Clinical Biochemistry, Drug Delivery & Therapy
The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.
With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.
In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.
Research lines
Anàlisi de dades massives (big data), explotació de dades i mostres als Laboratoris Clínics
IP: Roser Ferrer Costa
Desenvolupament de models animals per l'avaluació ràpida i eficient de tractaments nanotecnològics
IP: Zamira Vanessa Diaz Riascos
Desenvolupament i optimització de mètodes diagnòstics
IP: Joan López Hellin
Diagnosis, prognosis i monitoratge de malalties minoritàries, especialment malalties metabòliques
IP: Clara Carnicer Cáceres
Publications
Integrating viral hepatitis management into the emergency department: A further step towards viral hepatitis elimination.
PMID: 38074506
Journal: JHEP Reports
Year: 2024
Reference: JHEP Rep. 2023 Oct 12;6(1):100932. doi: 10.1016/j.jhepr.2023.100932. eCollection 2024 Jan.
Impact factor:
Publication type: Paper in international publication
Authors: Banares, Juan; Barreira-Diaz, Ana; Blanco-Grau, Albert; Buti, Maria; Campins, Magda; Casado, Miguel Angel; Colom, Joan; Dominguez-Hernandez, Raquel; Esteban, Rafael; Falco-Roget, Anna et al.
DOI: 10.1016/j.jhepr.2023.100932
Solid Lipid Nanoparticles: Multitasking Nano-Carriers for Cancer Treatment.
PMID: 36986692
Journal: Pharmaceutics
Year: 2023
Reference: Pharmaceutics. 2023 Mar 3;15(3):831. doi: 10.3390/pharmaceutics15030831.
Impact factor:
Publication type: Review in international publication
Authors: Abasolo, Ibane; Andrade, Fernanda; German-Cortes, Julia; Rafael, Diana; Vilar-Hernandez, Mireia et al.
DOI: 10.3390/pharmaceutics15030831
Molecular characterization of epithelial-mesenchymal transition and medical treatment related-genes in non-functioning pituitary neuroendocrine tumors.
PMID: 37033229
Journal: Frontiers in Endocrinology
Year: 2023
Reference: Front Endocrinol (Lausanne). 2023 Mar 22;14:1129213. doi: 10.3389/fendo.2023.1129213. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Aulinas, Anna; Biagetti, Betina; Blanco, Alberto; Carrato, Cristina; Casano-Sancho, Paula; Cordero, Esteban; Gil, Joan; Hostalot, Cristina; Ibanez-Dominguez, Javier; Jorda, Mireia et al.
DOI: 10.3389/fendo.2023.1129213
Delivery Systems in Ocular Retinopathies: The Promising Future of Intravitreal Hydrogels as Sustained-Release Scaffolds.
PMID: 37242726
Journal: Pharmaceutics
Year: 2023
Reference: Pharmaceutics. 2023 May 12;15(5):1484. doi: 10.3390/pharmaceutics15051484.
Impact factor:
Publication type: Review in international publication
Authors: Arango, Diego; Clark, Simon J; Duran-Lara, Esteban F; Ferrer, Roser; Guerrero, Marcelo; Marican, Adolfo; Rafael, Diana; Sarmento, Bruno; Schwartz, Simo Jr et al.
DOI: 10.3390/pharmaceutics15051484
Edoxaban Versus Low-Molecular-Weight Heparin in Hospitalized COVID-19 Patients With Atrial Fibrillation.
PMID: 37282505
Journal: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
Year: 2023
Reference: Clin Appl Thromb Hemost. 2023 Jan-Dec;29:10760296231180865. doi: 10.1177/10760296231180865.
Impact factor:
Publication type: Paper in international publication
Authors: Campoy, Desiree; Canals, Tania; Cerezo-Manchado, Juan Jose; Flores, Katia; Herranz, Maria Jose; Johansson, Erik; Martinez, Laia; Olivera, Pavel; Salinas, Ramon; Velasquez-Escandon, Cesar et al.
DOI: 10.1177/10760296231180865
Rapid and accurate method for quantifying busulfan in plasma samples by isocratic liquid chromatography-tandem mass spectrometry (LC-MS/MS)
PMID: NOPMID0100
Journal: Advances in Laboratory Medicine
Year: 2022
Reference: Adv Lab Med / Av en Med Lab. 2022;3(3):263-271. doi:10.1515/almed-2022-0016
Impact factor:
Publication type: Paper in national publication
Authors: Barquin Del Pino , Raquel ; Benitez Carabante, Maria Isabel ; Casis Saenz, Ernesto; Castellote Bellés, Laura; Ferrer Costa, Roser; López Hellin, Joan; Martinez Sánchez, Luisa; Miarons Font , Marta; Paciucci Barzanti, Rosanna; Rodríguez Frias, Francisco et al.
DOI: 10.1515/almed-2022-0016
Scanning pulsed laser ablation in liquids: An alternative route to obtaining biocompatible YbFe nanoparticles as multiplatform contrast agents for combined MRI and CT imaging
PMID: NOPMID0101
Journal: Ceramics International
Year: 2022
Reference: Ceram Int. 2023;49(6):9324-9337. doi:10.1016/j.ceramint.2022.11.099
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Bomati-Miguel, Óscar; Felix, Eduardo; Fernández-Ponce, Cecilia; García-Cózar, Francisco; Kriwet, Jürgen; Lahoz, Ruth; Litrán, Rocío; Llaguno-Munive, Monserrat; Mánuel, Jose M et al.
DOI: 10.1016/j.ceramint.2022.11.099
Enzyme replacement therapy: current challenges and drug delivery prospects via extracellular vesicles
PMID: PMID0102
Journal: Rare Disease and Orphan Drugs Journal
Year: 2022
Reference: Rare Dis Orphan Drugs J. 2022;1(3):13. doi:10.20517/rdodj.2022.09
Impact factor:
Publication type: Editorail in international publication
Authors: Abasolo, Ibane; Gazeau, Florence; K. A. Silva, Amanda; Sagné, Corinne et al.
DOI: 10.20517/rdodj.2022.09
Multiparametric analysis of the effectiveness of cisplatin on cutaneous squamous carcinoma cells using two different types of adjuvants.
PMID: 32143211
Journal: PLoS One
Year: 2020
Reference: PLoS One. 2020 Mar 6;15(3):e0230022. doi: 10.1371/journal.pone.0230022. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Alsina, Merce; Conesa, Jose Javier; Gil, Silvia; Kamma-Lorger, Christina; Martinez-Esain, Jordi; Martinez-Trucharte, Francesc; Perez-Berna, Ana J; Sabes, Manel; Solano, Eduardo et al.
DOI: 10.1371/journal.pone.0230022
Perioperative nutrition prevents the early protein losses in patients submitted to gastrointestinal surgery.
PMID: 15380889
Journal: CLINICAL NUTRITION
Year: 2004
Reference: Clin Nutr. 2004 Oct;23(5):1001-8. doi: 10.1016/j.clnu.2003.12.006.
Impact factor:
Publication type: Paper in international publication
Authors: Baena-Fustegueras, Juan Antonio; Garcia-Arumi, Elena; Lopez-Hellin, Joan; Riera, Simon Schwartz; Vidal, Montse et al.
DOI: 10.1016/j.clnu.2003.12.006
News
Researchers from all over Europe gathered to kick off the SPM4.0 project, an innovative Marie Curie Skłodowska (MSCA-DN) doctoral network that promotes the development of autonomous Scanning Probe Microscopy with AI.
The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.
The European Rare Diseases Research Alliance (ERDERA) kicked off this September, with an estimated budget of 380 million euros and the aim of improving the lives of 30 million rare disease patients in Europe and beyond.