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Matilde Lleonart Pajarin

I am group leader of "Biomedical Research in Cancer Stem Cells" at VHIR. I arrived at VHIR 21 years ago after having worked in different prestigious international research centers: World Health Organization (WHO) at the International Agency for Research on Cancer (IARC) (Lyon, France), the Wolfson Institute for Biomedical Research (WIBR) in London and the Queen´s Mary University of London.

Institutions of which they are part

Head of group
Head and Neck Cancer: Biomedical Research Cancer Stem cells
Vall Hebron Institut de Recerca

Matilde Lleonart Pajarin

Institutions of which they are part

Head of group
Head and Neck Cancer: Biomedical Research Cancer Stem cells
Vall Hebron Institut de Recerca

I am group leader of "Biomedical Research in Cancer Stem Cells" at VHIR. I arrived at VHIR 21 years ago after having worked in different prestigious international research centers: World Health Organization (WHO) at the International Agency for Research on Cancer (IARC) (Lyon, France), the Wolfson Institute for Biomedical Research (WIBR) in London and the Queen´s Mary University of London.

My Research Group was recognized as an Emerging Research Group in 2009 by the Generalitat de Catalunya and later in 2014 as a Consolidated Research Group.
Throughout my career I have been involved in cancer research from a more molecular point of view correlating key mutations in oncogenes and tumor suppressor genes with anatomical, pathological and clinical features of patients' tumors and also through cell culture studies to determine important key cell signaling pathways in tumorigenesis.
Currently, the main lines of research of my Research Group focus on the identification and characterization of biological mechanisms in resistant cancer cells, including cancer stem cells, to unravel the pathways responsible for their resistance in breast, lung and head and neck cancer models.
In addition, we are particularly focused on identifying molecular targets in resistant cancer cells and cancer stem cells affecting particularly aggressive tumors. The aim is to attack them pharmacologically in order to propose new cancer therapies: new drugs and/or drug combinations to combat resistant tumors in mouse models.

Projects

Identificación de nuevos factores pronóstico y diagnóstico en cáncer basados en microRNAs y sus proteínas diana que se asocian a tumores de carácter más agresivo

IP: Matilde Lleonart Pajarin
Collaborators: César Serrano Garcia, Angel García Jiménez, Teresa Moline Marimon, Carmela Iglesias i Felip, Vicente Peg Camara
Funding agency: Instituto de Salud Carlos III
Funding: 145200
Reference: PI12/01104
Duration: 01/01/2013 - 30/06/2017

Desarrollo de dianas terapéuticas basadas en microRNAs sobreexpresados en cáncer de pulmón

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Fundación BBVA
Funding: 147000
Reference: BBVA/CONV.LLEONART/2010
Duration: 01/06/2010 - 01/06/2014

Genetic screen for detecting genes expressed in embryonic stem cells that bypass immortalisation in primary cells

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding: 31959
Reference: MERG-510300
Duration: 01/02/2004 - 31/01/2005

Desarrollo de dianas terapéuticas basadas en micro-RNAs sobreexpresados en cáncer

IP: Matilde Lleonart Pajarin
Collaborators: -
Funding agency: Fundación Caja Navarra
Funding: 9463.18
Reference: CAN2009-16708
Duration: 01/01/2010 - 31/12/2010

Related news

The ten groups within the Cancer Area combine basic, translational and clinical research to identify new targets, biomarkers and therapeutic strategies

Researchers from the Vall d’Hebron Research Institute (VHIR) have participated in a study showing that, after just a few seconds of illumination, the activated molecule prevents the formation of tumor spheres.

Experts addressed the main current and future challenges to improve therapeutic options for patients with this type of tumor.

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