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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Team

Montserrat Romero Reinaldos

Montserrat Romero Reinaldos

Research technician
Clinical Neuroimmunology
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Neus Mongay Ochoa

Neus Mongay Ochoa

Predoctoral researcher
Clinical Neuroimmunology
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Nuria  Martínez Sabaté

Nuria Martínez Sabaté

Administration and Management
Clinical Neuroimmunology
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Nuria Martínez Royuela

Nuria Martínez Royuela

Administration and Management
Clinical Neuroimmunology
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Patricia Arrieta Perna

Patricia Arrieta Perna

Clinical Neuroimmunology
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Paula Tagliani

Paula Tagliani

Predoctoral researcher
Clinical Neuroimmunology
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Montserrat Romero Reinaldos

Montserrat Romero Reinaldos

Research technician
Clinical Neuroimmunology
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Neus Mongay Ochoa

Neus Mongay Ochoa

Predoctoral researcher
Clinical Neuroimmunology
Read more
Nuria  Martínez Sabaté

Nuria Martínez Sabaté

Administration and Management
Clinical Neuroimmunology
Read more
Nuria Martínez Royuela

Nuria Martínez Royuela

Administration and Management
Clinical Neuroimmunology
Read more
Patricia Arrieta Perna

Patricia Arrieta Perna

Clinical Neuroimmunology
Read more
Paula Tagliani

Paula Tagliani

Predoctoral researcher
Clinical Neuroimmunology
Read more

Publications

SCALA: a randomized phase I trial comparing subcutaneous and intravenous alemtuzumab in patients with progressive multiple sclerosis.

PMID: 39513023
Journal: Therapeutic Advances in Neurological Disorders
Year: 2024
Reference: Ther Adv Neurol Disord. 2024 Nov 6;17:17562864241291655. doi: 10.1177/17562864241291655. eCollection 2024.
Impact factor:
Publication type: Paper in international publication
Authors: Chirieac, Magdalena; Forner, Mireia; Montalban, Xavier; Nos, Carlos; Resina, Mireia; Rodriguez-Acevedo, Breogan; Wu, Yanzhen et al.
DOI: 10.1177/17562864241291655

Soluble TREM2 distinguishes neuromyelitis optica spectrum disorder from MOG antibody disease.

PMID: 39530260
Journal: BRAIN
Year: 2024
Reference: Brain. 2024 Nov 12:awae335. doi: 10.1093/brain/awae335.
Impact factor:
Publication type: Paper in international publication
Authors: Chuquisana, Omar; Comabella, Manuel; Dinoto, Alessandro; Lunemann, Jan D; Mariotto, Sara; Montalban, Xavier; Sepulveda, Maria; Spatola, Marianna; Tintore, Mar et al.
DOI: 10.1093/brain/awae335

Secondary organising pneumonia associated to COVID-19 infection in patients with central nervous system inflammatory demyelinating diseases treated with anti-CD20 therapies.

PMID: 39520297
Journal: Multiple Sclerosis Journal
Year: 2024
Reference: Mult Scler. 2024 Nov 9:13524585241297038. doi: 10.1177/13524585241297038.
Impact factor:
Publication type: Paper in international publication
Authors: Arino, Helena; Arrambide, Georgina; Bollo, Luca; Cabello-Clotet, Noemi; Carvajal, Rene; Castillo, Joaquin; Cobo-Calvo, Alvaro; Comabella, Manuel; Falco-Roget, Anna; Galan, Ingrid et al.
DOI: 10.1177/13524585241297038

Towards a Unified Set of Diagnostic Criteria for Multiple Sclerosis.

PMID: 39605172
Journal: ANNALS OF NEUROLOGY
Year: 2024
Reference: Ann Neurol. 2024 Nov 28. doi: 10.1002/ana.27145.
Impact factor:
Publication type: Paper in international publication
Authors: Azzimonti, Matteo; Barkhof, Frederik; Bodini, Benedetta; Bollo, Luca; Brownlee, Wallace J; Ciccarelli, Olga; Esposito, Federica; Filippi, Massimo; Killestein, Joep; Lazzarotto, Andrea et al.
DOI: 10.1002/ana.27145

MOG antibodies in adults with a first demyelinating event suggestive of multiple sclerosis.

PMID: 37705507
Journal: ANNALS OF NEUROLOGY
Year: 2023
Reference: Ann Neurol. 2023 Sep 14. doi: 10.1002/ana.26793.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Auger, Cristina; Auger, Cristina; Bollo, Luca; Carbonell-Mirabent, Pere; Castillo, Joaquin; Castillo, Mireia; Cobo-Calvo, Alvaro; Cobo-Calvo, Alvaro; Comabella, Manuel et al.
DOI: 10.1002/ana.26793

Development and multi-center validation of a fully automated digital immunoassay for neurofilament light chain: toward a clinical blood test for neuronal injury.

PMID: 37702323
Journal: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Year: 2023
Reference: Clin Chem Lab Med. 2023 Sep 13. doi: 10.1515/cclm-2023-0518.
Impact factor:
Publication type: Paper in international publication
Authors: Akgun, Katja; Bar-Or, Amit; Bielekova, Bibi; Bittner, Stefan; Blennow, Kaj; Bruck, Wolfgang; Chan, Dandan; Chang, Lei; Chitnis, Tanuja; Comabella, Manuel et al.
DOI: 10.1515/cclm-2023-0518

Association between cannabis use and symptom dimensions in schizophrenia spectrum disorders: an individual participant data meta-analysis on 3053 individuals.

PMID: 37731936
Journal: EClinicalMedicine
Year: 2023
Reference: EClinicalMedicine. 2023 Sep 8;64:102199. doi: 10.1016/j.eclinm.2023.102199. eCollection 2023 Oct.
Impact factor:
Publication type: Paper in international publication
Authors: Addington, Jean Margaret; Amoretti, Silvia; Andreassen, Ole Andreas; Argote, Mathilde; Asmal, Laila; Baudin, Gregoire; Bechdolf, Andreas; Brambilla, Paolo; Brunelin, Jerome; Cookey, Jacob et al.
DOI: 10.1016/j.eclinm.2023.102199

A single-dose strategy for immunization with live attenuated vaccines is an effective option before treatment initiation in multiple sclerosis patients.

PMID: 37728389
Journal: Multiple Sclerosis Journal
Year: 2023
Reference: Mult Scler. 2023 Sep 20:13524585231200303. doi: 10.1177/13524585231200303.
Impact factor:
Publication type: Paper in international publication
Authors: Arrambide, Georgina; Bollo, Luca; Borras-Bemejo, Blanca; Borras-Bemejo, Blanca; Braga, Nathane; Braga, Nathane; Carbonell, Pere; Carbonell, Pere; Carvajal, Rene; Castillo, Joaquin et al.
DOI: 10.1177/13524585231200303

Factors associated with treatment escalation among MS specialists and general neurologists: Results from an International cojoint study.

PMID: 35216786
Journal: Multiple Sclerosis and Related Disorders
Year: 2022
Reference: Mult Scler Relat Disord. 2022 Feb;58:103404. doi: 10.1016/j.msard.2021.103404. Epub 2021 Nov 16.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, M P; Andhavarapu, S; Bermel, R; Caceres, F; Celius, E; Costa, A; Fernandez, O; Foss, M; Havrdova, E K; Kalincik, T et al.
DOI: 10.1016/j.msard.2021.103404

T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations.

PMID: 35202997
Journal: NeuroImage-Clinical
Year: 2022
Reference: Neuroimage Clin. 2022;34:102967. doi: 10.1016/j.nicl.2022.102967. Epub 2022 Feb 16.
Impact factor:
Publication type: Paper in international publication
Authors: Alberich, Manel; Auger, Cristina; Boaventura, Mateus; Carvajal, Rene; Garcia-Vidal, Aran; Montalban, Xavier; Pareto, Deborah; Quartana, Davide; Rovira, Alex; Sastre-Garriga, Jaume et al.
DOI: 10.1016/j.nicl.2022.102967

The risk of infections for multiple sclerosis and neuromyelitis optica spectrum disorder disease-modifying treatments: Eighth European Committee for Treatment and Research in Multiple Sclerosis Focused Workshop Review. April 2021.

PMID: 35196927
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 Aug;28(9):1424-1456. doi: 10.1177/13524585211069068. Epub 2022 Feb 23.
Impact factor:
Publication type: Review in international publication
Authors: Abboud, Hesham; Achiron, Anat; Amato, Maria Pia; Bellinvia, Angelo; Boyko, Alexey; Casanova, Jean-Laurent; Clifford, David; Derfuss, Tobias; Di Pauli, Franziska; Dobson, Ruth et al.
DOI: 10.1177/13524585211069068

Correction to: Impact of COVID-19 pandemic on frequency of clinical visits, performance of MRI studies, and therapeutic choices in a multiple sclerosis referral centre.

PMID: 35192034
Journal: JOURNAL OF NEUROLOGY
Year: 2022
Reference: J Neurol. 2022 Apr;269(4):1773. doi: 10.1007/s00415-022-11019-9.
Impact factor:
Publication type: Letter or abstract
Authors: Arrambide, Georgina; Auger, Cristina; Carbonell, Pere; Cardenas-Robledo, Simon; Castillo, Joaquin; Castillo, Mireia; Cobo-Calvo, Alvaro; Comabella, Manuel; Espejo, Carmen; Galan, Ingrid et al.
DOI: 10.1007/s00415-022-11019-9

U-turn speed is a valid and reliable smartphone-based measure of multiple sclerosis-related gait and balance impairment.

PMID: 33310432
Journal: GAIT & POSTURE
Year: 2021
Reference: Gait Posture. 2021 Feb;84:120-126. doi: 10.1016/j.gaitpost.2020.11.025. Epub 2020 Nov 25.
Impact factor:
Publication type: Paper in international publication
Authors: Belachew, Shibeshih; Bernasconi, Corrado; Bourke, Alan K; Cheng, Wei-Yi; Gossens, Christian; Graves, Jennifer S; Lindemann, Michael; Lipsmeier, Florian; Montalban, Xavier et al.
DOI: 10.1016/j.gaitpost.2020.11.025

The introduction of new medications in pediatric multiple sclerosis: Open issues and challenges.

PMID: 32539596
Journal: Multiple Sclerosis Journal
Year: 2021
Reference: Mult Scler. 2021 Mar;27(3):479-482. doi: 10.1177/1352458520930620. Epub 2020 Jun 16.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, Maria Pia; Comi, Giancarlo; Edan, Gilles; Ghezzi, Angelo; Hartung, Hans-Peter; Havrdova, Eva Kubala; Kappos, Ludwig; Montalban, Xavier; Pozzilli, Carlo; Sorensen, Per Soelber et al.
DOI: 10.1177/1352458520930620

Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study.

PMID: 33401136
Journal: NeuroImage-Clinical
Year: 2021
Reference: Neuroimage Clin. 2021;29:102549. doi: 10.1016/j.nicl.2020.102549. Epub 2020 Dec 25.
Impact factor:
Publication type: Paper in international publication
Authors: Barkhof, Frederik; Brouwer, Iman; Burggraaff, Jessica; Ciccarelli, Olga; de Sitter, Alexandra; De Stefano, Nicola; Enzinger, Christian; Filippi, Massimo; Gallo, Antonio; Gasperini, Claudio et al.
DOI: 10.1016/j.nicl.2020.102549

Effect of Ozanimod on Symbol Digit Modalities Test Performance in Relapsing MS.

PMID: 33454584
Journal: Multiple Sclerosis and Related Disorders
Year: 2021
Reference: Mult Scler Relat Disord. 2021 Feb;48:102673. doi: 10.1016/j.msard.2020.102673. Epub 2020 Dec 10.
Impact factor:
Publication type: Paper in international publication
Authors: Arnold, Douglas L; Cohen, Jeffrey A; Comi, Giancarlo; Cree, Bruce A C; DeLuca, John; Hartung, Hans-Peter; Kappos, Ludwig; Liu, Hongjuan; Montalban, Xavier; Schippling, Sven et al.
DOI: 10.1016/j.msard.2020.102673

Vitamin D, smoking, EBV, and long-term cognitive performance in MS: 11-year follow-up of BENEFIT.

PMID: 32300060
Journal: NEUROLOGY
Year: 2020
Reference: Neurology. 2020 May 5;94(18):e1950-e1960. doi: 10.1212/WNL.0000000000009371. Epub 2020 Apr 16.
Impact factor:
Publication type: Paper in international publication
Authors: Ascherio, Alberto; Barro, Christian; Cortese, Marianna; Edan, Gilles; Foley, Frederick W; Fox, Edward J; Freedman, Mark S; Hartung, Hans-Peter; Hemmer, Bernhard; Kappos, Ludwig et al.
DOI: 10.1212/WNL.0000000000009371

Tumefactive inflammatory leukoencephalopathy in cocaine users: Report of three cases.

PMID: 31707217
Journal: Multiple Sclerosis and Related Disorders
Year: 2020
Reference: Mult Scler Relat Disord. 2020 Feb;38:101496. doi: 10.1016/j.msard.2019.101496. Epub 2019 Nov 4.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, Cristina; Castillo, Joaquin; de Seze, Jerome; Kremer, Stephane; Lhermitte, Benoit; Maciag, Ewa; Pessini, Lucas M; Pottecher, Julien; Rovira, Alex et al.
DOI: 10.1016/j.msard.2019.101496

Reduced dynamics of functional connectivity and cognitive impairment in multiple sclerosis.

PMID: 30887862
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Apr;26(4):476-488. doi: 10.1177/1352458519837707. Epub 2019 Mar 19.
Impact factor:
Publication type: Paper in international publication
Authors: Arevalo, Maria J; Barkhof, Frederik; Ciccarelli, Olga; d'Ambrosio, Alessandro; De Stefano, Nicola; Enzinger, Christian; Filippi, Massimo; Gallo, Antonio; Hulst, Hanneke E; Koini, Marisa et al.
DOI: 10.1177/1352458519837707

The ACROSS study: Long-term efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis.

PMID: 32284874
Journal: Multiple sclerosis journal - experimental, transla
Year: 2020
Reference: Mult Scler J Exp Transl Clin. 2020 Mar 30;6(1):2055217320907951. doi: 10.1177/2055217320907951. eCollection 2020 Jan-Mar.
Impact factor:
Publication type: Paper in international publication
Authors: Azmon, A; Derfuss, T; Gaetano, L; Kappos, L; Montalban, X; Rodegher, M; Sastre-Garriga, J; Tomic, D; Wolf, C; Wuerfel, J et al.
DOI: 10.1177/2055217320907951

Frequency and relevance of IgM, and IgA antibodies against MOG in MOG-IgG-associated disease.

PMID: 30623863
Journal: Multiple Sclerosis and Related Disorders
Year: 2019
Reference: Mult Scler Relat Disord. 2019 Feb;28:230-234. doi: 10.1016/j.msard.2019.01.007. Epub 2019 Jan 3.
Impact factor:
Publication type: Paper in international publication
Authors: Armangue, Thais; Arrambide, Georgina; Blanco, Yolanda; Dalmau, Josep; Graus, Francesc; Llufriu, Sara; Martinez-Hernandez, Eugenia; Martinez-Lapiscina, Elena H; Mulero, Patricia; Pedreno, Marta et al.
DOI: 10.1016/j.msard.2019.01.007

Treatment of multiple sclerosis - success from bench to bedside.

PMID: 30315270
Journal: Nature Reviews Neurology
Year: 2019
Reference: Nat Rev Neurol. 2019 Jan;15(1):53-58. doi: 10.1038/s41582-018-0082-z.
Impact factor:
Publication type: Review in international publication
Authors: Sastre-Garriga, Jaume; Tintore, Mar; Vidal-Jordana, Angela et al.
DOI: 10.1038/s41582-018-0082-z

Patient and caregiver involvement in formulation of guideline questions: Findings from the EAN Guideline on Palliative Care of People with Severe Multiple Sclerosis.

PMID: 30035845
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2019
Reference: Eur J Neurol. 2019 Jan;26(1):41-50. doi: 10.1111/ene.13760. Epub 2018 Sep 9.
Impact factor:
Publication type: Paper in international publication
Authors: Basedow-Rajwich, Birgit; Battaglia, Mario Alberto; Bay, Jette; Drulovic, Jelena; Fornari, Arianna; Giordano, Andrea; Kleiter, Ingo; Kooij, Liesbeth; Koops, Johan; Kopke, Sascha et al.
DOI: 10.1111/ene.13760

Multi-centre validation of a flow cytometry method to identify optimal responders to interferon-beta in multiple sclerosis.

PMID: 30408481
Journal: CLINICA CHIMICA ACTA
Year: 2019
Reference: Clin Chim Acta. 2019 Jan;488:135-142. doi: 10.1016/j.cca.2018.11.008. Epub 2018 Nov 5.
Impact factor:
Publication type: Paper in international publication
Authors: Alari-Pahissa, Elisenda; Aragon, Larraitz; Camara, Carmen; Castillo-Trivino, Tamara; Cuello, Juan Pablo; Eixarch, Herena; Ferrer, Joana Maria; Gascon-Gimenez, Francisco; Gil-Herrera, Juana; Gomez-Gutierrez, Montserrat et al.
DOI: 10.1016/j.cca.2018.11.008

Radiologically isolated syndrome or subclinical multiple sclerosis: MAGNIMS consensus recommendations.

PMID: 29451440
Journal: Multiple Sclerosis Journal
Year: 2018
Reference: Mult Scler. 2018 Feb;24(2):214-221. doi: 10.1177/1352458517717808.
Impact factor:
Publication type: Paper in international publication
Authors: Ciccarelli, Olga; De Stefano, Nicola; Enzinger, Christian; Filippi, Massimo; Frederiksen, Jette; Giorgio, Antonio; Kappos, Ludwig; Palace, Jacqueline; Pia Amato, Maria; Rocca, Maria A et al.
DOI: 10.1177/1352458517717808

Cervical Cord Atrophy and Long-Term Disease Progression in Patients with Primary-Progressive Multiple Sclerosis.

PMID: 29284602
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2018
Reference: AJNR Am J Neuroradiol. 2018 Feb;39(2):399-404. doi: 10.3174/ajnr.A5495. Epub 2017 Dec 28.
Impact factor:
Publication type: Paper in international publication
Authors: Alberich, M; Alonso, J; Auger, C; Aymerich, F X; Montalban, X; Rovira, A; Sastre-Garriga, J; Tintore, M et al.
DOI: 10.3174/ajnr.A5495

[Remodelling of the Scientific Committee and a new series of neuroepidemiology reviews].

PMID: 29435965
Journal: REVISTA DE NEUROLOGIA
Year: 2018
Reference: Rev Neurol. 2018 Feb 16;66(4):103.
Impact factor:
Publication type: Editorail in international publication
Authors: Otero-Romero, S; Sastre-Garriga, J et al.
DOI: 10.33588/rn.6604.2018036

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria.

PMID: 29275977
Journal: LANCET NEUROLOGY
Year: 2018
Reference: Lancet Neurol. 2018 Feb;17(2):162-173. doi: 10.1016/S1474-4422(17)30470-2. Epub 2017 Dec 21.
Impact factor:
Publication type: Review in national publication
Authors: Banwell, Brenda L; Barkhof, Frederik; Carroll, William M; Coetzee, Timothy; Cohen, Jeffrey A; Comi, Giancarlo; Correale, Jorge; Fazekas, Franz; Filippi, Massimo; Freedman, Mark S et al.
DOI: 10.1016/S1474-4422(17)30470-2

Brain Atrophy in Multiple Sclerosis: Clinical Relevance and Technical Aspects.

PMID: 28391787
Journal: NEUROIMAGING CLINICS OF NORTH AMERICA
Year: 2017
Reference: Neuroimaging Clin N Am. 2017 May;27(2):289-300. doi: 10.1016/j.nic.2017.01.002. Epub 2017 Feb 20.
Impact factor: 1.325
Publication type: Review in national publication
Authors: Sastre-Garriga, Jaume, Pareto, Deborah, Rovira, Alex et al.
DOI: 10.1016/j.nic.2017.01.002

MR Imaging in Monitoring and Predicting Treatment Response in Multiple Sclerosis.

PMID: 28391786
Journal: NEUROIMAGING CLINICS OF NORTH AMERICA
Year: 2017
Reference: Neuroimaging Clin N Am. 2017 May;27(2):277-287. doi: 10.1016/j.nic.2017.01.001. Epub 2017 Feb 14.
Impact factor: 1.325
Publication type: Review in national publication
Authors: Rio, Jordi, Auger, Cristina, Rovira, Alex et al.
DOI: 10.1016/j.nic.2017.01.001

Measurement of Cortical Thickness and Volume of Subcortical Structures in Multiple Sclerosis: Agreement between 2D Spin-Echo and 3D MPRAGE T1-Weighted Images.

PMID: 27884876
Journal: AMERICAN JOURNAL OF NEURORADIOLOGY
Year: 2017
Reference: AJNR Am J Neuroradiol. 2017 Feb;38(2):250-256. doi: 10.3174/ajnr.A4999. Epub 2016 Nov 24.
Impact factor: 3.55
Publication type: Paper in international publication
Authors: Vidal-Jordana, A, Pareto, D, Sastre-Garriga, J, Auger, C, Ciampi, E, Montalban, X, Rovira, A et al.
DOI: 10.3174/ajnr.A4999

Brain networks associated with cognitive and hedonic responses to a meal.

PMID: 28116817
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2017
Reference: Neurogastroenterol Motil. 2017 Jun;29(6). doi: 10.1111/nmo.13031. Epub 2017 Jan 23.
Impact factor: 3.617
Publication type: Paper in international publication
Authors: Pribic, T, Kilpatrick, L, Ciccantelli, B, Malagelada, C, Accarino, A, Rovira, A, Pareto, D, Mayer, E, Azpiroz, F et al.
DOI: 10.1111/nmo.13031

Tocilizumab and multiple sclerosis: a causal relationship? Clinical Commentary on the case report entitled - MS arising during Tocilizumab therapy for rheumatoid arthritis.

PMID: 26743639
Journal: Multiple Sclerosis Journal
Year: 2016
Reference: Mult Scler. 2016 Feb;22(2):257-8. doi: 10.1177/1352458515623863. Epub 2016 Jan 7.
Impact factor:
Publication type: Paper in international publication
Authors: Comabella, Manuel et al.
DOI: 10.1177/1352458515623863

Primary Progressive Multiple Sclerosis Evolving From Radiologically Isolated Syndrome.

PMID: 26599831
Journal: ANNALS OF NEUROLOGY
Year: 2016
Reference: Ann Neurol. 2016 Feb;79(2):288-94. doi: 10.1002/ana.24564. Epub 2015 Dec 29.
Impact factor:
Publication type: Paper in international publication
Authors: Amato, Maria Pia; Azevedo, Christina J; De Stefano, Nicola; Durand-Dubief, Francoise; Inglese, Matilde; Kantarci, Orhun H; Keegan, Mark B; Lebrun, Christine; Newton, Braeden D; Okuda, Darin T et al.
DOI: 10.1002/ana.24564

Cytokine profiles show heterogeneity of interferon-beta response in multiple sclerosis patients.

PMID: 26894205
Journal: Neurologia i Neurochirurgia Polska
Year: 2016
Reference: Neurol Neuroimmunol Neuroinflamm. 2016 Jan 27;3(2):e202. doi: 10.1212/NXI.0000000000000202. eCollection 2016 Apr.
Impact factor:
Publication type: Paper in international publication
Authors: Adrianto, Indra; Axtell, Robert C; Bertolotto, Antonio; Comabella, Manuel; Deisenhammer, Florian; Fazekas, Franz; Giovannoni, Gavin; Guger, Michael; Hegen, Harald; Hoelzl, Martina et al.
DOI: 10.1212/NXI.0000000000000202

Lesion filling effect in regional brain volume estimations: a study in multiple sclerosis patients with low lesion load.

PMID: 26847633
Journal: NEURORADIOLOGY
Year: 2016
Reference: Neuroradiology. 2016 May;58(5):467-74. doi: 10.1007/s00234-016-1654-5. Epub 2016 Feb 4.
Impact factor:
Publication type: Paper in international publication
Authors: Auger, C; Aymerich, F X; Montalban, X; Pareto, D; Rovira, A; Sastre-Garriga, J; Tintore, M et al.
DOI: 10.1007/s00234-016-1654-5

Cell-specific effects in different immune subsets associated with SOCS1 genotypes in multiple sclerosis.

PMID: 25623250
Journal: MULT SCLER J
Year: 2015
Reference: Mult Scler. 2015 Oct;21(12):1498-512. doi: 10.1177/1352458514566418. Epub 2015 Jan 26.
Impact factor:
Publication type: Paper in international publication
Authors: Alloza, Iraide; Astobiza, Ianire; Comabella, Manuel; Fernandez, Oscar; Lopez de Lapuente, Aitzkoa; Malhotra, Sunny; Montalban, Xavier; Pinto-Medel, Maria Jesus; Rodriguez-Antiguedad, Alfredo; Vandenbroeck, Koen et al.
DOI: 10.1177/1352458514566418

Genetic variants are major determinants of CSF antibody levels in multiple sclerosis.

PMID: 25616667
Journal: BRAIN
Year: 2015
Reference: Brain. 2015 Mar;138(Pt 3):632-43. doi: 10.1093/brain/awu405. Epub 2015 Jan 22.
Impact factor:
Publication type: Paper in international publication
Authors: Aarseth, Jan; Alfredsson, Lars; Andreassen, Bettina Kullle; Bang Oturai, Annette; Barizzone, Nadia; Bedri, Sahl Khalid; Berg-Hansen, Pal; Berthele, Achim; Biberacher, Viola; Bos, Steffan D et al.
DOI: 10.1093/brain/awu405

Chitinase 3-like 1: prognostic biomarker in clinically isolated syndromes.

PMID: 25688078
Journal: BRAIN
Year: 2015
Reference: Brain. 2015 Apr;138(Pt 4):918-31. doi: 10.1093/brain/awv017. Epub 2015 Feb 13.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Cermeno, Jose C; Arrambide, Georgina; Bartos, Ales; Blanco, Yolanda; Brassat, David; Canto, Ester; Comabella, Manuel; Costa, Carme; de Andres, Clara; Deisenhammer, Florian et al.
DOI: 10.1093/brain/awv017

Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study.

PMID: 25680984
Journal: MULT SCLER J
Year: 2015
Reference: Mult Scler. 2015 Jul;21(8):1013-24. doi: 10.1177/1352458514568827. Epub 2015 Feb 13.
Impact factor:
Publication type: Paper in international publication
Authors: Adiutori, R; Altintas, A; Alvarez-Cermeno, Jc; Annibali, V; Avsar, T; Barizzone, N; Bergamaschi, R; Bestwick, Jp; Bianchi, L; Bosca, I et al.
DOI: 10.1177/1352458514568827

Progressive Presynaptic Dopaminergic Deterioration in Huntington Disease: A [123I]-FP-CIT SPECT Two-Year Follow-Up Study.

PMID: 23531734
Journal: CLINICAL NUCLEAR MEDICINE
Year: 2014
Reference: Clin Nucl Med. 2014 Mar;39(3):e227-8. doi: 10.1097/RLU.0b013e31828162cd.
Impact factor:
Publication type: Paper in international publication
Authors: Badia, Mercedes; Badia, Mercedes; Carmona, Francesc; Castell-Conesa, Joan; Castillo, Joaquin; Cuberas-Borros, Gemma; de Fabregues, Oriol; Gamez, Josep; Hernandez-Vara, Jorge; Lorenzo-Bosquet, Carles et al.
DOI: 10.1097/RLU.0b013e31828162cd

Interferon beta-1b reduces black holes in a randomised trial of clinically isolated syndrome.

PMID: 23842212
Journal: Multiple Sclerosis Journal
Year: 2014
Reference: Mult Scler. 2014 Feb;20(2):234-42. doi: 10.1177/1352458513494491. Epub 2013 Jul 10.
Impact factor:
Publication type: Clinical Trials
Authors: Barkhof, Frederik; Beckman, Karola; Edan, Gilles; Freedman, Mark S; Hartung, Hans-Peter; Hulst, Hanneke E; Kappos, Ludwig; Miller, David; Montalban, Xavier; Nagtegaal, Gijsbert Ja et al.
DOI: 10.1177/1352458513494491

FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS.

PMID: 24531377
Journal: NATURE MEDICINE
Year: 2014
Reference: Nat Med. 2014 Mar;20(3):272-82. doi: 10.1038/nm.3485. Epub 2014 Feb 16.
Impact factor:
Publication type: Paper in international publication
Authors: Carlsson, Robert; Carrion, Belinda; Comabella, Manuel; Dziegiel, Morten Hanefeld; Hasan, Maruf; Helin, Kristian; Issazadeh-Navikas, Shohreh; Kosicki, Michael; Liu, Yawei; Montalban, Xavier et al.
DOI: 10.1038/nm.3485

Body fluid biomarkers in multiple sclerosis.

PMID: 24331797
Journal: LANCET NEUROLOGY
Year: 2014
Reference: Lancet Neurol. 2014 Jan;13(1):113-26. doi: 10.1016/S1474-4422(13)70233-3.
Impact factor:
Publication type: Paper in international publication
Authors: Comabella, Manuel; Montalban, Xavier et al.
DOI: 10.1016/S1474-4422(13)70233-3

Location of brain lesions predicts conversion of clinically isolated syndromes to multiple sclerosis.

PMID: 23223533
Journal: NEUROLOGY
Year: 2013
Reference: Neurology. 2013 Jan 15;80(3):234-241. Epub 2012 Dec 5.
Impact factor:
Publication type: Paper in international publication
Authors: Absinta, Martina; Barkhof, Frederik; Battaglini, Marco; Chard, Declan; Ciccarelli, Olga; De Leucio, Alessandro; De Stefano, Nicola; Enzinger, Christian; Filippi, Massimo; Frederiksen, Jette et al.
DOI: 10.1212/WNL.0b013e31827debeb

Treatment with interferon-beta does not induce anti-nuclear and anti-neuronal serum autoantibodies in multiple sclerosis patients.

PMID: 23182615
Journal: JOURNAL OF NEUROIMMUNOLOGY
Year: 2013
Reference: J Neuroimmunol. 2013 Feb 15;255(1-2):102-4. doi: 10.1016/j.jneuroim.2012.10.016. Epub 2012 Nov 22.
Impact factor:
Publication type: Paper in international publication
Authors: Borowski, K; Bustamante, M F; Comabella, M; Montalban, X; Rentzsch, K; Rio, J; Stoecker, W et al.
DOI: 10.1016/j.jneuroim.2012.10.016

[Therapy adherence to immunomodulator treatment in patients with multiple sclerosis].

PMID: 23250676
Journal: Revista de neurologia
Year: 2013
Reference: Rev Neurol. 2013 Jan 1;56(1):8-12.
Impact factor:
Publication type: Paper in national publication
Authors: Cardona-Pascual, I; Gomez-Domingo, M R; Lopez-Mendez, P; Montalban, X; Perez-Ricart, A; Rio, J; Sastre-Garriga, J; Tintore, M et al.
DOI:

In vivo imaging of brain aromatase in female baboons: [11C]vorozole kinetics and effect of the menstrual cycle.

PMID: 24447618
Journal: Molecular Imaging
Year: 2013
Reference: Mol Imaging. 2013 Nov-Dec;12(8). doi: 10.2310/7290.2013.00068.
Impact factor: 3.408
Publication type: Paper in international publication
Authors: Pareto, Deborah, Biegon, Anat, Alexoff, David, Carter, Pauline, Shea, Coreen, Muench, Lisa, Xu, Youwen, Fowler, Joanna S, Kim, Sunny W, Logan, Jean et al.
DOI: 10.2310/7290.2013.00068

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In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

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Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

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