Catalogue of animal models from Vall d'Hebron Barcelona Hospital Campus Use the search engine to find the models you need for your research. Animal species - None -Mice (Mus musculus)Pig (Sus scrofa)Mice (Muss musculus); Rat (Rattus norvegicus)Rat (Rattus norvegicus)Mice (Mus-musculus); NOD SCID gammaSheep (Ovis Linnaeus) Thematic area - None -Cardiovascular diseases Neuroscience, Rare diseasesOrthopedicNeuroscienceOncologyOncology, Rare diseaseLiver DiseasesImmunologyDiseases of the sense organs (skin, eyes and ears)Metabolic diseasesType 2 Diabetes; Type 1 DiabetesMusculoskeletal diseasesNeuroimmunologyDiseases of the sense organs (skin, eyes and ears)/DiabetesNeurovascular diseasesRare diseasesEndocrinologyInflammationNephrology Physiology and Pathophysiology of the Digestive Tract Specific pathology - None -Colorectal CancerEndometrial cancerOvarian cancerSarcomaEndometrial cancer; Ovarian cancerMetastasis of glioblastoma, brain, bone, uterine cervix, endometrial and nasopharyngeal cancerLung cancer, glioblastoma and skin cancerCholangiocarcinoma, gastric cancerBreast cancerCancerDisorders of body’s energy balance; Obesity; Type 2 diabetesPhysiological cardiac remodellingMyocardium infarctHeart failureParkinson's disease; neuromelanin productionGlioblastomaProstate cancer and bone metastasisColorectal cancerLung cancerNeuroblastomaOncology & Immuno-OncologyGlioblastoma, breast, colorectal, prostate and pancreatic cancerParkinson's disease; mutant GBA gene carrying D409V mutationParkinson's disease; mutant GBA gene carrying L444P mutationParkinson's diseasePortal Hypertension Type 2 Diabetes; Type 1 DiabetesProstate cancer Colon cancerMelanomaPancreatic ductal adenocarcinoma (PDAC)Small intestinal tumors and Colorectal cancer Metastasis of prostate cancerOncology & Inmuno Oncology, pharmacologyDifferent type of human cancers, including colorectal, breast, prostate, brain, lung and pancreatic, Ewing's sarcoma, glioblastomaPancreatic, lung, colon cancer and glioblastomRight heart failurePigmentary retinosisHepatic cirrhosisSkin Cancer; melanomaCerebral ischemiaHepatocellular CarcinomaPancreatic cancer Alzheimer Renal toxicity GlaucomaDiabetic Macular EdemaAge-related macular degenerationMultiple SclerosisRetinal neurodegeneration and microvascular abnormalities; diabetic macular edemaCardiac IschemiaCardiac deletion of Cx43: arrhythmias and sudden death (50% after 14 days of induction)Renal ischemia Air pollutionAneurysmAlzheimer and Sporadic Cerebral Amyloid AngiopathyBone regenerationCardiac Ischemia, reperfussionIschemia/reperfussionRenal fibrosisFabry disease; lysosomal storage disordersMultiple myelomaCancer models: human, mouse and syngeneic; melanomaTransplant rejectionTransplant rejection and immuno-modulationSepsisInsulin Resistance; Type 2 diabetes mellitusOncology & Inmuno oncologyMuscle pathologySteatohepatitis with fibrosis and portal hypertension Steatohepatitis with portal hypertension (NO fibrosis)MigraineCartilage InjuryGlaucoma (retinal neurodegeneration)Malignant infarction of the middle cerebral arteryLung cancer, Lymphoma; Multiple MyelomaHypertensionDigestive, autoinmunology; ulcerative colitisCirrhosis; NASH; healthy ratsExperimental model of Irritable Bowel syndrome; intestinal barrier dysfunctionGNB1 EncephalopathyWet age-related macular degeneration; diabetic retinopathyLymphomaOncology & Immuno-Oncology; melanomaSpina bifida Animal model name - None -Orthotopic models derived from Colorectal Organoid models modified with FmC (lentivirus luciferase and mCherry) from Msh2loxP/vCre/Braf mouse model Patient-derived Orthotopic Xenograft (PDXO) models of Endometrial CancerPDX model of Ovarian Cancer cells PDX model of SarcomaPDX models of Endometrial and Ovarian Cancers PDX models of Glioblastoma, Brain, Bone, Uterine cervix, Endometrial and Nasopharyngeal MetastasisPDX models of Lung, Glioblastoma and Skin CancerPDX of Cholangiocarcinoma and Gastric CancerPDX Orthotopic Xenograft of Breast CancerPDX Orthotopic Xenograft of Cancer cellsPGC1alpha/beta-FAT-DKOPGC-1alpha-FAT-KO PGC1-beta-FAT-KOPhysiologycal Cardiac Remodeling mouse modelPorcine model of Myocardium Infarct-closed thoraxPorcine model of Myocardium Infarct-open thoraxPathological Cardiac Remodelling induced by pressure overloadParkinson's disease modelOrthotopic Xenograft model of Breast Cancer Orthotopic Xenograft model of Breast Cancer and Pancreatic CancerOrthotopic Xenograft model of Glioblastoma Orthotopic Xenograft model of Prostate Cancer Orthotopic Xenograft of Breast Cancer Orthotopic Xenograft of Colorectal CancerOrthotopic Xenograft of GlioblastomaOrthotopic Xenograft of Lung CancerOrthotopic Xenograft of NeuroblastomaOrthotopic Xenograft of Ovarian Cancer cells (disseminated model)Orthotopic Xenograft of Ovarian Cancer cells and Ascitic cells Orthotopic Xenografts models of Human Cancer cell lines and PDXParkinson and Gaucher modelPortal Hypertention by portal vein ligation modelPpargc1a flox/floxPpargc1b flox/floxSubcutaneous Xenografts of prostate Cancer cell linesSubcutanous Xenograft model of Colon CancerSubcutanous Xenograft model of MelanomaSubcutanous Xenograft of Colorectal CancerSubcutanous Xenograft of GlioblastomaSubcutanous Xenograft of NeuroblastomaSubcutanous Xenograft of Pancreatic CancerSyngeneic models derived from Intestinal and Colorectal Organoid models from Msh2loxP/vCre mouse model Syngeneic models derived from Intestinal and Colorectal Organoid models from Msh2loxP/vCre/Braf mouse model Syngeneic models derived from Intestinal Organoid models from vCre/Braf mouse model Syngeneic Orthotopic or intravenous model of Lung CancervCre/BrafXenograft model of metastasis Prostate CancerXenograft model of Ovarian CancerXenograft model of pharynx and Larynx CancerSubcutaneous Xenografts of human Cancer cell lines and PDXSubcutaneous Xenograft Tumor modelSubcutaneous Xenograft of MelanomaPrimary tumor of SarcomaRat model of transient Coronary OcclusionRight Heart Failure mouse modelRoyal College of Surgeons (RCS) rat model of Retinal DegenerationSecondary Cholestasis due to bile duct ligation (BDL) modelSpontaneous murine model of Skin Cancer induced by UV radiationStroke modelSubcutaneous and Orthotopic Xenograft murine models of Endometrial and Ovarian Cancer using commercial cell linesSubcutaneous Xenograft model of Hepatocellular Carcinoma Subcutaneous Xenograft models of Pancreatic Cancer in inmunodeficient mouseSubcutaneous Xenograft of Cholangiocarcinoma and Gastric CancerSubcutaneous Xenograft of Lung CancerXenograft model of Pharynx and Larynx CancerOrthotopic models derived from Colorectal Organoid models modified with FmC (lentivirus luciferase and mCherry) from Msh2loxP/vCre mouse model 5xFAD model Alzheimer Cyclosporine (CsA)-induced Renal Toxicity modelDexamethasone-induced GlaucomaDiabetic rats by injection with streptozotocin (STZ)DIO (diet-induced obesity)Drug-induced pathological Cardiac Remodelling mouse modelDry macular degeneration murine model EAE - Experimental Autoimmune Encephalomyelitis - Chronic model EAE - Experimental Autoimmune Encephalomyelitis - Chronic progressive modelEAE - Experimental Autoimmune Encephalomyelitis - Relapsing-remitting modelEarly non-proliferative Diabetic Retinopathy Ectopic xenograft model of Neuroblastoma Ex vivo Cardiac Ischemia mouse modelEx vivo Cardiac Ischemia rat modelCx43-deficiency in mice induced by 4-hydroxytamoxifen intraperitoneal administrationChronic Liver Disease induced by intraperitoneal injection of thioacetamide (TAA)Chronic Liver Disease induced by inhalation of carbon tetrachloride (CCl4)Acute Cold exposureAcute Kidney Injury and regeneration modelAir Pollution rat modelAneurysm modelAPP23 model Alzheimer Cerebral Beta-amyloidosis Bone Defects in metaphysis (cylindrical)Caloric RestrictionCancer modelsCardiac Ischemia mouse modelCardiac Ischemia pig modelCardiac Ischemia rat modelCardiac Ischemia-Reperfussion mouse modelCardiac Ischemia-Reperfussion pig modelCardiac Ischemia-Reperfussion rat modelChronic Kidney disease (CKD) modelEx vivo cardiac Ischemia-Reperfussion mouse modelEx vivo cardiac Ischemia-Reperfussion rat modelFabry modelMsh2loxP/vCre/BrafMultiple Myeloma disseminated mice modelMurine model of Melanoma Murine model of Allloimmune Response Activation in Kidney TransplantsMurine model of Alloimmune Response Activation and Immune Reconstitution with allogeneic and autologous bone marrow transplantsMurine model of Alloimmune Response Activation in Heart TransplantsMurine model of SepsisMurine model of Transient Coronary OcclusionMurine model of Type 2 Diabetes (insulin resistance)Murine models of Glioblastoma, Lung and Prostate tumorMuscle Injuries modelNon-Alcoholic Steatohepatitis with fibrosis and portal Hypertension (NASH model)Non-Alcoholic Steatohepatitis with portal Hypertension and NASH without fibrosis (NASH model)NR1F3-FAT-KOMsh2loxP/vCreMigraine model and its chronificationMetastatic model of Neuroblastoma Focal Articular Cartilage Knee Defects Glaucoma (retinal neurodegeneration) genetic modelGyrencephalic porcine animal model of Malignant Infarction of the middle cerebral artery Humanized mice PBMCHypertension model Inflamatory Bowel Disease (humanized and non-humanized)Intestinal Decontamination and Microbiota TransplantIrritable Bowel Syndrome in ratsTransgenic de novo animal model Laser-induced Choroidal Neovascularization model (CNV)Lung colonization of Breast cancerLymphoma disseminated mice modelMelanoma Cancer modelMetastatic model of SarcomaOpen Spinal Neural tube defects in sheep fetuses Reference Name Animal specie Strain Thematic area Specific pathology Description AT122 Cardiac Ischemia mouse model Mice (Mus musculus) C57BL/6J Cardiovascular diseases Cardiac Ischemia Model generated by myocardial infarction induction AT123 Cardiac Ischemia pig model Pig (Sus scrofa) Cardiovascular diseases Cardiac Ischemia Model generated by myocardial infarction induction AT011 Cx43-deficiency in mice induced by 4-hydroxytamoxifen intraperitoneal administration Mice (Mus musculus) Hybrid strain C57BL6J y OlaHsd: Cx43Cre-ER(T)/fl Cardiovascular diseases Cardiac deletion of Cx43: arrhythmias and sudden death (50% after 14 days of induction) Ablation of Cx43 expression is achieved by 4-hydroxytamoxifen (4-OHT) treatment in adult mice intraperitoneally injected once a day, for 5 consecutive days, with 3 mg of 4-OHT. AT009 Chronic Liver Disease induced by intraperitoneal injection of thioacetamide (TAA) Rat (Rattus norvegicus) Sprague-Dawley OFA Liver Diseases Hepatic cirrhosis Rats receive the first week a dose of 250mg/Kg IP of TAA twice a week, the following 7 weeks they receive a dose of 200mg/Kg IP twice a week, being a total of 8 weeks and 16 injections After 8 weeks of treatment at a dose of 250-200mg/kg, twice a week, all animals will develop histological features of cirrhosis AT008 Chronic Liver Disease induced by inhalation of carbon tetrachloride (CCl4) Rat (Rattus norvegicus) Wistar Han Liver Diseases Hepatic cirrhosis With the administration of CCl4 we produce an acute hepatitis, and with its continued administration we generate a chronic liver injury that leads to the development of cirrhosis. To speed up the model, phenobarbital is administered to water (0.3 g/L) one week before starting the hepatotoxic exposure and until the end of the experiment We will consider that the animal has developed cirrhosis with portal hypertension after 12 weeks of inhalation. AT128 Chronic Kidney disease (CKD) model Mice (Mus musculus) CypB KO Nephrology Renal fibrosis Model generated by unilateral uretral obstruction (UUO). The ureter is doubly ligated at the midpoint between the kidney and the bladder. AT127 Cardiac Ischemia-Reperfussion rat model Rat (Rattus norvegicus) Sprague Dawley® Cardiovascular diseases Cardiac Ischemia, reperfussion Myocardial infarction followed by reperfussion AT126 Cardiac Ischemia-Reperfussion pig model Pig (Sus scrofa) Cardiovascular diseases Ischemia/reperfussion Myocardial infarction followed by reperfussion AT125 Cardiac Ischemia-Reperfussion mouse model Mice (Mus musculus) C57BL/6J Cardiovascular diseases Cardiac Ischemia, reperfussion Myocardial infarction followed by reperfussion AT124 Cardiac Ischemia rat model Rat (Rattus norvegicus) Sprague Dawley® Cardiovascular diseases Cardiac Ischemia Model generated by myocardial infarction induction Pagination First page « Primera Previous page ‹ Previous Page 1 Page 2 Page 3 Current page 4 Page 5 Page 6 Page 7 Page 8 Page 9 … Next page Next › Last page Últim » Animal samples request This catalog is updated annually. For additional information and/or to request animal models, you can contact us at catalogo.animales@vhir.org. You can also search for animal models on the ISCIII Biobanks and Biomodels Platform.
