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Joan Sahuquillo Barris

Institutions of which they are part

Neurotraumatology and Neurosurgery Research Unit (UNINN)
Vall Hebron Institut de Recerca

Research lines

Neurotraumatology (Consolidated Line)

General aims: To study alterations in brain metabolism, neurochemical alterations, pathophysiology, and new monitoring techniques and treatments in traumatic brain injury (TBI) and in neurocritical patients. Specific aims: 1) To increase knowledge of tissular metabolic and O2 transport alterations in acute brain lesions; 2) To study cerebral and systemic neuro-inflammatory response through high resolution microdialysis techniques; 3) To analyze peri-infarct depolarization phenomena in patients with acute brain injury (COSBID European study); 4) To apply of high-resolution microdialysis to define the molecular profile of post-traumatic brain edema and the contribution of non-selective cationic channels to its formation; and 5) To study mitochondrial dysfunction after traumatic brain injury (TBI) in patients and in histotóxica hypoxia can be modeled and reproduced in adult human brain slices obtained from surgically extracted specimens.

IP: Joan Sahuquillo Barris

Hydrocephalus and alterations in the dynamics of cerebrospinal fluid (CSF) (Consolidated Line)

General aim: To study the pathophysiology of intracranial pressure (ICP) and alterations in CSF dynamics in patients with hydrocephalus and other intracranial pathologies. Specific aims: 1) To gain greater insight into the physiopathology of normal pressure hydrocephalus and idiopathic intracranial hypertension (pseudotumor cerebri) and to study new diagnostic and therapeutic strategies; 2) To determine the biochemical alterations (neurotransmitters and neuropeptides) in these patients, as well as their role in cognitive function and sleep disturbances; and 3) To correlate cognitive deficit with morphological and functional alterations in different cerebral structures, such as the corpus callosum and subcortical white matter.

IP: Ma Antonia Poca Pastor, Joan Sahuquillo Barris

Malignant Middle Cerebral Artery Infarction (MMCAI) (Consolidated Line)

General aim: To expand on the physiopathology, metabolic alterations, and monitoring of patients with malignant MCA infarction. Specific aims: 1) To gain greater insight into the physiopathology, metabolic alterations, and monitoring of patients with malignant middle cerebral artery infarction; 2) To optimize treatment through the use of novel techniques, such as moderate hypothermia and decompressive craniectomy; 3) To characterize the inflammatory response profile (cerebral and systemic) triggered by massive ischemic stroke; 4) To optimize the treatment of severe head injury and MMCAI using new therapeutic techniques such as the combination of moderate hypothermia and decompressive craniotomy, and 5) To study and evaluate the quality of life of patients who survive a malignant middle cerebral artery infarction (MMCAI).

IP: Joan Sahuquillo Barris, José Alvarez Sabin

Congenital malformations of the cranio-vertebral junction (Emerging line)

Aims: 1) To improve knowledge of the physiopathology of craniocervical malformations, particularly Chiari Type I (MC-I), and quantify the clinical, social and occupational repercussions of this malformation; 2) To study the genetic bases of this malformation and its penetrance in family members; 3) To study sleep disturbances (particularly type and frequency of sleep apneas) associated with Chiari Type I malformations; and 4) Study the quality of life of patients with a craniocervical malformation without surgical treatment, as well as those with surgical treatment before and after surgery.

IP: Ma Antonia Poca Pastor, Joan Sahuquillo Barris

Projects

ADQUISICIÓN DE UN MICROSCOPIO MULTIDIMENSIONAL WIDEFIELD EQUIPADO PARA REALIZAR EXPERIMENTOS IN VIVO, DESTINADO A LA PLATAFORMA DE MICROSCOPÍA DE LA UNIDAD DE ALTA TECNOLOGÍA (UAT)

IP: Inmaculada Fuentes Camps
Collaborators: Maria Vicario Perez, Soledad Gallego Melcón, Fco Javier Santos Vicente, Diego Arango Corro, Gema Ariceta Iraola, Santiago Ramon y Cajal Agüeras, Marta Martínez Vicente, Anna Meseguer Navarro, Manuel Comabella Lopez, Ricardo Pujol Borrell, Joan Sahuquillo Barris, Joan Xavier Comella Carnicé, Miguel Segura Ginard, Simon Schwartz Navarro, Anna Rosell Novel, Meritxell Genesca Ferrer
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 177204.2
Reference: EQC2019-006309-P
Duration: 01/01/2019 - 31/12/2020

Ministerio de Ciencia

Study of the Tumor Microenvironment in Brain Cancer / Estudio del microambiente tumoral en el cáncer de cerebro

IP: Joan Sahuquillo Barris
Collaborators: -
Funding agency:
Funding:
Reference: PR(AG)200/2019
Duration: -

Estudio de los tumores cerebrales (glioblastoma y metástasis) para la identificación de mejores tratamientos y desarrollo de métodos de diagnóstico molecular no invasivo

IP: Joan Sahuquillo Barris
Collaborators: -
Funding agency: Asociación Española Contra el Cáncer
Funding:
Reference: AECC/2017/TRASLACIONAL--DUPLICAT
Duration: 06/02/2018 - 06/02/2018

Anemia or Blood Transfusion: A Clinical Dilemma in patient with traumatic brain injury

IP: Ma Antonia Poca Pastor
Collaborators: Dario Fabian Gándara Sabatini, Marylin Riveiro Vilaboa, Joan Sahuquillo Barris, Anna Rey Pérez, Miriam de Nadal Clanchet, Verónica Pons Escoll
Funding agency: Fundació La Marató de TV3
Funding: 191336.25
Reference: 20172430
Duration: 27/06/2018 - 31/12/2021

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