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Childhood Cancer and Blood Disorders

The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.

Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.

Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours

Team

Ajla Idrizovic

Ajla Idrizovic

Research technician
Childhood Cancer and Blood Disorders
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Alperi Garcia, Sofia

Alperi Garcia, Sofia

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Balbastre Ubeda, Ferran

Balbastre Ubeda, Ferran

Research technician
Childhood Cancer and Blood Disorders
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Daiana Natali Lopez

Daiana Natali Lopez

Research technician
Childhood Cancer and Blood Disorders
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Espinosa Lopez, Blanca

Espinosa Lopez, Blanca

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Jon Ander Aguirre Carrillo

Jon Ander Aguirre Carrillo

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Ajla Idrizovic

Ajla Idrizovic

Research technician
Childhood Cancer and Blood Disorders
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Alperi Garcia, Sofia

Alperi Garcia, Sofia

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Balbastre Ubeda, Ferran

Balbastre Ubeda, Ferran

Research technician
Childhood Cancer and Blood Disorders
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Daiana Natali Lopez

Daiana Natali Lopez

Research technician
Childhood Cancer and Blood Disorders
Read more
Espinosa Lopez, Blanca

Espinosa Lopez, Blanca

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Jon Ander Aguirre Carrillo

Jon Ander Aguirre Carrillo

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Projects

Development of prognostic and therapeutic tools targeting epigenetic regulators in metastatic neuroblastoma

IP: Miguel Segura Ginard
Collaborators: María Rosario Pérez- Torres Lobato, Maria Jose Pérez García, Lorena Valero Arrese, Adria Molero Valenzuela, Khloud Abdo Soliman Elsharawy
Funding agency: Instituto de Salud Carlos III
Funding: 315000
Reference: PI23/01144
Duration: 01/01/2024 - 31/12/2026

Unveiling the role of chromatin remodelers in pediatric tumors of the central nervous system.

IP: Miguel Segura Ginard
Collaborators: Khloud Abdo Soliman Elsharawy, Judit Álvarez González
Funding agency: Instituto de Salud Carlos III
Funding: 95000
Reference: CD23/00035
Duration: 01/01/2024 - 31/12/2026

HUB D'INNOVACIÓ PEDIÀTRICA - I4KIDS

IP: Ramon Martí Seves
Collaborators: Alfons Macaya Ruíz, Lucas Moreno Martín-Retortillo
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 0.01
Reference: 2022 XARDI 00006
Duration: 01/01/2023 - 31/12/2025

IMPACT- AML

IP: M Mar Mañu Pereira
Collaborators: IMPACT- AML, Reidel , Sara Isabel, Sara Isabel Reidel, Ferran Balbastre Ubeda, Daiana Natali Lopez
Funding agency: EUROPEAN COMMISSION
Funding: 253750
Reference: IMPACT-AML_HE--MISS-CANCER2022
Duration: 01/04/2023 - 31/03/2028

Publications

Localized incompletely resected standard risk rhabdomyosarcoma in children and adolescents: Results from the European Paediatric Soft Tissue Sarcoma Study Group RMS 2005 trial.

PMID: 39058728
Journal: CANCER
Year: 2024
Reference: Cancer. 2024 Jul 26. doi: 10.1002/cncr.35497.
Impact factor:
Publication type: Paper in international publication
Authors: Alaggio, Rita; Albiac, Monica Ramos; Alvaro, Raquel Hladun; Ben-Arush, Myriam; Bisogno, Gianni; Chargari, Cyrus; Coppadoro, Beatrice; Craigie, Ross; Devalck, Christine; Ferman, Sima et al.
DOI: 10.1002/cncr.35497

Advances in the approaches used to repurpose drugs for neuroblastoma.

PMID: 39258785
Journal: Expert Opinion on Drug Discovery
Year: 2024
Reference: Expert Opin Drug Discov. 2024 Sep 11:1-11. doi: 10.1080/17460441.2024.2402413.
Impact factor:
Publication type: Paper in international publication
Authors: Butjosa-Espin, Maria; Manas, Adriana; Miera-Maluenda, Marta; Moreno, Lucas; Perez-Torres, Maria; Rubio-San-Simon, Alba; Ruiz-Duran, Paula; Segura, Miguel F; Seoane, Jose A et al.
DOI: 10.1080/17460441.2024.2402413

Early therapeutic drug monitoring of methotrexate and its association with acute kidney injury: A retrospective cohort study.

PMID: 39254047
Journal: Cancer Medicine
Year: 2024
Reference: Cancer Med. 2024 Sep;13(17):e70176. doi: 10.1002/cam4.70176.
Impact factor:
Publication type: Paper in international publication
Authors: Aumente, Maria Dolores; Carrillo, Thais Murciano; Combs, Ryan; Howard, Scott C; Hwang, Miriam; Lopez-Vinau Lopez, Teresa; Lowe, Jennifer; Ramsey, Laura B; Rizzari, Carmelo; Taylor, Zachary L et al.
DOI: 10.1002/cam4.70176

Safety and outcome of children, adolescents and young adults participating in phase I/II clinical oncology trials: a 9-year center experience.

PMID: 39318620
Journal: Frontiers in Pediatrics
Year: 2024
Reference: Front Pediatr. 2024 Sep 4;12:1423484. doi: 10.3389/fped.2024.1423484. eCollection 2024.
Impact factor:
Publication type: Paper in international publication
Authors: Andion, Maitane; Artigas, Andrea; Bautista Sirvent, Francisco; Buendia Lopez, Susana; Cortes Hernandez, Marta; de Rojas, Teresa; Hernandez-Marques, Carmen; Herrero, Blanca; Herreros Lopez, Pilar; Lassaletta, Alvaro et al.
DOI: 10.3389/fped.2024.1423484

Second allogeneic stem cell transplantation can rescue a significant proportion of patients with JMML relapsing after first allograft.

PMID: 36823455
Journal: BONE MARROW TRANSPLANTATION
Year: 2023
Reference: Bone Marrow Transplant. 2023 May;58(5):607-609. doi: 10.1038/s41409-023-01942-4. Epub 2023 Feb 23.
Impact factor:
Publication type: Letter whit IF
Authors: Bodova, Ivana; Bresters, Dorine; Buechner, Jochen; de Haas, Valerie; de Heredia, Cristina Diaz; De Moerloose, Barbara; Dworzak, Michael; Erlacher, Miriam; Flotho, Christian; Gohring, Gudrun et al.
DOI: 10.1038/s41409-023-01942-4

Epigenetic therapies for neuroblastoma: Immunogenicity awakens.

PMID: 36840349
Journal: Molecular Oncology
Year: 2023
Reference: Mol Oncol. 2023 May;17(5):718-721. doi: 10.1002/1878-0261.13404. Epub 2023 Mar 8.
Impact factor:
Publication type: Letter or abstract
Authors: Jimenez, Carlos; Moreno, Lucas; Segura, Miguel F et al.
DOI: 10.1002/1878-0261.13404

Challenges and Opportunities of Precision Medicine in Sickle Cell Disease: Novel European Approach by GenoMed4All Consortium and ERN-EuroBloodNet.

PMID: 36844183
Journal: HemaSphere
Year: 2023
Reference: Hemasphere. 2023 Feb 22;7(3):e844. doi: 10.1097/HS9.0000000000000844. eCollection 2023 Mar.
Impact factor:
Publication type: Editorail in international publication
Authors: Alvarez, Federico; Bartolucci, Pablo; Beneitez Pastor, David; Biemond, Bart J; Biondi, Riccardo; Boaro, Maria Paola; Castellani, Gastone; Cela, Elena; Collado, Anna; Collado, Anna et al.
DOI: 10.1097/HS9.0000000000000844

Nonmetastatic Rhabdomyosarcoma in Children and Adolescents: Overall Results of the European Pediatric Soft Tissue Sarcoma Study Group RMS2005 Study.

PMID: 36848614
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2023
Reference: J Clin Oncol. 2023 May 1;41(13):2342-2349. doi: 10.1200/JCO.22.02093. Epub 2023 Feb 27.
Impact factor:
Publication type: Paper in international publication
Authors: Alaggio, Rita; Ben-Arush, Myriam; Bisogno, Gianni; Davila Fajardo, Raquel; Defachelles, Anne Sophie; Devalck, Christine; Ferman, Sima; Ferrari, Andrea; Gallego, Soledad; Glosli, Heidi et al.
DOI: 10.1200/JCO.22.02093

Therapy and prognostic significance of regional lymph node involvement in embryonal rhabdomyosarcoma: a report from the European paediatric Soft tissue sarcoma Study Group.

PMID: 35763871
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2022
Reference: Eur J Cancer. 2022 Sep;172:119-129. doi: 10.1016/j.ejca.2022.05.033. Epub 2022 Jun 25.
Impact factor:
Publication type: Paper in international publication
Authors: Ben-Arush, Myriam; Bernier, Valerie; Bisogno, Gianni; Cesen, Maja; Fajardo, Raquel D; Gallego, Soledad; Jenney, Meriel; Merks, Johannes H M; Minard-Colin, Veronique; Scarzello, Giovanni et al.
DOI: 10.1016/j.ejca.2022.05.033

Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high-hyperdiploid B-cell acute lymphoblastic leukemia.

PMID: 35726693
Journal: Molecular Oncology
Year: 2022
Reference: Mol Oncol. 2022 Aug;16(16):2899-2919. doi: 10.1002/1878-0261.13276. Epub 2022 Jul 19.
Impact factor:
Publication type: Paper in international publication
Authors: Ballerini, Paola; Bataller, Alex; Blanco, Joan; Blanco, Maria L; Boer, Judith; Bueno, Clara; Calasanz, Maria J; Camos, Mireia; Cazzaniga, Giovanni; Cuatrecasas, Esther et al.
DOI: 10.1002/1878-0261.13276

Cobimetinib in Pediatric and Young Adult Patients with Relapsed or Refractory Solid Tumors (iMATRIX-cobi): A Multicenter, Phase I/II Study.

PMID: 35715627
Journal: Targeted Oncology
Year: 2022
Reference: Target Oncol. 2022 Jun 17. pii: 10.1007/s11523-022-00888-9. doi: 10.1007/s11523-022-00888-9.
Impact factor:
Publication type: Paper in international publication
Authors: Aerts, Isabelle; Bernardi, Ronald; Campbell Hewson, Quentin; Cheeti, Sravanthi; Devlin, Clare; Gallego, Soledad; Geoerger, Birgit; Howell, Lisa; Hutchinson, Katherine E; Langevin, Anne-Marie et al.
DOI: 10.1007/s11523-022-00888-9

Metastatic Rhabdomyosarcoma: Results of the European Paediatric Soft Tissue Sarcoma Study Group MTS 2008 Study and Pooled Analysis With the Concurrent BERNIE Study.

PMID: 35709412
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2022
Reference: J Clin Oncol. 2022 Nov 10;40(32):3730-3740. doi: 10.1200/JCO.21.02981. Epub 2022 Jun 16.
Impact factor:
Publication type: Paper in international publication
Authors: Ben-Arush, Myriam; Bisogno, Gianni; Cameron, Alison L; Casanova, Michela; Chisholm, Julia C; Coppadoro, Beatrice; Elze, Markus; Ferman, Sima; Ferrari, Andrea; Gallego, Soledad et al.
DOI: 10.1200/JCO.21.02981

Phase I/II study of single-agent lenvatinib in children and adolescents with refractory or relapsed solid malignancies and young adults with osteosarcoma (ITCC-050)().

PMID: 34562750
Journal: ESMO Open
Year: 2021
Reference: ESMO Open. 2021 Oct;6(5):100250. doi: 10.1016/j.esmoop.2021.100250. Epub 2021 Sep 22.
Impact factor:
Publication type: Paper in international publication
Authors: Aerts, I; Bautista, F; Campbell-Hewson, Q; Canete Nieto, A; Casanova, M; Dutta, L; Entz-Werle, N; Gallego Melcon, S; Gambart, M; Gaspar, N et al.
DOI: 10.1016/j.esmoop.2021.100250

[Multidisciplinary consensus on optimizing the detection of NTRK gene alterations in tumours].

PMID: 34544555
Journal: Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica
Year: 2021
Reference: Rev Esp Patol. 2021 Oct-Dec;54(4):250-262. doi: 10.1016/j.patol.2021.05.003. Epub 2021 Jul 10.
Impact factor:
Publication type: Review in national publication
Authors: Alvarez, Rosa; Bautista, Francisco; Colomer, Ramon; de Alava, Enrique; Garrido, Pilar; Hladun, Raquel; Lopez-Rios, Fernando; Rojo, Federico et al.
DOI: 10.1016/j.patol.2021.05.003

Improved collection of hematopoietic stem cells and progenitors from Fanconi anemia patients for gene therapy purposes.

PMID: 34485595
Journal: Molecular Therapy-Methods & Clinical Development
Year: 2021
Reference: Mol Ther Methods Clin Dev. 2021 Jun 12;22:66-75. doi: 10.1016/j.omtm.2021.06.001. eCollection 2021 Sep 10.
Impact factor:
Publication type: Paper in international publication
Authors: Alberquilla, Omaira; Azqueta, Carmen; Bogliolo, Massimo; Bueren, Juan A; Casado, Jose A; Castillo, Ana; Catala, Albert; Diaz-de-Heredia, Cristina; Fernandez, Jesus; Galvez, Eva et al.
DOI: 10.1016/j.omtm.2021.06.001

Recommendations on hematopoietic stem cell transplantation for patients with Diamond-Blackfan anemia. On behalf of the Pediatric Diseases and Severe Aplastic Anemia Working Parties of the EBMT.

PMID: 34462566
Journal: BONE MARROW TRANSPLANTATION
Year: 2021
Reference: Bone Marrow Transplant. 2021 Dec;56(12):2956-2963. doi: 10.1038/s41409-021-01449-w. Epub 2021 Aug 31.
Impact factor:
Publication type: Paper in international publication
Authors: Bresters, Dorine; Corbacioglu, Selim; Dalle, Jean-Hugues; Diaz-de-Heredia, Cristina; Faulkner, Lawrence; Miano, Maurizio; Peffault de Latour, Regis; Strahm, Brigitte; Yesilipek, Akif et al.
DOI: 10.1038/s41409-021-01449-w

Local staging and treatment in extremity rhabdomyosarcoma. A report from the EpSSG-RMS2005 study.

PMID: 32869534
Journal: Cancer Medicine
Year: 2020
Reference: Cancer Med. 2020 Oct;9(20):7580-7589. doi: 10.1002/cam4.3365. Epub 2020 Sep 1.
Impact factor:
Publication type: Paper in international publication
Authors: Bisogno, Giani; Chisholm, Julia; Corradini, Nadege; De Salvo, Gian Luca; Ferrari, Andrea; Gallego, Soledad; Gaze, Mark N; Glosli, Heidi; Jenney, Meriel; Kelsey, Anna et al.
DOI: 10.1002/cam4.3365

Long-term follow-up of differentiated thyroid carcinoma in children and adolescents.

PMID: 32877364
Journal: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
Year: 2020
Reference: J Pediatr Endocrinol Metab. 2020 Nov 26;33(11):1431-1441. doi: 10.1515/jpem-2020-0194.
Impact factor:
Publication type: Paper in international publication
Authors: Boronat de Ferrater, Maria; Castell Conesa, Joan; Cuberas Borros, Gemma; Galofre Mora, Pere; Garcia Burillo, Amparo; Negre Buso, Montserrat; Sabado Alvarez, Constantino; Simo Perdigo, Marc et al.
DOI: 10.1515/jpem-2020-0194

Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistance.

PMID: 32801295
Journal: Cell Death & Disease
Year: 2020
Reference: Cell Death Dis. 2020 Aug 15;11(8):634. doi: 10.1038/s41419-020-02887-y.
Impact factor:
Publication type: Paper in international publication
Authors: Alcon, Clara; Gallego, Soledad; Guillen, Gabriela; Manzano-Munoz, Albert; Montero, Joan; Mora, Jaume; Prada, Estela; Roma, Josep; Samitier, Josep; Soriano, Aroa et al.
DOI: 10.1038/s41419-020-02887-y

CN133, a Novel Brain-Penetrating Histone Deacetylase Inhibitor, Hampers Tumor Growth in Patient-Derived Pediatric Posterior Fossa Ependymoma Models.

PMID: 32708733
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Jul 16;12(7). pii: cancers12071922. doi: 10.3390/cancers12071922.
Impact factor:
Publication type: Paper in international publication
Authors: Antonelli, Roberta; Bove, Jordi; Gallego, Soledad; Hooker, Jacob M; Jimenez, Carlos; Martinez-Saez, Elena; Martini, Maurizio; Moreno, Lucas; Riccardi, Riccardo; Riley, Misha et al.
DOI: 10.3390/cancers12071922

Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia.

PMID: 31501599
Journal: NATURE MEDICINE
Year: 2019
Reference: Nat Med. 2019 Sep;25(9):1396-1401. doi: 10.1038/s41591-019-0550-z. Epub 2019 Sep 9.
Impact factor:
Publication type: Paper in international publication
Authors: Alberquilla, Omaira; Alvarez, Lara; Barquinero, Jordi; Bogliolo, Massimo; Bueren, Juan A; Casado, Jose A; Catala, Albert; Cerrato, Laura; Diaz de Heredia, Cristina; Galvez, Eva et al.
DOI: 10.1038/s41591-019-0550-z

High-dose etoposide and cyclophosphamide in adults and children with primary refractory and multiply relapsed acute leukaemias: The Royal Marsden experience.

PMID: 31493701
Journal: LEUKEMIA RESEARCH
Year: 2019
Reference: Leuk Res. 2019 Oct;85:106217. doi: 10.1016/j.leukres.2019.106217. Epub 2019 Aug 13.
Impact factor:
Publication type: Paper in international publication
Authors: Atra, Ayad; Carceller, Fernando; Ethell, Mark; Guerra-Garcia, Pilar; Hirsch, Steffen G; Khabra, Komel; Lancaster, Donna; Malik, Rubina; Marshall, Lynley V; Moreno, Lucas et al.
DOI: 10.1016/j.leukres.2019.106217

[Pilot experience with indocyanine green navigation in pediatric surgery].

PMID: 31486303
Journal: Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
Year: 2019
Reference: Cir Pediatr. 2019 Jul 29;32(3):121-127.
Impact factor:
Publication type: Paper in national publication
Authors: Bueno, J; Guillen, G; Lopez, M; Lopez-Fernandez, S; Molino, J A et al.
DOI:

A High-Throughput Screening Identifies MicroRNA Inhibitors That Influence Neuronal Maintenance and/or Response to Oxidative Stress.

PMID: 31302497
Journal: Molecular Therapy-Nucleic Acids
Year: 2019
Reference: Mol Ther Nucleic Acids. 2019 Sep 6;17:374-387. doi: 10.1016/j.omtn.2019.06.007. Epub 2019 Jun 20.
Impact factor:
Publication type: Paper in international publication
Authors: Escaramis, Georgia; Marti, Eulalia; Pallares-Albanell, Joan; Pantano, Lorena; Segura, Miguel F; Soriano, Aroa; Zomeno-Abellan, M Teresa et al.
DOI: 10.1016/j.omtn.2019.06.007

Cutaneous involvement in an 8-year-old boy with Ras-associated autoimmune leucoproliferative disorder (RALD).

PMID: 29908030
Journal: CLINICAL AND EXPERIMENTAL DERMATOLOGY
Year: 2018
Reference: Clin Exp Dermatol. 2018 Dec;43(8):913-916. doi: 10.1111/ced.13668. Epub 2018 Jun 16.
Impact factor:
Publication type: Paper in international publication
Authors: Bauza Alonso, A; Dapena Diaz, J L; Duran Pastor, M A; Ferres Ramis, L; Giacaman, A; Martin-Santiago, A; Ramos Asensio, R; Salinas Sanz, J A et al.
DOI: 10.1111/ced.13668

Fusion status in patients with lymph node-positive (N1) alveolar rhabdomyosarcoma is a powerful predictor of prognosis: Experience of the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG).

PMID: 29797665
Journal: CANCER
Year: 2018
Reference: Cancer. 2018 Aug 1;124(15):3201-3209. doi: 10.1002/cncr.31553. Epub 2018 May 24.
Impact factor:
Publication type: Paper in international publication
Authors: Bergeron, Christophe; Bisogno, Gianni; Chisholm, Julia; de Salvo, Gian Luca; Ferman, Sima; Ferrari, Andrea; Gallego, Soledad; Glosli, Heidi; Jenney, Meriel; Mandeville, Henry C et al.
DOI: 10.1002/cncr.31553

Localized vaginal/uterine rhabdomyosarcoma-results of a pooled analysis from four international cooperative groups.

PMID: 29781567
Journal: PEDIATRIC BLOOD & CANCER
Year: 2018
Reference: Pediatr Blood Cancer. 2018 Sep;65(9):e27096. doi: 10.1002/pbc.27096. Epub 2018 May 21.
Impact factor:
Publication type: Paper in international publication
Authors: Anderson, James; Arndt, Carola; Bergeron, Christophe; Bisogno, Gianni; De Salvo, Gianluca; Ferrari, Andrea; Gallego, Soledad; Haie-Meder, Christine; Hawkins, Douglas; Jenney, Meriel et al.
DOI: 10.1002/pbc.27096

Hemorrhagic cystitis after hematopoietic stem cell transplantation: A challenge for the pediatric urologist.

PMID: 29776868
Journal: Journal of Pediatric Urology
Year: 2018
Reference: J Pediatr Urol. 2018 Oct;14(5):366-373. doi: 10.1016/j.jpurol.2018.03.018. Epub 2018 Apr 20.
Impact factor:
Publication type: Review in national publication
Authors: Asensio, Marino; Benitez, Maribel; Bolanos, Andrea; Diaz-De-Heredia, Cristina; Gander, Romy; Guillen, Gabriela; Lopez, Manuel; Perez, Mercedes; Royo, Gloria Fatou et al.
DOI: 10.1016/j.jpurol.2018.03.018

Engraftment and in vivo proliferation advantage of gene corrected mobilized CD34+ cells from Fanconi anemia patients.

PMID: 28801449
Journal: BLOOD
Year: 2017
Reference: Blood. 2017 Sep 28;130(13):1535-1542. doi: 10.1182/blood-2017-03-774174. Epub 2017 Aug 11.
Impact factor:
Publication type: Paper in international publication
Authors: Bueren, Juan; Casado, Jose A; Charrier, Sabine; Diaz de Heredia, Cristina; Galy, Anne; Guenechea, Guillermo; Lamana, Maria Luisa; Mehta, Parinda A; Navarro, Susana; Pujol, Maria Roser et al.
DOI: 10.1182/blood-2017-03-774174

An Integrative Scoring System for Survival Prediction Following Umbilical Cord Blood Transplantation in Acute Leukemia.

PMID: 28754820
Journal: CLINICAL CANCER RESEARCH
Year: 2017
Reference: Clin Cancer Res. 2017 Nov 1;23(21):6478-6486. doi: 10.1158/1078-0432.CCR-17-0489. Epub 2017 Jul 28.
Impact factor:
Publication type: Paper in international publication
Authors: Al-Seraihy, Amal; Arcese, William; Baron, Frederic; Blaise, Didier; Chevallier, Patrice; Diaz Heredia, Cristina; Fein, Joshua; Gluckman, Eliane; Kuball, Jurgen; Labopin, Myriam et al.
DOI: 10.1158/1078-0432.CCR-17-0489

Fertility preservation issues in pediatric hematopoietic stem cell transplantation: practical approaches from the consensus of the Pediatric Diseases Working Party of the EBMT and the International BFM Study Group.

PMID: 28737775
Journal: BONE MARROW TRANSPLANTATION
Year: 2017
Reference: Bone Marrow Transplant. 2017 Oct;52(10):1406-1415. doi: 10.1038/bmt.2017.147. Epub 2017 Jul 24.
Impact factor:
Publication type: Paper in international publication
Authors: Ahler, A; Ansari, M; Bader, P; Balduzzi, A; Beohou, E; Bresters, D; Corbacioglu, S; Dalissier, A; Dalle, J-H; De Heredia Rubio, C D et al.
DOI: 10.1038/bmt.2017.147

[Endovascular embolization in the treatment of the pulmonary intralobar sequestration].

PMID: 28585792
Journal: Cirugia pediatrica : organo oficial de la Sociedad
Year: 2017
Reference: Cir Pediatr. 2017 Jan 25;30(1):57-63.
Impact factor:
Publication type: Letter or abstract
Authors: Guillen, G; Lain, A; Lloret, J; Lopez-Fernandez, S; Perez, M; Santiago-Martinez, S et al.
DOI:

Conservative strategy in infantile fibrosarcoma is possible: The European paediatric Soft tissue sarcoma Study Group experience.

PMID: 26849118
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2016
Reference: Eur J Cancer. 2016 Apr;57:1-9. doi: 10.1016/j.ejca.2015.12.028. Epub 2016 Feb 2.
Impact factor:
Publication type: Paper in international publication
Authors: Alaggio, Rita; Bergeron, Christophe; Bisogno, Gianni; Brennan, Bernadette; Casanova, Michela; De Paoli, Angela; De Salvo, Gian Luca; Ferrari, Andrea; Francotte, Nadine; Gallego, Soledad et al.
DOI: 10.1016/j.ejca.2015.12.028

BRG1/SMARCA4 is essential for neuroblastoma cell viability through modulation of cell death and survival pathways.

PMID: 26996667
Journal: ONCOGENE
Year: 2016
Reference: Oncogene. 2016 Sep 29;35(39):5179-90. doi: 10.1038/onc.2016.50. Epub 2016 Mar 21.
Impact factor:
Publication type: Paper in international publication
Authors: Almazan-Moga, A; Comella, J X; Gallego, S; Jubierre, L; Molist, C; Moubarak, R S; Navarro, S; Noguera, R; Palmer, H G; Paris-Coderch, L et al.
DOI: 10.1038/onc.2016.50

Editorial: Embryonic signaling pathways as potential targets for the treatment of rhabdomyosarcoma.

PMID: 26947582
Journal: CURRENT DRUG TARGETS
Year: 2016
Reference: Curr Drug Targets. 2016 Jul 29;17(11):1226-7.
Impact factor:
Publication type: Editorail in international publication
Authors: Gallego, Soledad; Roma, Josep et al.
DOI:

MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes.

PMID: 26824183
Journal: Oncotarget
Year: 2016
Reference: Oncotarget. 2016 Feb 23;7(8):9271-87. doi: 10.18632/oncotarget.7005.
Impact factor:
Publication type: Paper in international publication
Authors: Almazan-Moga, Ana; Bayascas, Jose R; Bray, Isabella; Casanovas, Oriol; Gallego, Soledad; Jubierre, Luz; Martinez, Alba; Molist, Carla; Paris-Coderch, Laia; Piskareva, Olga et al.
DOI: 10.18632/oncotarget.7005

[Survival analysis of hematopoietic stem cell transplantation in children with primary immunodeficiency in Spain].

PMID: 24857430
Journal: Anales de Psicologia
Year: 2015
Reference: An Pediatr (Barc). 2015 Feb;82(2):62-7. doi: 10.1016/j.anpedi.2014.04.014. Epub 2014 May 22.
Impact factor: 0.833
Publication type: Paper in national publication
Authors: Hladun, R, Badell, I, Gonzalez, M, Martinez, A M, Sanchez de Toledo, J, Olive, M T, Gonzalez, M E, Elorza, I, Diaz de Heredia, C et al.
DOI: 10.1016/j.anpedi.2014.04.014

MicroRNA-101 is repressed by EZH2 and its restoration inhibits tumorigenic features in embryonal rhabdomyosarcoma.

PMID: 26251675
Journal: Clinical Epigenetics
Year: 2015
Reference: Clin Epigenetics. 2015 Aug 6;7(1):82. doi: 10.1186/s13148-015-0107-z. eCollection 2015.
Impact factor: 6.219
Publication type: Paper in international publication
Authors: Vella, Serena, Pomella, Silvia, Leoncini, Pier Paolo, Colletti, Marta, Conti, Beatrice, Marquez, Victor E, Strillacci, Antonio, Roma, Josep, Gallego, Soledad, Milano, Giuseppe M et al.
DOI: 10.1186/s13148-015-0107-z

Modulation of chemotherapeutic drug resistance in neuroblastoma SK-N-AS cells by the neural apoptosis inhibitory protein and miR-520f.

PMID: 25137037
Journal: INTERNATIONAL JOURNAL OF CANCER
Year: 2015
Reference: Int J Cancer. 2015 Apr 1;136(7):1579-88. doi: 10.1002/ijc.29144. Epub 2014 Sep 2.
Impact factor: 5.085
Publication type: Paper in international publication
Authors: Harvey, Harry, Piskareva, Olga, Creevey, Laura, Alcock, Leah C, Buckley, Patrick G, O'Sullivan, Maureen J, Segura, Miguel F, Gallego, Soledad, Stallings, Raymond L, Bray, Isabella M et al.
DOI: 10.1002/ijc.29144

Few and nonsevere adverse infusion events using an automated method for diluting and washing before unrelated single cord blood transplantation.

PMID: 25545727
Journal: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Year: 2015
Reference: Biol Blood Marrow Transplant. 2015 Apr;21(4):682-7. doi: 10.1016/j.bbmt.2014.12.015. Epub 2014 Dec 27.
Impact factor: 3.404
Publication type: Paper in international publication
Authors: Castillo, Nerea, Garcia-Cadenas, Irene, Garcia, Olga, Barba, Pere, Diaz-Heredia, Cristina, Martino, Rodrigo, Azqueta, Carmen, Ferra, Christelle, Canals, Carme, Elorza, Izaskun et al.
DOI: 10.1016/j.bbmt.2014.12.015

Engraftment kinetics and graft failure after single umbilical cord blood transplantation using a myeloablative conditioning regimen.

PMID: 24972767
Journal: HAEMATOLOGICA
Year: 2014
Reference: Haematologica. 2014 Sep;99(9):1509-15. doi: 10.3324/haematol.2014.109280. Epub 2014 Jun 27.
Impact factor: 5.868
Publication type: Paper in international publication
Authors: Ruggeri, Annalisa, Labopin, Myriam, Sormani, Maria Pia, Sanz, Guillermo, Sanz, Jaime, Volt, Fernanda, Michel, Gerard, Locatelli, Franco, Diaz De Heredia, Cristina, O'Brien, Tracey et al.
DOI: 10.3324/haematol.2014.109280

Optimization of rhabdomyosarcoma disseminated disease assessment by flow cytometry.

PMID: 25155056
Journal: CYTOPATHOLOGY
Year: 2014
Reference: Cytometry A. 2014 Dec;85(12):1020-9. doi: 10.1002/cyto.a.22514. Epub 2014 Aug 22.
Impact factor: 3.181
Publication type: Paper in international publication
Authors: Almazan-Moga, Ana, Roma, Josep, Molist, Carla, Vidal, Isaac, Jubierre, Luz, Soriano, Aroa, Segura, Miguel Francisco, Llort, Anna, Sanchez de Toledo, Josep, Gallego, Soledad et al.
DOI: 10.1002/cyto.a.22514

MYCN repression of Lifeguard/FAIM2 enhances neuroblastoma aggressiveness.

PMID: 25188511
Journal: CELL DEATH DIS
Year: 2014
Reference: Cell Death Dis. 2014 Sep 4;5:e1401. doi: 10.1038/cddis.2014.356.
Impact factor: 5.177
Publication type: Paper in international publication
Authors: Planells-Ferrer, L, Urresti, J, Soriano, A, Reix, S, Murphy, D M, Ferreres, J C, Borras, F, Gallego, S, Stallings, R L, Moubarak, R S et al.
DOI: 10.1038/cddis.2014.356

Caveolin-1 is down-regulated in alveolar rhabdomyosarcomas and negatively regulates tumor growth.

PMID: 25313138
Journal: ONCOTARGET
Year: 2014
Reference: Oncotarget. 2014 Oct 30;5(20):9744-55.
Impact factor: 6.627
Publication type: Paper in international publication
Authors: Huertas-Martinez, Juan, Rello-Varona, Santiago, Herrero-Martin, David, Barrau, Ignasi, Garcia-Monclus, Silvia, Sainz-Jaspeado, Miguel, Lagares-Tena, Laura, Nunez-Alvarez, Yaiza, Mateo-Lozano, Silvia, Roma, Josep et al.
DOI:

Evaluation of surgical margins in Basal cell carcinoma by surgical specialty.

PMID: 22835227
Journal: Actas dermo-sifiliograficas
Year: 2013
Reference: Actas Dermosifiliogr. 2013 Mar;104(2):133-40. doi: 10.1016/j.ad.2012.06.001. Epub 2012 Jul 24.
Impact factor: 0
Publication type: Paper in national publication
Authors: Bassas, P, Hilari, H, Bodet, D, Serra, M, Kennedy, F E, Garcia-Patos, V et al.
DOI: 10.1016/j.ad.2012.06.001

At-risk brain tissue identified with arterial spin labeling in neurotuberculosis.

PMID: 23377538
Journal: PEDIATRIC RADIOLOGY
Year: 2013
Reference: Pediatr Radiol. 2013 Aug;43(8):1049-52. doi: 10.1007/s00247-013-2624-2. Epub 2013 Feb 2.
Impact factor: 1.565
Publication type: Letter or abstract
Authors: Delgado, Ignacio, Elorza Alvarez, Izaskun, Vazquez, Elida, Sanchez-Montanez, Angel, Margariti, Persefoni et al.
DOI: 10.1007/s00247-013-2624-2

Successful treatment of congenital erythropoietic porphyria using matched unrelated hematopoietic stem cell transplantation.

PMID: 23557135
Journal: PEDIATRIC DERMATOLOGY
Year: 2013
Reference: Pediatr Dermatol. 2013 Jul-Aug;30(4):484-9. doi: 10.1111/pde.12117. Epub 2013 Apr 5.
Impact factor: 1.041
Publication type: Paper in international publication
Authors: Martinez Peinado, Carmen, Diaz de Heredia, Cristina, To-Figueras, Jordi, Arias-Santiago, Salvador, Nogueras, Paloma, Elorza, Izaskun, Badenas, Celia, Moreno, M Jose, Tercedor, Jesus, Herrero, Carmen et al.
DOI: 10.1111/pde.12117

Surviving Childhood Cancer: Relationship between Exercise and Coping on Quality of Life.

PMID: 23866202
Journal: The Spanish journal of psychology.
Year: 2013
Reference: Span J Psychol. 2013 Jan;16:E1. doi: 10.1017/sjp.2013.1.
Impact factor:
Publication type: Letter or abstract
Authors: Blasco, Tomas, Castellano, Carmina, Perez-Campdepadros, Marta, Capdevila, Lluis, Sanchez de Toledo, Jose, Gallego, Soledad et al.
DOI: 10.1017/sjp.2013.1

Voriconazole drug monitoring in the management of invasive fungal infection in immunocompromised children: a prospective study.

PMID: 22190607
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2012
Reference: J Antimicrob Chemother. 2012 Mar;67(3):700-6. Epub 2011 Dec 21.
Impact factor: 5.068
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1093/jac/dkr517

[Chromosomal translocations in soft tissue sarcomas: from molecular biology to clinical application.]

PMID: 22075174
Journal: ANALES DE PEDIATRIA
Year: 2012
Reference: An Pediatr (Barc). 2012 Feb;76(2):103.e1-7. Epub 2011 Nov 9.
Impact factor: 0.77
Publication type: Review in national publication
Authors: , , , , , , et al.
DOI: 10.1016/j.anpedi.2011.09.007

NOTCH PATHWAY INHIBITION SIGNIFICANTLY REDUCES RHABDOMYOSARCOMA INVASIVENESS AND MOBILITY IN VITRO.

PMID: 21177409
Journal: CLINICAL CANCER RESEARCH
Year: 2011
Reference: Clin Cancer Res. 2011 Feb 1;17(3):505-13. Epub 2010 Dec 21.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; et al.
DOI: 10.1158/1078-0432.CCR-10-0166

[Protocol for the study and treatment of Immune Thrombocytopenic Purpura (ITP). ITP-2010.]

PMID: 21439923
Journal: ANALES DE PEDIATRIA
Year: 2011
Reference: An Pediatr (Barc). 2011 Jun;74(6):414.e1-8. Epub 2011 Mar 24.
Impact factor:
Publication type: Paper in national publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.anpedi.2010.11.004

Myeloproliferative Disorder in Noonan Syndrome.

PMID: 20829714
Journal: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
Year: 2011
Reference: J Pediatr Hematol Oncol. 2011 Jan;33(1):e43-5.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; et al.
DOI: 10.1097/MPH.0b013e3181e7571e

Prognostic Factors After Relapse in Nonmetastatic Rhabdomyosarcoma: A Nomogram to Better Define Patients Who Can Be Salvaged With Further Therapy.

PMID: 21357778
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2011
Reference: J Clin Oncol. 2011 Apr 1;29(10):1319-25. Epub 2011 Feb 28.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1200/JCO.2010.32.1984

[Haemophagocytic syndrome: A common pathogenic mechanism of various aetiologies].

PMID: 19481995
Journal: ANALES DE PEDIATRIA
Year: 2009
Reference: An Pediatr (Barc). 2009 Aug;71(2):110-6. doi: 10.1016/j.anpedi.2009.04.008. Epub 2009 May 29.
Impact factor: 0
Publication type: Paper in national publication
Authors: Dapena Diaz, J L, Diaz de Heredia Rubio, C, Bastida Vila, P, Llort Sales, A, Elorza Alvarez, I, Olive Oliveras, T, Sanchez de Toledo Codina, J et al.
DOI: 10.1016/j.anpedi.2009.04.008

[Acute postinfectious pityriasis rubra pilaris: a superantigen-mediated dermatosis].

PMID: 19775549
Journal: Actas dermo-sifiliograficas
Year: 2009
Reference: Actas Dermosifiliogr. 2009 Oct;100(8):706-9. doi: 10.1016/s0001-7310(09)72284-7.
Impact factor: 0
Publication type: Letter or abstract
Authors: Ferrandiz-Pulido, C, Bartralot, R, Bassas, P, Bodet, D, Repiso, T, Aparicio, G, Mollet, J, Serra, M, Garcia-Patos, V et al.
DOI: 10.1016/s0001-7310(09)72284-7

Lentiviral-mediated genetic correction of hematopoietic and mesenchymal progenitor cells from Fanconi anemia patients.

PMID: 19277017
Journal: MOLECULAR THERAPY
Year: 2009
Reference: Mol Ther. 2009 Jun;17(6):1083-92.
Impact factor: 5.97
Publication type: Paper in international publication
Authors: Jacome, Ariana, Navarro, Susana, Rio, Paula, Yanez, Rosa M, Gonzalez-Murillo, Africa, Lozano, M Luz, Lamana, Maria Luisa, Sevilla, Julian, Olive, Teresa, Diaz-Heredia, Cristina et al.
DOI: 10.1038/mt.2009.26

Allogeneic stem cell transplantation for myelodysplastic syndromes in children: a report from the Spanish Working Party for Blood and Marrow Transplantation in Children (GETMON).

PMID: 19579081
Journal: PEDIATRIC HEMATOLOGY AND ONCOLOGY
Year: 2009
Reference: Pediatr Hematol Oncol. 2009 Jul-Aug;26(5):345-55.
Impact factor: 0.897
Publication type: Paper in international publication
Authors: Maldonado, Maria Soledad, Gonzalez-Vicent, Marta, Fernandez-Delgado, Rafael, Perez-Hurtado, Jose Maria, Munoz, Arturo, Diaz-Heredia, Cristina, Badell, Isabel, Bureo, Encarna, Gomez, Pedro, Martinez, Ana et al.
DOI: 10.1080/08880010902976742

Blog

News

The association, once again, has shown its commitment to oncological research with a donation of €19,197 to the Cancer and Hematological Diseases Group for Children at VHIR.

The prestigious journal The Lancet has published the results of this study, which is the result of more than 20 years of pre-clinical research and 7 years of patient follow-up.

During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.