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Matilde Lleonart Pajarin

I am group leader of "Biomedical Research in Cancer Stem Cells" at VHIR. I arrived at VHIR 21 years ago after having worked in different prestigious international research centers: World Health Organization (WHO) at the International Agency for Research on Cancer (IARC) (Lyon, France), the Wolfson Institute for Biomedical Research (WIBR) in London and the Queen´s Mary University of London.

Institutions of which they are part

Head of group
Head and Neck Cancer: Biomedical Research Cancer Stem cells
Vall Hebron Institut de Recerca

Matilde Lleonart Pajarin

Institutions of which they are part

Head of group
Head and Neck Cancer: Biomedical Research Cancer Stem cells
Vall Hebron Institut de Recerca

I am group leader of "Biomedical Research in Cancer Stem Cells" at VHIR. I arrived at VHIR 21 years ago after having worked in different prestigious international research centers: World Health Organization (WHO) at the International Agency for Research on Cancer (IARC) (Lyon, France), the Wolfson Institute for Biomedical Research (WIBR) in London and the Queen´s Mary University of London.

My Research Group was recognized as an Emerging Research Group in 2009 by the Generalitat de Catalunya and later in 2014 as a Consolidated Research Group.
Throughout my career I have been involved in cancer research from a more molecular point of view correlating key mutations in oncogenes and tumor suppressor genes with anatomical, pathological and clinical features of patients' tumors and also through cell culture studies to determine important key cell signaling pathways in tumorigenesis.
Currently, the main lines of research of my Research Group focus on the identification and characterization of biological mechanisms in resistant cancer cells, including cancer stem cells, to unravel the pathways responsible for their resistance in breast, lung and head and neck cancer models.
In addition, we are particularly focused on identifying molecular targets in resistant cancer cells and cancer stem cells affecting particularly aggressive tumors. The aim is to attack them pharmacologically in order to propose new cancer therapies: new drugs and/or drug combinations to combat resistant tumors in mouse models.

Projects

Cirp function as a chaperone molecule interacting with RNA and microRNA and microRNAs

IP: Santiago Ramon y Cajal Agüeras
Collaborators: Matilde Lleonart Pajarin
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 7600
Reference: 2007 BE-1 00296
Duration: 20/08/2007 - 20/12/2007

Identificación y caracterización de nuevos genes que inmortalizan células primarias y su papel en tumores humanos

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 86052
Reference: FI06/00608
Duration: 08/02/2007 - 07/02/2011

RTICC - Red Temática de Investigación cooperativa de cáncer

IP: Santiago Ramon y Cajal Agüeras
Collaborators: Matilde Lleonart Pajarin, Cleofé Romagosa Pérez-Portabell, Teresa Moline Marimon, Carmela Iglesias i Felip, Josep Castellví Vives, Elena Antima Martinez Saez, Javier Hernandez Losa, Trond Aasen
Funding agency: Instituto de Salud Carlos III
Funding: 631500.61
Reference: RD06/0020/0104
Duration: 02/01/2007 - 31/12/2014

Estudi i identificació de nous gens de senescència i factors pivot o comodí en senyalització cel·lular, l'angiogènesi i la invasivitat en carcinomes de còlon i mama. Una correlació clinicopatològica

IP: Santiago Ramon y Cajal Agüeras
Collaborators: Matilde Lleonart Pajarin, Manuel Armengol Carrasco, Eloy Espín Basany, Javier Hernandez Losa
Funding agency: Fundació La Marató de TV3
Funding: 245453
Reference: TV3/052710
Duration: 01/01/2006 - 31/12/2008

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