Professor Jordi Rello, head of the group http://www.ciberes.org/ Centre for Biomedical Research Network for Respiratory Diseases (CIBERES) under the Institute of Health Carlos III, in the Vall d'Hebron Research Institute (VHIR) in Barcelona, has coordinated an international research who has analysed the intratracheal administration of antibiotics in mechanically ventilated adults in 192 intensive care units, from Europe, Australia and America, to evaluate the most commonly used devices, current practices and security measures implemented. The findings of this study suggest a standardization of procedures to reduce variability and improve safety and efficiency.The authors of this work, which has just been published in http://rc.rcjournal.com/content/early/2016/03/08/respcare.04519.full.pdf+html Respiratory Care have identified that intratracheal administration of antibiotics for the treatment of respiratory infections in mechanically ventilated adults has emerged as a common therapy, of great diversity, but it is often associated with inadequate practices. This is regardless of the experience of healthcare professionals in this technique. It is necessary, therefore, standardization of procedures to increase efficiency and minimize the risk of potential adverse effects.Recently, it has been approved the use of some nebulized antibiotics for respiratory infections in cystic fibrosis, bronchiectasis and COPD. The proliferation of multi-resistant bacteria has led to incorporate their compassionate use in patients on mechanical ventilation. Technology has evolved to a new generation of devices that have shown greater efficacy but there was a need of a global use perspective.The study, part of the doctoral thesis at the Autonomous University of Barcelona, with Candela Solé as the main author, is one of the strategic objectives of WP5 of the cooperative Project Pneumonia of CIBERES and is sponsored by the ESGCIP of the European Society of Clinical Microbiology and Infectious Diseases.The findings of this research are attached to other parallel work, also coordinated by Dr. Rello, which analysed antibiotics by nebulization in mechanically ventilated patients. This research, published in Clinical Microbiology and Infection, identified colistin and tobramycin as the most commonly used antibiotics. Professionals prescribe different doses, which are superior to pneumonia than to tracheobronchitis. There is a marked heterogeneity in clinical practice in different regions of the world.Both articles suggest the urgent need for some international guidelines on indications, doses and combinations of antibiotics as well as to establish an administration technique protocol.