsells, Joaquim, Merino, Xavier, Allende, Helena, Ramon Y Cajal Agueras, Santiago et al.
DOI: 10.1097/MPA.0000000000000867

peIF4E as an independent prognostic factor and a potential therapeutic target in diffuse infiltrating astrocytomas.

PMID: 27440383
Journal: Cancer Medicine
Year: 2016
Reference: Cancer Med. 2016 Sep;5(9):2501-12. doi: 10.1002/cam4.817. Epub 2016 Jul 20.
Impact factor: 2.915
Publication type: Paper in international publication
Authors: Ortega-Aznar, Arantxa, Martinez-Ricarte, Francisco, Camacho, Jessica, Hernandez-Losa, Javier, Ferreres Pinas, Joan Carles, Ramon Y Cajal, Santiago, Peg, Vicente, Martinez-Saez, Elena et al.
DOI: 10.1002/cam4.817

The cancer stem-cell signaling network and resistance to therapy.

PMID: 27434881
Journal: CANCER TREATMENT REVIEWS
Year: 2016
Reference: Cancer Treat Rev. 2016 Sep;49:25-36. doi: 10.1016/j.ctrv.2016.07.001. Epub 2016 Jul 9.
Impact factor: 7.983
Publication type: Review in international publication
Authors: Carnero, A, Garcia-Mayea, Y, Mir, C, Lorente, J, Rubio, I T, LLeonart, M E et al.
DOI: 10.1016/j.ctrv.2016.07.001

The hypoxic microenvironment: A determinant of cancer stem cell evolution.

PMID: 27417124
Journal: BIOESSAYS
Year: 2016
Reference: Bioessays. 2016 Jul;38 Suppl 1:S65-74. doi: 10.1002/bies.201670911.
Impact factor: 4.725
Publication type: Review in national publication
Authors: Carnero, Amancio, Lleonart, Matilde et al.
DOI: 10.1002/bies.201670911

Different Prognostic Implications of Residual Disease After Neoadjuvant Treatment: Impact of Ki 67 and Site of Response.

PMID: 27357178
Journal: ANNALS OF SURGICAL ONCOLOGY
Year: 2016
Reference: Ann Surg Oncol. 2016 Nov;23(12):3831-3837. doi: 10.1245/s10434-016-5339-4. Epub 2016 Jun 29.
Impact factor: 3.655
Publication type: Paper in international publication
Authors: Diaz-Botero, Sebastian, Espinosa-Bravo, Martin, Goncalves, Victor Rodrigues, Esgueva-Colmenarejo, Antonio, Peg, Vicente, Perez, Jose, Cortes, Javier, Rubio, Isabel T et al.
DOI: 10.1245/s10434-016-5339-4

Expression of semaphorin 3A, semaphorin 7A and their receptors in multiple sclerosis lesions.

PMID: 26432853
Journal: Multiple Sclerosis Journal
Year: 2015
Reference: Mult Scler. 2015 Nov;21(13):1632-43. doi: 10.1177/1352458515599848. Epub 2015 Oct 2.
Impact factor: 4.822
Publication type: Paper in international publication
Authors: Costa, C, Martinez-Saez, E, Gutierrez-Franco, A, Eixarch, H, Castro, Z, Ortega-Aznar, A, Ramon Y Cajal, S, Montalban, X, Espejo, C et al.
DOI: 10.1177/1352458515599848

Identification of somatic gene mutations in penile squamous cell carcinoma.

PMID: 26216163
Journal: GENES CHROMOSOMES & CANCER
Year: 2015
Reference: Genes Chromosomes Cancer. 2015 Oct;54(10):629-37. doi: 10.1002/gcc.22274. Epub 2015 Jul 27.
Impact factor: 4.041
Publication type: Paper in international publication
Authors: Valverde, Claudia, Salvador, Carlos, Placer, Jose, Morote, Juan, Pujol, Ramon M, Ramon, Santiago, Cajal, Y, de Torres, Ines, Toll, Agusti, Garcia-Patos, Vicente et al.
DOI: 10.1002/gcc.22274

Tenofovir discontinuation after long-term viral suppression in HBeAg negative chronic hepatitis B. Can HBsAg levels be useful?

PMID: 26071338
Journal: JOURNAL OF CLINICAL VIROLOGY
Year: 2015
Reference: J Clin Virol. 2015 Jul;68:61-8. doi: 10.1016/j.jcv.2015.05.002. Epub 2015 May 8.
Impact factor: 3.016
Publication type: Paper in international publication
Authors: Buti, Maria, Casillas, Rosario, Riveiro-Barciela, Mar, Homs, Maria, Tabernero, David, Salcedo, Maria Teresa, Rodriguez-Frias, Francisco, Esteban, Rafael et al.
DOI: 10.1016/j.jcv.2015.05.002

Expression of YY1 in Differentiated Thyroid Cancer.

PMID: 25698133
Journal: ENDOCRINE PATHOLOGY
Year: 2015
Reference: Endocr Pathol. 2015 May;26(2):111-8. doi: 10.1007/s12022-015-9359-6.
Impact factor: 1.757
Publication type: Paper in international publication
Authors: Arribas, Jessica, Castellvi, Josep, Marcos, Ricard, Zafon, Carles, Velazquez, Antonia et al.
DOI: 10.1007/s12022-015-9359-6

Comparing transplant glomerulopathy in the absence of C4d deposition and donor-specific antibodies to chronic antibody-mediated rejection.

PMID: 25103874
Journal: CLIN TRANSPLANT
Year: 2014
Reference: Clin Transplant. 2014 Oct;28(10):1148-54. doi: 10.1111/ctr.12433. Epub 2014 Sep 11.
Impact factor: 1.486
Publication type: Paper in international publication
Authors: Torres, Irina B, Salcedo, Maite, Moreso, Francesc, Sellares, Joana, Castella, Eva, Azancot, M Antonieta, Perello, Manel, Cantarell, Carme, Seron, Daniel et al.
DOI: 10.1111/ctr.12433

Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer.

PMID: 25261936
Journal: MOL CANCER
Year: 2014
Reference: Mol Cancer. 2014 Sep 27;13:223. doi: 10.1186/1476-4598-13-223.
Impact factor: 5.397
Publication type: Paper in international publication
Authors: Cueva, Juan, Vieito, Maria, Ortega, Eugenia, Mariscal, Javier, Colas, Eva, Castellvi, Josep, Cusido, Maite, Dolcet, Xavier, Nijman, Hans W, Bosse, Tjalling et al.
DOI: 10.1186/1476-4598-13-223

MicroRNAs as prognostic markers in ovarian cancer.

PMID: 24747602
Journal: MOL CELL ENDOCRINOL
Year: 2014
Reference: Mol Cell Endocrinol. 2014 Jun 5;390(1-2):73-84. doi: 10.1016/j.mce.2014.03.006. Epub 2014 Apr 18.
Impact factor: 4.241
Publication type: Review in international publication
Authors: Altadill, Tatiana, Llaurado, Marta, Majem, Blanca, Sanchez-Iglesias, Jose Luis, Cabrera, Silvia, De la Torre, Javier, Diaz-Feijoo, Berta, Perez-Benavente, Asuncion, Colas, Eva, Olivan, Mireia et al.
DOI: 10.1016/j.mce.2014.03.006

Ghost cell odontogenic carcinoma: A rare case report and review of literature.

PMID: 25674335
Journal: J CLIN EXP NEUROPSYC
Year: 2014
Reference: J Clin Exp Dent. 2014 Dec 1;6(5):e602-6. doi: 10.4317/jced.51809. eCollection 2014 Dec.
Impact factor:
Publication type: Letter or abstract
Authors: Martos-Fernandez, Miriam, Alberola-Ferranti, Margarita, Hueto-Madrid, Juan Antonio, Bescos-Atin, Coro et al.
DOI: 10.4317/jced.51809

Prediction of non-sentinel lymph node metastasis in early breast cancer by assessing total tumoral load in the sentinel lymph node by molecular assay.

PMID: 23607911
Journal: EJSO
Year: 2013
Reference: Eur J Surg Oncol. 2013 Jul;39(7):766-73. doi: 10.1016/j.ejso.2013.03.011. Epub 2013 Apr 19.
Impact factor: 2.614
Publication type: Paper in international publication
Authors: Espinosa-Bravo, M, Sansano, I, Perez-Hoyos, S, Ramos, M, Sancho, M, Xercavins, J, Rubio, I T, Peg, V et al.
DOI: 10.1016/j.ejso.2013.03.011

SPECT/CT sentinel lymph node identification in papillary thyroid cancer: lymphatic staging and surgical management improvement.

PMID: 23907326
Journal: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
Year: 2013
Reference: Eur J Nucl Med Mol Imaging. 2013 Oct;40(11):1645-55. doi: 10.1007/s00259-013-2476-x. Epub 2013 Aug 2.
Impact factor: 5.114
Publication type: Paper in international publication
Authors: Vilallonga, Ramon, Caubet, Enric, Fort, Jose Manuel, Mesa, Jordi, Armengol, Manuel, Castell-Conesa, Joan, Iglesias, Carmela, Serres, Xavier, Sabate, Monica, Garcia-Burillo, Amparo et al.
DOI: 10.1007/s00259-013-2476-x

Emerging role for the voltage-dependent K+ channel Kv1.5 in B-lymphocyte physiology: expression associated with human lymphoma malignancy.

PMID: 23847097
Journal: JOURNAL OF LEUKOCYTE BIOLOGY
Year: 2013
Reference: J Leukoc Biol. 2013 Oct;94(4):779-89. doi: 10.1189/jlb.0213094. Epub 2013 Jul 11.
Impact factor: 4.568
Publication type: Paper in international publication
Authors: Vallejo-Gracia, Albert, Bielanska, Joanna, Hernandez-Losa, Javier, Castellvi, Josep, Ruiz-Marcellan, M Carmen, Ramon Y Cajal, Santiago, Condom, Enric, Manils, Joan, Soler, Concepcio, Comes, Nuria et al.
DOI: 10.1189/jlb.0213094

Multidisciplinary management of a giant plexiform neurofibroma by double sequential preoperative embolization and surgical resection.

PMID: 23607010
Journal: Case Reports in Neurological Medicine
Year: 2013
Reference: Case Rep Neurol Med. 2013;2013:987623. doi: 10.1155/2013/987623. Epub 2013 Mar 28.
Impact factor:
Publication type: Letter or abstract
Authors: Velez, Roberto, Barrera-Ochoa, Sergi, Barastegui, David, Perez-Lafuente, Mercedes, Romagosa, Cleofe, Perez, Manuel et al.
DOI: 10.1155/2013/987623

Risk factors for progression or persistence of squamous intraepithelial lesions diagnosed during pregnancy.

PMID: 22126830
Journal: Journal of Lower Genital Tract Disease
Year: 2012
Reference: J Low Genit Tract Dis. 2012 Jan;16(1):34-8.
Impact factor: 1.069
Publication type: Paper in international publication
Authors: Cubo-Abert, Montserrat, Centeno-Mediavilla, Cristina, Franco-Zabala, Patricia, Merced-Vazquez, Carmen, Castellvi, Josep, Garcia, Angel, Gil-Moreno, Antonio, Xercavins, Jordi et al.
DOI: 10.1097/LGT.0b013e31822e83cf

ErbB3 expression predicts sensitivity to elisidepsin treatment: in vitro synergism with cisplatin, paclitaxel and gemcitabine in lung, breast and colon cancer cell lines.

PMID: 22485250
Journal: INTERNATIONAL JOURNAL OF ONCOLOGY
Year: 2012
Reference: Int J Oncol. 2012 Jul;41(1):317-24. doi: 10.3892/ijo.2012.1425. Epub 2012 Apr 3.
Impact factor: 2.399
Publication type: Paper in international publication
Authors: , , , , , , , , et al.
DOI: 10.3892/ijo.2012.1425

Molecular prescreening to select patient population in early clinical trials.

PMID: 22473105
Journal: Nature Reviews Clinical Oncology
Year: 2012
Reference: Nat Rev Clin Oncol. 2012 Apr 3;9(6):359-66. doi: 10.1038/nrclinonc.2012.48.
Impact factor: 11.963
Publication type: Paper in international publication
Authors: , , , , , , et al.
DOI: 10.1038/nrclinonc.2012.48

Differential expression of Kv1.3 and Kv1.5 voltage-dependent K+ channels in human skeletal muscle sarcomas.

PMID: 22360360
Journal: CANCER INVESTIGATION
Year: 2012
Reference: Cancer Invest. 2012 Mar;30(3):203-8.
Impact factor: 1.847
Publication type: Paper in international publication
Authors: Moline, Teresa, Somoza, Rosa, Ramon y Cajal, Santiago, Condom, Enric, Ferreres, Joan Carles, Felipe, Antonio, Hernandez-Losa, Javier, Bielanska, Joanna et al.
DOI: 10.3109/07357907.2012.654872

Molecular markers of endometrial carcinoma detected in uterine aspirates.

PMID: 21207424
Journal: INTERNATIONAL JOURNAL OF CANCER
Year: 2011
Reference: Int J Cancer. 2011 Nov 15;129(10):2435-44. doi: 10.1002/ijc.25901. Epub 2011 Apr 8.
Impact factor: 4.926
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1002/ijc.25901

RSK4 Inhibition Results in Bypass of Stress-Induced and Oncogene-Induced Senescence.

PMID: 21239520
Journal: CARCINOGENESIS
Year: 2011
Reference: Carcinogenesis. 2011 Apr;32(4):470-6. Epub 2011 Jan 14.
Impact factor: 5.402
Publication type: Paper in international publication
Authors: , , , , , , et al.
DOI: 10.1093/carcin/bgr003

[Oral nutritional supplementation in hematologic patients]

PMID: 19266107
Journal: Nutricion Hospitalaria
Year: 2009
Reference: Nutr Hosp. 2009 Jan-Feb;24(1):10-6.
Impact factor: 1.096
Publication type: Review or editorial in national publication
Authors: Perez-Portabella, C, Palacios, A, Julia, A, Planas, M, Rossello, J, San Martin, A, Penalva, A et al.
DOI:

Association of congenital hypothalamic hamartoma and hairy polyp.

PMID: 19241449
Journal: ULTRASOUND IN OBSTETRICS & GYNECOLOGY
Year: 2009
Reference: Ultrasound Obstet Gynecol. 2009 May;33(5):609-10.
Impact factor: 2.69
Publication type: Letter or abstract
Authors: Planas, S, Ferreres, J C, Ortega, A, Higueras, T, Carreras, E, Ramon Y Cajal, S, Toran, N et al.
DOI: 10.1002/uog.6314

Rplp1 bypasses replicative senescence and contributes to transformation.

PMID: 19233166
Journal: EXPERIMENTAL CELL RESEARCH
Year: 2009
Reference: Exp Cell Res. 2009 May 1;315(8):1372-83.
Impact factor: 3.948
Publication type: Paper in international publication
Authors: Kondoh, H, Fernandez-Marcos, P J, Serrano, M, Ramon y Cajal, S, Lleonart, M E, Lleonart Pajarin, Matilde, Artero-Castro, A et al.
DOI: 10.1016/j.yexcr.2009.02.007

Cold-inducible RNA-binding protein bypasses replicative senescence in primary cells through extracellular signal-regulated kinase 1 and 2 activation.

PMID: 19158277
Journal: MOLECULAR AND CELLULAR BIOLOGY
Year: 2009
Reference: Mol Cell Biol. 2009 Apr;29(7):1855-68.
Impact factor: 5.942
Publication type: Paper in international publication
Authors: Artero-Castro, Ana, Callejas, Francisco B, Castellvi, Josep, Kondoh, Hiroshi, Carnero, Amancio, Fernandez-Marcos, Pablo J, Serrano, Manuel, Ramon y Cajal, Santiago, Lleonart, Matilde E et al.
DOI: 10.1128/MCB.01386-08

Blog

News

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

On World Cancer Research Day, we highlight the oncology research model of the Vall d'Hebron Campus that allows laboratory results to be transferred as quickly as possible to clinical practice.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

Icona fitxers

Current Rates

PDF 0.25 MB

Icona fitxers

Rates Anatomia Patologica VHIR 2021

PDF 0.22 MB