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Childhood Cancer and Blood Disorders

The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.

Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.

Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours

Team

Khloud Abdo Soliman Elsharawy

Khloud Abdo Soliman Elsharawy

Postdoctoral researcher
Childhood Cancer and Blood Disorders
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Laura Garriga Grimau

Laura Garriga Grimau

Postdoctoral researcher
Childhood Cancer and Blood Disorders
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María Paula Pérez Albert

María Paula Pérez Albert

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Mariona Morell Daniel

Mariona Morell Daniel

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Miera Maluenda, Marta

Miera Maluenda, Marta

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Mosull del Campo, Raquel

Mosull del Campo, Raquel

Administration and Management
Childhood Cancer and Blood Disorders
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Khloud Abdo Soliman Elsharawy

Khloud Abdo Soliman Elsharawy

Postdoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Laura Garriga Grimau

Laura Garriga Grimau

Postdoctoral researcher
Childhood Cancer and Blood Disorders
Read more
María Paula Pérez Albert

María Paula Pérez Albert

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Mariona Morell Daniel

Mariona Morell Daniel

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Miera Maluenda, Marta

Miera Maluenda, Marta

Predoctoral researcher
Childhood Cancer and Blood Disorders
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Mosull del Campo, Raquel

Mosull del Campo, Raquel

Administration and Management
Childhood Cancer and Blood Disorders
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Projects

ERICA - European Rare dIsease research Coordination and support Action

IP: M Mar Mañu Pereira
Collaborators: Claire Diot, Raquel Mosull del Campo
Funding agency: EUROPEAN COMMISSION
Funding: 105250
Reference: ERICA_H2020-SC1-BHC-2020
Duration: 01/03/2021 - 28/02/2025

GENOMED4ALL - Genomics and Personalized Medicine for all though Artificial Intelligence in Haematological Diseases

IP: M Mar Mañu Pereira
Collaborators: Reidel , Sara Isabel, Ali Haidar, Ferran Balbastre Ubeda, Amira Idrizovic
Funding agency: EUROPEAN COMMISSION
Funding: 434000
Reference: GENOMED4ALL_H2020-SC1-FA-DTS-2018-20
Duration: 01/01/2021 - 31/12/2024

Desarrollo de nuevos fármacos basados en la inhibición de los co-receptores de la vía Hedgehog

IP: Josep Roma Castanyer
Collaborators: Soledad Gallego Melcón, Guillem Pons Barcons, Constantino Sábado Álvarez, Raquel Hladun Alvaro, Patricia Zarzosa Martinez
Funding agency: Instituto de Salud Carlos III
Funding: 122815
Reference: PI21/00640
Duration: 01/01/2022 - 31/12/2024

Next generation personalised medicine for childhood cancers

IP: Lucas Moreno Martín-Retortillo
Collaborators: Aroa Soriano Fernández, Jessica Camacho Soriano, Raquel Hladun Alvaro, Gabriela Guillén Burrieza, Andrea Vilaplana Blanes, Paula Cabre Fernandez, Lorena Valero Arrese, Sergio Manresa Vera, Mariona Morell Daniel
Funding agency: Instituto de Salud Carlos III
Funding: 214170
Reference: PI21/01661
Duration: 01/01/2022 - 31/12/2024

Publications

Syndemic conditions and quality of life in the PISCIS Cohort of people living with HIV in Catalonia and the Balearic Islands: a cross sectional study.

PMID: 37165368
Journal: Health and Quality of Life Outcomes
Year: 2023
Reference: Health Qual Life Outcomes. 2023 May 10;21(1):42. doi: 10.1186/s12955-023-02120-2.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Garcia, Lucia; Bruguera, Andreu; Casabona, Jordi; Diaz, Yesika; Egea-Cortes, Laia; Folch, Cinta; Forero, Carlos G; Hernandez, Juan; Mesias-Gazmuri, Jocelyn; Miro, Jose M et al.
DOI: 10.1186/s12955-023-02120-2

TALAPRO-3 clinical trial protocol: phase III study of talazoparib plus enzalutamide in metastatic castration-sensitive prostate cancer.

PMID: 37882449
Journal: Future Oncology
Year: 2023
Reference: Future Oncol. 2023 Oct 26. doi: 10.2217/fon-2023-0526.
Impact factor:
Publication type: Paper in international publication
Authors: Agarwal, Neeraj; Alonso, Lucia; Azad, Arun A; Bordas, Anna; Casabona, Jordi; Chakrabarti, Jayeta; Chen, Hsiang-Chun; Colom-Cadena, Andreu; Fizazi, Karim; Ganem, Fabiana et al.
DOI: 10.2217/fon-2023-0526

Pralsetinib in patients with RET fusion-positive non-small cell lung cancer: A plain language summary of the ARROW study.

PMID: 37916501
Journal: Future Oncology
Year: 2023
Reference: Future Oncol. 2023 Nov 2. doi: 10.2217/fon-2023-0155.
Impact factor:
Publication type: Paper in international publication
Authors: Baik, Christina S; Boral, Andy L; Bowles, Daniel W; Chakravorty, Subarna; Colombatti, Raffaella; Curigliano, Giuseppe; de Montalembert, Mariane; Del Mar Manu Pereira, Maria; Gainor, Justin F; Garralda, Elena et al.
DOI: 10.2217/fon-2023-0155

Formation of an invasion-permissive matrix requires TGFbeta/SNAIL1-regulated alternative splicing of fibronectin.

PMID: 37964360
Journal: BREAST CANCER RESEARCH
Year: 2023
Reference: Breast Cancer Res. 2023 Nov 14;25(1):143. doi: 10.1186/s13058-023-01736-y.
Impact factor:
Publication type: Paper in international publication
Authors: Baulida, Josep; Benitez-Carbante, Maria Isabel; Diaz de Heredia, Cristina; Eyras, Eduardo; Fernandez Ledesma, Berta; Fernandez-Polo, Aurora; Franco-Valls, Hector; Garcia de Herreros, Antonio; Grau Cerrato, Santiago; Iaconcig, Alessandra et al.
DOI: 10.1186/s13058-023-01736-y

Neuroblastoma in Spain: Linking the national clinical database and epidemiological registries - A study by the Joint Action on Rare Cancers.

PMID: 35344745
Journal: Cancer Epidemiology
Year: 2022
Reference: Cancer Epidemiol. 2022 Jun;78:102145. doi: 10.1016/j.canep.2022.102145. Epub 2022 Mar 25.
Impact factor: 2.984
Publication type: Paper in international publication
Authors: Pardo-Romaguera, Elena, Segura, Vanessa, Munoz-Lopez, Ana, Galceran-Padros, Jaume, Fernandez-Teijeiro, Ana, Gatta, Gemma, Cruz, O, Benito, A I, Buedo, M I, Calvo, C et al.
DOI: 10.1016/j.canep.2022.102145

Post thawing viable CD34+ Cells dose is a better predictor of clinical outcome in lymphoma patients undergoing autologous stem cell transplantation.

PMID: 35614316
Journal: BONE MARROW TRANSPLANTATION
Year: 2022
Reference: Bone Marrow Transplant. 2022 May 25. pii: 10.1038/s41409-022-01722-6. doi: 10.1038/s41409-022-01722-6.
Impact factor: 5.483
Publication type: Letter whit IF
Authors: Talarn, Carme, Cid, Joan, Azqueta, Carmen, Valdivia, Elena, Martorell, Lluis, Codinach, Margarita, Marsal, Julia, Mussetti, Alberto, Esquirol, Albert, Trabazo, Maria et al.
DOI: 10.1038/s41409-022-01722-6

Southeast Asian ovalocytosis detected in a critical patient with COVID-19 pneumonia.

PMID: 35580896
Journal: International Journal of Laboratory Hematology
Year: 2022
Reference: Int J Lab Hematol. 2022 May 17. doi: 10.1111/ijlh.13878.
Impact factor: 2.877
Publication type: Letter whit IF
Authors: Faneca, Joana, Moreno-Castano, Ana Belen, Diaz-Ricart, Maribel, Escolar, Gines, Garcia, Estefania, Manu-Pereira, Maria Del Mar, Idrizovic, Amira, Matute, Monica, Molina, Angel, Merino, Anna et al.
DOI: 10.1111/ijlh.13878

MET Inhibition Sensitizes Rhabdomyosarcoma Cells to NOTCH Signaling Suppression.

PMID: 35574376
Journal: Frontiers in Oncology
Year: 2022
Reference: Front Oncol. 2022 Apr 27;12:835642. doi: 10.3389/fonc.2022.835642. eCollection 2022.
Impact factor: 6.244
Publication type: Paper in international publication
Authors: Cassandri, Matteo, Perrone, Clara, Pomella, Silvia, Colletti, Marta, Cossetti, Cristina, Pericoli, Giulia, Di Giannatale, Angela, de Billy, Emmanuel, Vinci, Maria, Petrini, Stefania et al.
DOI: 10.3389/fonc.2022.835642

GEIS-SEHOP clinical practice guidelines for the treatment of rhabdomyosarcoma.

PMID: 34212338
Journal: Clinical & Translational Oncology
Year: 2021
Reference: Clin Transl Oncol. 2021 Dec;23(12):2460-2473. doi: 10.1007/s12094-021-02654-1. Epub 2021 Jul 1.
Impact factor: 3.405
Publication type: Paper in international publication
Authors: Ruano, D, Rubio, P, Verges, R, Valverde, C, Gallego, S, Bernabeu, D, Hindi, N, Mata, C, Marquez, C, Orcajo, J et al.
DOI: 10.1007/s12094-021-02654-1

Combining microfluidics with machine learning algorithms for RBC classification in rare hereditary hemolytic anemia.

PMID: 34193899
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 Jun 30;11(1):13553. doi: 10.1038/s41598-021-92747-2.
Impact factor: 4.38
Publication type: Paper in international publication
Authors: Rizzuto, Valeria, Mencattini, Arianna, Alvarez-Gonzalez, Begona, Di Giuseppe, Davide, Martinelli, Eugenio, Beneitez-Pastor, David, Lopez-Martinez, Maria Jose, Samitier, Josep, Manu-Pereira, Maria Del Mar et al.
DOI: 10.1038/s41598-021-92747-2

Kaposi Sarcoma in a child after hematopoietic stem cell transplantation: should pre-transplant HHV-8 screening be considered in recipients from high prevalence areas?

PMID: 33231901
Journal: Transplant Infectious Disease
Year: 2021
Reference: Transpl Infect Dis. 2021 Jun;23(3):e13525. doi: 10.1111/tid.13525. Epub 2020 Dec 7.
Impact factor: 2.228
Publication type: Review in international publication
Authors: Soques Vallejo, Elena, Roca, Isabel, Navarro, Alexandra, Diaz-de-Heredia, Cristina, Benitez-Carabante, Maria Isabel, Valero Arrese, Lorena et al.
DOI: 10.1111/tid.13525

Cryopreservation of unrelated donor hematopoietic stem cells: the right answer for transplantations during the COVID-19 pandemic?

PMID: 34127808
Journal: BONE MARROW TRANSPLANTATION
Year: 2021
Reference: Bone Marrow Transplant. 2021 Oct;56(10):2489-2496. doi: 10.1038/s41409-021-01367-x. Epub 2021 Jun 14.
Impact factor: 5.483
Publication type: Paper in international publication
Authors: Linares, Monica, Ancochea, Agueda, Garcia-Rey, Enric, Garcia-Munoz, Nadia, Medina, Laura, Castillo, Nerea, Carreras, Enric, Villa, Juliana, Querol, Sergio, Valcarcel, David et al.
DOI: 10.1038/s41409-021-01367-x

[Tocilizumab in a child with acute lymphoblastic leukaemia and COVID-19-related cytokine release syndrome].

PMID: 32593520
Journal: ANALES DE PEDIATRIA
Year: 2020
Reference: An Pediatr (Barc). 2020 Aug;93(2):132-133. doi: 10.1016/j.anpedi.2020.05.002. Epub 2020 Jun 9.
Impact factor: 1.313
Publication type: Letter whit IF
Authors: Velasco Puyo, Pablo, Riviere, Jacques G, Soler Palacin, Pere, Diaz de Heredia, Cristina, Moreno, Lucas et al.
DOI: 10.1016/j.anpedi.2020.05.002

Phase II results from a phase I/II study to assess the safety and efficacy of weekly nab-paclitaxel in paediatric patients with recurrent or refractory solid tumours: A collaboration with the European Innovative Therapies for Children with Cancer Network.

PMID: 32554315
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2020
Reference: Eur J Cancer. 2020 Aug;135:89-97. doi: 10.1016/j.ejca.2020.04.031. Epub 2020 Jun 15.
Impact factor: 7.275
Publication type: Paper in international publication
Authors: Amoroso, Loredana, Castel, Victoria, Bisogno, Gianni, Casanova, Michela, Marquez-Vega, Catalina, Chisholm, Julia C, Doz, Francois, Moreno, Lucas, Ruggiero, Antonio, Gerber, Nicolas U et al.
DOI: 10.1016/j.ejca.2020.04.031

Dermatofibrosarcoma protuberans in children and adolescents: The European Paediatric Soft Tissue Sarcoma Study Group prospective trial (EpSSG NRSTS 2005).

PMID: 32558231
Journal: PEDIATRIC BLOOD & CANCER
Year: 2020
Reference: Pediatr Blood Cancer. 2020 Oct;67(10):e28351. doi: 10.1002/pbc.28351. Epub 2020 Jun 18.
Impact factor: 2.355
Publication type: Paper in international publication
Authors: Brennan, Bernadette, Zanetti, Ilaria, De Salvo, Gian Luca, Orbach, Daniel, Gallego, Soledad, Francotte, Nadine, Schifflers, Stefan, Van Noesel, Max, Kelsey, Anna, Casanova, Michela et al.
DOI: 10.1002/pbc.28351

Cost-Effectiveness Analysis of Tisagenlecleucel in the Treatment of Relapsed or Refractory B-Cell Acute Lymphoblastic Leukaemia in Children and Young Adults in Spain.

PMID: 32523362
Journal: ClinicoEconomics and outcomes research : CEOR
Year: 2020
Reference: Clinicoecon Outcomes Res. 2020 May 15;12:253-264. doi: 10.2147/CEOR.S241880. eCollection 2020.
Impact factor: 0
Publication type: Paper in international publication
Authors: Ribera Santasusana, Josep Maria, de Andres Saldana, Alejandra, Garcia-Munoz, Nuria, Gostkorzewicz, Joana, Martinez Llinas, Diana, Diaz de Heredia, Cristina et al.
DOI: 10.2147/CEOR.S241880

Frequency, characteristics and outcome of PTLD after allo-SCT: a multicenter study from the Spanish group of blood and marrow transplantation (GETH).

PMID: 30828868
Journal: EUROPEAN JOURNAL OF HAEMATOLOGY
Year: 2019
Reference: Eur J Haematol. 2019 Jun;102(6):465-471. doi: 10.1111/ejh.13226. Epub 2019 Apr 10.
Impact factor: 2.217
Publication type: Paper in international publication
Authors: Heras, Inmaculada, Viguria, M, Batlle, M, Vazquez, L, Lopez, J, Solano, C, Gonzalez Vicent, M, Suarez-Lledo, M, Alonso, L, Garcia, E et al.
DOI: 10.1111/ejh.13226

Multidisciplinary, evidence-based consensus guidelines for human papillomavirus (HPV) vaccination in high-risk populations, Spain, 2016.

PMID: 30782268
Journal: Eurosurveillance
Year: 2019
Reference: Euro Surveill. 2019 Feb;24(7). doi: 10.2807/1560-7917.ES.2019.24.7.1700857.
Impact factor: 7.421
Publication type: Review in international publication
Authors: Martinez-Gomez, Xavier, Curran, Adrian, Campins, Magda, Alemany, Laia, Rodrigo-Pendas, Jose Angel, Borruel, Natalia, Castellsague, Xavier, Diaz-de-Heredia, Cristina, Moraga-Llop, Fernando A, Del Pino, Marta et al.
DOI: 10.2807/1560-7917.ES.2019.24.7.1700857

Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma.

PMID: 30770954
Journal: CELLULAR AND MOLECULAR LIFE SCIENCES
Year: 2019
Reference: Cell Mol Life Sci. 2019 Jun;76(11):2231-2243. doi: 10.1007/s00018-019-03041-4. Epub 2019 Feb 15.
Impact factor: 7.014
Publication type: Paper in international publication
Authors: Soriano, Aroa, Masanas, Marc, Boloix, Ariadna, Masia, Nuria, Paris-Coderch, Laia, Piskareva, Olga, Jimenez, Carlos, Henrich, Kai-Oliver, Roma, Josep, Westermann, Frank et al.
DOI: 10.1007/s00018-019-03041-4

Author Correction: Donor lymphocyte infusions for B-cell malignancies relapse after T-cell replete allogeneic hematopoietic cell transplantation.

PMID: 30733543
Journal: BONE MARROW TRANSPLANTATION
Year: 2019
Reference: Bone Marrow Transplant. 2019 Jul;54(7):1176. doi: 10.1038/s41409-019-0471-y.
Impact factor: 4.674
Publication type: Letter or abstract
Authors: Lopez-Corral, Lucia, Perez, Ariadna, Jimenez, Maria Jose, Sanchez-Ortega, Isabel, Alonso, Laura, Sisinni, Luisa, Fox, Laura, Villacampa, Guillermo, Badell, Isabel, de Heredia, Cristina Diaz et al.
DOI: 10.1038/s41409-019-0471-y

Alveolar soft part sarcoma in children and adolescents: The European Paediatric Soft Tissue Sarcoma study group prospective trial (EpSSG NRSTS 2005).

PMID: 29286582
Journal: PEDIATRIC BLOOD & CANCER
Year: 2018
Reference: Pediatr Blood Cancer. 2018 Apr;65(4). doi: 10.1002/pbc.26942. Epub 2017 Dec 29.
Impact factor: 2.646
Publication type: Paper in international publication
Authors: Ferrari, Andrea, Bisogno, Gianni, De Salvo, Gian Luca, Casanova, Michela, Brennan, Bernadette, Zanetti, Ilaria, Orbach, Daniel, Gallego, Soledad, Francotte, Nadine, Van Noesel, Max et al.
DOI: 10.1002/pbc.26942

Prognostic relevance of early radiologic response to induction chemotherapy in pediatric rhabdomyosarcoma: A report from the International Society of Pediatric Oncology Malignant Mesenchymal Tumor 95 study.

PMID: 29211298
Journal: CANCER
Year: 2018
Reference: Cancer. 2018 Mar 1;124(5):1016-1024. doi: 10.1002/cncr.31157. Epub 2017 Dec 6.
Impact factor: 6.537
Publication type: Paper in international publication
Authors: Vaarwerk, Bas, van der Lee, Johanna H, Breunis, Willemijn B, Orbach, Daniel, Chisholm, Julia C, Cozic, Nathalie, Jenney, Meriel, van Rijn, Rick R, McHugh, Kieran, Gallego, Soledad et al.
DOI: 10.1002/cncr.31157

State-of-the-art fertility preservation in children and adolescents undergoing haematopoietic stem cell transplantation: a report on the expert meeting of the Paediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) in Baden, Austria, 29-30 September 2015.

PMID: 28287638
Journal: BONE MARROW TRANSPLANTATION
Year: 2017
Reference: Bone Marrow Transplant. 2017 Jul;52(7):1029-1035. doi: 10.1038/bmt.2017.21. Epub 2017 Mar 13.
Impact factor: 3.874
Publication type: Paper in international publication
Authors: Dalle, J-H, Lucchini, G, Balduzzi, A, Ifversen, M, Jahnukainen, K, Macklon, K T, Ahler, A, Jarisch, A, Ansari, M, Beohou, E et al.
DOI: 10.1038/bmt.2017.21

[Early clinical trials in paediatric oncology in Spain: a nationwide perspective].

PMID: 28279690
Journal: ANALES DE PEDIATRIA
Year: 2017
Reference: An Pediatr (Barc). 2017 Sep;87(3):155-163. doi: 10.1016/j.anpedi.2016.07.007. Epub 2017 Mar 6.
Impact factor: 1.14
Publication type: Review in national publication
Authors: Hladun, Raquel, Juan Ribelles, Antonio, Madero, Luis, Ramirez, Manuel, Fernandez Delgado, Rafael, Perez-Martinez, Antonio, Mata, Cristina, Llort, Anna, Martin Broto, Javier, Cela, Maria Elena et al.
DOI: 10.1016/j.anpedi.2016.07.007

Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma.

PMID: 28243259
Journal: Stem Cells International
Year: 2017
Reference: Stem Cells Int. 2017;2017:7507380. doi: 10.1155/2017/7507380. Epub 2017 Jan 24.
Impact factor: 3.54
Publication type: Paper in international publication
Authors: Almazan-Moga, Ana, Zarzosa, Patricia, Vidal, Isaac, Molist, Carla, Giralt, Irina, Navarro, Natalia, Soriano, Aroa, Segura, Miguel F, Alfranca, Arantza, Garcia-Castro, Javier et al.
DOI: 10.1155/2017/7507380

Paratesticular rhabdomyosarcoma in children and adolescents-Outcome and patterns of relapse when utilizing a nonsurgical strategy for lymph node staging: Report from the International Society of Paediatric Oncology (SIOP) Malignant Mesenchymal Tumour 89 and 95 studies.

PMID: 28205365
Journal: PEDIATRIC BLOOD & CANCER
Year: 2017
Reference: Pediatr Blood Cancer. 2017 Sep;64(9). doi: 10.1002/pbc.26486. Epub 2017 Feb 16.
Impact factor: 2.513
Publication type: Paper in international publication
Authors: Rogers, Timothy, Minard-Colin, Veronique, Cozic, Nathalie, Jenney, Meriel, Merks, Johannes H M, Gallego, Soledad, Devalck, Christine, Gaze, Mark N, Kelsey, Anna, Oberlin, Odile et al.
DOI: 10.1002/pbc.26486

Blog

News

La iniciativa "Sin Piedad" explica la història d'en David, un nen que s'està tractant d'un càncer pediàtric, un exemple d'actitud lluitadora davant la malaltia.

The money will allow research into paediatric nervous system tumours and childhood sarcomas to continue, with the aim of improving children's chances of survival and reducing the side effects of treatment.

The association makes the fifth annual donation of 52,390€ that will finance a project to study new therapies for this childhood tumor.

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Laboratory Technician
Start date:
12/09/2023
End date:
26/09/2023
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Junior Researcher in Drug Development
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25/07/2023
End date:
08/08/2023
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Experienced EU Project Manager – Scientific projects (AI and Genomics)
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10/05/2023
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24/05/2023
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