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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Belen Garcia Prats

Belen Garcia Prats

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Clara Ramírez Serra

Clara Ramírez Serra

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Julia German Cortes

Julia German Cortes

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura García Latorre

Laura García Latorre

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Marina Giralt Arnaiz

Marina Giralt Arnaiz

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Sandra Mancilla Zamora

Sandra Mancilla Zamora

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Belen Garcia Prats

Belen Garcia Prats

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Clara Ramírez Serra

Clara Ramírez Serra

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Julia German Cortes

Julia German Cortes

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Laura García Latorre

Laura García Latorre

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Marina Giralt Arnaiz

Marina Giralt Arnaiz

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Sandra Mancilla Zamora

Sandra Mancilla Zamora

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more

Projects

RED NACIONAL DE LABORATORIOS DE FUNCION RENAL

IP: Francesc Moreso Mateos
Collaborators: Gema Ariceta Iraola, Joan López Hellin
Funding agency: Instituto de Salud Carlos III
Funding: 42900
Reference: PMP22/00119
Duration: 01/01/2023 - 31/12/2025

Optimización del test de deposición ex vivo de C5b9 para monitorizar la actividad y la respuesta al tratamiento en SHUa y otras glomerulopatías complejas

IP: Concepció Jacobs Cachá
Collaborators: Manuel Hernández González, Natalia Ramos Terrades, Joana Sellarés Roig, Carmen Llorens Cebriá, Mercedes López González, Janire Perurena Prieto
Funding agency: Sociedad Española de Nefrología (S.E.N.)
Funding: 24000
Reference: SENEFRO/PROJECTES/2023/JACOBS
Duration: 23/12/2023 - 22/12/2025

MycoMatrix: engineering of a recombinant live biotherapeutic to normalise tumour extracellular matrix in KRAS-driven Non-Small Cell Lung Cancer

IP: Ibane Abasolo Olaortua
Collaborators: Joaquin Seras Franzoso, Fernanda Raquel Da Silva Andrade
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 333099
Reference: CPP2022-009780
Duration: 01/07/2023 - 30/06/2026

Ministerio de Ciencia

HydroTheC

IP: Ibane Abasolo Olaortua
Collaborators: Miriam Izquierdo Sans, Diana Fernandes de Rafael, Simon Schwartz Navarro
Funding agency: EUROPEAN COMMISSION
Funding: 221390.88
Reference: HYDROTEC_HE-MSCA-PF-GF2022
Duration: 01/01/2024 - 31/12/2026

Publications

Nanoceria as Safe Contrast Agents for X-ray CT Imaging.

PMID: 37570527
Journal: Nanomaterials
Year: 2023
Reference: Nanomaterials (Basel). 2023 Jul 29;13(15):2208. doi: 10.3390/nano13152208.
Impact factor:
Publication type: Paper in international publication
Authors: Abasolo, Ibane; Bastus, Neus G; Boullosa, Ana Maria; Camara, Juan Antonio; Casals, Eudald; Garcia, Ana; Gusta, Muriel F; Mondragon, Laura; Puntes, Victor; Schwartz, Simo Jr et al.
DOI: 10.3390/nano13152208

Transfusion-transmission of hepatitis E virus through red blood cell transfusion but not through platelet concentrates: A case report from Spain.

PMID: 37593971
Journal: TRANSFUSION
Year: 2023
Reference: Transfusion. 2023 Aug 18. doi: 10.1111/trf.17498.
Impact factor:
Publication type: Letter or abstract
Authors: Alvarez Arguelles, Marta Elena; Garcia-Gala, Jose Maria; Mata, Pablo; Munoz, Maria Del Carmen; Ojea, Ana Maria; Quer Sivila, Josep; Rando Segura, Ariadna; Rodriguez, Mercedes; Rodriguez-Frias, Francisco; Seco, Carolina et al.
DOI: 10.1111/trf.17498

Use of Biomarkers to Improve 28-Day Mortality Stratification in Patients with Sepsis and SOFA </= 6.

PMID: 37626646
Journal: Biomedicines
Year: 2023
Reference: Biomedicines. 2023 Jul 30;11(8):2149. doi: 10.3390/biomedicines11082149.
Impact factor:
Publication type: Paper in international publication
Authors: Baldira, Jaume; Chiscano, Luis; Comas, Inma; Cortes, Alejandro; Ferrer, Ricard; Ferrer-Costa, Roser; Gonzalez-Lopez, Juan Jose; Larrosa, Maria Nieves; Ruiz-Rodriguez, Juan Carlos; Ruiz-Sanmartin, Adolfo et al.
DOI: 10.3390/biomedicines11082149

Timing of umbilical cord occlusion, delayed vs early, in preterm babies: A randomized controlled trial (CODE-P Trial).

PMID: 37696147
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology
Year: 2023
Reference: Eur J Obstet Gynecol Reprod Biol. 2023 Aug 23;289:203-207. doi: 10.1016/j.ejogrb.2023.08.376.
Impact factor:
Publication type: Paper in international publication
Authors: Beneitez, D; Beneitez, D; Bergamo, S; Carbonell, M; Carbonell, M; Carreras, E; Carreras, E; Castillo, F; Castillo, F; Cespedes, M C et al.
DOI: 10.1016/j.ejogrb.2023.08.376

Blog

News

The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

During the last year, the collaboration between Vall d’Hebron and ZeClinics has found three nanobody candidates with potent anticancer properties in zebrafish model.