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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Roser Ferrer  Costa

Roser Ferrer Costa

Head of group
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Ibane Abasolo Olaortua

Ibane Abasolo Olaortua

Head of group
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Joan López Hellin

Joan López Hellin

Senior researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Joaquin Seras Franzoso

Joaquin Seras Franzoso

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Simon Schwartz Navarro

Simon Schwartz Navarro

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Zamira Vanessa Diaz Riascos

Zamira Vanessa Diaz Riascos

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Roser Ferrer  Costa

Roser Ferrer Costa

Head of group
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Ibane Abasolo Olaortua

Ibane Abasolo Olaortua

Head of group
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Joan López Hellin

Joan López Hellin

Senior researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Joaquin Seras Franzoso

Joaquin Seras Franzoso

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Simon Schwartz Navarro

Simon Schwartz Navarro

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Zamira Vanessa Diaz Riascos

Zamira Vanessa Diaz Riascos

Main researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Research lines

Anàlisi de dades massives (big data), explotació de dades i mostres als Laboratoris Clínics

IP: Roser Ferrer Costa

Desenvolupament de models animals per l'avaluació ràpida i eficient de tractaments nanotecnològics

IP: Zamira Vanessa Diaz Riascos

Desenvolupament i optimització de mètodes diagnòstics

IP: Joan López Hellin

Diagnosis, prognosis i monitoratge de malalties minoritàries, especialment malalties metabòliques

IP: Clara Carnicer Cáceres

Projects

Evaluation of an innovative strategy based on nanoparticles-loaded hydrogels as a safe and sustained intraperitoneal chemotherapy in mucinous adenocarcinomas

IP: Fernanda Raquel Da Silva Andrade
Collaborators: Roser Ferrer Costa, Julia German Cortes, Angels Alcina Mila, Diana Fernandes de Rafael
Funding agency: Asociación Española Contra el Cáncer
Funding: 10000
Reference: SNRGS247164DASI
Duration: 01/06/2024 - 31/05/2026

Estudio multicéntrico de la reactividad de PSA de las vesículas extracelulares frente a inmunoensayos comerciales

IP: Roser Ferrer Costa
Collaborators: -
Funding agency: FUNDACIÓN JOSÉ LUIS CASTAÑO
Funding: 0.01
Reference: SECQ/FERRER/2023
Duration: 01/01/2024 - 31/12/2026

Cálculo de intervalos de referencia para magnitudes biológicas empleando un método indirecto

IP: Yolanda Villena Ortiz
Collaborators: -
Funding agency: FUNDACIÓN JOSÉ LUIS CASTAÑO
Funding: 6000
Reference: SEQC 001
Duration: 01/07/2023 - 01/07/2024

ARTEMIs: AcceleRating the Translation of virtual twins towards a pErsonalised Management of fatty lIver patients

IP: José Raul Herance Camacho
Collaborators: Beatriz Minguez Rosique, Clara Ramírez Serra, Cristina Gamez Cenzano, Juan Manuel Pericàs Pulido, Nuria Roson Gradaille, Andreea Ciudin Mihai, Alberto Roque Pérez, Queralt Martin Saladich, Maria Nazarena Pizzi, Ramón Vilallonga Puy
Funding agency: EUROPEAN COMMISSION
Funding: 724000
Reference: ARTEMIS_HE-HLTH2023
Duration: 01/01/2024 - 31/12/2027

Publications

Integrating viral hepatitis management into the emergency department: A further step towards viral hepatitis elimination.

PMID: 38074506
Journal: JHEP Reports
Year: 2024
Reference: JHEP Rep. 2023 Oct 12;6(1):100932. doi: 10.1016/j.jhepr.2023.100932. eCollection 2024 Jan.
Impact factor:
Publication type: Paper in international publication
Authors: Banares, Juan; Barreira-Diaz, Ana; Blanco-Grau, Albert; Buti, Maria; Campins, Magda; Casado, Miguel Angel; Colom, Joan; Dominguez-Hernandez, Raquel; Esteban, Rafael; Falco-Roget, Anna et al.
DOI: 10.1016/j.jhepr.2023.100932

Solid Lipid Nanoparticles: Multitasking Nano-Carriers for Cancer Treatment.

PMID: 36986692
Journal: Pharmaceutics
Year: 2023
Reference: Pharmaceutics. 2023 Mar 3;15(3):831. doi: 10.3390/pharmaceutics15030831.
Impact factor:
Publication type: Review in international publication
Authors: Abasolo, Ibane; Andrade, Fernanda; German-Cortes, Julia; Rafael, Diana; Vilar-Hernandez, Mireia et al.
DOI: 10.3390/pharmaceutics15030831

Molecular characterization of epithelial-mesenchymal transition and medical treatment related-genes in non-functioning pituitary neuroendocrine tumors.

PMID: 37033229
Journal: Frontiers in Endocrinology
Year: 2023
Reference: Front Endocrinol (Lausanne). 2023 Mar 22;14:1129213. doi: 10.3389/fendo.2023.1129213. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Aulinas, Anna; Biagetti, Betina; Blanco, Alberto; Carrato, Cristina; Casano-Sancho, Paula; Cordero, Esteban; Gil, Joan; Hostalot, Cristina; Ibanez-Dominguez, Javier; Jorda, Mireia et al.
DOI: 10.3389/fendo.2023.1129213

Delivery Systems in Ocular Retinopathies: The Promising Future of Intravitreal Hydrogels as Sustained-Release Scaffolds.

PMID: 37242726
Journal: Pharmaceutics
Year: 2023
Reference: Pharmaceutics. 2023 May 12;15(5):1484. doi: 10.3390/pharmaceutics15051484.
Impact factor:
Publication type: Review in international publication
Authors: Arango, Diego; Clark, Simon J; Duran-Lara, Esteban F; Ferrer, Roser; Guerrero, Marcelo; Marican, Adolfo; Rafael, Diana; Sarmento, Bruno; Schwartz, Simo Jr et al.
DOI: 10.3390/pharmaceutics15051484

Edoxaban Versus Low-Molecular-Weight Heparin in Hospitalized COVID-19 Patients With Atrial Fibrillation.

PMID: 37282505
Journal: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
Year: 2023
Reference: Clin Appl Thromb Hemost. 2023 Jan-Dec;29:10760296231180865. doi: 10.1177/10760296231180865.
Impact factor:
Publication type: Paper in international publication
Authors: Campoy, Desiree; Canals, Tania; Cerezo-Manchado, Juan Jose; Flores, Katia; Herranz, Maria Jose; Johansson, Erik; Martinez, Laia; Olivera, Pavel; Salinas, Ramon; Velasquez-Escandon, Cesar et al.
DOI: 10.1177/10760296231180865

Rapid and accurate method for quantifying busulfan in plasma samples by isocratic liquid chromatography-tandem mass spectrometry (LC-MS/MS)

PMID: NOPMID0100
Journal: Advances in Laboratory Medicine
Year: 2022
Reference: Adv Lab Med / Av en Med Lab. 2022;3(3):263-271. doi:10.1515/almed-2022-0016
Impact factor:
Publication type: Paper in national publication
Authors: Barquin Del Pino , Raquel ; Benitez Carabante, Maria Isabel ; Casis Saenz, Ernesto; Castellote Bellés, Laura; Ferrer Costa, Roser; López Hellin, Joan; Martinez Sánchez, Luisa; Miarons Font , Marta; Paciucci Barzanti, Rosanna; Rodríguez Frias, Francisco et al.
DOI: 10.1515/almed-2022-0016

Scanning pulsed laser ablation in liquids: An alternative route to obtaining biocompatible YbFe nanoparticles as multiplatform contrast agents for combined MRI and CT imaging

PMID: NOPMID0101
Journal: Ceramics International
Year: 2022
Reference: Ceram Int. 2023;49(6):9324-9337. doi:10.1016/j.ceramint.2022.11.099
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Bomati-Miguel, Óscar; Felix, Eduardo; Fernández-Ponce, Cecilia; García-Cózar, Francisco; Kriwet, Jürgen; Lahoz, Ruth; Litrán, Rocío; Llaguno-Munive, Monserrat; Mánuel, Jose M et al.
DOI: 10.1016/j.ceramint.2022.11.099

Enzyme replacement therapy: current challenges and drug delivery prospects via extracellular vesicles

PMID: PMID0102
Journal: Rare Disease and Orphan Drugs Journal
Year: 2022
Reference: Rare Dis Orphan Drugs J. 2022;1(3):13. doi:10.20517/rdodj.2022.09
Impact factor:
Publication type: Editorail in international publication
Authors: Abasolo, Ibane; Gazeau, Florence; K. A. Silva, Amanda; Sagné, Corinne et al.
DOI: 10.20517/rdodj.2022.09

Multiparametric analysis of the effectiveness of cisplatin on cutaneous squamous carcinoma cells using two different types of adjuvants.

PMID: 32143211
Journal: PLoS One
Year: 2020
Reference: PLoS One. 2020 Mar 6;15(3):e0230022. doi: 10.1371/journal.pone.0230022. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Alsina, Merce; Conesa, Jose Javier; Gil, Silvia; Kamma-Lorger, Christina; Martinez-Esain, Jordi; Martinez-Trucharte, Francesc; Perez-Berna, Ana J; Sabes, Manel; Solano, Eduardo et al.
DOI: 10.1371/journal.pone.0230022

Perioperative nutrition prevents the early protein losses in patients submitted to gastrointestinal surgery.

PMID: 15380889
Journal: CLINICAL NUTRITION
Year: 2004
Reference: Clin Nutr. 2004 Oct;23(5):1001-8. doi: 10.1016/j.clnu.2003.12.006.
Impact factor:
Publication type: Paper in international publication
Authors: Baena-Fustegueras, Juan Antonio; Garcia-Arumi, Elena; Lopez-Hellin, Joan; Riera, Simon Schwartz; Vidal, Montse et al.
DOI: 10.1016/j.clnu.2003.12.006

Thesis

Mechanisms of androgen metabolism reprogramming in aggressive prostate cancer models and the association between androgens and COVID-19

PhD student: Emily Marisol Toscano Guerra
Director/s: Rosanna Paciucci Barzanti
University: Universitat Autònoma de Barcelona
Year: 2023

Blog

News

The meeting was an opportunity to get to know projects from both institutions and to promote interaction between professionals.

The European Rare Diseases Research Alliance (ERDERA) kicked off this September, with an estimated budget of 380 million euros and the aim of improving the lives of 30 million rare disease patients in Europe and beyond.

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.