Jaume Alijotas Reig Institutions of which they are part Head of group Systemic Diseases Vall Hebron Institut de Recerca Email Jaume Alijotas Reig Email Institutions of which they are part Head of group Systemic Diseases Vall Hebron Institut de Recerca
Research lines Proinflammatory cytokines TNF and IL-6 in cellular senescence. A HUVEC aging model. Cells that are chronically exposed to inflammatory signals are more prone to aging than those which are not exposed to such signals. Human vascular endothelial cell (HUVEC) primary cultures activated with TNF-alpha probably increase the expression of ICAM and VCAM, synthesize ROS, and express senescence markers. It is not known what the principal intracellular pathway is (although it is thought that STAT may play a role) and it is unknown if one or more proinflammatory cytokines are needed to activate NF-KB. We are trying to find out the role that IFN-alpha and/or IL-6 and IL-1B may have on the aging inflammatory phenomena and we aim at detecting the intracellular signal pathways (STAT). We are also working on the characterization of the genes involved in these abnormal biologic responses. IP: Jaume Alijotas Reig Immunological basis and new therapeutic options in severe preeclampsia. Three to five percent of pregnancies are complicated by preeclampsia (PE). PE is a multisystemic-related endothelial dysfunction disorder characterized by hypertension, proteinuria and renal injury. Despite considerable research, its etiology and pathophysiology still remains unclear. Different theories involving many pathways including thrombophilia, immunologic changes, circulating angiogenic /antiangiogenic factors and increased oxidative stress have been related to its pathogenesis. The role played by antiphospholipid antibodies (aPL) is a matter of discussion in PE. Biological evidence of endothelial dysfunction related to PE/FGR has been shown by modified plasma markers including fibronectin, von Willebrand factor and ICAM-1 in a similar manner to that which occurs in aPL-related obstetric complications. We are searching now the role played by different aPL and cofactor antibodies, as well as its relationship with angiogenic /antiangiogenic factors and microparticle number in severe PE. IP: Jaume Alijotas Reig, Elisa Llurba Olivé, Anna Suy Franch Pagination First page « Previous page ‹ Page 1 Page 2 Current page 3 Projects Heparina de Bajo Peso Molecular (HBPM) para la prevención de complicaciones derivadas de la insuficiencia placentaria en las pacientes de riesgo sin trombofilia: estudio multicéntrico randomizado IP: - Collaborators: Jaume Alijotas Reig, Inés Zulema Calero Fernández, Elisa Llurba Olivé, Josep Perapoch López Funding agency: Ministerio Sanidad Funding: 80000 Reference: EC10-205 Duration: 01/01/2011 - 31/12/2016 Envejecimiento endotelial y sus efectos pleiotrópicos sobre procesos inflamatorios, de la respuesta inmune y angiogénesis IP: Francesc Miro Mur Collaborators: Jaume Alijotas Reig, Simon Schwartz Navarro Funding agency: Fundación Invest. Médica Mutua Madrileña Funding: 36000 Reference: FMMA/05/2008 Duration: 24/09/2008 - 23/09/2011 CIBER: Bioingenieria, biomateriales y nanomedicina IP: - Collaborators: Manuel López Cano, Jaume Alijotas Reig, Francesc Miro Mur, Eloy Espín Basany Funding agency: CIBER Bioing., Biomateriales y Nanomedicina , BBN Funding: 480000 Reference: CB06/01/0012 Duration: 01/01/2007 - 31/12/2010 Pagination First page « Previous page ‹ Page 1 Page 2 Current page 3
