Childhood Cancer and Blood Disorders
The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.
Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.
Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours
Publications
Engineering pH-Sensitive Stable Nanovesicles for Delivery of MicroRNA Therapeutics.
PMID: 34786859
Journal: Small
Year: 2022
Reference: Small. 2022 Jan;18(3):e2101959. doi: 10.1002/smll.202101959. Epub 2021 Nov 16.
Impact factor:
Publication type: Paper in international publication
Authors: Abutbul-Ionita, Inbal; Albertazzi, Lorenzo; Boloix, Ariadna; Cordoba, Alba; Danino, Dganit; de Toledo, Josep Sanchez; Feiner-Gracia, Natalia; Foradada, Laia; Gallego, Soledad; Kober, Mariana et al.
DOI: 10.1002/smll.202101959
Access to early-phase clinical trials for children with relapsed and refractory neuroblastoma: A multicentre international study.
PMID: 35029330
Journal: PEDIATRIC BLOOD & CANCER
Year: 2022
Reference: Pediatr Blood Cancer. 2022 Aug;69(8):e29551. doi: 10.1002/pbc.29551. Epub 2022 Jan 14.
Impact factor:
Publication type: Paper in international publication
Authors: Bautista, Francisco; Carceller, Fernando; Cortes, Marta; Moreno, Lucas; Rubio-San-Simon, Alba; Vaidya, Sucheta J et al.
DOI: 10.1002/pbc.29551
Congenital rhabdomyosarcoma: A report from the European paediatric Soft tissue sarcoma Study Group.
PMID: 34582098
Journal: PEDIATRIC BLOOD & CANCER
Year: 2022
Reference: Pediatr Blood Cancer. 2022 Feb;69(2):e29376. doi: 10.1002/pbc.29376. Epub 2021 Sep 28.
Impact factor:
Publication type: Paper in international publication
Authors: Alaggio, Rita; Arush, Myriam Ben; Bisogno, Gianni; Coppadoro, Beatrice; Daragjati, Julia; Gallego, Soledad; Merks, Johannes H M; Minard-Colin, Veronique; Mudry, Peter; Slater, Olga et al.
DOI: 10.1002/pbc.29376
Localised rhabdomyosarcoma in infants (<12 months) and young children (12-36 months of age) treated on the EpSSG RMS 2005 study.
PMID: 34865946
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2022
Reference: Eur J Cancer. 2022 Jan;160:206-214. doi: 10.1016/j.ejca.2021.10.031. Epub 2021 Dec 2.
Impact factor:
Publication type: Paper in international publication
Authors: Bisogno, Gianni; Cesen, Maja; Coppadoro, Beatrice; De Corti, Federica; Ferrari, Andrea; Gains, Jennifer E; Gallego, Soledad; Gaze, Mark N; Glosli, Heidi; Jenney, Meriel et al.
DOI: 10.1016/j.ejca.2021.10.031
Next-generation Sequencing in Bone Marrow Failure Syndromes and Isolated Cytopenias: Experience of the Spanish Network on Bone Marrow Failure Syndromes.
PMID: 33718801
Journal: HemaSphere
Year: 2021
Reference: Hemasphere. 2021 Mar 9;5(4):e539. doi: 10.1097/HS9.0000000000000539. eCollection 2021 Apr.
Impact factor:
Publication type: Paper in international publication
Authors: Arias-Salgado, Elena G; Badell, Isabel; Belendez, Cristina; Bogliolo, Massimo; Bueren, Juan; Catala, Albert; Diaz de Heredia, Cristina; Galera, Ana; Galvez, Eva; Gimenez, Yari et al.
DOI: 10.1097/HS9.0000000000000539
Adjuvant therapy of histopathological risk factors of retinoblastoma in Europe: A survey by the European Retinoblastoma Group (EURbG).
PMID: 33720495
Journal: PEDIATRIC BLOOD & CANCER
Year: 2021
Reference: Pediatr Blood Cancer. 2021 Jun;68(6):e28963. doi: 10.1002/pbc.28963. Epub 2021 Mar 15.
Impact factor:
Publication type: Paper in international publication
Authors: Abbink, Floor C H; Aerts, Isabelle; Atalay, Hatice Tuba; Bechrakis, Nikolaos E; Biewald, Eva; Brecht, Ines B; Caspi, Shani; Cassoux, Nathalie; Castela, Guilherme; Chantada, Guillermo et al.
DOI: 10.1002/pbc.28963
Ruxolitinib for steroid-refractory graft versus host disease in pediatric HSCT: high response rate and manageable toxicity.
PMID: 33661711
Journal: PEDIATRIC HEMATOLOGY AND ONCOLOGY
Year: 2021
Reference: Pediatr Hematol Oncol. 2021 May;38(4):331-345. doi: 10.1080/08880018.2020.1868637. Epub 2021 Mar 4.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Laura; Benitez-Carabante, Maria Isabel; Bueno, David; Escudero, Adela; Fernandez-Arroyo, Alba; Heredia, Cristina Diaz de; Losantos, Itsaso; Martinez, Antonio Perez; Mestre-Duran, Carmen; Mozo, Yasmina et al.
DOI: 10.1080/08880018.2020.1868637
Opportunities and Challenges in Drug Development for Pediatric Cancers.
PMID: 33277309
Journal: Cancer Discovery
Year: 2021
Reference: Cancer Discov. 2021 Mar;11(3):545-559. doi: 10.1158/2159-8290.CD-20-0779. Epub 2020 Dec 4.
Impact factor:
Publication type: Review in international publication
Authors: Bender, Julia Glade; DuBois, Steven G; Laetsch, Theodore W; Macy, Margaret E; Moreno, Lucas et al.
DOI: 10.1158/2159-8290.CD-20-0779
[Immunotherapy with CAR-T cells in paediatric haematology-oncology].
PMID: 32107177
Journal: ANALES DE PEDIATRIA
Year: 2020
Reference: An Pediatr (Barc). 2020 Jul;93(1):59.e1-59.e10. doi: 10.1016/j.anpedi.2019.12.014. Epub 2020 Feb 24.
Impact factor:
Publication type: Paper in national publication
Authors: Alonso, Laura; Alonso, Marta M; Anguita, Javier; Blanquer, Miguel; Diaz, Miguel Angel; Fuster, Jose Luis; Garcia-Castro, Javier; Garcia-Morin, Marina; Gonzalez, Marta; Guerra-Garcia, Pilar et al.
DOI: 10.1016/j.anpedi.2019.12.014
Correction: Supportive care during pediatric hematopoietic stem cell transplantation: beyond infectious diseases. A report from workshops on supportive care of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT).
PMID: 32080355
Journal: BONE MARROW TRANSPLANTATION
Year: 2020
Reference: Bone Marrow Transplant. 2020 Jun;55(6):1214. doi: 10.1038/s41409-020-0838-0.
Impact factor:
Publication type: Letter or abstract
Authors: Ansari, Marc; Bader, Peter; Bakhtiar, Shahrzad; Balduzzi, Adriana; Bertaina, Alice; Boenig, Halvard; Buechner, Jochen; Cesaro, Simone; Corbacioglu, Selim; Dalissier, Arnaud et al.
DOI: 10.1038/s41409-020-0838-0
Radiological and surgical differences between congenital end-to-side (Abernethy malformation) and side-to-side portocaval shunts.
PMID: 32067808
Journal: JOURNAL OF PEDIATRIC SURGERY
Year: 2020
Reference: J Pediatr Surg. 2020 Sep;55(9):1897-1902. doi: 10.1016/j.jpedsurg.2020.01.053. Epub 2020 Feb 1.
Impact factor:
Publication type: Paper in international publication
Authors: Bueno, Javier; Diez, Iratxe; Guillen, Gabriela; Lopez, Manuel; Lopez, Sergio; Lopez-Ben, Santiago; Molino, Jose A; Perez, Mercedes; Venturi, Carla et al.
DOI: 10.1016/j.jpedsurg.2020.01.053
Supportive care during pediatric hematopoietic stem cell transplantation: beyond infectious diseases. A report from workshops on supportive care of the Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT).
PMID: 32029909
Journal: BONE MARROW TRANSPLANTATION
Year: 2020
Reference: Bone Marrow Transplant. 2020 Jun;55(6):1126-1136. doi: 10.1038/s41409-020-0818-4. Epub 2020 Feb 6.
Impact factor:
Publication type: Paper in international publication
Authors: Ansari, Marc; Bader, Peter; Bakhtiar, Shahrzad; Balduzzi, Adriana; Bertaina, Alice; Boenig, Halvard; Buchner, Jochen; Cesaro, Simone; Corbacioglu, Selim; Dalissier, Arnaud et al.
DOI: 10.1038/s41409-020-0818-4
High-dose etoposide and cyclophosphamide in adults and children with primary refractory and multiply relapsed acute leukaemias: The Royal Marsden experience.
PMID: 31493701
Journal: LEUKEMIA RESEARCH
Year: 2019
Reference: Leuk Res. 2019 Oct;85:106217. doi: 10.1016/j.leukres.2019.106217. Epub 2019 Aug 13.
Impact factor: 2.066
Publication type: Paper in international publication
Authors: Carceller, Fernando, Hirsch, Steffen G, Khabra, Komel, Petterson, Toni, Malik, Rubina, Guerra-Garcia, Pilar, Moreno, Lucas, Marshall, Lynley V, Taj, Mary, Atra, Ayad et al.
DOI: 10.1016/j.leukres.2019.106217
Donor lymphocyte infusions for B-cell malignancies relapse after T-cell replete allogeneic hematopoietic cell transplantation.
PMID: 30546069
Journal: BONE MARROW TRANSPLANTATION
Year: 2019
Reference: Bone Marrow Transplant. 2019 Jul;54(7):1133-1137. doi: 10.1038/s41409-018-0422-z. Epub 2018 Dec 13.
Impact factor: 4.674
Publication type: Paper in international publication
Authors: Sanchez-Ortega, Isabel, Alonso, Laura, Sisinni, Luisa, Fox, Laura, Villacampa, Guillermo, Badell, Isabel, de Heredia, Cristina Diaz, Parody, Rocio, Ferra, Christelle, Solano, Carlos et al.
DOI: 10.1038/s41409-018-0422-z
Prominent venous circulation and thick lips in an 8-year-old boy with congenital neutropenia.
PMID: 31099923
Journal: PEDIATRIC DERMATOLOGY
Year: 2019
Reference: Pediatr Dermatol. 2019 May;36(3):e69-e70. doi: 10.1111/pde.13760.
Impact factor: 1.178
Publication type: Paper in international publication
Authors: Giacaman, Aniza, Salinas Sanz, Jose Antonio, Navarro Noguera, Samuel, Diaz de Heredia Rubio, Cristina, Martin-Santiago, Ana et al.
DOI: 10.1111/pde.13760
Red Blood Cell Membrane Conductance in Hereditary Haemolytic Anaemias.
PMID: 31040790
Journal: Frontiers in Physiology
Year: 2019
Reference: Front Physiol. 2019 Apr 16;10:386. doi: 10.3389/fphys.2019.00386. eCollection 2019.
Impact factor: 3.201
Publication type: Paper in international publication
Authors: Petkova-Kirova, Polina, Hertz, Laura, Danielczok, Jens, Huisjes, Rick, Makhro, Asya, Bogdanova, Anna, Manu-Pereira, Maria Del Mar, Vives Corrons, Joan-Lluis, van Wijk, Richard, Kaestner, Lars et al.
DOI: 10.3389/fphys.2019.00386
State-of-the-art fertility preservation in children and adolescents undergoing haematopoietic stem cell transplantation: a report on the expert meeting of the Paediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) in Baden, Austria, 29-30 September 2015.
PMID: 28287638
Journal: BONE MARROW TRANSPLANTATION
Year: 2017
Reference: Bone Marrow Transplant. 2017 Jul;52(7):1029-1035. doi: 10.1038/bmt.2017.21. Epub 2017 Mar 13.
Impact factor: 3.874
Publication type: Paper in international publication
Authors: Dalle, J-H, Lucchini, G, Balduzzi, A, Ifversen, M, Jahnukainen, K, Macklon, K T, Ahler, A, Jarisch, A, Ansari, M, Beohou, E et al.
DOI: 10.1038/bmt.2017.21
[Early clinical trials in paediatric oncology in Spain: a nationwide perspective].
PMID: 28279690
Journal: ANALES DE PEDIATRIA
Year: 2017
Reference: An Pediatr (Barc). 2017 Sep;87(3):155-163. doi: 10.1016/j.anpedi.2016.07.007. Epub 2017 Mar 6.
Impact factor: 1.14
Publication type: Review in national publication
Authors: Hladun, Raquel, Juan Ribelles, Antonio, Madero, Luis, Ramirez, Manuel, Fernandez Delgado, Rafael, Perez-Martinez, Antonio, Mata, Cristina, Llort, Anna, Martin Broto, Javier, Cela, Maria Elena et al.
DOI: 10.1016/j.anpedi.2016.07.007
Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma.
PMID: 28243259
Journal: Stem Cells International
Year: 2017
Reference: Stem Cells Int. 2017;2017:7507380. doi: 10.1155/2017/7507380. Epub 2017 Jan 24.
Impact factor: 3.54
Publication type: Paper in international publication
Authors: Almazan-Moga, Ana, Zarzosa, Patricia, Vidal, Isaac, Molist, Carla, Giralt, Irina, Navarro, Natalia, Soriano, Aroa, Segura, Miguel F, Alfranca, Arantza, Garcia-Castro, Javier et al.
DOI: 10.1155/2017/7507380
Paratesticular rhabdomyosarcoma in children and adolescents-Outcome and patterns of relapse when utilizing a nonsurgical strategy for lymph node staging: Report from the International Society of Paediatric Oncology (SIOP) Malignant Mesenchymal Tumour 89 and 95 studies.
PMID: 28205365
Journal: PEDIATRIC BLOOD & CANCER
Year: 2017
Reference: Pediatr Blood Cancer. 2017 Sep;64(9). doi: 10.1002/pbc.26486. Epub 2017 Feb 16.
Impact factor: 2.513
Publication type: Paper in international publication
Authors: Rogers, Timothy, Minard-Colin, Veronique, Cozic, Nathalie, Jenney, Meriel, Merks, Johannes H M, Gallego, Soledad, Devalck, Christine, Gaze, Mark N, Kelsey, Anna, Oberlin, Odile et al.
DOI: 10.1002/pbc.26486
News
The association, once again, has shown its commitment to oncological research with a donation of €19,197 to the Cancer and Hematological Diseases Group for Children at VHIR.
The prestigious journal The Lancet has published the results of this study, which is the result of more than 20 years of pre-clinical research and 7 years of patient follow-up.
During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.