Jaume Alijotas Reig Institutions of which they are part Head of group Systemic Diseases Vall Hebron Institut de Recerca Email Jaume Alijotas Reig Email Institutions of which they are part Head of group Systemic Diseases Vall Hebron Institut de Recerca
Research lines Immunological basis and new therapeutic options in severe preeclampsia. Three to five percent of pregnancies are complicated by preeclampsia (PE). PE is a multisystemic-related endothelial dysfunction disorder characterized by hypertension, proteinuria and renal injury. Despite considerable research, its etiology and pathophysiology still remains unclear. Different theories involving many pathways including thrombophilia, immunologic changes, circulating angiogenic /antiangiogenic factors and increased oxidative stress have been related to its pathogenesis. The role played by antiphospholipid antibodies (aPL) is a matter of discussion in PE. Biological evidence of endothelial dysfunction related to PE/FGR has been shown by modified plasma markers including fibronectin, von Willebrand factor and ICAM-1 in a similar manner to that which occurs in aPL-related obstetric complications. We are searching now the role played by different aPL and cofactor antibodies, as well as its relationship with angiogenic /antiangiogenic factors and microparticle number in severe PE. IP: Jaume Alijotas Reig, Elisa Llurba Olivé, Anna Suy Franch Immunological alterations as basis of inmunosenescencein pathological aging. This research line is centered into the study of the role of cross-reactivity among oxidized lipoproteins (oxLDL), antiB2-GP1 and membrane phospholipids, as well as between these complexes and heat shock proteins. We also focus into the role of proinflamatory (IL2 / IL6 / TNFalpha) and anti-inflamatory (IL4 / IL-10) cytokines, as well as with the different activation profiles of TCR and/or CD14 (TLR4) and the role of hormones such as melatonin and the growth hormone. IP: Jaume Alijotas Reig Pagination First page « Previous page ‹ Page 1 Page 2 Current page 3 Projects GLOBE: Gestación Ligada a Obesidad y al Entorno. Estudio longitudinal multicéntrico de factores de riesgo asociados a la obesidad en el embarazo IP: - Collaborators: Jaume Alijotas Reig, Inés Zulema Calero Fernández, Maite Avilés García Funding agency: Instituto de Salud Carlos III Funding: 135883 Reference: PI10/01367 Duration: 01/01/2011 - 31/12/2014 Heparina de Bajo Peso Molecular (HBPM) para la prevención de complicaciones derivadas de la insuficiencia placentaria en las pacientes de riesgo sin trombofilia: estudio multicéntrico randomizado IP: - Collaborators: Jaume Alijotas Reig, Inés Zulema Calero Fernández, Elisa Llurba Olivé, Josep Perapoch López Funding agency: Ministerio Sanidad Funding: 80000 Reference: EC10-205 Duration: 01/01/2011 - 31/12/2016 Envejecimiento endotelial y sus efectos pleiotrópicos sobre procesos inflamatorios, de la respuesta inmune y angiogénesis IP: Francesc Miro Mur Collaborators: Jaume Alijotas Reig, Simon Schwartz Navarro Funding agency: Fundación Invest. Médica Mutua Madrileña Funding: 36000 Reference: FMMA/05/2008 Duration: 24/09/2008 - 23/09/2011 CIBER: Bioingenieria, biomateriales y nanomedicina IP: - Collaborators: Manuel López Cano, Jaume Alijotas Reig, Francesc Miro Mur, Eloy Espín Basany Funding agency: CIBER Bioing., Biomateriales y Nanomedicina , BBN Funding: 480000 Reference: CB06/01/0012 Duration: 01/01/2007 - 31/12/2010 Pagination First page « Previous page ‹ Page 1 Page 2 Current page 3
