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Matilde Lleonart Pajarin

I am group leader of "Biomedical Research in Cancer Stem Cells" at VHIR. I arrived at VHIR 21 years ago after having worked in different prestigious international research centers: World Health Organization (WHO) at the International Agency for Research on Cancer (IARC) (Lyon, France), the Wolfson Institute for Biomedical Research (WIBR) in London and the Queen´s Mary University of London.

Institutions of which they are part

Head of group
Head and Neck Cancer: Biomedical Research Cancer Stem cells
Vall Hebron Institut de Recerca

Matilde Lleonart Pajarin

Institutions of which they are part

Head of group
Head and Neck Cancer: Biomedical Research Cancer Stem cells
Vall Hebron Institut de Recerca

I am group leader of "Biomedical Research in Cancer Stem Cells" at VHIR. I arrived at VHIR 21 years ago after having worked in different prestigious international research centers: World Health Organization (WHO) at the International Agency for Research on Cancer (IARC) (Lyon, France), the Wolfson Institute for Biomedical Research (WIBR) in London and the Queen´s Mary University of London.

My Research Group was recognized as an Emerging Research Group in 2009 by the Generalitat de Catalunya and later in 2014 as a Consolidated Research Group.
Throughout my career I have been involved in cancer research from a more molecular point of view correlating key mutations in oncogenes and tumor suppressor genes with anatomical, pathological and clinical features of patients' tumors and also through cell culture studies to determine important key cell signaling pathways in tumorigenesis.
Currently, the main lines of research of my Research Group focus on the identification and characterization of biological mechanisms in resistant cancer cells, including cancer stem cells, to unravel the pathways responsible for their resistance in breast, lung and head and neck cancer models.
In addition, we are particularly focused on identifying molecular targets in resistant cancer cells and cancer stem cells affecting particularly aggressive tumors. The aim is to attack them pharmacologically in order to propose new cancer therapies: new drugs and/or drug combinations to combat resistant tumors in mouse models.

Projects

Relevancia terapéutica de las Células Madre de Cáncer en carcinoma epidermoide Faringo-Laríngeo

IP: Matilde Lleonart Pajarin
Collaborators: Yoelsis Garcia Mayea
Funding agency: Fundació Institut de Recerca HUVH
Funding: 46800
Reference: PRED-VHIR-2014-12
Duration: 01/06/2015 - 31/05/2018

Identificación de nuevos factores pronóstico y diagnóstico en cáncer basados en microRNAs y sus proteínas diana que se asocian a tumores de carácter más agresivo

IP: Matilde Lleonart Pajarin
Collaborators: César Serrano Garcia, Angel García Jiménez, Teresa Moline Marimon, Carmela Iglesias i Felip, Vicente Peg Camara
Funding agency: Instituto de Salud Carlos III
Funding: 145200
Reference: PI12/01104
Duration: 01/01/2013 - 30/06/2017

Desarrollo de dianas terapéuticas basadas en microRNAs sobreexpresados en cáncer de pulmón

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Fundación BBVA
Funding: 147000
Reference: BBVA/CONV.LLEONART/2010
Duration: 01/06/2010 - 01/06/2014

Genetic screen for detecting genes expressed in embryonic stem cells that bypass immortalisation in primary cells

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding: 31959
Reference: MERG-510300
Duration: 01/02/2004 - 31/01/2005

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