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Jordi Barquinero Mañez

I am an MD, specialized in Internal Medicine, and senior researcher at the Vall d'Hebron Research Institute (VHIR). Doctor from the UAB with Extraordinary Award. I received post-doctoral training at the Fred Hutchinson Cancer Research Center (Seattle). I am currently leading the Gene and Cell Therapy group at the VHIR. My interest has focused on understanding disease mechanisms and finding effective therapies for orphan diseases. In our laboratory we have worked on gene therapy research projects for several rare diseases, mainly of genetic origin.

Institutions of which they are part

Head of group
Gene and Cell Therapy
Vall Hebron Institut de Recerca

Jordi Barquinero Mañez

Institutions of which they are part

Head of group
Gene and Cell Therapy
Vall Hebron Institut de Recerca

I am an MD, specialized in Internal Medicine, and senior researcher at the Vall d'Hebron Research Institute (VHIR). Doctor from the UAB with Extraordinary Award. I received post-doctoral training at the Fred Hutchinson Cancer Research Center (Seattle). I am currently leading the Gene and Cell Therapy group at the VHIR. My interest has focused on understanding disease mechanisms and finding effective therapies for orphan diseases. In our laboratory we have worked on gene therapy research projects for several rare diseases, mainly of genetic origin.

I am an MD specialized in Internal Medicine (Vall d'Hebron University Hospital). I worked at the Intensive Care Unit (HUVH) and the Emergency Department of the Hospital de l'Esperança. I did pre-doctoral studies on autoimmunity at the University of Louisville (Dr. N. Harris) and got my PhD at the Autonomous University of Barcelona with Extraordinary Award, with a work that contributed to the description of a new disease, the primary antiphospholipid syndrome. I was a postdoc at the Fred Hutchinson Cancer Research Center (Dr. R. Storb, Seattle), where I was trained in hematopoietic stem cell gene therapy. I am currently group leader of the gene and cell therapy group (VHIR), where we investigate new therapeutic strategies for rare genetic diseases, mostly in collaboration with other groups on campus and from other national and international institutions. We have participated in research projects using models of multiple sclerosis, hemophilia, MNGIE, in a clinical trial for Fanconi anemia type A (coordinated by Drs. J. Bueren and P. Río, at the CIEMAT (Madrid)), and more recently, in a novel gene therapy approach for muscular dystrophy due to merosin deficiency, in collaboration with the Pediatric Neurology group (Drs. F. Munell and D. Gómez). Our group is part of the national network TERAV (RICORS). I have participated in European projects (INHERINET, CONSERT), including one as coordinator (HEMO-IPS, e-Rare-2), in which we experimentally demonstrated the mutagenic mechanism of the "Royal disease", the form of hemophilia B that affected several European royal families in the 19th and 20th centuries. I participate as a teacher in different master's degrees and I am a member of the American and European Gene and Cell Therapy Societies, and was one of the founding members of the Spanish Society of Gene and Cell Therapy.

Projects

Neuroimmunologia Clínica. Centre d'Esclerosi Múltiple de Catalunya (CEMCAT( (GRC)

IP: Xavier Montalban Gairín
Collaborators: Susana Otero Romero, Carlos Nos Llopis, Sunny Malhotra Sareen, José Ant. Graells Salvador, Jaume Sastre Garriga, Jordi Rio Izquierdo, Ingrid Galán Cartaña, Rosalia Horno Ocaña, Manuel Comabella Lopez, Margarida Capell Maymo, Silvia Soler García, Carmen Tur Gomez, Jordi Barquinero Mañez, Herena Eixarch Ahufinger, Carme Santoyo Medina, Oriol Nualart Mundo, Mar Tintore Subirana, M Jesus Arevalo Navines, Dunia Muñoz Valdivielso, Carmen Espejo Ruiz, Sergio Vergara Ruiz, Luciana Midaglia Fernandez, Joaquin Castillo Justribo, Milagros Fraga Pereira, Breogan Rodriguez Acevedo, Mireia Castillo Juarez, Nicolás Miguel Fissolo, Georgina Arrambide García
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 50000
Reference: 2014 SGR 1082
Duration: 01/01/2014 - 31/12/2016

Generación y caracterización de células mieloides supresoras a partir de monocitos y progenitores hematopoyéticos humanos

IP: Jordi Barquinero Mañez
Collaborators: Sergio López Estévez
Funding agency: Instituto de Salud Carlos III
Funding: 109505
Reference: PI12/01001
Duration: 01/01/2013 - 30/06/2017

Phase I/II Gene Therapy Trial of Fanconi anemia patients with a new Orphan Drug consisting of a lentiviral vector carrying the FANCA gene: A Coordinated International Action (EUROFANCOLEN) Grant Agreement nº 305421

IP: Josep Sánchez de Toledo Codina
Collaborators: Jordi Barquinero Mañez, Maria Cristina Díaz de Heredia Rubio, Raquel Hladun Alvaro
Funding agency: EUROPEAN COMMISSION
Funding: 285000
Reference: EUROFANCOLEN_FP7HEALTH2012
Duration: 01/01/2013 - 31/12/2018

Nuevas estrategias basadas en las células mieloides supresoras expresando autoantígenos para inducir tolerancia. Aplicación en un modelo experimental de esclerosis múltiple

IP: Jordi Barquinero Mañez
Collaborators: Laia Perez Lasarte
Funding agency: Fundació Institut de Recerca HUVH
Funding: 45135
Reference: PRED-VHIR-2011-08
Duration: 02/03/2012 - 01/03/2015

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