Skip to main content

Childhood Cancer and Blood Disorders

The research group is focused on finding new molecular therapeutic targets and biomarkers based on knowledge of the biology of paediatric tumours, leukemias and hematologic diseases. The experience of the group in recent years has permitted the identification of new molecular targets that are very close to the clinical phase. In this stage, we have consolidated collaborations with the biotechnological industry in order to develop small molecules able to inhibit pro-oncogenic processes such as invasion or proliferation, with the aim of providing patients with innovative and more specific biological evidence-based therapies.

Another line of research is based on the study of liquid biopsy to develop a system based on NGS to monitor the probability of relapses.

Furthermore, we have implemented a personalized medicine program to guide the management of patients based on the molecular alterations of their tumours

Team

Melissa Panesso Romero

Melissa Panesso Romero

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Raquel Andreu Vilarroig

Raquel Andreu Vilarroig

Research technician
Childhood Cancer and Blood Disorders
Read more
Raquel Anta Peña

Raquel Anta Peña

Research technician
Childhood Cancer and Blood Disorders
Read more
Raquel Hladun Alvaro

Raquel Hladun Alvaro

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Thaïs Murciano Carrillo

Thaïs Murciano Carrillo

Childhood Cancer and Blood Disorders
Read more
Valeria Rizzuto

Valeria Rizzuto

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Melissa Panesso Romero

Melissa Panesso Romero

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Raquel Andreu Vilarroig

Raquel Andreu Vilarroig

Research technician
Childhood Cancer and Blood Disorders
Read more
Raquel Anta Peña

Raquel Anta Peña

Research technician
Childhood Cancer and Blood Disorders
Read more
Raquel Hladun Alvaro

Raquel Hladun Alvaro

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more
Thaïs Murciano Carrillo

Thaïs Murciano Carrillo

Childhood Cancer and Blood Disorders
Read more
Valeria Rizzuto

Valeria Rizzuto

Predoctoral researcher
Childhood Cancer and Blood Disorders
Read more

Publications

A nomogram of clinical and biologic factors to predict survival in children newly diagnosed with high-risk neuroblastoma: An International Neuroblastoma Risk Group project.

PMID: 33205902
Journal: PEDIATRIC BLOOD & CANCER
Year: 2021
Reference: Pediatr Blood Cancer. 2021 Mar;68(3):e28794. doi: 10.1002/pbc.28794. Epub 2020 Nov 18.
Impact factor: 3.167
Publication type: Paper in international publication
Authors: Irwin, Meredith S, Berthold, Frank, Hogarty, Michael, Kamijo, Takehiko, Morgenstern, Daniel, Pasqualini, Claudia, Ash, Shifra, Potschger, Ulrike, Ladenstein, Ruth, Valteau-Couanet, Dominique et al.
DOI: 10.1002/pbc.28794

Alveolar rhabdomyosarcoma with regional nodal involvement: Results of a combined analysis from two cooperative groups.

PMID: 33245207
Journal: PEDIATRIC BLOOD & CANCER
Year: 2021
Reference: Pediatr Blood Cancer. 2021 Mar;68(3):e28832. doi: 10.1002/pbc.28832. Epub 2020 Nov 27.
Impact factor: 3.167
Publication type: Paper in international publication
Authors: Hawkins, Douglas S, Gallego, Soledad, Chi, Yueh-Yun, De Salvo, Gian Luca, Li, Minjie, Merks, Johannes H M, Rodeberg, David A, van Scheltinga, Sheila Terwisscha, Mascarenhas, Leo, Orbach, Daniel et al.
DOI: 10.1002/pbc.28832

Total Body Irradiation or Chemotherapy Conditioning in Childhood ALL: A Multinational, Randomized, Noninferiority Phase III Study.

PMID: 33332189
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2021
Reference: J Clin Oncol. 2021 Feb 1;39(4):295-307. doi: 10.1200/JCO.20.02529. Epub 2020 Dec 17.
Impact factor: 44.544
Publication type: Paper in international publication
Authors: Ariffin, Hany, Peters, Christina, Dalle, Jean-Hugues, Locatelli, Franco, Poetschger, Ulrike, Sedlacek, Petr, Buechner, Jochen, Shaw, Peter J, Staciuk, Raquel, Ifversen, Marianne et al.
DOI: 10.1200/JCO.20.02529

Haploidentical transplantation in pediatric non-malignant diseases: a retrospective analysis on behalf of the Spanish Group for Hematopoietic Transplantation (GETH).

PMID: 33084101
Journal: EUROPEAN JOURNAL OF HAEMATOLOGY
Year: 2021
Reference: Eur J Haematol. 2021 Feb;106(2):196-204. doi: 10.1111/ejh.13536. Epub 2020 Nov 17.
Impact factor: 2.997
Publication type: Paper in international publication
Authors: Benito, Ana, Couselo, Jose Miguel, Fuster, Jose Luis, Diaz-Almiron, Mariana, Bueno, David, Mozo, Yasmina, Gomez Lopez, Alicia, Vicario, Jose Luis, Balas, Antonio, Sisinni, Luisa et al.
DOI: 10.1111/ejh.13536

IRF4-rearranged Large B-cell lymphoma (LBCL) has a genomic profile distinct to other LBCL in children and young adults.

PMID: 31738823
Journal: BLOOD
Year: 2020
Reference: Blood. 2020 Jan 23;135(4):274-286. doi: 10.1182/blood.2019002699.
Impact factor: 17.543
Publication type: Paper in international publication
Authors: Azorin, Daniel, Ramis-Zaldivar, Joan Enric, Gonzalez-Farre, Blanca, Balague, Olga, Celis, Veronica, Nadeu, Ferran, Salmeron-Villalobos, Julia, Andres, Mara, Martin-Guerrero, Idoia, Garrido-Pontnou, Marta et al.
DOI: 10.1182/blood.2019002699

Clinical research tools in pediatric oncology: challenges and opportunities.

PMID: 31939050
Journal: CANCER AND METASTASIS REVIEWS
Year: 2020
Reference: Cancer Metastasis Rev. 2020 Mar;39(1):149-160. doi: 10.1007/s10555-020-09856-z.
Impact factor: 6.4
Publication type: Review in international publication
Authors: de Rojas, Teresa, Neven, Anouk, Towbin, Alexander J, Carceller, Fernando, Bautista, Francisco, Riedl, David, Sodergren, Samantha, Darlington, Anne-Sophie, Fernandez-Teijeiro, Ana, Moreno, Lucas et al.
DOI: 10.1007/s10555-020-09856-z

A new standard of care for patients with high-risk rhabdomyosarcoma? - Authors' reply.

PMID: 31908304
Journal: LANCET ONCOLOGY
Year: 2020
Reference: Lancet Oncol. 2020 Jan;21(1):e3. doi: 10.1016/S1470-2045(19)30812-5.
Impact factor: 33.752
Publication type: Letter or abstract
Authors: Bisogno, Gianni, Ferrari, Andrea, Melcon, Soledad Gallego, De Salvo, Gian Luca, Bergeron, Christophe, Jenney, Meriel et al.
DOI: 10.1016/S1470-2045(19)30812-5

Haploidentical transplantation in high-risk pediatric leukemia: A retrospective comparative analysis on behalf of the Spanish Working Group for Bone Marrow Transplantation in Children (GETMON) and the Spanish Grupo for Hematopoietic Transplantation (GETH).

PMID: 31625177
Journal: AMERICAN JOURNAL OF HEMATOLOGY
Year: 2020
Reference: Am J Hematol. 2020 Jan;95(1):28-37. doi: 10.1002/ajh.25661. Epub 2019 Nov 5.
Impact factor: 6.973
Publication type: Paper in international publication
Authors: Diaz, Miguel Angel, de Heredia, Cristina Diaz, Perez-Martinez, Antonio, Ferreras, Cristina, Pascual, Antonia, Gonzalez-Vicent, Marta, Alonso, Laura, Badell, Isabel, Navarro, Jose Maria Fernandez, Regueiro, Alexandra et al.
DOI: 10.1002/ajh.25661

Blog

News

La iniciativa "Sin Piedad" explica la història d'en David, un nen que s'està tractant d'un càncer pediàtric, un exemple d'actitud lluitadora davant la malaltia.

The money will allow research into paediatric nervous system tumours and childhood sarcomas to continue, with the aim of improving children's chances of survival and reducing the side effects of treatment.

The association makes the fifth annual donation of 52,390€ that will finance a project to study new therapies for this childhood tumor.

Job offers

Postdoctoral Researcher-Group of Childhood Cancer & Blood Disorders. Laboratory of Neural Tumors.
Start date:
15/11/2022
End date:
31/12/2022
Document: Download
Scientific Coordinator - European Rare blood disorders Registries
Start date:
22/09/2022
End date:
06/10/2022
Document: Download
Drug Development Fellow for Childhood Cancer Trials
Start date:
23/08/2022
End date:
06/09/2022
Document: Download