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Joan Sahuquillo Barris

Sóc llicenciat en Medicina i Cirurgia i especialista en Neurocirurgia. Vaig acabar la Tesi Doctoral el 1985. Des de 1985 treballo en el Servei de Neurocirurgia de l'Hospital Universitari Vall d’Hebron. Actualment Catedràtic del departament de cirurgia de la Universitat Autònoma de Barcelona i coordinador de la Unitat de Recerca de Neurotraumatologia i Neurocirurgia (UNINN) de l'Institut de Recerca Vall d’Hebron.

Institutions of which they are part

Main researcher
Neurotraumatology and Neurosurgery Research Unit (UNINN)
Vall Hebron Institut de Recerca
Neurosurgery
General Hospital
Joan Sahuquillo Barris

Joan Sahuquillo Barris

Joan Sahuquillo Barris

Institutions of which they are part

Main researcher
Neurotraumatology and Neurosurgery Research Unit (UNINN)
Vall Hebron Institut de Recerca
Neurosurgery
General Hospital

Sóc llicenciat en Medicina i Cirurgia i especialista en Neurocirurgia. Vaig acabar la Tesi Doctoral el 1985. Des de 1985 treballo en el Servei de Neurocirurgia de l'Hospital Universitari Vall d’Hebron. Actualment Catedràtic del departament de cirurgia de la Universitat Autònoma de Barcelona i coordinador de la Unitat de Recerca de Neurotraumatologia i Neurocirurgia (UNINN) de l'Institut de Recerca Vall d’Hebron.

He estat el Cap de Servei de Neurocirurgia de l'Hospital Universitari Vall d'Hebron (HUVH) des del mes de juliol del 2009 fins al mes de juny del 2021 i sóc Catedràtic del Departament de Cirurgia de la Universitat Autònoma de Barcelona des de l'octubre del 2020. A més, exerceixo el càrrec de coordinador de la Unitat de Recerca de Neurotraumatologia i Neurocirurgia (UNINN), unitat multidisciplinària en què investigadors clínics i bàsics col·laboren en el desenvolupament de recerca translacional en tres línies consolidades: neurotraumatologia, hidrocefàlia i malformacions congènites de la unió craneocervical i en una línia emergent de neurooncologia.

L'HUVH i la UNINN formen part de l'European Brain Injury Consortium (EBIC), una xarxa d'hospitals que es consideren centres d'excel·lència en el tractament del traumatisme cranioencefàlic. Sóc membre del comitè executiu de l'EBIC, membre del comitè directiu de la xarxa Brain IT i col·laborador i revisor de la Cochrane Collaboration, de la McMaster Online Rating of Evidence (MORE) i de Faculty of 1000.

Les meves àrees clíniques d'interès són: La cirurgia de les malformacions complexes de la xarnela craneocervical, la cirurgia de la base del crani, el tractament de les alteracions de la dinàmica del líquid cefaloraquidi i els traumatismes craneoencefàlics.

Research lines

Congenital malformations of the cranio-vertebral junction (Consolidated line)

General aims: Chiari malformation is an entity that is diagnosed more and more frequently. The fundamental diagnostic element of this congenital malformation is a descent of the cerebellum towards the cervical canal, which produces local compression phenomena and alterations in the circulation of the cerebrospinal fluid. However, there are great discrepancies about how the study and treatment of these patients is carried out in the different centers, which affects their final result. Our main objective in this line of research is to better understand the origin and repercussions of these malformations and contribute to improving treatment and, therefore, its final result.


Specific aims: 1) To deepen the knowledge of the pathophysiology of craniocervical malformations, especially Chiari Type 1 (MC-1) malformation, and to quantify the repercussion of these malformations in the clinical, social, and occupational fields. 2) Study the genetic bases of this malformation and its penetrance at the family level. 3) To study sleep disturbances (particularly the type and frequency of nocturnal apnea) associated with CM-1. 4) Study of the quality of life in patients with a malformation of the craniocervical joint before and after surgical treatment. 5) To deepen the knowledge of the cognitive-affective syndrome that patients affected by CM-1 may present (research project FIS PI22/01082). 6) Contribute to the homogenization in the management of MC-1 from the participation of our group in the consensus conferences aimed at the elaboration of clinical practice guidelines to be applied in the diagnosis and treatment of these patients.


IP: Ma Antonia Poca Pastor, Joan Sahuquillo Barris

Neurotraumatology and acute neurological pathology (Consolidated Line)

General aims: To study the neurochemical, physiopathological and cerebral metabolism alterations, as well as the application of new monitoring techniques in patients who have suffered a head injury (TBI) or other acute neurological pathology (neurocritical patients).


Specific aims: 1) To deepen the knowledge of metabolic alterations and oxygen transport at the tissue level in acute brain injuries. 2) Deepen the repercussions of anemia and blood transfusions on the ability to supply oxygen to the brain (research project La Marató TV3 201724 30 31). 3) To study the cerebral and systemic inflammatory response induced by acute brain injury, using high-resolution microdialysis techniques. 4) To analyze the phenomena of periinfarct depolarization in patients with acute brain injuries and their metabolic repercussions. 5) Applications of high-resolution microdialysis to the definition of the molecular profile of post-traumatic and ischemic cerebral edema and study of the contribution of non-selective cation channels in its formation. 6) Study mitochondrial dysfunction in patients who have suffered a TBI and develop a histotoxic hypoxia model from cultures in adult human brain slices obtained in surgical resections. 7) Validate the use of early blood cell biomarkers to define specific risk populations in adult and pediatric patients who have presented a mild TBI (BRAINI2 research project).

IP: Joan Sahuquillo Barris

Hydrocephalus and alterations in the dynamics of cerebrospinal fluid (CSF) (Consolidated Line)

General aim: Hydrocephalus is a very frequent pathology in the neurosurgical field, especially in pediatric patients. Its presence can lead to cognitive sequelae and disability that may be preventable with proper treatment. Our group has focused on a better understanding of its pathophysiology, on improving early diagnoses, and on the development of more specific biomarkers aimed at improving the clinical outcomes of these patients.


Specific aims: 1) Acquire new knowledge about the pathophysiology of normal pressure hydrocephalus and idiopathic intracranial hypertension (pseudotumor cerebri) and optimize diagnostic and therapeutic strategies in these patients. 2) To establish the brain biochemical alterations (neurotransmitters and neuropeptides) that occur in these patients and their involvement in cognitive functions and sleep disorders. 3) To correlate the cognitive deficit with the morphological and functional alterations of different brain structures such as the corpus callosum and the subcortical white matter. 4) Search for less invasive systems that offer reliable information on intracranial pressure (SafeICP research project).

IP: Ma Antonia Poca Pastor, Joan Sahuquillo Barris

Projects

(SafeICP) Plataforma fotónica no invasiva para la detección a pie de cama de la hipertensión intracraneal y otras anomalías de la dinámica del líquido cerebroespinal.

IP: Ma Antonia Poca Pastor
Collaborators: Joan Sahuquillo Barris, Maria Sueiras Gil, Diego Fernando Lopez Bermeo
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 335384
Reference: PLEC2022-009290
Duration: 01/12/2022 - 30/11/2025

Ministerio de Ciencia

Impacto del síndrome afectivo-cognitivo cerebeloso (Síndrome de Schmahmann) en los pacientes con una malformación de Chiari tipo 1.

IP: Ma Antonia Poca Pastor
Collaborators: Joan Sahuquillo Barris, Alejandro Ferré Masó, Diego Fernando Lopez Bermeo
Funding agency: Instituto de Salud Carlos III
Funding: 99220
Reference: PI22/01082
Duration: 01/01/2023 - 31/12/2025

Unitat recerca en neurotraumatologia i neurocirurg

IP: Ma Antonia Poca Pastor
Collaborators: Dulce María Moncho Rodríguez, Joan Sahuquillo Barris, Fuat Arikan Abello, Miriam de Nadal Clanchet, Maria Sueiras Gil, Alejandro Ferré Masó, Francisco Ramón Martínez Ricarte
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 60000
Reference: 2021 SGR 00810
Duration: 01/01/2022 - 30/06/2025

ADQUISICIÓN DE UN MICROSCOPIO MULTIDIMENSIONAL WIDEFIELD EQUIPADO PARA REALIZAR EXPERIMENTOS IN VIVO, DESTINADO A LA PLATAFORMA DE MICROSCOPÍA DE LA UNIDAD DE ALTA TECNOLOGÍA (UAT)

IP: Inmaculada Fuentes Camps
Collaborators: ADQUISICIÓN DE UN MICROSCOPIO MULTIDIMENSIONAL WIDEFIELD EQUIPADO PARA REALIZAR EXPERIMENTOS IN VIVO, DESTINADO A LA PLATAFORMA, Fco Javier Santos Vicente, Gema Ariceta Iraola, Santiago Ramon y Cajal Agüeras, Marta Martínez Vicente, Anna Meseguer Navarro, Manuel Comabella Lopez, Joan Sahuquillo Barris, Miguel Segura Ginard, Simon Schwartz Navarro, Anna Rosell Novel, Meritxell Genesca Ferrer
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 177204.2
Reference: EQC2019-006309-P
Duration: 01/01/2019 - 31/12/2020

Ministerio de Ciencia

Related news

The goal is to test a low-cost, easy-to-use and non-invasive monitor, which will serve to control intracranial pressure (PICO) values, which will help to control and treat different acute brain pathologies.

The new tool will improve patient care and allow early detection of complications, as the hospital previously did not have a specific form.

Entre els projectes es troben 12 investigacions on participen investigadors i investigadores de Vall d’Hebron.

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