Jaume Alijotas Reig Instituciones de las que forman parte Jefe de grupo Enfermedades Sistémicas Vall Hebron Institut de Recerca Email Jaume Alijotas Reig Email Instituciones de las que forman parte Jefe de grupo Enfermedades Sistémicas Vall Hebron Institut de Recerca
Líneas de investigación Immunobiology and immunopathology of recurrent pregnancy loses and spontaneous loses. Around 2-3% of reproductive-age couples suffer recurrent pregnancy loses. Almost 18% of couples that wish to have children suffer infertility problems. Simultaneously, 2-3% of all pregnant women are diagnosed with spontaneous loses. The expression of HLA molecules, specially type G, the degree of trophoblastic apoptosis, the outsourcing of new neoantigens such as phospholipids, the balance between Th1/Th2/Th3 cytokines, the type and quantity of CD4+CD25+Foxp3+ lymphocytes, the kind and the activity of uterine NK cells (uNK) cells, the presence or absence of blocking antibodies, and other mechanisms play different roles in the achievement of the so-called "tolerant microenvironment" needed to develop a normal pregnancy. Therefore, both autoimmune and alloimmune mechanisms are important. We aim at studying which isolated, and specially associated, anomalies can be identified as risk markers to be able to evaluate possible treatments. IP: Jaume Alijotas Reig Cellular microparticles study in women with and without antiphospholipid antibodies with recurrent pregnancy loses and preeclampsia. Cellular microparticles (CMP) are released depending on the activation and/or the presence of cell apoptosis. They are capable of activating both inflammatory and coagulation pathways. It seems that levels of CMP are higher in healthy pregnant women. A working hypothesis establishes that an increase of CMP levels may be found in recurrent pregnancy loses and preeclampsia. It is thought that their thrombophilic capacity may be higher in those patients with anti-phospholipid antibodies, especially among those with lupus anticoagulant. We want to determine MPC levels in non-pregnant healthy women, pregnant women without previous abnormal obstetric events, women with recurrent pregnancy loses, and women with severe preeclampsia. We are also evaluating whether there are differences related to the presence or absence of antiphospholipid antibodies. Finally, we will also characterize the exact type of CMP (endothelial, platelet-like, leuco-monocyte, and throphoblastic). IP: Jaume Alijotas Reig Paginación Primera página « Página anterior ‹ Página 1 Página 2 Página actual 3 Proyectos GLOBE: Gestación Ligada a Obesidad y al Entorno. Estudio longitudinal multicéntrico de factores de riesgo asociados a la obesidad en el embarazo IP: - Colaboradores: Jaume Alijotas Reig, Inés Zulema Calero Fernández, Maite Avilés García Entidad financiadora: Instituto de Salud Carlos III Financiación: 135883 Referencia: PI10/01367 Duración: 01/01/2011 - 31/12/2014 Heparina de Bajo Peso Molecular (HBPM) para la prevención de complicaciones derivadas de la insuficiencia placentaria en las pacientes de riesgo sin trombofilia: estudio multicéntrico randomizado IP: - Colaboradores: Jaume Alijotas Reig, Inés Zulema Calero Fernández, Elisa Llurba Olivé, Josep Perapoch López Entidad financiadora: Ministerio Sanidad Financiación: 80000 Referencia: EC10-205 Duración: 01/01/2011 - 31/12/2016 Envejecimiento endotelial y sus efectos pleiotrópicos sobre procesos inflamatorios, de la respuesta inmune y angiogénesis IP: Francesc Miro Mur Colaboradores: Jaume Alijotas Reig, Simon Schwartz Navarro Entidad financiadora: Fundación Invest. Médica Mutua Madrileña Financiación: 36000 Referencia: FMMA/05/2008 Duración: 24/09/2008 - 23/09/2011 CIBER: Bioingenieria, biomateriales y nanomedicina IP: - Colaboradores: Manuel López Cano, Jaume Alijotas Reig, Francesc Miro Mur, Eloy Espín Basany Entidad financiadora: CIBER Bioing., Biomateriales y Nanomedicina , BBN Financiación: 480000 Referencia: CB06/01/0012 Duración: 01/01/2007 - 31/12/2010 Paginación Primera página « Página anterior ‹ Página 1 Página 2 Página actual 3
