About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.
Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.
Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours
PMID: 37369988 Journal: PEDIATRIC BLOOD & CANCER Year: 2023 Reference: Pediatr Blood Cancer. 2023 Jun 27:e30506. doi: 10.1002/pbc.30506. Impact factor: Publication type: Paper in international publication Authors: Daugherty, Claire; Gallardo, Eva; Gros, Luis; Hill, Christon; Janeway, Katherine A; Rizzari, Carmelo; Schwartz, Stefan; Thomas, Emma; Ward, Suzanne et al. DOI: 10.1002/pbc.30506
PMID: 37533171 Journal: VOX SANGUINIS Year: 2023 Reference: Vox Sang. 2023 Aug 2. doi: 10.1111/vox.13499. Impact factor: Publication type: Paper in international publication Authors: Azqueta, Carmen; Badell, Isabel; Carreras, Enric; Diaz-de-Heredia, Cristina; Esquirol, Albert; Fernandez-Sojo, Jesus; Ferra, Christelle; Garcia-Buendia, Ana; Gomez, David; Lozano, Miquel et al. DOI: 10.1111/vox.13499
PMID: 37595686 Journal: Transplantation and cellular therapy Year: 2023 Reference: Transplant Cell Ther. 2023 Aug 16:S2666-6367(23)01473-2. doi: 10.1016/j.jtct.2023.08.016. Impact factor: Publication type: Paper in international publication Authors: Belendez, Cristina; Benitez, Isabel; Benitez, Isabel; Bueno, David; de Heredia, Cristina Diaz; Echecopar, Carlos; Estival, Pablo; Fuentes, Carolina; Fuster, Jose Luis; Galan, Victor et al. DOI: 10.1016/j.jtct.2023.08.016
PMID: 37646983 Journal: Clinical & Translational Oncology Year: 2023 Reference: Clin Transl Oncol. 2023 Aug 30. doi: 10.1007/s12094-023-03301-7. Impact factor: Publication type: Paper in international publication Authors: Cruz Martinez, Ofelia; de Noriega, Inigo; Garcia Abos, Miriam; Garrido Colino, Carmen; Gros Subias, Luis; Huidobro Labarga, Beatriz; Lassaletta, Alvaro; Llort Sales, Anna; Lopez Ibor, Blanca; Marquez Vega, Catalina et al. DOI: 10.1007/s12094-023-03301-7
PMID: 35460336 Journal: PEDIATRIC BLOOD & CANCER Year: 2022 Reference: Pediatr Blood Cancer. 2022 Sep;69(9):e29739. doi: 10.1002/pbc.29739. Epub 2022 Apr 23. Impact factor: Publication type: Paper in international publication Authors: Bisogno, Gianni; Coppadoro, Beatrice; De Corti, Federica; Fajardo, Raquel Davila; Glosli, Heidi; Guerin, Florent; Guillen, Gabriela; Jenney, Meriel; Kelsey, Anna; Mandeville, Henry et al. DOI: 10.1002/pbc.29739
PMID: 34718957 Journal: Clinical & Translational Oncology Year: 2022 Reference: Clin Transl Oncol. 2022 May;24(5):950-957. doi: 10.1007/s12094-021-02724-4. Epub 2021 Oct 30. Impact factor: Publication type: Review in international publication Authors: Cano, P; Guillen, G; Hladun, R; Lopez, M; Lopez-Fernandez, S; Martos, M; Molino, J A et al. DOI: 10.1007/s12094-021-02724-4
PMID: 35393436 Journal: Cell Death Discovery Year: 2022 Reference: Cell Death Discov. 2022 Apr 7;8(1):172. doi: 10.1038/s41420-022-00959-w. Impact factor: Publication type: Paper in international publication Authors: Alcon, Clara; Gallego, Soledad; Guillen, Gabriela; Martin, Fernando; Montero, Joan; Mora, Jaume; Prada, Estela; Roma, Josep; Samitier, Josep; Soriano, Aroa et al. DOI: 10.1038/s41420-022-00959-w
PMID: 35307252 Journal: EJSO Year: 2022 Reference: Eur J Surg Oncol. 2022 Jul;48(7):1536-1542. doi: 10.1016/j.ejso.2022.03.001. Epub 2022 Mar 12. Impact factor: Publication type: Paper in international publication Authors: Bisogno, G; Burrieza, G Guillen; Coppadoro, B; Craigie, R J; Dall'Igna, P; De Corti, F; Fajardo, R Davila; Guerin, F; Jenney, M; Mandeville, H C et al. DOI: 10.1016/j.ejso.2022.03.001
PMID: 34121983 Journal: Frontiers in Neuroscience Year: 2021 Reference: Front Neurosci. 2021 May 26;15:618098. doi: 10.3389/fnins.2021.618098. eCollection 2021. Impact factor: Publication type: Paper in international publication Authors: Aguilera, Cinthia; Gabau, Elisabeth; Guitart, Miriam; Hummer, Stefan; Jeyaprakash, A Arockia; Masanas, Marc; Ruiz, Anna; Santamaria, Anna; Segura, Miguel F et al. DOI: 10.3389/fnins.2021.618098
PMID: 34127808 Journal: BONE MARROW TRANSPLANTATION Year: 2021 Reference: Bone Marrow Transplant. 2021 Oct;56(10):2489-2496. doi: 10.1038/s41409-021-01367-x. Epub 2021 Jun 14. Impact factor: Publication type: Paper in international publication Authors: Ancochea, Agueda; Azqueta, Carmen; Canals, Carme; Carreras, Enric; Castillo, Nerea; Codinach, Margarita; Diaz de Heredia, Cristina; Elorza, Izaskun; Fernandez-Sojo, Jesus; Ferra, Christelle et al. DOI: 10.1038/s41409-021-01367-x
PMID: 32397857 Journal: Autophagy Year: 2021 Reference: Autophagy. 2021 Jun;17(6):1349-1366. doi: 10.1080/15548627.2020.1761651. Epub 2020 May 25. Impact factor: Publication type: Paper in international publication Authors: Abad, Jose L; Alfon, Jose; Bosch-Barrera, Joaquim; Casas, Josefina; Dieguez-Martinez, Nora; Domenech, Carles; Erazo, Tatiana; Espinosa-Gil, Sergio; Fabrias, Gemma; Lizcano, Jose M et al. DOI: 10.1080/15548627.2020.1761651
PMID: 34064518 Journal: Biomedicines Year: 2021 Reference: Biomedicines. 2021 May 4;9(5). pii: biomedicines9050508. doi: 10.3390/biomedicines9050508. Impact factor: Publication type: Paper in international publication Authors: Arias-Betancur, Alain; Benitez-Garcia, Cristina; Bonelli, Joaquin; Cusco, Cristina; Garcia-Valverde, Maria; Martinez-Garcia, David; Nuevo-Fonoll, Marina; Perez-Hernandez, Marta; Perez-Tomas, Ricardo; Quesada, Roberto et al. DOI: 10.3390/biomedicines9050508
PMID: 31147440 Journal: HAEMATOLOGICA Year: 2020 Reference: Haematologica. 2020 Jan 31;105(2):338-347. doi: 10.3324/haematol.2018.188151. Print 2020. Impact factor: Publication type: Paper in international publication Authors: Bogdanova, Anna; Corrons, Joan-LLuis Vives; Hertz, Laura; Huisjes, Rick; Kaestner, Lars; Llaudet-Planas, Esther; Makhro, Asya; Manu-Pereira, Maria; Petkova-Kirova, Polina; Pignatelli, Silvia et al. DOI: 10.3324/haematol.2018.188151
PMID: 32335674 Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY Year: 2020 Reference: J Antimicrob Chemother. 2020 Aug 1;75(8):2264-2271. doi: 10.1093/jac/dkaa149. Impact factor: Publication type: Paper in international publication Authors: Benitez-Carabante, Maria Isabel; Diaz-de-Heredia, Cristina; Fernandez-Polo, Aurora; Gonzalez-Amores, Miriam; Martin, Maria Teresa; Mendoza-Palomar, Natalia; Renedo, Berta; Soler-Palacin, Pere; Soques, Elena et al. DOI: 10.1093/jac/dkaa149
PMID: 32314348 Journal: BRITISH JOURNAL OF HAEMATOLOGY Year: 2020 Reference: Br J Haematol. 2020 Sep;190(5):764-771. doi: 10.1111/bjh.16647. Epub 2020 Apr 21. Impact factor: Publication type: Paper in international publication Authors: Bautista, Francisco; Dapena, Jose L; Fernandez, Jose M; Fuentes, Carolina; Fuster, Jose L; Garcia-Morin, Marina; Gonzalez-Vicent, Marta; Lopez-Duarte, Monica; Lopez-Godino, Oriana; Molinos-Quintana, Agueda et al. DOI: 10.1111/bjh.16647
PMID: 31799703 Journal: CLINICAL AND EXPERIMENTAL IMMUNOLOGY Year: 2020 Reference: Clin Exp Immunol. 2020 Apr;200(1):61-72. doi: 10.1111/cei.13405. Epub 2020 Jan 19. Impact factor: Publication type: Paper in international publication Authors: Alonso, Laura; Arcas-Garcia, Andrea; Colobran, Roger; Drechsel, Oliver; Franco-Jarava, Clara; Garcia-Prat, Marina; Magallon-Lorenz, Miriam; Martin-Nalda, Andrea; Martinez-Gallo, Monica; Ossowski, Stephan et al. DOI: 10.1111/cei.13405
PMID: 30733272 Journal: HAEMATOLOGICA Year: 2019 Reference: Haematologica. 2019 Sep;104(9):1822-1829. doi: 10.3324/haematol.2018.207928. Epub 2019 Feb 7. Impact factor: Publication type: Paper in international publication Authors: Andres, Mara; Astigarraga, Itziar; Balague, Olga; Campo, Elias; Celis, Veronica; de la Maya, Maria Dolores; Ferrandez, Antonio; Garcia-Bragado, Federico; Garrido, Marta; Gonzalez-Farre, Blanca et al. DOI: 10.3324/haematol.2018.207928
PMID: 30733543 Journal: BONE MARROW TRANSPLANTATION Year: 2019 Reference: Bone Marrow Transplant. 2019 Jul;54(7):1176. doi: 10.1038/s41409-019-0471-y. Impact factor: Publication type: Letter or abstract Authors: Alonso, Laura; Badell, Isabel; Caballero, Dolores; de Heredia, Cristina Diaz; Ferra, Christelle; Fox, Laura; Garcia-Cadenas, Irene; Jimenez, Maria Jose; Lopez-Corral, Lucia; Martino, Rodrigo et al. DOI: 10.1038/s41409-019-0471-y
PMID: 30001893 Journal: MEDICINA CLINICA Year: 2019 Reference: Med Clin (Barc). 2019 Feb 15;152(4):135-140. doi: 10.1016/j.medcli.2018.05.013. Epub 2018 Jul 9. Impact factor: Publication type: Paper in national publication Authors: Alonso, Laura; Badell, Isabel; Belendez, Cristina; Bermudez-Cortes, Mar; Diaz de Heredia, Cristina; Gonzalez-Vicent, Marta; Hladun, Raquel; Rodriguez-Villa, Antonia; Sastre, Ana et al. DOI: 10.1016/j.medcli.2018.05.013
PMID: 30679331 Journal: HAEMATOLOGICA Year: 2019 Reference: Haematologica. 2019 Aug;104(8):e335-e339. doi: 10.3324/haematol.2018.206623. Epub 2019 Jan 24. Impact factor: Publication type: Letter whit IF Authors: Al-Seiraihy, Amal; Aljurf, Mahmoud; Antmen, Ali Bulent; Dalle, Jean-Hugues; Diaz de Heredia, Cristina; Dufour, Carlo; Eikema, Dirk-Jan; Giardino, Stefano; Hamladji, Rose Marie; Kitra-Roussou, Vassiliki et al. DOI: 10.3324/haematol.2018.206623
PMID: 30031939 Journal: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION Year: 2018 Reference: Biol Blood Marrow Transplant. 2018 Nov;24(11):2316-2323. doi: 10.1016/j.bbmt.2018.07.016. Epub 2018 Jul 19. Impact factor: 4.484 Publication type: Paper in international publication Authors: L, Sisinni, Gasior, M, de Paz, R, Querol, S, Bueno, D, Fernandez, L, Marsal, J, Sastre, A, Gimeno, R, Alonso, L et al. DOI: 10.1016/j.bbmt.2018.07.016
PMID: 29984823 Journal: BRITISH JOURNAL OF HAEMATOLOGY Year: 2018 Reference: Br J Haematol. 2018 Oct;183(1):110-118. doi: 10.1111/bjh.15495. Epub 2018 Jul 9. Impact factor: 5.128 Publication type: Paper in international publication Authors: Maschan, Michael, O'Brien, Tracey, Diaz, Miguel A, Sevilla, Julian, Smith, Owen, Peffault de Latour, Regis, de la Fuente, Josue, Or, Reuven, Van Lint, Maria T, Tolar, Jakub et al. DOI: 10.1111/bjh.15495
PMID: 29941280 Journal: LANCET ONCOLOGY Year: 2018 Reference: Lancet Oncol. 2018 Aug;19(8):1061-1071. doi: 10.1016/S1470-2045(18)30337-1. Epub 2018 Jun 22. Impact factor: 36.418 Publication type: Paper in international publication Authors: Bisogno, Gianni, Jenney, Meriel, Bergeron, Christophe, Melcon, Soledad Gallego, Ferrari, Andrea, Oberlin, Odile, Carli, Modesto, Stevens, Michael, Kelsey, Anna, Paoli, Angela De et al. DOI: 10.1016/S1470-2045(18)30337-1
PMID: 29936064 Journal: EUROPEAN JOURNAL OF CANCER Year: 2018 Reference: Eur J Cancer. 2018 Sep;100:27-34. doi: 10.1016/j.ejca.2018.05.002. Epub 2018 Jun 21. Impact factor: 7.191 Publication type: Clinical Trials Authors: Moreno, Lucas, Casanova, Michela, Chisholm, Julia C, Berlanga, Pablo, Chastagner, Pascal B, Baruchel, Sylvain, Amoroso, Loredana, Melcon, Soledad Gallego, Gerber, Nicolas U, Bisogno, Gianni et al. DOI: 10.1016/j.ejca.2018.05.002
PMID: 28160394 Journal: LIVER TRANSPLANTATION Year: 2017 Reference: Liver Transpl. 2017 Apr;23(4):498-509. doi: 10.1002/lt.24738. Impact factor: Publication type: Paper in international publication Authors: Cuervas-Mons, Valentin; D'Avola, Delia; Fabrega, Emilio; Fraga, Enrique; Gomez, Miguel-Angel; Herrero, Jose Ignacio; Jimenez, Carlos; Llado, Laura; Lopez, Pedro; Marti, Josep et al. DOI: 10.1002/lt.24738
PMID: 27777140 Journal: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION Year: 2017 Reference: Biol Blood Marrow Transplant. 2017 Jan;23(1):96-102. doi: 10.1016/j.bbmt.2016.10.014. Epub 2016 Oct 21. Impact factor: 4.704 Publication type: Paper in international publication Authors: Rocha, Vanderson, Peters, Christina, Bader, Peter, Gluckman, Eliane, Dalle, Jean Hugues, Cornish, Jacqueline, Giardino, Stefano, Yakouben, Karima, Ruggeri, Annalisa, Volt, Fernanda et al. DOI: 10.1016/j.bbmt.2016.10.014
PMID: 28899930 Journal: EMBO Molecular Medicine Year: 2017 Reference: EMBO Mol Med. 2017 Nov;9(11):1574-1588. doi: 10.15252/emmm.201707540. Impact factor: 9.249 Publication type: Paper in international publication Authors: Diez, Begona, Genovese, Pietro, Roman-Rodriguez, Francisco J, Alvarez, Lara, Schiroli, Giulia, Ugalde, Laura, Rodriguez-Perales, Sandra, Sevilla, Julian, Diaz de Heredia, Cristina, Holmes, Michael C et al. DOI: 10.15252/emmm.201707540
PMID: 27894957 Journal: CANCER LETTERS Year: 2017 Reference: Cancer Lett. 2017 Feb 1;386:196-207. doi: 10.1016/j.canlet.2016.11.020. Epub 2016 Nov 25. Impact factor: 5.992 Publication type: Paper in international publication Authors: Sainz-Jaspeado, Miguel, Garcia-Monclus, Silvia, Lagares-Tena, Laura, Buj, Raquel, Hontecillas-Prieto, Lourdes, Sastre, Ana, Azorin, Daniel, Sanjuan, Xavier, Lopez-Alemany, Roser, Moran, Sebastian et al. DOI: 10.1016/j.canlet.2016.11.020
PMID: 21273304 Journal: BLOOD Year: 2011 Reference: Blood. 2011 Apr 7;117(14):3759-69. Epub 2011 Jan 27. Impact factor: 10.558 Publication type: Paper in international publication Authors: , , , , , , , , , et al. DOI: 10.1182/blood-2010-08-299917
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The association, once again, has shown its commitment to oncological research with a donation of €19,197 to the Cancer and Hematological Diseases Group for Children at VHIR.
The prestigious journal The Lancet has published the results of this study, which is the result of more than 20 years of pre-clinical research and 7 years of patient follow-up.
During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.
