Joan Sahuquillo Barris Institucions de les que formen part Unitat de recerca en neurotraumatologia i neurocirurgia (UNINN) Vall Hebron Institut de Recerca
Línies de recerca Hydrocephalus and alterations in the dynamics of cerebrospinal fluid (CSF) (Consolidated Line) General aim: To study the pathophysiology of intracranial pressure (ICP) and alterations in CSF dynamics in patients with hydrocephalus and other intracranial pathologies. Specific aims: 1) To gain greater insight into the physiopathology of normal pressure hydrocephalus and idiopathic intracranial hypertension (pseudotumor cerebri) and to study new diagnostic and therapeutic strategies; 2) To determine the biochemical alterations (neurotransmitters and neuropeptides) in these patients, as well as their role in cognitive function and sleep disturbances; and 3) To correlate cognitive deficit with morphological and functional alterations in different cerebral structures, such as the corpus callosum and subcortical white matter. IP: Ma Antonia Poca Pastor, Joan Sahuquillo Barris Malignant Middle Cerebral Artery Infarction (MMCAI) (Consolidated Line) General aim: To expand on the physiopathology, metabolic alterations, and monitoring of patients with malignant MCA infarction. Specific aims: 1) To gain greater insight into the physiopathology, metabolic alterations, and monitoring of patients with malignant middle cerebral artery infarction; 2) To optimize treatment through the use of novel techniques, such as moderate hypothermia and decompressive craniectomy; 3) To characterize the inflammatory response profile (cerebral and systemic) triggered by massive ischemic stroke; 4) To optimize the treatment of severe head injury and MMCAI using new therapeutic techniques such as the combination of moderate hypothermia and decompressive craniotomy, and 5) To study and evaluate the quality of life of patients who survive a malignant middle cerebral artery infarction (MMCAI). IP: Joan Sahuquillo Barris, José Alvarez Sabin Congenital malformations of the cranio-vertebral junction (Emerging line) Aims: 1) To improve knowledge of the physiopathology of craniocervical malformations, particularly Chiari Type I (MC-I), and quantify the clinical, social and occupational repercussions of this malformation; 2) To study the genetic bases of this malformation and its penetrance in family members; 3) To study sleep disturbances (particularly type and frequency of sleep apneas) associated with Chiari Type I malformations; and 4) Study the quality of life of patients with a craniocervical malformation without surgical treatment, as well as those with surgical treatment before and after surgery. IP: Ma Antonia Poca Pastor, Joan Sahuquillo Barris Neuro-oncology (Emerging line) In this new line of translational research, we collaborate actively with the Vall d'Hebron Institute of Oncology (VHIO) lead by Dr. J. Baselga and especially with the "Gene Expression and Cancer" laboratory led by Dr. J. Seoane. Aims: 1) To develop a patient registry, centralized in external servers, to study the epidemiology, diagnosis and treatment results of primary and secondary brain tumors (Gliomas and metastases); 2) To develop a methodology for studying quality of life and cost-effectiveness of surgery and certain treatments in patients with malignant CNS tumors; 3) To study the cost-effectiveness of cortical mapping in low-grade tumors removed by awake craniotomy; 4) To develop cell lines of glioma primary cultures and glioma stem cells for improving knowledge of route regulation at all levels, especially pre- and-post-transcriptional; and 5) To study potential therapeutic targets derived from knowledge of the factors involved in the regulation of neuro-oncogenesis in glial cell tumors. IP: Joan Sahuquillo Barris, Francisco Ramón Martínez Ricarte Paginació Pàgina actual 1 Page 2 Pàgina següent › Última pàgina » Projectes ADQUISICIÓN DE UN MICROSCOPIO MULTIDIMENSIONAL WIDEFIELD EQUIPADO PARA REALIZAR EXPERIMENTOS IN VIVO, DESTINADO A LA PLATAFORMA DE MICROSCOPÍA DE LA UNIDAD DE ALTA TECNOLOGÍA (UAT) IP: Inmaculada Fuentes Camps Col·laboradors: Maria Vicario Perez, Soledad Gallego Melcón, Fco Javier Santos Vicente, Diego Arango Corro, Gema Ariceta Iraola, Santiago Ramon y Cajal Agüeras, Marta Martínez Vicente, Anna Meseguer Navarro, Manuel Comabella Lopez, Ricardo Pujol Borrell, Joan Sahuquillo Barris, Joan Xavier Comella Carnicé, Miguel Segura Ginard, Simon Schwartz Navarro, Anna Rosell Novel, Meritxell Genesca Ferrer Entitat finançadora: Ministerio de Ciencia e Innovación-MICINN Finançament: 177204.2 Referència: EQC2019-006309-P Durada: 01/01/2019 - 31/12/2020 Study of the Tumor Microenvironment in Brain Cancer / Estudio del microambiente tumoral en el cáncer de cerebro IP: Joan Sahuquillo Barris Col·laboradors: - Entitat finançadora: Finançament: Referència: PR(AG)200/2019 Durada: - Estudio de los tumores cerebrales (glioblastoma y metástasis) para la identificación de mejores tratamientos y desarrollo de métodos de diagnóstico molecular no invasivo IP: Joan Sahuquillo Barris Col·laboradors: - Entitat finançadora: Asociación Española Contra el Cáncer Finançament: Referència: AECC/2017/TRASLACIONAL--DUPLICAT Durada: 06/02/2018 - 06/02/2018 Anemia or Blood Transfusion: A Clinical Dilemma in patient with traumatic brain injury IP: Ma Antonia Poca Pastor Col·laboradors: Dario Fabian Gándara Sabatini, Marylin Riveiro Vilaboa, Joan Sahuquillo Barris, Anna Rey Pérez, Miriam de Nadal Clanchet, Verónica Pons Escoll Entitat finançadora: Fundació La Marató de TV3 Finançament: 191336.25 Referència: 20172430 Durada: 27/06/2018 - 31/12/2021 Paginació Pàgina actual 1 Page 2 Page 3 Page 4 Page 5 … Pàgina següent › Última pàgina »
