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Translational Molecular Pathology

Our group aims to unravel the molecular mechanisms of cancer progression and metastasis to identify new diagnostic, prognostic and therapeutic targets in cancer. By combining the knowledge and availability of human tumors in the Pathology department with the expertise of the basic molecular cell biology research group, we focus on:

  • Understanding: the molecular mechanisms underlying clonal cooperation and intercellular communication in heterogeneous tumors.
  • The role of MNK kinases in cellular stress resistance.
  • The role of ITGB3 in intercellular communication via extracellular vesicles in cancer metastasis (Santiago Ramon y Cajal).
  • The role of direct cell-cell communication via gap junctions and intercellular protrusions in cancer (Trond Aasen)
  • The malignant transition of Plexiform Neurofibromas (Cleofe Romagosa).

Team

Milena Marcela Riaño Rodríguez

Milena Marcela Riaño Rodríguez

Research assistant
Translational Molecular Pathology
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Sara Garcia Ortega

Sara Garcia Ortega

Predoctoral researcher
Translational Molecular Pathology
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Sonia Borao Arriazu

Sonia Borao Arriazu

Research technician
Translational Molecular Pathology
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Aldo Di  Vito

Aldo Di Vito

Predoctoral researcher
Translational Molecular Pathology
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Cleofé Romagosa Pérez-Portabell

Cleofé Romagosa Pérez-Portabell

Main researcher
Translational Molecular Pathology
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Javier Hernandez Losa

Javier Hernandez Losa

Main researcher
Translational Molecular Pathology
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Milena Marcela Riaño Rodríguez

Milena Marcela Riaño Rodríguez

Research assistant
Translational Molecular Pathology
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Sara Garcia Ortega

Sara Garcia Ortega

Predoctoral researcher
Translational Molecular Pathology
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Sonia Borao Arriazu

Sonia Borao Arriazu

Research technician
Translational Molecular Pathology
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Aldo Di  Vito

Aldo Di Vito

Predoctoral researcher
Translational Molecular Pathology
Read more
Cleofé Romagosa Pérez-Portabell

Cleofé Romagosa Pérez-Portabell

Main researcher
Translational Molecular Pathology
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Javier Hernandez Losa

Javier Hernandez Losa

Main researcher
Translational Molecular Pathology
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Research lines

Study of PTOV1 modulation in tumor proliferation and progression : Interaction with IGF1 pathways. Notch and Wnt expression in TMAs of tumors.

To evaluate the expression (nuclear and cytoplasmatic) of PTOV1 , Notch and Wnt on TMAs in c different histological types of carcinomas with low and high grades of malignancy  . To correlate the inmunoexpression with classical parameters of  tumor behaviour : tumoral size, grade of malignancy, vascular permeation, lymph nodes metastasis in each histological subtype and demonstrated the role of PTOV1 as predictive molecular marker in carcinomas.

(Research Biomedical Unit)


IP: Inés de Torres Ramirez

Projects

Papel de la proteína MFGE8 como potencial biomarcador y diana terapéutica en la angiopatía amiloide cerebral

IP: Maria Mar Hernandez Guillamon
Collaborators: Berta Paez Montserrat, Kerrie Adrián Campbell, Jessica Camacho Soriano, Anas Chaachou Charradi, Olalla Pancorbo Rosal
Funding agency: Instituto de Salud Carlos III
Funding: 208750
Reference: PI23/00082
Duration: 01/01/2024 - 31/12/2026

Targeting extracelluar vesicel mediated intercellular communication as a novel approach to combat cancer metastasis.

IP: Stefan Hummer
Collaborators: Santiago Ramon y Cajal Agüeras, Elena Muro Blanc, Vicente Peg Camara, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras, Santiago Ramon y Cajal Agüeras
Funding agency: Fundación Ramón Areces
Funding: 127486
Reference: CIVP21S13325
Duration: 06/07/2023 - 05/07/2026

ESTUDIO DEL PAPEL DE LA CENTRALIZACIÓN DEL DIAGNÓSTICO ANATOMOPATOLÓGICO Y LA APLICACIÓN DE ESTRATÉGIAS DE MEDICINA DE PRECISIÓN EN SARCOMAS

IP: Cleofé Romagosa Pérez-Portabell
Collaborators: Xavier Martínez Gómez, Ximena Garcia Torres
Funding agency: Asociación Española Contra el Cáncer
Funding: 270130
Reference: ECAEC222952DEAL
Duration: 01/12/2022 - 30/11/2027

Protuberancias intercelulares reguladas por Cx43 en cáncer: elucidación funcional, descubrimiento de objetivos, desarrollo de biomarcadores y detección de tumores

IP: Trond Aasen
Collaborators: Maria Rosa Somoza Lopez de Haro, Jordi Temprana Salvador, Teresa Moline Marimon, Marta Sese Faustino, Irene Sansano Valero, Stefan Hummer
Funding agency: Instituto de Salud Carlos III
Funding: 147620
Reference: PI21/00470
Duration: 01/01/2022 - 30/06/2026

Blog

News

The grants promote new therapeutic strategies and diagnostic tools in highly complex tumors such as glioblastoma, triple-negative breast cancer, and endometrial cancer.

The Department of Health of the Generalitat de Catalunya grants subsidies for carrying out validation tests on innovative projects in the field of health that are in the early stages of development.

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

Rates

Check the current rates for the services offered by the Translational Molecular Pathology research group.

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Current Rates

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Rates Anatomia Patologica VHIR 2021

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