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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Fernando Moreno Flores

Fernando Moreno Flores

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Gertruda Chomiciute

Gertruda Chomiciute

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Gonzalo González Silva

Gonzalo González Silva

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Maria Fidel Lledò

Maria Fidel Lledò

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Sarai Garriga Edo

Sarai Garriga Edo

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Verónica Villagrasa Araya

Verónica Villagrasa Araya

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Fernando Moreno Flores

Fernando Moreno Flores

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Gertruda Chomiciute

Gertruda Chomiciute

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Gonzalo González Silva

Gonzalo González Silva

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Maria Fidel Lledò

Maria Fidel Lledò

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Sarai Garriga Edo

Sarai Garriga Edo

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Verónica Villagrasa Araya

Verónica Villagrasa Araya

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Projects

Hacia un manejo clínico personalizado de pacientes oncológicos con fracaso renal agudo asociado a los immune-checkpoint inhibitors (ICIs)

IP: Maria Jose Soler Romeo
Collaborators: Oriol Bestard Matamoros, Sheila Bermejo Garcia, Concepció Jacobs Cachá, Elena Isabel Crespo Gimeno
Funding agency: Instituto de Salud Carlos III
Funding: 246840
Reference: AC22/00029
Duration: 01/01/2023 - 31/12/2025

(Standard-D) Standardization of HDV-RNA quantification: a need that can no longer be ignored.

IP: Francisco Rodríguez Frias
Collaborators: David Tabernero Caellas
Funding agency: GILEAD SCIENCES SLU
Funding: 49961.71
Reference: GLD22/00080
Duration: 28/02/2023 - 27/02/2025

Bioquímica Clínica, Vehiculització de Fàrmacs i Teràpia (Clinical Biochemistry, Drug Delivery & Therapy, CB-DDT)

IP: Ibane Abasolo Olaortua
Collaborators: José Antonio Arranz Amo, Raquel Barquin Del Pino, Laura Conesa Milian, Clara Ramírez Serra, Yolanda Villena Ortiz, Joan López Hellin, Albert Blanco Grau, Francisco Rodríguez Frias, Roser Ferrer Costa, Joaquin Seras Franzoso, Diego Baranda Martínez-Abasca, Laura Castillo Ribelles, Clara Carnicer Cáceres, Marina Giralt Arnaiz, Ana Gomez Garcia, Simon Schwartz Navarro, Pablo Gabriel Medina, Rosanna Paciucci Barzanti, Zamira Vanessa Diaz Riascos, Marc Miquel Moltó Abad, Laura Castellote Bellés, Daniel Bravo Nieto, Luz María Cruz Carlos, Clara Sanz Gea, Alba Estela García Fernández, Maria del Pilar Reimundo Diaz-Fierros, Belen Garcia Prats, Noelia Díaz Troyano, JAUME VIMA BOFARULL, Beatriz Pacín Ruíz, Fernanda Raquel Da Silva Andrade, Diana Fernandes de Rafael, Maria Francesca Cortese, Sandra Mancilla Zamora
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 60000
Reference: 2021 SGR 01173
Duration: 01/01/2022 - 30/06/2025

Nefrologia i Trasplantament Renal

IP: Oriol Bestard Matamoros
Collaborators: Marina Lopez Martinez, Francesc Moreso Mateos, Natalia Ramos Terrades, Maria Jose Soler Romeo, Joana Sellarés Roig, Pamela Dominguez Baez, Vergara Arana, Ander, Irene Agraz Pamplona, Sheila Bermejo Garcia, Mariona Juvé Torres, Irina Betsabe Torres Rodriguez, Alba Torija Recasens, Concepció Jacobs Cachá, Elena Isabel Crespo Gimeno, Laura Donadeu Casassas, Carmen Llorens Cebriá, Nuria Bolaños Peruga, Manel Perelló Carrascosa, Maria Antonia Emilia Meneghini
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 40000
Reference: 2021 SGR 00883
Duration: 01/01/2022 - 30/06/2025

Publications

HBsAg protein composition and clinical outcomes in chronic hepatitis D and variations across HBeAg-negative chronic HBsAg carriers.

PMID: 37745192
Journal: JHEP Reports
Year: 2023
Reference: JHEP Rep. 2023 Jul 13;5(10):100842. doi: 10.1016/j.jhepr.2023.100842. eCollection 2023 Oct.
Impact factor:
Publication type: Paper in international publication
Authors: Berg, Thomas; Bes, Marta; Buti, Maria; Buti, Maria; Casillas, Rosario; Esteban, Rafael; Esteban, Rafael; Palom, Adriana; Pfefferkorn, Maria; Rando-Segura, Ariadna et al.
DOI: 10.1016/j.jhepr.2023.100842

Time-Tested Strategies in Modern Context: A Bibliometric Study of Chemotherapy's Continued Importance in Colorectal Cancer Treatment.

PMID: 37760489
Journal: Cancers
Year: 2023
Reference: Cancers (Basel). 2023 Sep 12;15(18):4520. doi: 10.3390/cancers15184520.
Impact factor:
Publication type: Paper in international publication
Authors: Clar-Marmaneu, Helena; Garcia-Fernandez, Alba Estela; Garcia-Fernandez, Francisco Javier et al.
DOI: 10.3390/cancers15184520

Impact of time of culture specimen collection on the recovery of Neisseria gonorrhoeae after a positive nucleic acid amplification test.

PMID: 37802652
Journal: SEXUALLY TRANSMITTED INFECTIONS
Year: 2023
Reference: Sex Transm Infect. 2023 Oct 6:sextrans-2023-055899. doi: 10.1136/sextrans-2023-055899.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Lopez, Patricia; Alvarez-Lopez, Patricia; Arando, Maider; Arando, Maider; Blanco-Grau, Albert; Curran, Adrian; Curran, Adrian; Descalzo, Vicente; El Ouazzani, Rachid; Garcia, Jorge Nestor et al.
DOI: 10.1136/sextrans-2023-055899

Solved the enigma of pediatric severe acute hepatitis of unknown origin?

PMID: 37808908
Journal: Frontiers in Cellular and Infection Microbiology
Year: 2023
Reference: Front Cell Infect Microbiol. 2023 Sep 21;13:1175996. doi: 10.3389/fcimb.2023.1175996. eCollection 2023.
Impact factor:
Publication type: Review in international publication
Authors: Quer, Josep; Rando-Segura, Ariadna; Rodriguez-Frias, Francisco et al.
DOI: 10.3389/fcimb.2023.1175996

Blog

News

The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

During the last year, the collaboration between Vall d’Hebron and ZeClinics has found three nanobody candidates with potent anticancer properties in zebrafish model.