Matilde Lleonart Pajarin I am group leader of "Biomedical Research in Cancer Stem Cells" at VHIR. I arrived at VHIR 21 years ago after having worked in different prestigious international research centers: World Health Organization (WHO) at the International Agency for Research on Cancer (IARC) (Lyon, France), the Wolfson Institute for Biomedical Research (WIBR) in London and the Queen´s Mary University of London. Institutions of which they are part Head of group Head and Neck Cancer: Biomedical Research Cancer Stem cells Vall Hebron Institut de Recerca LinkedIn Twitter Orcid Matilde Lleonart Pajarin LinkedIn Twitter Orcid Institutions of which they are part Head of group Head and Neck Cancer: Biomedical Research Cancer Stem cells Vall Hebron Institut de Recerca I am group leader of "Biomedical Research in Cancer Stem Cells" at VHIR. I arrived at VHIR 21 years ago after having worked in different prestigious international research centers: World Health Organization (WHO) at the International Agency for Research on Cancer (IARC) (Lyon, France), the Wolfson Institute for Biomedical Research (WIBR) in London and the Queen´s Mary University of London.
My Research Group was recognized as an Emerging Research Group in 2009 by the Generalitat de Catalunya and later in 2014 as a Consolidated Research Group. Throughout my career I have been involved in cancer research from a more molecular point of view correlating key mutations in oncogenes and tumor suppressor genes with anatomical, pathological and clinical features of patients' tumors and also through cell culture studies to determine important key cell signaling pathways in tumorigenesis. Currently, the main lines of research of my Research Group focus on the identification and characterization of biological mechanisms in resistant cancer cells, including cancer stem cells, to unravel the pathways responsible for their resistance in breast, lung and head and neck cancer models. In addition, we are particularly focused on identifying molecular targets in resistant cancer cells and cancer stem cells affecting particularly aggressive tumors. The aim is to attack them pharmacologically in order to propose new cancer therapies: new drugs and/or drug combinations to combat resistant tumors in mouse models.
Research lines Estudio de proteínas de unión a RNA como nuevos factores pronóstico y diagnóstico en cáncer En nuestro laboratorio hemos efectuado diversos “screenings” genéticos para detectar nuevos genes implicados en proliferación celular in vitro que además poséan un papel relevante en cáncer humano. De entre ellos descubrimos la proteínas CIRP, la cual hemos descrito como proteína oncogénica. Actualmente estamos valorando la función de CIRP en diversos tipos tumorales en correlación con la evolución clínica de los pacientes. IP: Matilde Lleonart Pajarin Pagination First page « Previous page ‹ Page 1 Current page 2 Projects NANORESCAN IP: Matilde Lleonart Pajarin Collaborators: Katerin Ingrid Rojas Laimito, Irene Braña Garcia, David Virós Porcuna, Josep Castellví Vives, Marina Bataller Fernández, Juan Fernando Fuentes Cabrera, Juan Fernando Fuentes Cabrera Funding agency: Instituto de Salud Carlos III Funding: 318750 Reference: AC24/00057 Duration: 01/01/2025 - 31/12/2027 NANORESCAN: Nanocapsules combining novel drugs with conventional chemotherapy to cure resistant cancers IP: Matilde Lleonart Pajarin Collaborators: - Funding agency: EUROPEAN COMMISSION Funding: 0.01 Reference: EC/NANOTECMEC/2024/LLEONART Duration: - Beca VHIR PhD IP: Matilde Lleonart Pajarin Collaborators: Laia Perez Lasarte, Marina Bataller Fernández Funding agency: Fundació Institut de Recerca HUVH Funding: 69188.74 Reference: VPHD/MARINA_B Duration: 01/04/2023 - 31/03/2026 New compounds targeting head and neck cancer as Trojan horses against chemoresistant cells IP: Matilde Lleonart Pajarin Collaborators: Yoelsis Garcia Mayea, Marina Bataller Fernández, Gabriela Isabel Fuentes Llopis Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 20000 Reference: 2023 LLAV 00102 Duration: 01/02/2024 - 31/07/2024 Pagination First page « Previous page ‹ Page 1 Current page 2 Page 3 Page 4 Page 5 … Next page › Last page »
