About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.
Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.
Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours
PMID: 37800011 Journal: Frontiers in Pediatrics Year: 2023 Reference: Front Pediatr. 2023 Sep 20;11:1269560. doi: 10.3389/fped.2023.1269560. eCollection 2023. Impact factor: Publication type: Paper in international publication Authors: Aguilar, Yurena; Alvarez, Federico; Bautista, Francisco; Bueno, Clara; Camos, Mireia; Chulian, Salvador; Cirillo, Davide; Dapena, Jose L; Dapena, Jose L; Escudero, Adela et al. DOI: 10.3389/fped.2023.1269560
PMID: 37194337 Journal: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA Year: 2023 Reference: Acta Obstet Gynecol Scand. 2023 May 16. doi: 10.1111/aogs.14584. Impact factor: Publication type: Paper in international publication Authors: Arevalo, Silvia; Carreras, Elena; Garcia-Aguilar, Paula; Garcia-Manau, Pablo; Guillen, Gabriela; Maiz, Nerea; Molino, Jose Andres; Rodo, Carlota et al. DOI: 10.1111/aogs.14584
PMID: 37165368 Journal: Health and Quality of Life Outcomes Year: 2023 Reference: Health Qual Life Outcomes. 2023 May 10;21(1):42. doi: 10.1186/s12955-023-02120-2. Impact factor: Publication type: Paper in international publication Authors: Alonso-Garcia, Lucia; Bruguera, Andreu; Casabona, Jordi; Diaz, Yesika; Egea-Cortes, Laia; Folch, Cinta; Forero, Carlos G; Hernandez, Juan; Mesias-Gazmuri, Jocelyn; Miro, Jose M et al. DOI: 10.1186/s12955-023-02120-2
PMID: 37164827 Journal: Anales de pediatria Year: 2023 Reference: An Pediatr (Engl Ed). 2023 May 8:S2341-2879(23)00097-2. doi: 10.1016/j.anpede.2023.04.006. Impact factor: Publication type: Paper in international publication Authors: Martin Begue, Nieves; Melendo Perez, Susana; Mirabet Mas, Julia; Morell Daniel, Mariona; Morell Daniel, Mariona et al. DOI: 10.1016/j.anpede.2023.04.006
PMID: 34781360 Journal: Blood Advances Year: 2022 Reference: Blood Adv. 2022 Mar 8;6(5):1512-1524. doi: 10.1182/bloodadvances.2021005294. Impact factor: Publication type: Paper in international publication Authors: Algeri, Mattia; Amartino, Hernan M; Boelens, Jaap Jan; Bunin, Nancy; Chiesa, Robert; Diaz-de-Heredia, Cristina; Dietz, Andrew C; Duncan, Christine N; Jones, Simon A; Kapoor, Neena et al. DOI: 10.1182/bloodadvances.2021005294
PMID: 35152364 Journal: Clinical & Translational Oncology Year: 2022 Reference: Clin Transl Oncol. 2022 May;24(5):809-815. doi: 10.1007/s12094-021-02759-7. Epub 2022 Feb 12. Impact factor: Publication type: Paper in international publication Authors: Alonso, J; Astigarraga, I; Bautista, F; Calabria, I; Canete, A; Castaneda-Heredia, A; de Alava, E; de Rojas, T; Escudero, A; Fernandez-Teijeiro, A et al. DOI: 10.1007/s12094-021-02759-7
PMID: 35124293 Journal: Transplantation and Cellular Therapy Year: 2022 Reference: Transplant Cell Ther. 2022 May;28(5):261.e1-261.e7. doi: 10.1016/j.jtct.2022.01.025. Epub 2022 Feb 4. Impact factor: Publication type: Paper in international publication Authors: Abdel-Azim, Hisham; Carpenter, Paul A; Dalle, Jean-Hugues; Diaz-de-Heredia, Cristina; Gaspari, Stefania; Gennery, Andrew R; Handgretinger, Rupert; Kitko, Carrie L; Lawitschka, Anita et al. DOI: 10.1016/j.jtct.2022.01.025
PMID: 35130027 Journal: JOURNAL OF CLINICAL ONCOLOGY Year: 2022 Reference: J Clin Oncol. 2022 Mar 20;40(9):1030-1032. doi: 10.1200/JCO.21.02612. Epub 2022 Feb 7. Impact factor: Publication type: Letter or abstract Authors: Bisogno, Gianni; Bogart, Emilie; Calareso, Giuseppina; Casanova, Michela; Chisholm, Julia C; Defachelles, Anne-Sophie; Gatz, Susanne Andrea; Le Deley, Marie-Cecile; McHugh, Kieran; Melcon, Soledad Gallego et al. DOI: 10.1200/JCO.21.02612
PMID: 33984160 Journal: AMERICAN JOURNAL OF HEMATOLOGY Year: 2021 Reference: Am J Hematol. 2021 Aug 1;96(8):989-999. doi: 10.1002/ajh.26234. Epub 2021 May 25. Impact factor: Publication type: Paper in international publication Authors: Argiles, Bienvenida; Badell, Isabel; Balmana, Judith; Belendez, Cristina; Bogliolo, Massimo; Bueren, Juan A; Carrasco, Estela; Casado, Jose A; Catala, Albert; de Heredia, Cristina Diaz et al. DOI: 10.1002/ajh.26234
PMID: 33303901 Journal: BONE MARROW TRANSPLANTATION Year: 2021 Reference: Bone Marrow Transplant. 2021 May;56(5):1213-1216. doi: 10.1038/s41409-020-01172-y. Epub 2020 Dec 10. Impact factor: Publication type: Paper in international publication Authors: Argiles Aparicio, B; Badell Serra, I; Belendez-Bieler, C; Diaz-de-Heredia, C; Gonzalez-Vicent, M; Lopez-Duarte, M; Murillo-Sanjuan, L; Rodriguez Villa, A; Sastre Urgelles, A; Sevilla Navarro, J et al. DOI: 10.1038/s41409-020-01172-y
PMID: 33971448 Journal: EUROPEAN JOURNAL OF CANCER Year: 2021 Reference: Eur J Cancer. 2021 Jul;151:84-93. doi: 10.1016/j.ejca.2021.04.007. Epub 2021 May 7. Impact factor: Publication type: Paper in international publication Authors: Bisogno, Gianni; Chisholm, Julia C; Corradini, Nadege; De Salvo, Gian L; Ferrari, Andrea; Gallego, Soledad; Gaze, Mark; Glosli, Heidi; Jenney, Meriel; Kelsey, Anna et al. DOI: 10.1016/j.ejca.2021.04.007
PMID: 33827367 Journal: LEUKEMIA & LYMPHOMA Year: 2021 Reference: Leuk Lymphoma. 2021 Sep;62(9):2202-2210. doi: 10.1080/10428194.2021.1907375. Epub 2021 Apr 7. Impact factor: Publication type: Review in international publication Authors: Blanco, Adoracion; Bosch, Francesc; Diaz-Heredia, Cristina; Gallur, Laura; Hidalgo-Gomez, Gloria; Martinez, Noemi; Murciano, Thais; Murillo, Laura; Ortega, Margarita; Palacio-Garcia, Carlos et al. DOI: 10.1080/10428194.2021.1907375
PMID: 32240714 Journal: JOURNAL OF HEPATOLOGY Year: 2020 Reference: J Hepatol. 2020 Aug;73(2):328-341. doi: 10.1016/j.jhep.2020.03.025. Epub 2020 Mar 30. Impact factor: Publication type: Paper in international publication Authors: Abril-Fornaguera, Jordi; Akers, Nicholas; Armengol, Carolina; Arnal, Magdalena; Bajciova, Viera; Belendez, Cristina; Blanco, Julia; Branchereau, Sophie; Buendia, Marie Annick; Cairo, Stefano et al. DOI: 10.1016/j.jhep.2020.03.025
PMID: 32203264 Journal: BONE MARROW TRANSPLANTATION Year: 2020 Reference: Bone Marrow Transplant. 2020 Sep;55(9):1796-1809. doi: 10.1038/s41409-020-0863-z. Epub 2020 Mar 19. Impact factor: Publication type: Review in international publication Authors: Afanasyev, Boris; Ansari, Marc; Badell, Isabel; Bosman, Paul; Cesaro, Simone; Chevalier, Patrice; Chybicka, Alicja; de Heredia, Cristina Diaz; de Latour, Regis Peffault; Dufour, Carlo et al. DOI: 10.1038/s41409-020-0863-z
PMID: 32203263 Journal: BONE MARROW TRANSPLANTATION Year: 2020 Reference: Bone Marrow Transplant. 2020 Aug;55(8):1540-1551. doi: 10.1038/s41409-020-0854-0. Epub 2020 Mar 17. Impact factor: Publication type: Paper in international publication Authors: Abecasis, Manuel; Afanasyev, Boris; Aleinikova, Olga; Alseraihy, Amal; Ansari, Marc; Bader, Peter; Balduzzi, Adriana; Bertaina, Alice; Bertrand, Yves; Bierings, Marc et al. DOI: 10.1038/s41409-020-0854-0
PMID: 32179448 Journal: EUROPEAN JOURNAL OF CANCER Year: 2020 Reference: Eur J Cancer. 2020 May;130:72-80. doi: 10.1016/j.ejca.2020.01.029. Epub 2020 Mar 13. Impact factor: Publication type: Paper in international publication Authors: Bergeron, Christophe; Bisogno, Gianni; Brennan, Bernadette; Caron, Hubert N; Casanova, Michela; Chisholm, Julia C; Corradini, Nadege; De Salvo, Gian Luca; Ferrari, Andrea; Gallego, Soledad et al. DOI: 10.1016/j.ejca.2020.01.029
PMID: 30485640 Journal: PEDIATRIC BLOOD & CANCER Year: 2019 Reference: Pediatr Blood Cancer. 2019 Apr;66(4):e27562. doi: 10.1002/pbc.27562. Epub 2018 Nov 28. Impact factor: 2.486 Publication type: Letter or abstract Authors: Velasco, Pablo, Murillo, Laura, Dapena, Jose Luis, de Heredia, Cristina Diaz et al. DOI: 10.1002/pbc.27562
PMID: 30358897 Journal: AMERICAN JOURNAL OF HEMATOLOGY Year: 2019 Reference: Am J Hematol. 2019 Jan;94(1):149-161. doi: 10.1002/ajh.25325. Epub 2018 Nov 28. Impact factor: 6.137 Publication type: Paper in international publication Authors: Bianchi, Paola, Elisa Fermo, E, Glader, Bertil, Kanno, Hitoshi, Agarwal, Archana, Barcellini, Wilma, Eber, Stefan, Hoyer, James D, Kuter, David J, Maia, Tabita Magalhaes et al. DOI: 10.1002/ajh.25325
PMID: 31631027 Journal: CANCER CELL Year: 2019 Reference: Cancer Cell. 2019 Nov 11;36(5):512-527.e9. doi: 10.1016/j.ccell.2019.09.002. Epub 2019 Oct 17. Impact factor: 23.916 Publication type: Paper in international publication Authors: Cheung, Nai-Kong V, Jin, Jian, Segura, Miguel F, Dyer, Michael A, Bernstein, Emily, Roberts, Stephen S, Weiss, William A, Meni, David, Valle-Garcia, David, Hasson, Dan et al. DOI: 10.1016/j.ccell.2019.09.002
PMID: 31598904 Journal: Clinical & Translational Oncology Year: 2019 Reference: Clin Transl Oncol. 2019 Dec;21(12):1763-1770. doi: 10.1007/s12094-019-02221-9. Epub 2019 Oct 9. Impact factor: 2.441 Publication type: Paper in international publication Authors: Canete, A, Ramirez-Villar, G L, Fernandez, J M, Fuster, J L, Diaz de Heredia, C, Astigarraga, I, Garcia-Ariza, M, Rives, S, Dapena, J L, Marquez, C et al. DOI: 10.1007/s12094-019-02221-9
PMID: 29615461 Journal: CLINICAL CANCER RESEARCH Year: 2018 Reference: Clin Cancer Res. 2018 Jun 15;24(12):2812-2819. doi: 10.1158/1078-0432.CCR-17-3800. Epub 2018 Apr 3. Impact factor: 10.199 Publication type: Paper in international publication Authors: Poca, Maria A, Martinez-Ricarte, Francisco, Mayor, Regina, Martinez-Saez, Elena, Rubio-Perez, Carlota, Pineda, Estela, Cordero, Esteban, Cicuendez, Marta, Vieito, Maria, Carles, Joan et al. DOI: 10.1158/1078-0432.CCR-17-3800
PMID: 29573905 Journal: TRANSFUSION MEDICINE REVIEWS Year: 2018 Reference: Transfusion Medicine Reviews. 2018 Jul;32(3):179-85. doi: 10.1016/j.tmrv.2018.02.005. Impact factor: 4.111 Publication type: Paper in international publication Authors: Gonzalez-Vicent, Marta, Sanz, Jaime, Fuster, Jose Luis, Cid, Joan, de Heredia, Cristina Diaz, Morillo, Daniel, Fernandez, Jose Maria, Pascual, Antonia, Badell, Isabel, Serrano, David et al. DOI: 10.1016/j.tmrv.2018.02.005
PMID: 29526774 Journal: EXPERIMENTAL HEMATOLOGY Year: 2018 Reference: Exp Hematol. 2018 Jun;62:24-32. doi: 10.1016/j.exphem.2018.03.002. Epub 2018 Mar 8. Impact factor: 2.436 Publication type: Paper in international publication Authors: Parody, Rocio, Sanz, Miguel Angel, Sierra, Jorge, Pinana, Jose Luis, Querol, Sergi, Valcarcel, David, Diaz de Heredia, Cristina, Ferra, Christelle, Badell, Isabel, Salamero, Olga et al. DOI: 10.1016/j.exphem.2018.03.002
PMID: 29286582 Journal: PEDIATRIC BLOOD & CANCER Year: 2018 Reference: Pediatr Blood Cancer. 2018 Apr;65(4). doi: 10.1002/pbc.26942. Epub 2017 Dec 29. Impact factor: 2.646 Publication type: Paper in international publication Authors: Ferrari, Andrea, Bisogno, Gianni, De Salvo, Gian Luca, Casanova, Michela, Brennan, Bernadette, Zanetti, Ilaria, Orbach, Daniel, Gallego, Soledad, Francotte, Nadine, Van Noesel, Max et al. DOI: 10.1002/pbc.26942
PMID: 29296947 Journal: Blood advances Year: 2017 Reference: Blood Adv. 2017 Jan 23;1(5):319-329. doi: 10.1182/bloodadvances.2016000943. eCollection 2017 Jan 24. Impact factor: 0 Publication type: Paper in international publication Authors: Reina-Castillon, Judith, Pujol, Roser, Lopez-Sanchez, Marcos, Rodriguez-Santiago, Benjamin, Aza-Carmona, Miriam, Gonzalez, Juan Ramon, Casado, Jose Antonio, Bueren, Juan Antonio, Sevilla, Julian, Badel, Isabel et al. DOI: 10.1182/bloodadvances.2016000943
PMID: 28881358 Journal: BRITISH JOURNAL OF CANCER Year: 2017 Reference: Br J Cancer. 2017 Oct 24;117(9):1314-1325. doi: 10.1038/bjc.2017.305. Epub 2017 Sep 7. Impact factor: 6.176 Publication type: Paper in international publication Authors: Velasco, P, Pyczek, J, Simon-Keller, K, Giralt, I, Vidal, I, Navarro, N, Segura, M F, Soriano, A, Navarro, S, Tirado, O M et al. DOI: 10.1038/bjc.2017.305
PMID: 28801449 Journal: BLOOD Year: 2017 Reference: Blood. 2017 Sep 28;130(13):1535-1542. doi: 10.1182/blood-2017-03-774174. Epub 2017 Aug 11. Impact factor: 13.164 Publication type: Paper in international publication Authors: Segovia, Jose C, Diaz de Heredia, Cristina, Sevilla, Julian, Bueren, Juan, Galy, Anne, Charrier, Sabine, Pujol, Maria Roser, Rio, Paula, Navarro, Susana, Guenechea, Guillermo et al. DOI: 10.1182/blood-2017-03-774174
PMID: 28797779 Journal: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION Year: 2017 Reference: Biol Blood Marrow Transplant. 2017 Nov;23(11):1939-1948. doi: 10.1016/j.bbmt.2017.08.004. Epub 2017 Aug 7. Impact factor: 4.704 Publication type: Paper in international publication Authors: Comoli, Patrizia, Vettenranta, Kim, Diaz, Miguel Angel, Reuven, Or, Bertrand, Yves, de Heredia, Cristina Diaz, Nagler, Arnon, Ghavamzadeh, Ardeshir, Sufliarska, Sabina, Lawson, Sarah et al. DOI: 10.1016/j.bbmt.2017.08.004
The association, once again, has shown its commitment to oncological research with a donation of €19,197 to the Cancer and Hematological Diseases Group for Children at VHIR.
The prestigious journal The Lancet has published the results of this study, which is the result of more than 20 years of pre-clinical research and 7 years of patient follow-up.
During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.
