About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.
Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.
Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours
PMID: 37882449 Journal: Future Oncology Year: 2023 Reference: Future Oncol. 2023 Oct 26. doi: 10.2217/fon-2023-0526. Impact factor: Publication type: Paper in international publication Authors: Agarwal, Neeraj; Alonso, Lucia; Azad, Arun A; Bordas, Anna; Casabona, Jordi; Chakrabarti, Jayeta; Chen, Hsiang-Chun; Colom-Cadena, Andreu; Fizazi, Karim; Ganem, Fabiana et al. DOI: 10.2217/fon-2023-0526
PMID: 37916501 Journal: Future Oncology Year: 2023 Reference: Future Oncol. 2023 Nov 2. doi: 10.2217/fon-2023-0155. Impact factor: Publication type: Paper in international publication Authors: Baik, Christina S; Boral, Andy L; Bowles, Daniel W; Chakravorty, Subarna; Colombatti, Raffaella; Curigliano, Giuseppe; de Montalembert, Mariane; Del Mar Manu Pereira, Maria; Gainor, Justin F; Garralda, Elena et al. DOI: 10.2217/fon-2023-0155
PMID: 37964360 Journal: BREAST CANCER RESEARCH Year: 2023 Reference: Breast Cancer Res. 2023 Nov 14;25(1):143. doi: 10.1186/s13058-023-01736-y. Impact factor: Publication type: Paper in international publication Authors: Baulida, Josep; Benitez-Carbante, Maria Isabel; Benitez-Carbante, Maria Isabel; Diaz de Heredia, Cristina; Eyras, Eduardo; Fernandez Ledesma, Berta; Fernandez Ledesma, Berta; Fernandez-Polo, Aurora; Franco-Valls, Hector; Garcia de Herreros, Antonio et al. DOI: 10.1186/s13058-023-01736-y
PMID: 38135915 Journal: EPILEPSIA Year: 2023 Reference: Epilepsia. 2023 Dec 22. doi: 10.1111/epi.17876. Impact factor: Publication type: Paper in international publication Authors: Aledo-Serrano, Angel; Ananth, Amitha L; Brea-Fernandez, Alejandro J; Caumes, Roseline; Chatron, Nicolas; Dainelli, Alice; De Wachter, Matthias; Denomme-Pichon, Anne-Sophie; Dye, Thomas J; Fazzi, Elisa et al. DOI: 10.1111/epi.17876
PMID: 34489122 Journal: EJSO Year: 2022 Reference: Eur J Surg Oncol. 2022 Jan;48(1):283-291. doi: 10.1016/j.ejso.2021.08.013. Epub 2021 Aug 16. Impact factor: Publication type: Paper in international publication Authors: Basta, N; Bjornland, K; Cross, K; Faraj, S; Froeba-Pohl, A; Fuchs, J; Gabra, H O; Gomez Chacon Villalba, J; Guerin, F; Guillen Burrieza, G et al. DOI: 10.1016/j.ejso.2021.08.013
PMID: 34417960 Journal: Clinical & Translational Oncology Year: 2022 Reference: Clin Transl Oncol. 2022 Feb;24(2):388-392. doi: 10.1007/s12094-021-02693-8. Epub 2021 Aug 21. Impact factor: Publication type: Paper in international publication Authors: Balmana, J; Carrasco, E; de Pablo Garcia-Cuenca, A; Diaz-de-Heredia, C; Lorente Guerrero, J; Murillo-Sanjuan, L; Uria Oficialdegui, M L et al. DOI: 10.1007/s12094-021-02693-8
PMID: 34807782 Journal: Expert Opinion on Drug Discovery Year: 2022 Reference: Expert Opin Drug Discov. 2022 Feb;17(2):167-179. doi: 10.1080/17460441.2022.2002297. Epub 2021 Nov 22. Impact factor: Publication type: Review in international publication Authors: Boloix, Ariadna; Canete, Adela; Cerda-Alberich, Leonor; Fletcher, Jamie I; Gallego, Soledad; Gray, Juliet C; Haber, Michelle; Jimenez, Carlos; Martinez de Las Heras, Blanca; Moreno, Lucas et al. DOI: 10.1080/17460441.2022.2002297
PMID: 34767629 Journal: CANCER Year: 2022 Reference: Cancer. 2022 Feb 15;128(4):797-807. doi: 10.1002/cncr.34007. Epub 2021 Nov 12. Impact factor: Publication type: Paper in international publication Authors: Agulnik, Asya; Alcasabas, Ana Patricia; Arce, Daniela; Arora, Ramandeep Singh; Gassant, Pascale Y; Graetz, Dylan E; Huang, Haiying; Kambugu, Joyce; Kaye, Erica C; Laptsevich, Aliaksandra et al. DOI: 10.1002/cncr.34007
PMID: 33781716 Journal: ANALES DE PEDIATRIA Year: 2021 Reference: An Pediatr (Engl Ed). 2021 Mar 26:S1695-4033(21)00148-X. doi: 10.1016/j.anpedi.2021.02.015. Impact factor: Publication type: Paper in national publication Authors: Badell Serra, Isabel; de la Fuente Regano, Lydia; Diaz de Heredia Rubio, Cristina; Fernandez, Jose Maria; Galan Gomez, Victor; Gonzalez Vicent, Marta; Lopez Duarte, Monica; Maldonado Regalado, M Soledad; Pascual Martinez, Antonia Isabel; Perez Hurtado, Jose Maria et al. DOI: 10.1016/j.anpedi.2021.02.015
PMID: 33067614 Journal: BLOOD Year: 2021 Reference: Blood. 2021 Mar 25;137(12):1582-1590. doi: 10.1182/blood.2020007848. Impact factor: Publication type: Paper in international publication Authors: Ammerlaan, Anneke Cj; Bielorai, Bella; Brethon, Benoit; Brivio, Erica; Chen, Ying; Chen-Santel, Christiane; Den Boer, Monique L; Diaz de Heredia, Cristina; Locatelli, Franco; Lopez-Yurda, Marta et al. DOI: 10.1182/blood.2020007848
PMID: 32979154 Journal: INFECTION Year: 2021 Reference: Infection. 2021 Apr;49(2):215-231. doi: 10.1007/s15010-020-01521-5. Epub 2020 Sep 26. Impact factor: Publication type: Review in international publication Authors: Aguilar-Guisado, Manuela; Alsina-Manrique, Laia; Barba, Pere; Diaz de Heredia, Cristina; Fortuny-Guasch, Claudia; Garcia-Cadenas, Irene; Garcia-Vidal, Carolina; Gonzalez-Vicent, Marta; Hernani, Rafael; Iacoboni, Gloria et al. DOI: 10.1007/s15010-020-01521-5
PMID: 33742757 Journal: PEDIATRIC TRANSPLANTATION Year: 2021 Reference: Pediatr Transplant. 2021 Jun;25(4):e14010. doi: 10.1111/petr.14010. Epub 2021 Mar 20. Impact factor: Publication type: Letter whit IF Authors: Alonso, Laura; Benitez-Carabante, M Isabel; Diaz-de-Heredia, Cristina; Oliveras, Maria; Renedo, Berta; Uria-Oficialdegui, M Luz et al. DOI: 10.1111/petr.14010
PMID: 32178817 Journal: Methods in Enzymology Year: 2020 Reference: Methods Enzymol. 2020;636:129-172. doi: 10.1016/bs.mie.2019.06.008. Epub 2019 Jul 12. Impact factor: Publication type: Paper in international publication Authors: Aranda, Fernando; Di Scala, Marianna; Dotor, Javier; Gallo-Oller, Gabriel et al. DOI: 10.1016/bs.mie.2019.06.008
PMID: 32133691 Journal: TRANSPLANT INTERNATIONAL Year: 2020 Reference: Transpl Int. 2020 Jul;33(7):762-772. doi: 10.1111/tri.13601. Epub 2020 Apr 2. Impact factor: Publication type: Paper in international publication Authors: Bader, P; Balduzzi, A; Bauer, D; Bordon, V; Corbacioglu, S; Dalissier, A; Dalle, J-H; Diaz De Heredia, C; Gibson, B; Lawitschka, A et al. DOI: 10.1111/tri.13601
PMID: 32142919 Journal: CANCER LETTERS Year: 2020 Reference: Cancer Lett. 2020 May 1;477:49-59. doi: 10.1016/j.canlet.2020.02.035. Epub 2020 Mar 3. Impact factor: Publication type: Paper in international publication Authors: Gallego, S; Gallo-Oller, G; Garrido, M; Giralt, I; Guillen, G; Hladun, R; Magdaleno, A; Molist, C; Moreno, L; Navarro, N et al. DOI: 10.1016/j.canlet.2020.02.035
PMID: 32113697 Journal: MEDICINA CLINICA Year: 2020 Reference: Med Clin (Barc). 2020 Aug 14;155(3):95-103. doi: 10.1016/j.medcli.2019.10.011. Epub 2020 Feb 26. Impact factor: Publication type: Paper in national publication Authors: Argiles, Bienvenida; Bardon Cancho, Eduardo J; Belendez, Cristina; Beneitez, David; Bermudez, Mar; Berrueco, Ruben; Cela, Elena; Cervera, Aurea; Garcia-Morin, Marina; Gondra, Ainhoa et al. DOI: 10.1016/j.medcli.2019.10.011
PMID: 31562043 Journal: LANCET ONCOLOGY Year: 2019 Reference: Lancet Oncol. 2019 Nov;20(11):1566-1575. doi: 10.1016/S1470-2045(19)30617-5. Epub 2019 Sep 24. Impact factor: 35.386 Publication type: Paper in international publication Authors: Devalck, Christine, Ben-Arush, Myriam, Mudry, Peter, Ferman, Sima, Jenney, Meriel, Ferrari, Andrea, Zanetti, Ilaria, Casanova, Michela, Glosli, Heidi, Bisogno, Gianni et al. DOI: 10.1016/S1470-2045(19)30617-5
PMID: 31556188 Journal: PEDIATRIC TRANSPLANTATION Year: 2019 Reference: Pediatr Transplant. 2019 Dec;23(8):e13584. doi: 10.1111/petr.13584. Epub 2019 Sep 26. Impact factor: 1.326 Publication type: Paper in international publication Authors: Querol, Sergio, Alonso, Laura, Rudilla, Francesc, Gimeno, Ramon, Codinach, Margarita, Blanco, Margarita, Diaz de Heredia, Cristina et al. DOI: 10.1111/petr.13584
PMID: 31543384 Journal: EUROPEAN JOURNAL OF CANCER Year: 2019 Reference: Eur J Cancer. 2019 Nov;121:224-235. doi: 10.1016/j.ejca.2019.07.027. Epub 2019 Sep 19. Impact factor: 6.68 Publication type: Paper in international publication Authors: George, Sally L, Izquierdo, Elisa, Campbell, James, Moreno, Lucas, Pearson, Andrew, Shipley, Janet, Jones, Chris, Hargrave, Darren, Jacques, Thomas S, Hubank, Michael et al. DOI: 10.1016/j.ejca.2019.07.027
PMID: 31501599 Journal: NATURE MEDICINE Year: 2019 Reference: Nat Med. 2019 Sep;25(9):1396-1401. doi: 10.1038/s41591-019-0550-z. Epub 2019 Sep 9. Impact factor: 30.641 Publication type: Paper in international publication Authors: Rio, Paula, Navarro, Susana, Wang, Wei, Sanchez-Dominguez, Rebeca, Pujol, Roser M, Segovia, Jose C, Bogliolo, Massimo, Merino, Eva, Wu, Ning, Salgado, Rocio et al. DOI: 10.1038/s41591-019-0550-z
PMID: 29211298 Journal: CANCER Year: 2018 Reference: Cancer. 2018 Mar 1;124(5):1016-1024. doi: 10.1002/cncr.31157. Epub 2017 Dec 6. Impact factor: 6.537 Publication type: Paper in international publication Authors: Vaarwerk, Bas, van der Lee, Johanna H, Breunis, Willemijn B, Orbach, Daniel, Chisholm, Julia C, Cozic, Nathalie, Jenney, Meriel, van Rijn, Rick R, McHugh, Kieran, Gallego, Soledad et al. DOI: 10.1002/cncr.31157
PMID: 28754820 Journal: CLINICAL CANCER RESEARCH Year: 2017 Reference: Clin Cancer Res. 2017 Nov 1;23(21):6478-6486. doi: 10.1158/1078-0432.CCR-17-0489. Epub 2017 Jul 28. Impact factor: 9.619 Publication type: Paper in international publication Authors: Shouval, Roni, Ruggeri, Annalisa, Labopin, Myriam, Mohty, Mohamad, Sanz, Guillermo, Michel, Gerard, Kuball, Jurgen, Chevallier, Patrice, Al-Seraihy, Amal, Milpied, Noel-Jean et al. DOI: 10.1158/1078-0432.CCR-17-0489
PMID: 28737775 Journal: BONE MARROW TRANSPLANTATION Year: 2017 Reference: Bone Marrow Transplant. 2017 Oct;52(10):1406-1415. doi: 10.1038/bmt.2017.147. Epub 2017 Jul 24. Impact factor: 3.874 Publication type: Paper in international publication Authors: Ahler, A, Balduzzi, A, Dalle, J-H, Jahnukainen, K, von Wolff, M, Lucchini, G, Ifversen, M, Macklon, K T, Poirot, C, Diesch, T et al. DOI: 10.1038/bmt.2017.147
PMID: 28557976 Journal: BRITISH JOURNAL OF CANCER Year: 2017 Reference: Br J Cancer. 2017 Jul 11;117(2):256-265. doi: 10.1038/bjc.2017.152. Epub 2017 May 30. Impact factor: 6.176 Publication type: Paper in international publication Authors: Forero-Castro, Maribel, Robledo, Cristina, Benito, Rocio, Bodega-Mayor, Irene, Rapado, Inmaculada, Hernandez-Sanchez, Maria, Abaigar, Maria, Maria Hernandez-Sanchez, Jesus, Quijada-Alamo, Miguel, Maria Sanchez-Pina, Jose et al. DOI: 10.1038/bjc.2017.152
PMID: 28438676 Journal: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION Year: 2017 Reference: Biol Blood Marrow Transplant. 2017 Aug;23(8):1350-1358. doi: 10.1016/j.bbmt.2017.04.015. Epub 2017 Apr 21. Impact factor: 4.704 Publication type: Paper in international publication Authors: Page, Kristin M, Labopin, Myriam, Ruggeri, Annalisa, Michel, Gerard, Diaz de Heredia, Cristina, O'Brien, Tracey, Picardi, Alessandra, Ayas, Mouhab, Bittencourt, Henrique, Vora, Ajay J et al. DOI: 10.1016/j.bbmt.2017.04.015
The association, once again, has shown its commitment to oncological research with a donation of €19,197 to the Cancer and Hematological Diseases Group for Children at VHIR.
The prestigious journal The Lancet has published the results of this study, which is the result of more than 20 years of pre-clinical research and 7 years of patient follow-up.
During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.
