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Biomedical Research in Melanoma

The Biomedical Research in Melanoma group is interested in skin cancer. We investigate the molecular causes for these diseases to design effective therapies against them. Our research is done in close proximity to patients, where our goal is to translate our discoveries as fast as possible to the clinic. To that end, we have a multidisciplinary group that associate dermatologists, oncologists, pathologists and basic-scientists that ask relevant clinical questions that need biological answers.

Our workflow contemplates information obtained from patients (genetic information, clinical history, functional data…) that is translated into animal models (genetic modified mouse models, PDX…) and in vitro experiments to answer the formulated questions. These results are used to design novel therapeutic approaches, including drug development and preclinical studies that ultimately will be translated to patients. 

The main lines of investigation are: 
•    Molecular mechanisms involved in melanoma development and progression, 
•    Targeting metabolism for melanoma treatment,
•    The mechanisms of resistance to immunotherapy.
 

Team

Gabriela Gomez Andrade

Gabriela Gomez Andrade

Research technician
Biomedical Research in Melanoma
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Kimberley Anne McGrail Fernández

Kimberley Anne McGrail Fernández

Postdoctoral researcher
Biomedical Research in Melanoma
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Pablo Marino Castro Garcia

Pablo Marino Castro Garcia

Research assistant
Biomedical Research in Melanoma
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Paula Granado Martinez

Paula Granado Martinez

Postdoctoral researcher
Biomedical Research in Melanoma
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Vicente García-Patos Briones

Vicente García-Patos Briones

Head of group
Biomedical Research in Melanoma
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Gabriela Gomez Andrade

Gabriela Gomez Andrade

Research technician
Biomedical Research in Melanoma
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Kimberley Anne McGrail Fernández

Kimberley Anne McGrail Fernández

Postdoctoral researcher
Biomedical Research in Melanoma
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Pablo Marino Castro Garcia

Pablo Marino Castro Garcia

Research assistant
Biomedical Research in Melanoma
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Paula Granado Martinez

Paula Granado Martinez

Postdoctoral researcher
Biomedical Research in Melanoma
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Vicente García-Patos Briones

Vicente García-Patos Briones

Head of group
Biomedical Research in Melanoma
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Projects

Recerca biomèdica and melanomes mod anim i càncer

IP: Juan Angel Recio Conde
Collaborators: Paula Granado Martinez, Kimberley Anne McGrail Fernández, Carlos González Cruz, Vicente García-Patos Briones
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 60000
Reference: 2021 SGR 00653
Duration: 01/01/2022 - 30/06/2025

Papel de p38a en melanoma

IP: Juan Angel Recio Conde
Collaborators: Paula Granado Martinez, Judit Álvarez González
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 63589.78
Reference: 2021 FI_B 00017
Duration: 01/04/2021 - 31/03/2024

Oncogene-mediated intratumoral immune-cell populations at different organs as biomarkers of immunotherapy response

IP: Juan Angel Recio Conde
Collaborators: Paula Granado Martinez, Kimberley Anne McGrail Fernández, Vicente García-Patos Briones, Berta Ferrer Fábrega, Sara Garcia Ortega
Funding agency: Instituto de Salud Carlos III
Funding: 341220
Reference: PI20/00384
Duration: 01/01/2021 - 30/04/2024

Novel therapeutic topical approach for discoid lupus cutaneous (DLE) treatment

IP: Cristina Solé Marce
Collaborators: Berta Ferrer Fábrega, Gloria Aparicio Español
Funding agency: Instituto de Salud Carlos III
Funding: 99099
Reference: PI21/01869
Duration: 01/01/2022 - 31/12/2025

Publications

Risk factors and clinical characteristics of acute and chronic cutaneous graft-versus-host disease in pediatric patients undergoing hematopoietic stem cell transplantation.

PMID: 37830789
Journal: PEDIATRIC DERMATOLOGY
Year: 2023
Reference: Pediatr Dermatol. 2023 Oct 13. doi: 10.1111/pde.15447.
Impact factor:
Publication type: Paper in international publication
Authors: Aracil, Belen; Calvo-Montes, Jorge; Canada-Garcia, Javier E; Canton, Rafael; Casquero-Garcia, Veronica; Cercenado, Emilia; El Mammery, Achraf; Ferrandiz-Pulido, Carla; Garcia-Cobos, Silvia; Garcia-Patos, Vicente et al.
DOI: 10.1111/pde.15447

Bacterial Polyhydroxyalkanoates-based Therapeutics-delivery Nanosystems.

PMID: 37828676
Journal: CURRENT MEDICINAL CHEMISTRY
Year: 2023
Reference: Curr Med Chem. 2023 Oct 11. doi: 10.2174/0109298673268775231003111540.
Impact factor:
Publication type: Paper in international publication
Authors: Andrade, Fernanda; Duran-Lara, Esteban F; Ferrandiz-Pulido, Carla; Garcia-Patos, Vicente; Gonzalez-Cruz, Carlos; Lobos G, Olga; Navarro, Alexandra; Rafael, Diana; Repiso, Trinidad; Vijayakumar, Sekar et al.
DOI: 10.2174/0109298673268775231003111540

Can the microcystic, elongated and fragmented pattern of invasion influence the evaluation of the depth of myometrial invasion in low-grade endometrioid endometrial cancer using imaging techniques?

PMID: 37929250
Journal:
Year: 2023
Reference: Ultrasound. 2023 Nov;31(4):292-299. doi: 10.1177/1742271X231157618. Epub 2023 Mar 17.
Impact factor:
Publication type: Paper in international publication
Authors: Albert, Eliseo; Amat, Paula; Balaguer, Aitana; Barba, Pere; Beas, Francisco; Benzaquen, Ana; Bradbury, Melissa; Campos, Diana; Capell-Morell, Montserrat; Carpio, Cecilia et al.
DOI: 10.1177/1742271X231157618

Impact of a successful percutaneous mitral paravalvular leak closure on long-term major clinical outcomes.

PMID: 38013065
Journal: CANADIAN JOURNAL OF CARDIOLOGY
Year: 2023
Reference: Can J Cardiol. 2023 Nov 25:S0828-282X(23)01952-9. doi: 10.1016/j.cjca.2023.11.025.
Impact factor:
Publication type: Paper in international publication
Authors: Abadias-Granado, Isabel; Aguasca, Gerard Marti; Almagro, Manuel; Almenara-Blasco, Manuel; Alujas, Teresa Gonzalez; Arias-Santiago, Salvador; Banuls, Jose; Barcelo, Maria Calvo; Barrabes, Jose A; Belahnech, Yassin et al.
DOI: 10.1016/j.cjca.2023.11.025

Slowly growing nodule in supralabial region.

PMID: 30226477
Journal: Indian Journal of Dermatology Venereology & Leprology
Year: 2020
Reference: Indian J Dermatol Venereol Leprol. 2020 Mar-Apr;86(2):215-217. doi: 10.4103/ijdvl.IJDVL_13_18.
Impact factor: 2.712
Publication type: Paper in international publication
Authors: Gonzalez-Cruz, Carlos, Bodet, Domingo, Garcia-Patos, Vicente et al.
DOI:

Blog

News

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

On World Cancer Research Day, we highlight research aimed at improving treatments for both pediatric and adult cancers through innovative techniques.

On World Cancer Research Day, we highlight the oncology research model of the Vall d'Hebron Campus that allows laboratory results to be transferred as quickly as possible to clinical practice.