Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
The role of MNK kinases in cellular stress resistance.
The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Team

Josep Castellví Vives

Translational Molecular Pathology
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Marta Cano Galietero

Research technician
Translational Molecular Pathology
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Marta Sese Faustino

Postdoctoral researcher
Translational Molecular Pathology
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Mercedes Martinez Mansilla

Research technician
Translational Molecular Pathology
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Miquel Roig Moline

Maintenance staff and general services
Translational Molecular Pathology
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Santiago Ramon y Cajal Agüeras

Head of group
Translational Molecular Pathology
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Josep Castellví Vives

Translational Molecular Pathology
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Marta Cano Galietero

Research technician
Translational Molecular Pathology
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Marta Sese Faustino

Postdoctoral researcher
Translational Molecular Pathology
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Mercedes Martinez Mansilla

Research technician
Translational Molecular Pathology
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Miquel Roig Moline

Maintenance staff and general services
Translational Molecular Pathology
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Santiago Ramon y Cajal Agüeras

Head of group
Translational Molecular Pathology
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Research lines

Study of PTOV1 modulation in tumor proliferation and progression : Interaction with IGF1 pathways. Notch and Wnt expression in TMAs of tumors.

To evaluate the expression (nuclear and cytoplasmatic) of PTOV1 , Notch and Wnt on TMAs in c different histological types of carcinomas with low and high grades of malignancy . To correlate the inmunoexpression with classical parameters of tumor behaviour : tumoral size, grade of malignancy, vascular permeation, lymph nodes metastasis in each histological subtype and demonstrated the role of PTOV1 as predictive molecular marker in carcinomas.

(Research Biomedical Unit)

IP: Inés de Torres Ramirez

Projects

Papel de la proteína MFGE8 como potencial biomarcador y diana terapéutica en la angiopatía amiloide cerebral

IP: Maria Mar Hernandez Guillamon
Collaborators: Berta Paez Montserrat, Kerrie Adrián Campbell, Jessica Camacho Soriano, Anas Chaachou Charradi, Olalla Pancorbo Rosal
Funding agency: Instituto de Salud Carlos III
Funding: 208750
Reference: PI23/00082
Duration: 01/01/2024 - 31/12/2026

Targeting extracelluar vesicel mediated intercellular communication as a novel approach to combat cancer metastasis.

IP: Stefan Hummer
Collaborators: Santiago Ramon y Cajal Agüeras, Elena Muro Blanc, Vicente Peg Camara, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras
Funding agency: Fundación Ramón Areces
Funding: 127486
Reference: CIVP21S13325
Duration: 06/07/2023 - 05/07/2026

INtegrative GENomic, digital Imaging and clinical information towars Precision Oncology Optimization – INGENIO

IP: Santiago Ramon y Cajal Agüeras
Collaborators: Jordi Temprana Salvador, Josep Castellví Vives, Joaquim Mateo Valderrama, Javier Hernandez Losa, Vicente Peg Camara, Irene Sansano Valero
Funding agency: Instituto de Salud Carlos III
Funding: 80400
Reference: PMP21/00107
Duration: 01/01/2022 - 31/12/2025

ESTUDIO DEL PAPEL DE LA CENTRALIZACIÓN DEL DIAGNÓSTICO ANATOMOPATOLÓGICO Y LA APLICACIÓN DE ESTRATÉGIAS DE MEDICINA DE PRECISIÓN EN SARCOMAS

IP: Cleofé Romagosa Pérez-Portabell
Collaborators: Xavier Martínez Gómez, Ximena Garcia Torres
Funding agency: Asociación Española Contra el Cáncer
Funding: 270130
Reference: ECAEC222952DEAL
Duration: 01/12/2022 - 30/11/2027

Publications

Decoding BCOR-ITD Sarcomas: Case Report of a Rare Pediatric Tumor With Challenges in Diagnosis.

PMID: 38762770
Journal: PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
Year: 2024
Reference: Pediatr Dev Pathol. 2024 May 19:10935266241249344. doi: 10.1177/10935266241249344.
Impact factor:
Publication type: Paper in international publication
Authors: Garrido-Pontnou, Marta; Medina-Ceballos, Emilio; Navarro, Samuel; Niveiro, Maria; Sese, Marta; Tasso, Maria; Urena-Horno, Laura et al.
DOI: 10.1177/10935266241249344

Intracranial thrombus composition is associated with occlusion location and endovascular treatment outcomes: results from ITACAT multicenter study.

PMID: 38816201
Journal: Journal of NeuroInterventional Surgery
Year: 2024
Reference: J Neurointerv Surg. 2024 May 30:jnis-2024-021654. doi: 10.1136/jnis-2024-021654.
Impact factor:
Publication type: Paper in international publication
Authors: Camacho, Jessica; Cardona Portela, Pere; de Dios Lascuevas, Marta; De La Torre, Carolina; Diana, Francesco; Dorado, Laura; Garcia-Tornel, Alvaro; Hernandez, David; Hernandez-Perez, Maria; Juega, Jesus et al.
DOI: 10.1136/jnis-2024-021654

Perivascular Epithelioid Cell Neoplasm (PEComa) harboring TFE3 gene rearrangements in a patient with Lynch syndrome.

PMID: 38852779
Journal: Gastroenterologia y Hepatologia
Year: 2024
Reference: Gastroenterol Hepatol. 2024 Jun 7:502217. doi: 10.1016/j.gastrohep.2024.502217.
Impact factor:
Publication type: Paper in international publication
Authors: B Larque, Ana; Balaguer, Francesc; Castrejon, Natalia; Cuatrecasas, Miriam; Diaz-Mercedes, Sherley; Frigola, Gerard; Landolfi, Stefania; M Lacy, Antonio; Martinez Ciarpaglini, Carolina; Musulen Palet, Eva et al.
DOI: 10.1016/j.gastrohep.2024.502217

Intraepithelial CD15 infiltration identifies high grade anal dysplasia in people with HIV.

PMID: 38900571
Journal: JCI Insight
Year: 2024
Reference: JCI Insight. 2024 Jun 20:e175251. doi: 10.1172/jci.insight.175251.
Impact factor:
Publication type: Paper in international publication
Authors: Astorga-Gamaza, Antonio; Benitez-Martinez, Aleix; Burgos, Joaquin; Buzon, Maria J; Castellvi, Josep; Curran, Adria; Falco, Vicenc; Garcia-Perez, Jorge N; Genesca, Meritxell; Landolfi, Stefania et al.
DOI: 10.1172/jci.insight.175251

Immunopathological Mechanisms of Bird-Related Hypersensitivity Pneumonitis.

PMID: 36769205
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2023
Reference: Int J Mol Sci. 2023 Feb 2;24(3):2884. doi: 10.3390/ijms24032884.
Impact factor:
Publication type: Paper in international publication
Authors: Cruz, Maria Jesus; de Homdedeu, Miquel; Munoz, Xavier; Ojanguren, Inigo; Romero-Mesones, Christian; Sanchez-Diez, Silvia; Sansano, Irene et al.
DOI: 10.3390/ijms24032884

Digital Quantification of Tumor Cellularity as a Novel Prognostic Feature of Non-Small Cell Lung Carcinoma.

PMID: 36788101
Journal: MODERN PATHOLOGY
Year: 2023
Reference: Mod Pathol. 2023 Mar;36(3):100055. doi: 10.1016/j.modpat.2022.100055. Epub 2023 Jan 10.
Impact factor:
Publication type: Paper in international publication
Authors: Bandari, Ela; Bikash, Binit; Cecchini, Matthew J; Keow, Samantha; Lam, Victor H K; Lin, Sherman; Loggie, John; Martinez-Acevedo, Jacobo; Misra, Tanya; Pham, Michelle et al.
DOI: 10.1016/j.modpat.2022.100055

Corrigendum to "New opacities in lung allograft after transbronchial cryobiopsy" [Respir. Med. 170 106043 (2020) 1-6/YRMED-D-20-00230].

PMID: 36796295
Journal: RESPIRATORY MEDICINE
Year: 2023
Reference: Respir Med. 2023 Apr;209:107151. doi: 10.1016/j.rmed.2023.107151. Epub 2023 Feb 14.
Impact factor:
Publication type: Letter or abstract
Authors: Alvarez, Antonio; Berastegui, Cristina; Clofent, David; Culebras, Mario; de Gracia, Javier; Deu, Maria; Loor, Karina; Loor, Karina; Pallisa, Esther; Polverino, Eva et al.
DOI: 10.1016/j.rmed.2023.107151

Thyroid cells from normal and autoimmune thyroid glands suppress T lymphocytes proliferation upon contact revealing a new regulatory inhibitory type of interaction independent of PD1/PDL1.

PMID: 36857863
Journal: JOURNAL OF AUTOIMMUNITY
Year: 2023
Reference: J Autoimmun. 2023 Apr;136:103013. doi: 10.1016/j.jaut.2023.103013. Epub 2023 Feb 27.
Impact factor:
Publication type: Paper in international publication
Authors: Abad, Maria; Alvarez-Sierra, Daniel; Bello, Irene; Caubet, Enric; Cruz Cobo, Maria; Cruz Cobo, Maria; Escriche, Alba; Escriche, Alba; Fernandez-Sanmartin, Marco Antonio; Gomez-Brey, Aroa et al.
DOI: 10.1016/j.jaut.2023.103013

Myosin Vb as a tumor suppressor gene in intestinal cancer.

PMID: 36316444
Journal: ONCOGENE
Year: 2022
Reference: Oncogene. 2022 Dec;41(49):5279-5288. doi: 10.1038/s41388-022-02508-2. Epub 2022 Nov 1.
Impact factor:
Publication type: Paper in international publication
Authors: Anguita, Estefania; Arango, Diego; Brotons, Bruno; Carton-Garcia, Fernando; Dalmau, Mariona; Dopeso, Higinio; Garcia-Vidal, Elia; Hernandez-Losa, Javier; Landolfi, Stefania; Macaya, Irati et al.
DOI: 10.1038/s41388-022-02508-2

Genetic and functional homologous repair deficiency as biomarkers for platinum sensitivity in TNBC: A case report.

PMID: 36185283
Journal: Frontiers in Oncology
Year: 2022
Reference: Front Oncol. 2022 Sep 14;12:963728. doi: 10.3389/fonc.2022.963728. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Balmana, Judith; Cruellas, Mara; De La Torre, Javier; Gomez-Puerto, Diego; Llop-Guevara, Alba; Peg, Vicente; Pimentel, Isabel; Torres-Esquius, Sara et al.
DOI: 10.3389/fonc.2022.963728

Risk of infections in patients with NAFLD and Type 2 Diabetes under treatment with SGLT2 inhibitors and relationship with liver outcomes: A retrospective case-control study.

PMID: 36093073
Journal: Frontiers in Endocrinology
Year: 2022
Reference: Front Endocrinol (Lausanne). 2022 Aug 24;13:945626. doi: 10.3389/fendo.2022.945626. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Banares, Juan; Camps-Relats, Laura; Ciudin, Andreea; Genesca, Joan; Manzano-Nunez, Ramiro; Pericas, Juan M; Pons, Monica; Prio, Alba; Rivera-Esteban, Jesus; Ruiz-Ortega, Lourdes et al.
DOI: 10.3389/fendo.2022.945626

High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER(+) breast cancer.

PMID: 36071033
Journal: Nature Communications
Year: 2022
Reference: Nat Commun. 2022 Sep 7;13(1):5258. doi: 10.1038/s41467-022-32828-6.
Impact factor:
Publication type: Paper in international publication
Authors: Arnedos, Monica; Arribas, Joaquin; Azaro, Analia; Bellet, Meritxell; Braso-Maristany, Fara; Bruna, Alejandra; Caldas, Carlos; Capelan, Marta; Clarke, Robert B; Dienstmann, Rodrigo et al.
DOI: 10.1038/s41467-022-32828-6

Genetic evolution to tyrosine kinase inhibitory therapy in patients with EGFR-mutated non-small-cell lung cancer.

PMID: 34599295
Journal: BRITISH JOURNAL OF CANCER
Year: 2021
Reference: Br J Cancer. 2021 Nov;125(11):1561-1569. doi: 10.1038/s41416-021-01558-9. Epub 2021 Oct 1.
Impact factor:
Publication type: Paper in international publication
Authors: Callejo, Ana; Caratu, Ginevra; Cedres, Susana; Diaz-Mejia, Nely; Felip, Enriqueta; Iranzo, Patricia; Mancuso, Francesco Mattia; Martinez-Marti, Alex; Matito, Judit; Miquel, Josep Maria et al.
DOI: 10.1038/s41416-021-01558-9

Predictive value of MRP-1 in localized high-risk soft tissue sarcomas: a translational research associated to ISG-STS 1001 randomized phase III trial.

PMID: 34552008
Journal: MOLECULAR CANCER THERAPEUTICS
Year: 2021
Reference: Mol Cancer Ther. 2021 Dec;20(12):2539-2552. doi: 10.1158/1535-7163.MCT-21-0315. Epub 2021 Sep 22.
Impact factor:
Publication type: Paper in international publication
Authors: Bague, Silvia; Barisella, Marta; Blay, Jean-Yves; Braglia, Luca; Brunello, Antonella; Casali, Paolo G; Coindre, Jean-Michel; Collini, Paola; Dei Tos, Angelo Paolo; Dopazo, Joaquin et al.
DOI: 10.1158/1535-7163.MCT-21-0315

MFG-E8 (LACTADHERIN): a novel marker associated with cerebral amyloid angiopathy.

PMID: 34530925
Journal: Acta Neuropathologica Communications
Year: 2021
Reference: Acta Neuropathol Commun. 2021 Sep 16;9(1):154. doi: 10.1186/s40478-021-01257-9.
Impact factor:
Publication type: Paper in international publication
Authors: Bonaterra-Pastra, Anna; Camacho, Jessica; Castillo-Ribelles, Laura; de Kort, Anna M; Delgado, Pilar; Hernandez-Guillamon, Mar; Klijn, Catharina J M; Kuiperij, H Bea; Marazuela, Paula; Martinez-Saez, Elena et al.
DOI: 10.1186/s40478-021-01257-9

Dissecting Breast Cancer Circulating Tumor Cells Competence via Modelling Metastasis in Zebrafish.

PMID: 34502201
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2021
Reference: Int J Mol Sci. 2021 Aug 27;22(17). pii: ijms22179279. doi: 10.3390/ijms22179279.
Impact factor:
Publication type: Paper in international publication
Authors: Abal, Miguel; Abuin, Carmen; Cajal, Santiago Ramon Y; Carmona-Ule, Nuria; Chaachou, Anas; Davila-Ibanez, Ana Belen; Hernandez-Losa, Javier; Hurtado, Pablo; Lopez-Lopez, Rafael; Martinez-Pena, Ines et al.
DOI: 10.3390/ijms22179279

Frequency and Clinicopathological Profile Associated with Braf Mutations in Patients with Advanced Melanoma in Spain.

PMID: 32422543
Journal: Translational Oncology
Year: 2020
Reference: Transl Oncol. 2020 Jun;13(6):100750. doi: 10.1016/j.tranon.2020.100750. Epub 2020 May 15.
Impact factor:
Publication type: Paper in international publication
Authors: Alos Hernandez, Lucia; Arance Fernandez, Ana; Cerezuela Fuentes, Pablo; Ferrer Fabrega, Berta; Hernandez-Losa, Javier; Lopez-Martin, Jose A; Marti, Rosa M; Ortega Izquierdo, Eugenia; Ortiz Reina, Sebastian; Rios-Martin, Juan Jose et al.
DOI: 10.1016/j.tranon.2020.100750

New opacities in lung allograft after transbronchial cryobiopsy.

PMID: 32843174
Journal: RESPIRATORY MEDICINE
Year: 2020
Reference: Respir Med. 2020 Aug - Sep;170:106043. doi: 10.1016/j.rmed.2020.106043. Epub 2020 May 25.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez, Antonio; Berastegui, Cristina; Clofent, David; Culebras, Mario; de Gracia, Javier; Deu, Maria; Loor, Karina; Loor, Karina; Pallisa, Esther; Polverino, Eva et al.
DOI: 10.1016/j.rmed.2020.106043

Five simple reasons to discard DIP, or why we should stop calling dolphins big fish.

PMID: 32843423
Journal: JOURNAL OF CLINICAL PATHOLOGY
Year: 2020
Reference: J Clin Pathol. 2020 Nov;73(11):762-768. doi: 10.1136/jclinpath-2020-206669. Epub 2020 Aug 25.
Impact factor:
Publication type: Review in international publication
Authors: Aesif, Scott W; Mukhopadhyay, Sanjay; Sansano, Irene et al.
DOI: 10.1136/jclinpath-2020-206669

ITGB3-mediated uptake of small extracellular vesicles facilitates intercellular communication in breast cancer cells.

PMID: 32848136
Journal: Nature Communications
Year: 2020
Reference: Nat Commun. 2020 Aug 26;11(1):4261. doi: 10.1038/s41467-020-18081-9.
Impact factor:
Publication type: Paper in international publication
Authors: Emperador, Marta; Fuentes, Pedro; Guijarro, Pedro J; Hummer, Stefan; Peinado, Hector; Ramon Y Cajal, Santiago; Sanchez-Redondo, Sara; Sese, Marta et al.
DOI: 10.1038/s41467-020-18081-9

Parkinsonism and spastic paraplegia type 7: Expanding the spectrum of mitochondrial Parkinsonism.

PMID: 31433872
Journal: MOVEMENT DISORDERS
Year: 2019
Reference: Mov Disord. 2019 Oct;34(10):1547-1561. doi: 10.1002/mds.27812. Epub 2019 Aug 21.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez, Victoria; Barahona-Hernando, Raul; Catalina, Irene; De la Casa-Fages, Beatriz; Fernandez-Eulate, Gorka; Fernandez-Pelayo, Uxoa; Gamez, Josep; Garcia-Barcina, Maria; Grandas, Francisco; Holt, Ian et al.
DOI: 10.1002/mds.27812

Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab.

PMID: 31420544
Journal: Nature Communications
Year: 2019
Reference: Nat Commun. 2019 Aug 16;10(1):3705. doi: 10.1038/s41467-019-11556-4.
Impact factor:
Publication type: Paper in international publication
Authors: Astorga-Gamaza, Antonio; Badia, Rosa; Burgos, Joaquin; Buzon, Maria J; Castellvi, Josep; Curran, Adria; Falco, Vicenc; Gallego-Rodriguez, Jenny; Garcia, Felipe; Genesca, Meritxell et al.
DOI: 10.1038/s41467-019-11556-4

Biological Functions of Connexin43 Beyond Intercellular Communication.

PMID: 31358412
Journal: TRENDS IN CELL BIOLOGY
Year: 2019
Reference: Trends Cell Biol. 2019 Oct;29(10):835-847. doi: 10.1016/j.tcb.2019.07.001. Epub 2019 Jul 26.
Impact factor:
Publication type: Review in international publication
Authors: Aasen, Trond; Batista-Almeida, Daniela; Girao, Henrique; Kwak, Brenda R; Martins-Marques, Tania; Ribeiro-Rodrigues, Teresa et al.
DOI: 10.1016/j.tcb.2019.07.001

An Exosomal Urinary miRNA Signature for Early Diagnosis of Renal Fibrosis in Lupus Nephritis.

PMID: 31349698
Journal: Cells
Year: 2019
Reference: Cells. 2019 Jul 25;8(8). pii: cells8080773. doi: 10.3390/cells8080773.
Impact factor:
Publication type: Paper in international publication
Authors: Cortes-Hernandez, Josefina; Moline, Teresa; Ordi-Ros, Josep; Sole, Cristina; Vidal, Marta et al.
DOI: 10.3390/cells8080773

A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation.

PMID: 30377213
Journal: EMBO Molecular Medicine
Year: 2018
Reference: EMBO Mol Med. 2018 Dec;10(12). pii: emmm.201809172. doi: 10.15252/emmm.201809172.
Impact factor:
Publication type: Paper in international publication
Authors: Balmana, Judith; Barrett, J Carl; Baselga, Jose; Bonache, Sandra; Bruna, Alejandra; Cairo, Stefano; Caldas, Carlos; Castroviejo-Bermejo, Marta; Cortes, Javier; Cruz, Cristina et al.
DOI: 10.15252/emmm.201809172

p95HER2-T cell bispecific antibody for breast cancer treatment.

PMID: 30282693
Journal: Science Translational Medicine
Year: 2018
Reference: Sci Transl Med. 2018 Oct 3;10(461). pii: 10/461/eaat1445. doi: 10.1126/scitranslmed.aat1445.
Impact factor:
Publication type: Paper in international publication
Authors: Albanell, Joan; Arenas, Enrique J; Arribas, Joaquin; Ast, Oliver; Bacac, Marina; Barriocanal, Agueda Martinez; Baselga, Jose; Chenna, Ahmed; Cortes, Javier; Cuartas, Isabel et al.
DOI: 10.1126/scitranslmed.aat1445

Thrombotic thrombocytopenic purpura relapse induced by acute hepatitis E transmitted by cryosupernatant plasma and successfully controlled with ribavirin.

PMID: 30284732
Journal: TRANSFUSION
Year: 2018
Reference: Transfusion. 2018 Nov;58(11):2501-2505. doi: 10.1111/trf.14831. Epub 2018 Oct 4.
Impact factor:
Publication type: Letter or abstract
Authors: Bes, Marta; Buti, Maria; Esteban, Rafael; Gregori, Josep; Llorens, Meritxell; Piriz, Sofia; Piron, Maria; Quer, Josep; Riveiro-Barciela, Mar; Salcedo, Maria-Teresa et al.
DOI: 10.1111/trf.14831

[Embolizing cardiac hibernoma and acute respiratory failure].

PMID: 30269781
Journal: Revista espanola de patologia : publicacion oficia
Year: 2018
Reference: Rev Esp Patol. 2018 Oct - Dec;51(4):267-270. doi: 10.1016/j.patol.2018.02.003. Epub 2018 Apr 5.
Impact factor:
Publication type: Paper in national publication
Authors: de Torres Ramirez, Ines; Garcia Jimenez, Angel; Montecino Romanini, Carolina; Ramon Y Cajal, Santiago; Reques Llanos, Armando; Rodriguez Morera, Jaime; Temprana Salvador, Jordi et al.
DOI: 10.1016/j.patol.2018.02.003

Selective sentinel lymph node biopsy in papillary thyroid carcinoma in patients with no preoperative evidence of lymph node metastasis.

PMID: 28895542
Journal: Endocrinologia, diabetes y nutricion
Year: 2017
Reference: Endocrinol Diabetes Nutr. 2017 Oct;64(8):451-455. doi: 10.1016/j.endinu.2017.05.001. Epub 2017 Jun 29.
Impact factor:
Publication type: Paper in national publication
Authors: Castell, Joan; Caubet, Enric; Fort, Jose Manuel; Garcia-Burillo, Amparo; Gonzalez, Oscar; Iglesias, Carmela; Mesa, Jordi; Ramon Y Cajal, Santiago; Roca, Isabel; Serres, Xavier et al.
DOI: 10.1016/j.endinu.2017.05.001

Convergent Akt activation drives acquired EGFR inhibitor resistance in lung cancer.

PMID: 28871105
Journal: Nature Communications
Year: 2017
Reference: Nat Commun. 2017 Sep 4;8(1):410. doi: 10.1038/s41467-017-00450-6.
Impact factor:
Publication type: Paper in international publication
Authors: Bertran-Alamillo, Jordi; Bivona, Trever G; Castellvi, Josep; Codony-Servat, Carles; Codony-Servat, Jordi; Ditzel, Henrik J; Drozdowskyj, Ana; Felip, Enriqueta; Garzon, Monica; Gimenez-Capitan, Ana et al.
DOI: 10.1038/s41467-017-00450-6

Ligand-dependent Hedgehog pathway activation in Rhabdomyosarcoma: the oncogenic role of the ligands.

PMID: 28881358
Journal: BRITISH JOURNAL OF CANCER
Year: 2017
Reference: Br J Cancer. 2017 Oct 24;117(9):1314-1325. doi: 10.1038/bjc.2017.305. Epub 2017 Sep 7.
Impact factor:
Publication type: Paper in international publication
Authors: Almazan-Moga, A; Ferreres, J C; Gallego, S; Giralt, I; Hahn, H; Molist, C; Navarro, N; Navarro, S; Pyczek, J; Roma, J et al.
DOI: 10.1038/bjc.2017.305

Clinical outcomes of patients undergoing antiviral therapy while awaiting liver transplantation.

PMID: 28842296
Journal: JOURNAL OF HEPATOLOGY
Year: 2017
Reference: J Hepatol. 2017 Dec;67(6):1168-1176. doi: 10.1016/j.jhep.2017.08.008. Epub 2017 Aug 24.
Impact factor:
Publication type: Paper in international publication
Authors: Castells, Lluis; Colmenero, Jordi; Ferrer, Maria Teresa; Forns, Xavier; Giraldez, Alvaro; Gonzalez-Dieguez, Luisa; Herrero, Jose Ignacio; Londono, Maria-Carlota; Lorente, Sara; Manzano, Maria Luisa et al.
DOI: 10.1016/j.jhep.2017.08.008

The New Antitumor Drug ABTL0812 Inhibits the Akt/mTORC1 Axis by Upregulating Tribbles-3 Pseudokinase.

PMID: 26671995
Journal: CLINICAL CANCER RESEARCH
Year: 2016
Reference: Clin Cancer Res. 2016 May 15;22(10):2508-19. doi: 10.1158/1078-0432.CCR-15-1808. Epub 2015 Dec 15.
Impact factor:
Publication type: Paper in international publication
Authors: Alfon, Jose; Bayascas, Jose Ramon; Bragado, Paloma; Cortal, Marc; Domenech, Carles; Erazo, Tatiana; Espadaler, Jordi; Fernandez-Nogueira, Patricia; Fuster, Gemma; Garcia-Martinez, Jose A et al.
DOI: 10.1158/1078-0432.CCR-15-1808

Immunohistochemical Expression of Estrogen Receptor-alpha and Progesterone Receptor in Patients with Papillary Thyroid Cancer.

PMID: 28101486
Journal: European thyroid journal
Year: 2016
Reference: Eur Thyroid J. 2016 Dec;5(4):224-230. doi: 10.1159/000452488. Epub 2016 Nov 24.
Impact factor:
Publication type: Paper in international publication
Authors: Castellvi, Josep; Mesa, Jordi; Moleti, Mariacarla; Sturniolo, Giacomo; Vermiglio, Francesco; Zafon, Carles et al.
DOI: 10.1159/000452488

Intraoperative Ultrasound-Guided Lumpectomy Versus Mammographic Wire Localization for Breast Cancer Patients After Neoadjuvant Treatment.

PMID: 26514120
Journal: ANNALS OF SURGICAL ONCOLOGY
Year: 2016
Reference: Ann Surg Oncol. 2016 Jan;23(1):38-43. doi: 10.1245/s10434-015-4935-z. Epub 2015 Oct 29.
Impact factor:
Publication type: Paper in international publication
Authors: Esgueva-Colmenarejo, Antonio; Espinosa-Bravo, Martin; Miranda, Ignacio; Peg, Vicente; Rubio, Isabel T; Salazar, Juan Pablo et al.
DOI: 10.1245/s10434-015-4935-z

Effect of Previous Irradiation on Vascular Thrombosis of Microsurgical Anastomosis: A Preclinical Study in Rats.

PMID: 27975009
Journal: Plastic and reconstructive surgery. Global open
Year: 2016
Reference: Plast Reconstr Surg Glob Open. 2016 Nov 23;4(11):e1073. eCollection 2016 Nov.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre-Canyadell, Marius; Barrera-Ochoa, Sergi; Gallardo-Calero, Irene; Lopez-Fernandez, Alba; Romagosa, Cleofe; Soldado, Francisco; Velez, Roberto; Verges, Ramona et al.
DOI: 10.1097/GOX.0000000000001073

Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells.

PMID: 26512918
Journal: ONCOTARGET
Year: 2015
Reference: Oncotarget. 2015 Nov 10;6(35):38239-56. doi: 10.18632/oncotarget.5664.
Impact factor:
Publication type: Paper in international publication
Authors: Aasen, Trond; Castellana, Barbara; Dunn, Sandra E; Moreno-Bueno, Gema; Ramon Y Cajal, Santiago et al.
DOI: 10.18632/oncotarget.5664

Detection of Thyroid Papillary Carcinoma Lymph Node Metastases Using One Step Nucleic Acid Amplification (OSNA): Preliminary Results.

PMID: 25536089
Journal: J INVEST SURG
Year: 2015
Reference: J Invest Surg. 2015 Jun;28(3):153-9. doi: 10.3109/08941939.2014.990123. Epub 2014 Dec 23.
Impact factor:
Publication type: Paper in international publication
Authors: Armengol, Manel; Cajal, Santiago Ramon Y; Castellvi, Josep; Caubet, Enric; Fort, Jose Manuel; Garcia-Burillo, Amparo; Gonzalez, Oscar; Iglesias, Carmela; Maria Balibrea, Jose; Mesa, Jordi et al.
DOI: 10.3109/08941939.2014.990123

Involvement of potassium channels in the progression of cancer to a more malignant phenotype.

PMID: 25517985
Journal: BBA-GEN SUBJECTS
Year: 2015
Reference: Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2477-92. doi: 10.1016/j.bbamem.2014.12.008. Epub 2014 Dec 14.
Impact factor:
Publication type: Review in international publication
Authors: Capera, Jesusa; Comes, Nuria; Condom, Enric; Felipe, Antonio; Ferreres, Joan Carles; Ramon Y Cajal, Santiago; Serrano-Albarras, Antonio; Serrano-Novillo, Clara et al.
DOI: 10.1016/j.bbamem.2014.12.008

MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients.

PMID: 26452030
Journal: ONCOTARGET
Year: 2015
Reference: Oncotarget. 2015 Nov 10;6(35):37269-80. doi: 10.18632/oncotarget.5495.
Impact factor:
Publication type: Paper in international publication
Authors: Bottai, Giulia; Calin, George A; Corsi, Fabio; Cortes, Javier; De Mattos-Arruda, Leticia; Di Tommaso, Luca; Giovannetti, Elisa; Losurdo, Agnese; Masci, Giovanna; Nuciforo, Paolo G et al.
DOI:

A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.

PMID: 25329316
Journal: PLoS Genetics
Year: 2014
Reference: PLoS Genet. 2014 Oct 16;10(10):e1004721. doi: 10.1371/journal.pgen.1004721. eCollection 2014 Oct.
Impact factor:
Publication type: Paper in international publication
Authors: Bastian, Boris; Bech-Serra, Joan Josep; Canals, Francesc; Cortes, Javier; Esteve-Puig, Rosaura; Ferrer, Berta; Flores, Juana Maria; Garcia-Patos, Vicenc; Gil, Rosa; Gonzalez-Sanchez, Elena et al.
DOI: 10.1371/journal.pgen.1004721

The intra-tumor heterogeneity of cell signaling factors in breast cancer: p4E-BP1 and peIF4E are diffusely expressed and are real potential targets.

PMID: 25060567
Journal: Clinical & Translational Oncology
Year: 2014
Reference: Clin Transl Oncol. 2014 Nov;16(11):937-41. doi: 10.1007/s12094-014-1203-9. Epub 2014 Jul 25.
Impact factor:
Publication type: Paper in international publication
Authors: Cortes, J; De Mattos-Arruda, L; Peg, V; Ramon Y Cajal, S; Sonenberg, N et al.
DOI: 10.1007/s12094-014-1203-9

MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness.

PMID: 25188511
Journal: Cell Death & Disease
Year: 2014
Reference: Cell Death Dis. 2014 Sep 4;5:e1401. doi: 10.1038/cddis.2014.356.
Impact factor:
Publication type: Paper in international publication
Authors: Borras, F; Comella, J X; Ferreres, J C; Gallego, S; Moubarak, R S; Murphy, D M; Planells-Ferrer, L; Reix, S; Segura, M F; Soriano, A et al.
DOI: 10.1038/cddis.2014.356

RHOA inactivation enhances Wnt signalling and promotes colorectal cancer.

PMID: 25413277
Journal: Nature Communications
Year: 2014
Reference: Nat Commun. 2014 Nov 21;5:5458. doi: 10.1038/ncomms6458.
Impact factor:
Publication type: Paper in international publication
Authors: Afonso, Elsa; Andretta, Elena; Arango, Diego; Bazzocco, Sarah; Bilic, Josipa; Cajal, Santiago Ramon Y; Carton-Garcia, Fernando; Dopeso, Higinio; Hernandez-Losa, Javier; Kobayashi, Kazuto et al.
DOI: 10.1038/ncomms6458

Factors secreted by endothelial progenitor cells enhance neurorepair responses after cerebral ischemia in mice.

PMID: 24023842
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Sep 4;8(9):e73244. doi: 10.1371/journal.pone.0073244.
Impact factor:
Publication type: Paper in international publication
Authors: Barcelo, Veronica; Borras, Francesc; Garcia-Bonilla, Lidia; Hernandez-Guillamon, Mar; Lope-Piedrafita, Silvia; Martinez-Saez, Elena; Montaner, Joan; Morancho, Anna; Navarro-Sobrino, Miriam; Penalba, Anna et al.
DOI: 10.1371/journal.pone.0073244

Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas.

PMID: 23825589
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Jun 25;8(6):e66933. doi: 10.1371/journal.pone.0066933. Print 2013.
Impact factor:
Publication type: Paper in international publication
Authors: Barbacid, Mariano; Cortes, Javier; Flores, Juana Maria; Gonzalez-Sanchez, Elena; Hernandez-Losa, Javier; Mares, Roso; Martin-Caballero, Juan; Recio, Juan A et al.
DOI: 10.1371/journal.pone.0066933

Lymphatic mapping could not be impaired in the presence of breast carcinoma and coexisting small lymphocytic lymphoma.

PMID: 23977406
Journal: The American journal of case reports
Year: 2013
Reference: Am J Case Rep. 2013 Aug 21;14:322-5. doi: 10.12659/AJCR.884000.
Impact factor:
Publication type: Letter or abstract
Authors: Arana, Sebastian; Espinosa, Martin; Peg, Vicente; Rubio, Isabel T; Vasquez-Del-Aguila, Jorge et al.
DOI: 10.12659/AJCR.884000

Prediction of non-sentinel lymph node metastasis in early breast cancer by assessing total tumoral load in the sentinel lymph node by molecular assay.

PMID: 23607911
Journal: EJSO
Year: 2013
Reference: Eur J Surg Oncol. 2013 Jul;39(7):766-73. doi: 10.1016/j.ejso.2013.03.011. Epub 2013 Apr 19.
Impact factor:
Publication type: Paper in international publication
Authors: Espinosa-Bravo, M; Peg, V; Perez-Hoyos, S; Ramos, M; Rubio, I T; Sancho, M; Sansano, I; Xercavins, J et al.
DOI: 10.1016/j.ejso.2013.03.011

Guidelines for biomarker testing in colorectal carcinoma (CRC): a national consensus of the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM).

PMID: 22855150
Journal: Clinical & Translational Oncology
Year: 2012
Reference: Clin Transl Oncol. 2012 Oct;14(10):726-39. doi: 10.1007/s12094-012-0856-5. Epub 2012 Jul 27.
Impact factor:
Publication type: Paper in international publication
Authors: Garcia-Alfonso, Pilar; Garcia-Carbonero, Rocio; Garcia-Foncillas, Jesus; Musulen, Eva; Navarro, Samuel; Paya, Artemio; Perez-Segura, Pedro; Ramon Y Cajal, Santiago; Salazar, Ramon et al.
DOI: 10.1007/s12094-012-0856-5

Increased voltage-dependent K(+) channel Kv1.3 and Kv1.5 expression correlates with leiomyosarcoma aggressiveness.

PMID: 22844358
Journal: Oncology Letters
Year: 2012
Reference: Oncol Lett. 2012 Aug;4(2):227-230. Epub 2012 May 16.
Impact factor:
Publication type: Paper in international publication
Authors: Bielanska, Joanna; Cajal, Santiago Ramon Y; Condom, Enric; Felipe, Antonio; Ferreres, Joan Carles; Hernandez-Losa, Javier; Moline, Teresa; Somoza, Rosa et al.
DOI: 10.3892/ol.2012.718

Targeting the voltage-dependent K(+) channels Kv1.3 and Kv1.5 as tumor biomarkers for cancer detection and prevention.

PMID: 22204339
Journal: CURRENT MEDICINAL CHEMISTRY
Year: 2012
Reference: Curr Med Chem. 2012;19(5):661-74.
Impact factor:
Publication type: Review in international publication
Authors: Bielanska, J; Comes, N; Condom, E; Felipe, A; Ferreres, J C; Hernandez-Losa, J; Ramon Y Cajal, S; Roig, S; Vallejo, A et al.
DOI:

Intestinal Schistosomiasis as Unusual Aetiology for Acute Appendicitis, Nowadays a Rising Disease in Western Countries.

PMID: 22792502
Journal: Case reports in infectious diseases
Year: 2012
Reference: Case Rep Infect Dis. 2012;2012:896820. Epub 2012 Jun 26.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; et al.
DOI: 10.1155/2012/896820

SRD5A2 gene mutations and polymorphisms in Spanish 46,XY patients with a disorder of sex differentiation.

PMID: 21631525
Journal: INTERNATIONAL JOURNAL OF ANDROLOGY
Year: 2011
Reference: Int J Androl. 2011 Dec;34(6 Pt 2):e526-35. doi: 10.1111/j.1365-2605.2010.01136.x. Epub 2011 Jun 2.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1365-2605.2010.01136.x

Successful treatment with GEMOX in patient with metastatic pancreatic adenosquamous carcinoma.

PMID: 21617724
Journal: TUMORI
Year: 2011
Reference: Tumori. 2011 Mar-Apr;97(2):239-42. doi: 10.1700/667.7792.
Impact factor:
Publication type: Paper in international publication
Authors: Aurilio, Gaetano; Fazio, Nicola; Iglesias i Felip, Carmela; Macarulla Mercadé, Teresa; Nole, Franco; Ramos, Javier Francisco et al.
DOI: 10.1700/667.7792

Multicentric liposarcoma.

PMID: 21473438
Journal: Acta Orthopaedica Belgica
Year: 2011
Reference: Acta Orthop Belg. 2011 Feb;77(1):9-14.
Impact factor:
Publication type: Paper in international publication
Authors: Ares, Oscar; Conesa, Xavier; Huguet, Pere; Perez-Dominguez, Manuel; Seijas, Roberto et al.
DOI:

PTOV1 is overexpressed in human high-grade malignant tumors.

PMID: 21181414
Journal: VIRCHOWS ARCHIV
Year: 2011
Reference: Virchows Arch. 2011 Mar;458(3):323-30. Epub 2010 Dec 23.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1007/s00428-010-1018-1

Methylthioadenosine (MTA) inhibits melanoma cell proliferation and in vivo tumor growth.

PMID: 20529342
Journal: BMC CANCER
Year: 2010
Reference: BMC Cancer. 2010 Jun 8;10:265. doi: 10.1186/1471-2407-10-265.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1186/1471-2407-10-265

ADAMTS1 Contributes to the Acquisition of an Endothelial-like Phenotype in Plastic Tumor Cells.

PMID: 20484033
Journal: CANCER RESEARCH
Year: 2010
Reference: Cancer Res. 2010 Jun 1;70(11):4676-86. Epub 2010 May 18.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1158/0008-5472.CAN-09-4197

Regulation of Aurora B kinase by the lipid raft protein Flotillin-1.

PMID: 20430883
Journal: JOURNAL OF BIOLOGICAL CHEMISTRY
Year: 2010
Reference: J Biol Chem. 2010 Jul 2;285(27):20683-90. Epub 2010 Apr 29.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1074/jbc.M110.130591

[Usefulness of the immunohistochemical analysis of several molecular markers in the characterization of papillary thyroid carcinoma with initial lymph node metastasis.]

PMID: 20403734
Journal: Endocrinol Nutr
Year: 2010
Reference: Endocrinol Nutr. 2010 Apr;57(4):165-9. Epub 2010 Apr 18.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; et al.
DOI: 10.1016/j.endonu.2010.02.005

[Diffuse astrocytoma presenting as an optic-spinal syndrome]

PMID: 19319816
Journal: REVISTA DE NEUROLOGIA
Year: 2009
Reference: Rev Neurol. 2009 Apr 1-15;48(7):354-6.
Impact factor:
Publication type: Paper in national publication
Authors: Alonso, J; Martinez, E; Montalban, X; Parees, I; Rovira, A et al.
DOI:

[Oral nutritional supplementation in hematologic patients]

PMID: 19266107
Journal: Nutricion Hospitalaria
Year: 2009
Reference: Nutr Hosp. 2009 Jan-Feb;24(1):10-6.
Impact factor:
Publication type: Review or editorial in national publication
Authors: Julia, A; Palacios, A; Penalva, A; Perez-Portabella, C; Planas, M; Rossello, J; San Martin, A et al.
DOI:

Association of congenital hypothalamic hamartoma and hairy polyp.

PMID: 19241449
Journal: ULTRASOUND IN OBSTETRICS & GYNECOLOGY
Year: 2009
Reference: Ultrasound Obstet Gynecol. 2009 May;33(5):609-10.
Impact factor:
Publication type: Letter or abstract
Authors: Carreras, E; Ferreres, J C; Higueras, T; Ortega, A; Planas, S; Ramon Y Cajal, S; Toran, N et al.
DOI: 10.1002/uog.6314

Rplp1 bypasses replicative senescence and contributes to transformation.

PMID: 19233166
Journal: EXPERIMENTAL CELL RESEARCH
Year: 2009
Reference: Exp Cell Res. 2009 May 1;315(8):1372-83.
Impact factor:
Publication type: Paper in international publication
Authors: Artero-Castro, A; Fernandez-Marcos, P J; Kondoh, H; Lleonart Pajarin, Matilde; Lleonart, M E; Ramon y Cajal, S; Serrano, M et al.
DOI: 10.1016/j.yexcr.2009.02.007