The aim of the meeting, which took place in the Center of Multiple sclerosis of Catalonia (Cemcat) on 14th of September, was to share knowledge and to determine the bases for the future of the investigation and the assistance in multiple sclerosis. Genetics, immunology, diagnosis and therapies were some of the aspects treated in the presentations that assembled 40 experts in multiple sclerosis. Dr. Jose Navas, manager of Vall d'Hebron University Hospital (HUVH) and Dr. Xavier Montalban, Chief of Neurology/Neuroimmunology Service at HUVH, head of the clinical neuroimmunology group at VHIR and Director of Cemcat, opened the day, in which was also VHIR's director, Dr. Joan Comella.Alastair Compston, professor and head of the department of Clinical Neurosciences at the University of Cambridge (UK), moderated the first part of the day, which opened Dr. Jerry Wolinsky, professor of Neurology of the Health Science Center in Texas's University (USA). Wolinsky reviewed the aims achieved in the investigation along last forty years.Dr. Jorge Oksenberg, from the California Univesity in San Francisco (USA) focused in the genetic facts of multiple sclerosis. Dr. Reinhard Hohlfeld, from Max Planck Institute of the University Ludwig Maximilians of Munich (Germany) abounded in the findings up to the moment and in the future of the research in the immunology of the multiple sclerosis.Professor Fred Lublin from Hospital Monte Sinaí of New York (USA) approached the controversies on the definition of the clinical forms of the multiple sclerosis (in outbreaks or progressive) and proposed new criteria to classify them.Professor Giancarlo Comi from Hospital San Raffaele of Milan (Italia) moderated the second part of the session. Diagnosis was the key theme of the first conference of the afternoon made by Prof. Chris Polman from the Free University of Amsterdam, highlighting the importance of magnetic resonance.Profesor Ludwig Kappos from the Neurology and Biomedicine Department at Basilea University Hospital analyzed the existing therapies, and their adjustment to the characteristics of every patient.Professor Michael Clanet, from Toulouse University Hospital and president of ECTRIMS, spoke about the different models of organization in the attention to patients with multiple sclerosis.