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Childhood Cancer and Blood Disorders

The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.

Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.

Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours

Team

Khloud Abdo Soliman Elsharawy

Khloud Abdo Soliman Elsharawy

Postdoctoral researcher
Childhood Cancer and Blood Disorders
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Laura Garriga Grimau

Laura Garriga Grimau

Postdoctoral researcher
Childhood Cancer and Blood Disorders
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Maria Luz Uría Oficialdegui

Maria Luz Uría Oficialdegui

Predoctoral researcher
Childhood Cancer and Blood Disorders
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María Paula Pérez Albert

María Paula Pérez Albert

Main researcher
Childhood Cancer and Blood Disorders
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Mariona Morell Daniel

Mariona Morell Daniel

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Melissa Panesso Romero

Melissa Panesso Romero

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Khloud Abdo Soliman Elsharawy

Khloud Abdo Soliman Elsharawy

Postdoctoral researcher
Childhood Cancer and Blood Disorders
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Laura Garriga Grimau

Laura Garriga Grimau

Postdoctoral researcher
Childhood Cancer and Blood Disorders
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Maria Luz Uría Oficialdegui

Maria Luz Uría Oficialdegui

Predoctoral researcher
Childhood Cancer and Blood Disorders
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María Paula Pérez Albert

María Paula Pérez Albert

Main researcher
Childhood Cancer and Blood Disorders
Read more
Mariona Morell Daniel

Mariona Morell Daniel

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Melissa Panesso Romero

Melissa Panesso Romero

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more

Projects

Grup de Recerca Emergent (GRE) Childood Cancer & Blood disorders

IP: Lucas Moreno Martín-Retortillo
Collaborators: Luís Gros Subias, Raquel Andreu Vilarroig, Andrea Vilaplana Blanes, Pablo Velasco Puyó, Laura Murillo Sanjuán, Maria Isabel Benitez Carabante, Aroa Soriano Fernández, Guillem Pons Barcons, Jose Miguel Lizcano De Vega, Maria Cristina Díaz de Heredia Rubio, Maria Luz Uría Oficialdegui, Maria Jose Pérez García, Miguel Segura Ginard, M Mar Mañu Pereira, Lorena Valero Arrese, Thaïs Murciano Carrillo, Constantino Sábado Álvarez, Anna Llort Sales, Grup de Recerca Emergent (GRE) Childood Cancer & Blood disorders, Raquel Hladun Alvaro, Carlota Aguilera Ordoñez, Adria Molero Valenzuela, Júlia Sansa Girona, Gabriela Guillén Burrieza, Laura Alonso Garcia, Victoria Gutierrez Valle, Idoia Bolinaga Ayala, Josep Roma Castanyer, Sergio Espinosa Gil, Elena Andretta, Grup de Recerca Emergent (GRE) Childood Cancer & Blood disorders, Amira Idrizovic
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 60000
Reference: 2021 SGR 00638
Duration: 01/01/2022 - 30/06/2025

SYNTHEMA: Synthetic generation of hematological data over federated computing frameworks

IP: M Mar Mañu Pereira
Collaborators: Reidel , Sara Isabel, SYNTHEMA: Synthetic generation of hematological data over federated computing frameworks , Sara Isabel Reidel, SYNTHEMA: Synthetic generation of hematological data over federated computing frameworks
Funding agency: EUROPEAN COMMISSION
Funding: 435938
Reference: SYNTHEMA_HE-HLTH22_IND13
Duration: 01/12/2022 - 30/11/2026

Desarrollo de una nueva diana terapéutica con elevado potencial anti-oncogénico para los sarcomas infantiles: bloqueo farmacológico del co-receptor de Hedgehog CDO.

IP: Josep Roma Castanyer
Collaborators: -
Funding agency: Fundación Inocente Inocente
Funding: 90000
Reference: INOCENTE/RECERCA/2022/ROMA
Duration: 10/10/2022 - 30/09/2025

Logotip Fundación Inocente Inocente

ENABLING PERSONALIZED MEDICINE OF SICKLE CELL DISEASE PATIENTS BASED ON INTEGRATIVE DIAGNOSIS OF NEW GENERATION METHODOLOGIES

IP: M Mar Mañu Pereira
Collaborators: Pablo Velasco Puyó, Bárbara Tazón Vega, Maria Cristina Díaz de Heredia Rubio, Thaïs Murciano Carrillo, Victoria Gutierrez Valle, Amira Idrizovic
Funding agency: Instituto de Salud Carlos III
Funding: 99220
Reference: PI20/01454
Duration: 01/01/2021 - 30/06/2025

Publications

Surgical treatment of invasive pulmonary fungal infections in immunocompromised pediatric patients: Aspergillus spp. and other emerging fungi.

PMID: 39367968
Journal: PEDIATRIC SURGERY INTERNATIONAL
Year: 2024
Reference: Pediatr Surg Int. 2024 Oct 5;40(1):263. doi: 10.1007/s00383-024-05851-5.
Impact factor:
Publication type: Paper in international publication
Authors: Guillen, Gabriela; Lopez, Manuel; Lopez-Fernandez, Sergio; Martos Rodriguez, Marta; Mendoza-Palomar, Natalia; Molino, Jose Andres; Soler-Palacin, Pere; Uria Oficialdegui, Maria Luz et al.
DOI: 10.1007/s00383-024-05851-5

Long-term sequelae and quality of life after childhood-onset craniopharyngioma: Results of a Spanish multicenter study.

PMID: 39380174
Journal: PEDIATRIC BLOOD & CANCER
Year: 2024
Reference: Pediatr Blood Cancer. 2024 Oct 8:e31343. doi: 10.1002/pbc.31343.
Impact factor:
Publication type: Paper in international publication
Authors: Clemente, Maria; Cordero-Asanza, Esteban X; de Las Morenas-Iglesias, Juan; Garcia-Ariza, Miguel A; Garrido-Colino, Carmen; Lassaletta, Alvaro; Llort, Anna; Menargez, Angela; Mora-Matilla, Maria; Morell, Mariona et al.
DOI: 10.1002/pbc.31343

Conservative Management of Necrotizing Enterocolitis in Newborns: Incidence and Management of Intestinal Strictures.

PMID: 39348873
Journal: EUROPEAN JOURNAL OF PEDIATRIC SURGERY
Year: 2024
Reference: Eur J Pediatr Surg. 2024 Oct 18. doi: 10.1055/a-2426-9723.
Impact factor:
Publication type: Paper in international publication
Authors: Guillen, Gabriela; Lopez, Manuel; Lopez-Fernandez, Sergio; Martos Rodriguez, Marta; Mena, Rach; Molino, Jose A; Montaner-Ramon, Alicia; Ruiz, Cesar W et al.
DOI: 10.1055/a-2426-9723

Newborn Screening for Sickle Cell Disease in Catalonia between 2015 and 2022-Epidemiology and Impact on Clinical Events.

PMID: 39449357
Journal:
Year: 2024
Reference: Int J Neonatal Screen. 2024 Oct 3;10(4):69. doi: 10.3390/ijns10040069.
Impact factor:
Publication type: Paper in international publication
Authors: Algar-Serrano, Marcelina; Almazan Castro, Francisco; Andres-Maso, Anna; Argudo-Ramirez, Ana; Beneitez-Pastor, David; Blanco-Alvarez, Adoracion; Coll-Sibina, Maria Teresa; Collado-Gimbert, Anna; Delgado-Lopez, Giovanna; Diaz de Heredia, Cristina et al.
DOI: 10.3390/ijns10040069

Atrial myxoma.

PMID: 36890091
Journal: MEDICINA CLINICA
Year: 2023
Reference: Med Clin (Barc). 2023 Jun 23;160(12):e23. doi: 10.1016/j.medcli.2023.01.018. Epub 2023 Mar 6.
Impact factor:
Publication type: Paper in national publication
Authors: Barriuso Barrado, Ignacio; Bascompte Claret, Ramon; Ramirez Martinez, Tania; Vigil-Escalera Lopez, Carlota; Vigil-Escalera Lopez, Carlota; Viles Beltran, Maria Dolors et al.
DOI: 10.1016/j.medcli.2023.01.018

Dyskeratosis congenita: natural history of the disease through the study of a cohort of patients diagnosed in childhood.

PMID: 37593443
Journal: Frontiers in Pediatrics
Year: 2023
Reference: Front Pediatr. 2023 Aug 1;11:1182476. doi: 10.3389/fped.2023.1182476. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Benitez-Carbante, M I; Blazquez-Goni, C; Diaz-de-Heredia, C; Murillo-Sanjuan, L; Navarro, S; Rodriguez-Vigil, C; Salinas, J A; Uria-Oficialdegui, M L et al.
DOI: 10.3389/fped.2023.1182476

The impact of clinical and translational research on the quality of life during the metastatic colorectal cancer patient journey.

PMID: 37909013
Journal: Frontiers in Oncology
Year: 2023
Reference: Front Oncol. 2023 Oct 16;13:1272561. doi: 10.3389/fonc.2023.1272561. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Agarwal, Kosh; Alcaraz, Adriana; Baraibar, Iosune; Buti, Maria; Carey, Ivana; Claassen, Mark A A; de Bruijne, Joep; de Knegt, Rob J; de Man, Rob A; Elez, Elena et al.
DOI: 10.3389/fonc.2023.1272561

Phase 1 first-in-human dose-escalation study of ANV419 in patients with relapsed/refractory advanced solid tumors.

PMID: 38243906
Journal: Journal for ImmunoTherapy of Cancer
Year: 2023
Reference: J Immunother Cancer. 2023 Nov 21;11(11):e007784. doi: 10.1136/jitc-2023-007784.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Guzman; Alonso-Saladrigues, Anna; Bucher, Christoph; Caballero-Velazquez, Teresa; Calvo, Emiliano; Castillo-Robleda, Ana; Corral de la Fuente, Elena; Delgado-Serrano, Javier; Diaz-de-Heredia, Cristina; Faura, Anna et al.
DOI: 10.1136/jitc-2023-007784

Adolescents and young adults with rhabdomyosarcoma treated in the European paediatric Soft tissue sarcoma Study Group (EpSSG) protocols: a cohort study.

PMID: 35690071
Journal: Lancet Child & Adolescent Health
Year: 2022
Reference: Lancet Child Adolesc Health. 2022 Aug;6(8):545-554. doi: 10.1016/S2352-4642(22)00121-3. Epub 2022 Jun 9.
Impact factor:
Publication type: Paper in international publication
Authors: Alaggio, Rita; Ben-Arush, Myriam; Bisogno, Gianni; Cameron, Alison L; Casanova, Michela; Chisholm, Julia C; Coppadoro, Beatrice; Defachelles, Anne-Sophie; Devalck, Christine; Ferrari, Andrea et al.
DOI: 10.1016/S2352-4642(22)00121-3

The Use of Next-generation Sequencing in the Diagnosis of Rare Inherited Anaemias: A Joint BSH/EHA Good Practice Paper.

PMID: 35686139
Journal: HemaSphere
Year: 2022
Reference: Hemasphere. 2022 Jun 6;6(6):e739. doi: 10.1097/HS9.0000000000000739. eCollection 2022 Jun.
Impact factor:
Publication type: Paper in international publication
Authors: Andolfo, Immacolata; Bianchi, Paola; Clark, Barnaby; Da Costa, Lydie; Del Mar Manu-Pereira, Maria; Fermo, Elisa; Iolascon, Achille; Layton, Mark; Proven, Melanie; Rees, David et al.
DOI: 10.1097/HS9.0000000000000739

Upregulation of NKG2D ligands impairs hematopoietic stem cell function in Fanconi anemia.

PMID: 35671096
Journal: JOURNAL OF CLINICAL INVESTIGATION
Year: 2022
Reference: J Clin Invest. 2022 Aug 1;132(15). pii: 142842. doi: 10.1172/JCI142842.
Impact factor:
Publication type: Paper in international publication
Authors: Alberquilla, Omaira; Bueren, Juan A; Casado, Jose A; Diaz-de-Heredia, Cristina; Hanenberg, Helmut; Lopez, Andrea; Minguillon, Jordi; Navarro, Susana; Pujol, Roser; Rio, Paula et al.
DOI: 10.1172/JCI142842

The use of next-generation sequencing in the diagnosis of rare inherited anaemias: A Joint BSH/EHA Good Practice Paper.

PMID: 35661144
Journal: BRITISH JOURNAL OF HAEMATOLOGY
Year: 2022
Reference: Br J Haematol. 2022 Aug;198(3):459-477. doi: 10.1111/bjh.18191. Epub 2022 Jun 6.
Impact factor:
Publication type: Paper in international publication
Authors: Andolfo, Immacolata; Bianchi, Paola; Clark, Barnaby; Da Costa, Lydie; Fermo, Elisa; Iolascon, Achille; Layton, Mark; Manu-Pereira, Maria Del Mar; Proven, Melanie; Rees, David et al.
DOI: 10.1111/bjh.18191

Dickkopf Proteins and Their Role in Cancer: A Family of Wnt Antagonists with a Dual Role.

PMID: 34451907
Journal: Pharmaceuticals
Year: 2021
Reference: Pharmaceuticals (Basel). 2021 Aug 18;14(8). pii: ph14080810. doi: 10.3390/ph14080810.
Impact factor:
Publication type: Review in international publication
Authors: Gallego, Soledad; Gallo-Oller, Gabriel; Giralt, Irina; Magdaleno, Ainara; Moreno, Lucas; Navarro, Natalia; Pons, Guillem; Roma, Josep; Sanchez de Toledo, Jose; Segura, Miguel F et al.
DOI: 10.3390/ph14080810

Correction: Myeloablative conditioning for allo-HSCT in pediatric ALL: FTBI or chemotherapy?-A multicenter EBMT-PDWP study.

PMID: 34413474
Journal: BONE MARROW TRANSPLANTATION
Year: 2021
Reference: Bone Marrow Transplant. 2021 Oct;56(10):2615. doi: 10.1038/s41409-021-01424-5.
Impact factor:
Publication type: Letter or abstract
Authors: Abecasis, Manuel; Afanasyev, Boris; Aleinikova, Olga; Alseraihy, Amal; Ansari, Marc; Bader, Peter; Balduzzi, Adriana; Bertaina, Alice; Bertrand, Yves; Bierings, Marc et al.
DOI: 10.1038/s41409-021-01424-5

Lenvatinib with etoposide plus ifosfamide in patients with refractory or relapsed osteosarcoma (ITCC-050): a multicentre, open-label, multicohort, phase 1/2 study.

PMID: 34416158
Journal: LANCET ONCOLOGY
Year: 2021
Reference: Lancet Oncol. 2021 Sep;22(9):1312-1321. doi: 10.1016/S1470-2045(21)00387-9. Epub 2021 Aug 17.
Impact factor:
Publication type: Paper in international publication
Authors: Aerts, Isabelle; Bautista, Francisco; Campbell-Hewson, Quentin; Casanova, Michela; Dutta, Lea; Entz-Werle, Natacha; Gambart, Marion; Gaspar, Nathalie; He, Cixin; Hecker-Nolting, Stefanie et al.
DOI: 10.1016/S1470-2045(21)00387-9

The International Hemoglobinopathy Research Network (INHERENT): an international initiative to study the role of genetic modifiers in hemoglobinopathies.

PMID: 34406671
Journal: AMERICAN JOURNAL OF HEMATOLOGY
Year: 2021
Reference: Am J Hematol. 2021 Nov 1;96(11):E416-E420. doi: 10.1002/ajh.26323. Epub 2021 Aug 30.
Impact factor:
Publication type: Letter or abstract
Authors: Adekile, Adekunle; Aggeli, Constantina; Akbulut-Jeradi, Nagihan; Al-Samkari, Hanny; Alauddin, Hafiza; Aliyeva, Gunay; Alwi, Zilfalil Bin; Andemariam, Biree; Andreou, Savanna; Anie, Kofi et al.
DOI: 10.1002/ajh.26323

Initial report on Spanish pediatric oncologic, hematologic, and post stem cell transplantation patients during SARS-CoV-2 pandemic.

PMID: 32672895
Journal: PEDIATRIC BLOOD & CANCER
Year: 2020
Reference: Pediatr Blood Cancer. 2020 Sep;67(9):e28557. doi: 10.1002/pbc.28557. Epub 2020 Jul 16.
Impact factor:
Publication type: Letter whit IF
Authors: Astigarraga, Itziar; Badell, Isabel; Baragano, Marta; Carbone, Ana; Dapena, Jose Luis; Dominguez-Pinilla, Nerea; Faura, Anna; Fernandez Sanmartin, Manuel; Fernandez-Teijeiro, Ana; Fuster, Jose Luis et al.
DOI: 10.1002/pbc.28557

[Primary immune thrombocytopenia: Experience of a specialised clinic].

PMID: 31257135
Journal: ANALES DE PEDIATRIA
Year: 2020
Reference: An Pediatr (Barc). 2020 Jul;93(1):16-23. doi: 10.1016/j.anpedi.2019.05.014. Epub 2019 Jun 27.
Impact factor:
Publication type: Paper in national publication
Authors: Calvo Escribano, Carlota; Garcia Iniguez, Juan Pablo; Martinez Faci, Cristina; Murillo Sanjuan, Laura; Rodriguez-Vigil Iturrate, Carmen; Samper Villagrasa, Maria Pilar; Sanz de Miguel, Maria Pilar et al.
DOI: 10.1016/j.anpedi.2019.05.014

Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma.

PMID: 32653773
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2020
Reference: Eur J Cancer. 2020 Sep;136:52-68. doi: 10.1016/j.ejca.2020.05.010. Epub 2020 Jul 9.
Impact factor:
Publication type: Review in international publication
Authors: Barone, Giuseppe; Bird, Nick; Blanchard, Guy B; Buckland, Sean; Caron, Hubert; Chesler, Louis; Davis, Susan; De Wilde, Bram; Deubzer, Hedwig E; Dolman, Emmy et al.
DOI: 10.1016/j.ejca.2020.05.010

Neuroinflammatory Disease as an Isolated Manifestation of Hemophagocytic Lymphohistiocytosis.

PMID: 32638196
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2020
Reference: J Clin Immunol. 2020 Aug;40(6):901-916. doi: 10.1007/s10875-020-00814-6. Epub 2020 Jul 7.
Impact factor:
Publication type: Paper in international publication
Authors: Ali, Salah; Alonso, Laura; Astigarraga, Itziar; Bednarski, Jeffrey J; Blincoe, Annaliesse; Booth, Claire; Bryceson, Yenan; Bulina, Inita; Campbell, Patrick K; Chiang, Kuang-Yueh et al.
DOI: 10.1007/s10875-020-00814-6

MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways.

PMID: 31278368
Journal: ONCOGENE
Year: 2019
Reference: Oncogene. 2019 Aug;38(32):6035-6050. doi: 10.1038/s41388-019-0860-0. Epub 2019 Jul 5.
Impact factor:
Publication type: Paper in international publication
Authors: Alameda, Francesc; Barber, Marta; Castellvi, Josep; Esteller, Manel; Gil-Moreno, Antonio; Jimenez, Carlos; Majem, Blanca; Marin, Andrea; Matias-Guiu, Xavier; Moran, Sebastian et al.
DOI: 10.1038/s41388-019-0860-0

Donor lymphocyte infusions for B-cell malignancies relapse after T-cell replete allogeneic hematopoietic cell transplantation.

PMID: 30546069
Journal: BONE MARROW TRANSPLANTATION
Year: 2019
Reference: Bone Marrow Transplant. 2019 Jul;54(7):1133-1137. doi: 10.1038/s41409-018-0422-z. Epub 2018 Dec 13.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Laura; Badell, Isabel; Caballero, Dolores; de Heredia, Cristina Diaz; Ferra, Christelle; Fox, Laura; Garcia-Cadenas, Irene; Jimenez, Maria Jose; Lopez, Lucia; Martino, Rodrigo et al.
DOI: 10.1038/s41409-018-0422-z

[Protocol for the study and treatment of primary immune thrombocytopenia: PTI-2018].

PMID: 31178291
Journal: ANALES DE PEDIATRIA
Year: 2019
Reference: An Pediatr (Barc). 2019 Aug;91(2):127.e1-127.e10. doi: 10.1016/j.anpedi.2019.04.014. Epub 2019 Jun 6.
Impact factor:
Publication type: Paper in national publication
Authors: Astigarraga, Itziar; Berrueco, Ruben; Cervera, Aurea; Dapena, Jose Luis; Dasi, Maria Angeles; Monteagudo, Emilio; Sastre, Ana et al.
DOI: 10.1016/j.anpedi.2019.04.014

Origins of DNA methylation defects in Wilms tumors.

PMID: 31103718
Journal: CANCER LETTERS
Year: 2019
Reference: Cancer Lett. 2019 Aug 10;457:119-128. doi: 10.1016/j.canlet.2019.05.013. Epub 2019 May 16.
Impact factor:
Publication type: Paper in international publication
Authors: Acurzio, Basilia; Anvar, Zahra; Cerrato, Flavia; Roma, Josep; Verde, Gaetano et al.
DOI: 10.1016/j.canlet.2019.05.013

Targeting of epigenetic regulators in neuroblastoma.

PMID: 29700278
Journal: EXPERIMENTAL AND MOLECULAR MEDICINE
Year: 2018
Reference: Exp Mol Med. 2018 Apr 27;50(4):51. doi: 10.1038/s12276-018-0077-2.
Impact factor:
Publication type: Review in international publication
Authors: Gallego, Soledad; Gros, Luis; Hladun, Raquel; Jimenez, Carlos; Jubierre, Luz; Llort, Anna; Roma, Josep; Rovira, Eric; Sabado, Constantino; Segura, Miguel F et al.
DOI: 10.1038/s12276-018-0077-2

Molecular diagnosis of diffuse gliomas through sequencing of cell-free circulating tumour DNA from cerebrospinal fluid.

PMID: 29615461
Journal: CLINICAL CANCER RESEARCH
Year: 2018
Reference: Clin Cancer Res. 2018 Jun 15;24(12):2812-2819. doi: 10.1158/1078-0432.CCR-17-3800. Epub 2018 Apr 3.
Impact factor:
Publication type: Paper in international publication
Authors: Carles, Joan; Cicuendez, Marta; Cordero, Esteban; Gallego, Soledad; Graus, Francesc; Lopez-Bigas, Nuria; Martinez-Ricarte, Francisco; Martinez-Saez, Elena; Mayor, Regina; Pineda, Estela et al.
DOI: 10.1158/1078-0432.CCR-17-3800

Autoimmune hemolytic anemia (AIHA) following allogeneic hematopoietic stem cell transplantation (HSCT): A retrospective analysis and a proposal of treatment on behalf of the Grupo Espanol De Trasplante de Medula Osea en Ninos (GETMON) and the Grupo Espanol de Trasplante Hematopoyetico (GETH).

PMID: 29573905
Journal: TRANSFUSION MEDICINE REVIEWS
Year: 2018
Reference: Transfusion Medicine Reviews. 2018 Jul;32(3):179-85. doi: 10.1016/j.tmrv.2018.02.005.
Impact factor:
Publication type: Paper in international publication
Authors: Badell, Isabel; Benito, Ana; Cid, Joan; Couselo, Jose Miguel; de Heredia, Cristina Diaz; de la Serna, Javier; Diaz, Miguel Angel; Fernandez, Jose Maria; Fox, Laura; Fuster, Jose Luis et al.
DOI: 10.1016/j.tmrv.2018.02.005

Analysis of relapse post transplant in acute leukemia, a comparative on second allogeneic hematopoietic cell transplant and donor lymphocyte infusions.

PMID: 29526774
Journal: EXPERIMENTAL HEMATOLOGY
Year: 2018
Reference: Exp Hematol. 2018 Jun;62:24-32. doi: 10.1016/j.exphem.2018.03.002. Epub 2018 Mar 8.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Laura; Azqueta, Carmen; Badell, Isabel; Diaz de Heredia, Cristina; Ferra, Christelle; Garcia-Cadenas, Irene; Jimenez, Maria Jose; Orti, Guillermo; Parody, Rocio; Pinana, Jose Luis et al.
DOI: 10.1016/j.exphem.2018.03.002

Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia.

PMID: 28557976
Journal: BRITISH JOURNAL OF CANCER
Year: 2017
Reference: Br J Cancer. 2017 Jul 11;117(2):256-265. doi: 10.1038/bjc.2017.152. Epub 2017 May 30.
Impact factor:
Publication type: Paper in international publication
Authors: Abaigar, Maria; Araujo-Silva, Fernanda; Arefi, Maryam; Barragan, Eva; Benito, Rocio; Bodega-Mayor, Irene; Camos Guijosa, Mireia; de Heredia Rubio, Cristina Diaz; de Las Heras, Natalia; Fernandez-Ruiz, Elena et al.
DOI: 10.1038/bjc.2017.152

Factors Associated with Long-Term Risk of Relapse after Unrelated Cord Blood Transplantation for Children with Acute Lymphoblastic Leukemia in Remission.

PMID: 28438676
Journal: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Year: 2017
Reference: Biol Blood Marrow Transplant. 2017 Aug;23(8):1350-1358. doi: 10.1016/j.bbmt.2017.04.015. Epub 2017 Apr 21.
Impact factor:
Publication type: Paper in international publication
Authors: Ayas, Mouhab; Bader, Peter; Bittencourt, Henrique; Bonfim, Carmen; Diaz de Heredia, Cristina; Gluckman, Eliane; Kurtzberg, Joanne; Labopin, Myriam; Michel, Gerard; O'Brien, Tracey et al.
DOI: 10.1016/j.bbmt.2017.04.015

Kruppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions.

PMID: 28412746
Journal: Oncotarget
Year: 2017
Reference: Oncotarget. 2017 Apr 18;8(16):26298-26311. doi: 10.18632/oncotarget.15459.
Impact factor:
Publication type: Paper in international publication
Authors: Dankert, John F; Gaziel-Sovran, Avital; Hernando, Eva; Jubierre, Luz; Kleffman, Kevin; Koetz, Lisa; Li, SiDe; Masanas, Marc; Segura, Miguel F; Soriano, Aroa et al.
DOI: 10.18632/oncotarget.15459

State-of-the-art fertility preservation in children and adolescents undergoing haematopoietic stem cell transplantation: a report on the expert meeting of the Paediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) in Baden, Austria, 29-30 September 2015.

PMID: 28287638
Journal: BONE MARROW TRANSPLANTATION
Year: 2017
Reference: Bone Marrow Transplant. 2017 Jul;52(7):1029-1035. doi: 10.1038/bmt.2017.21. Epub 2017 Mar 13.
Impact factor:
Publication type: Paper in international publication
Authors: Ahler, A; Ansari, M; Bader, P; Balduzzi, A; Beohou, E; Bresters, D; Corbacioglu, S; Dalissier, A; Dalle, J-H; Diaz de Heredia Rubio, C et al.
DOI: 10.1038/bmt.2017.21

Pin1 Modulates the Synaptic Content of NMDA Receptors via Prolyl-Isomerization of PSD-95.

PMID: 27194325
Journal: JOURNAL OF NEUROSCIENCE
Year: 2016
Reference: J Neurosci. 2016 May 18;36(20):5437-47. doi: 10.1523/JNEUROSCI.3124-15.2016.
Impact factor:
Publication type: Paper in international publication
Authors: Ammassari-Teule, Martine; Antonelli, Roberta; Barberis, Andrea; Cherubini, Enrico; De Filippo, Roberto; Middei, Silvia; Pastore, Beatrice; Stancheva, Stefka; Zacchi, Paola et al.
DOI: 10.1523/JNEUROSCI.3124-15.2016

Landscape of early clinical trials for childhood and adolescence cancer in Spain.

PMID: 26489424
Journal: Clinical & Translational Oncology
Year: 2016
Reference: Clin Transl Oncol. 2016 Jul;18(7):708-13. doi: 10.1007/s12094-015-1421-9. Epub 2015 Oct 21.
Impact factor: 2.075
Publication type: Paper in international publication
Authors: Guibelalde, M, Moreno, L, Munoz, A, Sastre, A, Acha, T, Bautista, F, Gallego, S, Canete, A, Mora, J, Diaz de Heredia, C et al.
DOI: 10.1007/s12094-015-1421-9

[Novel micro RNA-based therapies for the treatment of neuroblastoma].

PMID: 26323526
Journal: ANALES DE PEDIATRIA
Year: 2016
Reference: An Pediatr (Barc). 2016 Aug;85(2):109.e1-109.e6. doi: 10.1016/j.anpedi.2015.07.016. Epub 2015 Aug 29.
Impact factor: 0.833
Publication type: Paper in international publication
Authors: Paris-Coderch, L, Soriano, A, Roma, J, Gallego, S, Sanchez de Toledo, J, Segura, M F, Boloix, A et al.
DOI: 10.1016/j.anpedi.2015.07.016

Cord Blood Units with High CD3(+) Cell Counts Predict Early Lymphocyte Recovery After In Vivo T Cell-Depleted Single Cord Blood Transplantation.

PMID: 27038860
Journal: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
Year: 2016
Reference: Biol Blood Marrow Transplant. 2016 Jun;22(6):1073-9. doi: 10.1016/j.bbmt.2016.03.009. Epub 2016 Mar 30.
Impact factor: 3.98
Publication type: Paper in international publication
Authors: Castillo, Nerea, Garcia-Cadenas, Irene, Diaz-Heredia, Cristina, Martino, Rodrigo, Barba, Pere, Ferra, Christelle, Canals, Carme, Elorza, Izaskun, Olive, Teresa, Badell, Isabel et al.
DOI: 10.1016/j.bbmt.2016.03.009

Umbilical cord blood transplantation from unrelated donors in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia.

PMID: 24097633
Journal: HAEMATOLOGICA
Year: 2014
Reference: Haematologica. 2014 Feb;99(2):378-84. doi: 10.3324/haematol.2013.091009. Epub 2013 Oct 4.
Impact factor: 5.868
Publication type: Clinical Trials
Authors: Pinana, Jose Luis, Sanz, Jaime, Picardi, Alessandra, Ferra, Christelle, Martino, Rodrigo, Barba, Pere, Gonzalez-Vicent, Marta, Pascual, Maria Jesus, Martin, Carmen, Verdeguer, Amparo et al.
DOI: 10.3324/haematol.2013.091009

[Carbapenem antibiotics in hospitalised paediatric patients. Adherence to a therapeutic protocol.]

PMID: 24355607
Journal: ENFERM INFEC MICR CL
Year: 2014
Reference: Enferm Infecc Microbiol Clin. 2014 Dec;32(10):647-53. doi: 10.1016/j.eimc.2013.10.013. Epub 2013 Dec 17.
Impact factor: 1.478
Publication type: Paper in national publication
Authors: Montesinos-Sanchis, Elena, Moraga-Llop, Fernando A, Soler-Palacin, Pere, Oliveras-Arenas, Maria, Larrosa Escartin, M Nieves, Martinez Gomez, Xavier, Figueras-Nadal, Concepcion et al.
DOI: 10.1016/j.eimc.2013.10.013

Intravenous and subcutaneous immunoglobulin replacement: a two-way road. Optimizing healthcare quality in patients with primary immunodeficiencies.

PMID: 25190197
Journal: J CLIN IMMUNOL
Year: 2014
Reference: J Clin Immunol. 2014 Nov;34(8):1015-7. doi: 10.1007/s10875-014-0096-2. Epub 2014 Sep 5.
Impact factor: 2.654
Publication type: Paper in international publication
Authors: Figueras, Concepcio, Martinez-Cutillas, Julio, Oliveras, Maria, Soler-Palacin, Pere, Gaso-Gago, Ingrid, Fernandez-Polo, Aurora, Martin-Nalda, Andrea et al.
DOI: 10.1007/s10875-014-0096-2

Long-term outcome and prognostic factors of unrelated cord blood transplantation in children with haematological malignancies: a retrospective study using the Spanish Working Party for BMT in Children (GETMON) database.

PMID: 24614843
Journal: BONE MARROW TRANSPL
Year: 2014
Reference: Bone Marrow Transplant. 2014 Jun;49(6):767-72. doi: 10.1038/bmt.2014.30. Epub 2014 Mar 10.
Impact factor: 3.466
Publication type: Paper in international publication
Authors: Diaz de Heredia, C, Gonzalez, M, Verdeguer, A, Elorza, I, Rodriguez, A, Martinez, A, Perez, J M, Badell, I, Gonzalez, M E, Olive, T et al.
DOI: 10.1038/bmt.2014.30

Epileptic encephalopathy after HHV6 post-transplant acute limbic encephalitis in children: Confirmation of a new epilepsy syndrome.

PMID: 23535036
Journal: EPILEPSY RESEARCH
Year: 2013
Reference: Epilepsy Res. 2013 Aug;105(3):419-22. doi: 10.1016/j.eplepsyres.2013.02.019. Epub 2013 Mar 25.
Impact factor: 2.241
Publication type: Paper in international publication
Authors: Raspall-Chaure, Miquel, Armangue, Thais, Elorza, Izaskun, Sanchez-Montanez, Angel, Vicente-Rasoamalala, Monica, Macaya, Alfons et al.
DOI: 10.1016/j.eplepsyres.2013.02.019

microRNAs as pharmacological targets in cancer.

PMID: 23537752
Journal: PHARMACOLOGICAL RESEARCH
Year: 2013
Reference: Pharmacol Res. 2013 Sep;75:3-14. doi: 10.1016/j.phrs.2013.03.006. Epub 2013 Mar 25.
Impact factor: 4.346
Publication type: Review in international publication
Authors: Soriano, Aroa, Jubierre, Luz, Almazan-Moga, Ana, Molist, Carla, Roma, Josep, de Toledo, Jose Sanchez, Gallego, Soledad, Segura, Miguel F et al.
DOI: 10.1016/j.phrs.2013.03.006

[Results of hematopoietic stem cell transplantation in hemoglobinopathies: Thalassemia major and sickle cell disease.]

PMID: 23402775
Journal: ANALES DE PEDIATRIA
Year: 2013
Reference: An Pediatr (Barc). 2013 Aug;79(2):75-82. doi: 10.1016/j.anpedi.2012.12.002. Epub 2013 Feb 9.
Impact factor: 0.867
Publication type: Paper in national publication
Authors: Llort, A, Sanchez de Toledo, J, Diaz de Heredia, C, Dapena, J L, Olive, T, Hladun, R, Elorza, I et al.
DOI: 10.1016/j.anpedi.2012.12.002

Infantile Fibrosarcoma of the Retroperitoneum: A Site of Unfavorable Prognosis?

PMID: 21345076
Journal: PEDIATRIC HEMATOLOGY AND ONCOLOGY
Year: 2011
Reference: Pediatr Hematol Oncol. 2011 Aug;28(5):451-3. Epub 2011 Feb 23.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; et al.
DOI: 10.3109/08880018.2010.543450

Origin, functional role and clinical impact of Fanconi anemia FANCA mutations.

PMID: 21273304
Journal: BLOOD
Year: 2011
Reference: Blood. 2011 Apr 7;117(14):3759-69. Epub 2011 Jan 27.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1182/blood-2010-08-299917

Chromosome fragility in patients with Fanconi anaemia: diagnostic implications and clinical impact.

PMID: 21217111
Journal: JOURNAL OF MEDICAL GENETICS
Year: 2011
Reference: J Med Genet. 2011 Apr;48(4):242-50. Epub 2011 Jan 7.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1136/jmg.2010.084210

Prognostic factors in desmoid tumours: an example of translational oncology.

PMID: 21421456
Journal: Clinical & Translational Oncology
Year: 2011
Reference: Clin Transl Oncol. 2011 Mar;13(3):139-40.
Impact factor: 1.254
Publication type: Editorail in international publication
Authors: Gallego Melcon, Soledad et al.
DOI:

A novel G6PC3 homozygous 1-bp deletion as a cause of severe congenital neutropenia.

PMID: 19696212
Journal: BLOOD
Year: 2009
Reference: Blood. 2009 Aug 20;114(8):1718-9.
Impact factor: 10.432
Publication type: Letter or abstract
Authors: Arostegui, Juan I, de Toledo, Jose Sanchez, Pascal, Mariona, Garcia, Carlos, Yague, Jordi, Diaz de Heredia, Cristina et al.
DOI: 10.1182/blood-2009-04-219451

Blog

News

The association, once again, has shown its commitment to oncological research with a donation of €19,197 to the Cancer and Hematological Diseases Group for Children at VHIR.

The prestigious journal The Lancet has published the results of this study, which is the result of more than 20 years of pre-clinical research and 7 years of patient follow-up.

During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.