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Matilde Lleonart Pajarin

I am group leader of "Biomedical Research in Cancer Stem Cells" at VHIR. I arrived at VHIR 21 years ago after having worked in different prestigious international research centers: World Health Organization (WHO) at the International Agency for Research on Cancer (IARC) (Lyon, France), the Wolfson Institute for Biomedical Research (WIBR) in London and the Queen´s Mary University of London.

Institutions of which they are part

Head of group
Head and Neck Cancer: Biomedical Research Cancer Stem cells
Vall Hebron Institut de Recerca

Matilde Lleonart Pajarin

Institutions of which they are part

Head of group
Head and Neck Cancer: Biomedical Research Cancer Stem cells
Vall Hebron Institut de Recerca

I am group leader of "Biomedical Research in Cancer Stem Cells" at VHIR. I arrived at VHIR 21 years ago after having worked in different prestigious international research centers: World Health Organization (WHO) at the International Agency for Research on Cancer (IARC) (Lyon, France), the Wolfson Institute for Biomedical Research (WIBR) in London and the Queen´s Mary University of London.

My Research Group was recognized as an Emerging Research Group in 2009 by the Generalitat de Catalunya and later in 2014 as a Consolidated Research Group.
Throughout my career I have been involved in cancer research from a more molecular point of view correlating key mutations in oncogenes and tumor suppressor genes with anatomical, pathological and clinical features of patients' tumors and also through cell culture studies to determine important key cell signaling pathways in tumorigenesis.
Currently, the main lines of research of my Research Group focus on the identification and characterization of biological mechanisms in resistant cancer cells, including cancer stem cells, to unravel the pathways responsible for their resistance in breast, lung and head and neck cancer models.
In addition, we are particularly focused on identifying molecular targets in resistant cancer cells and cancer stem cells affecting particularly aggressive tumors. The aim is to attack them pharmacologically in order to propose new cancer therapies: new drugs and/or drug combinations to combat resistant tumors in mouse models.

Projects

GC16173720CARR Definición de mecanismos clave de la multiresistencia de tumores de cabeza y cuello a los tratamientos quimio- y radioterapéuticos. Identificación de nuevos antitumorales individualizados.

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea, Juan Lorente Guerrero, Sergio Benavente Norza, Josep Castellví Vives, Vicente Peg Camara, Almudena Sanchez Garcia
Funding agency: Asociación Española Contra el Cáncer
Funding: 380000
Reference: AECC/GCE/2016/LLEONART
Duration: 01/10/2016 - 30/09/2022

Nuevas terapias aplicables a cánceres mamarios de naturaleza agresiva y metastática en base a aniquilar la población de células madre de cáncer.

IP: Matilde Lleonart Pajarin
Collaborators: Irene Braña Garcia, Margarita Alberola Ferranti, Sergio Benavente Norza, Carmela Iglesias i Felip, Josep Castellví Vives, Maria Alsina Maqueda
Funding agency: Instituto de Salud Carlos III
Funding: 195415
Reference: PI15/01262
Duration: 01/01/2016 - 30/11/2020

RedOx status of cancer stem cells and their resistance to chemo- and radio-therapy

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding: 40986
Reference: INCOMED - FELLOW 6
Duration: 08/06/2016 - 28/02/2018

RNA binding proteins : Future markers for cancer progression

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Fundació Institut de Recerca HUVH
Funding: 197196
Reference: PHD4MD/LLEONART/2015
Duration: 08/07/2015 - 08/07/2018

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