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Clinical Neuroimmunology

The group of Clinical Neuroimmunology - Centre d'Esclerosi Múltiple de Catalunya (Cemcat) at the Vall d'Hebron Institut de Recerca (VHIR) is a multidisciplinary group dedicated to clinical assistance, physical and cognitive rehabilitation, and clinical and basic research on multiple sclerosis (MS). Cemcat is a national but also an international reference center in the clinical assistance of MS patients. The research performed in the group is divided and further combined in clinical and basic research. In addition, basic research has a marked translational character since the ultimate goal of the group is to improve the quality of life of patients suffering from MS, through in-depth knowledge of the pathogenic mechanisms of the disease and the development of new and more effective therapeutic approaches. 

Publications

Cognitive improvement following endovascular embolization in patients with intracranial dural arteriovenous fistula: The Neuropsychology in dural ArterIal Fistula (NAIF) Study.

PMID: 38071581
Journal: Journal of NeuroInterventional Surgery
Year: 2023
Reference: J Neurointerv Surg. 2023 Dec 7:jnis-2023-021033. doi: 10.1136/jnis-2023-021033.
Impact factor:
Publication type: Paper in international publication
Authors: Aixut, Sonia; Chirife Chaparro, Oscar; de Dios Lascuevas, Marta; Dinia, Lavinia; Gonzalez, Alejandro; Gramegna, Laura Ludovica; Hernandez, David; Luttich, Alex; Moreu, Manuel; Murias, Eduardo et al.
DOI: 10.1136/jnis-2023-021033

Diagnostic Performance of Cortical Lesions and the Central Vein Sign in Multiple Sclerosis.

PMID: 38079177
Journal: JAMA Neurology
Year: 2023
Reference: JAMA Neurol. 2023 Dec 11. doi: 10.1001/jamaneurol.2023.4737.
Impact factor:
Publication type: Paper in international publication
Authors: Absinta, Martina; Barakovic, Muhamed; Barkhof, Frederik; Cagol, Alessandro; Calabrese, Massimiliano; Castellaro, Marco; Ciccarelli, Olga; Cocozza, Sirio; Cortese, Rosa; De Stefano, Nicola et al.
DOI: 10.1001/jamaneurol.2023.4737

Reply to "MOG Antibody-Positive Patients Meeting the 2017 McDonald Criteria for MS: Challenges in Diagnosis and Treatment Decisions".

PMID: 38081749
Journal: ANNALS OF NEUROLOGY
Year: 2023
Reference: Ann Neurol. 2023 Dec 11. doi: 10.1002/ana.26856.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Alvarez-Fernandez, Antonio; Canete-Ramirez, Carme; Cobo-Calvo, Alvaro; Espejo, Carmen; Fernandez-Polo, Aurora; Gartner, Silvia; Jimenez-Lozano, Ines; Luna-Paredes, Carmen; Monte-Boquet, Emilio; Roch-Santed, Maria et al.
DOI: 10.1002/ana.26856

Type I error rates and power of two randomization test procedures for the changing criterion design.

PMID: 38082114
Journal: Behavior Research Methods
Year: 2023
Reference: Behav Res Methods. 2023 Dec 11. doi: 10.3758/s13428-023-02303-1.
Impact factor:
Publication type: Paper in international publication
Authors: Aixut, Sonia; Chirife Chaparro, Oscar; de Dios Lascuevas, Marta; Dinia, Lavinia; Gonzalez, Alejandro; Gramegna, Laura Ludovica; Hernandez, David; Luttich, Alex; Manolov, Rumen; Moreu, Manuel et al.
DOI: 10.3758/s13428-023-02303-1

CSF chitinase 3-like 1 is associated with iron rims in patients with a first demyelinating event.

PMID: 33870790
Journal: Multiple Sclerosis Journal
Year: 2022
Reference: Mult Scler. 2022 Jan;28(1):71-81. doi: 10.1177/13524585211010082. Epub 2021 Apr 19.
Impact factor: 6.312
Publication type: Paper in international publication
Authors: Pinteac, Rucsanda; Granziera, Cristina; Sastre-Garriga, Jaume; Benkert, Pascal; Auger, Cristina; Kuhle, Jens; Montalban, Xavier; Rovira, Alex; Fissolo, Nicolas; Pareto, Deborah et al.
DOI: 10.1177/13524585211010082

Performance of the 2017 and 2010 Revised McDonald Criteria in Predicting MS Diagnosis After a Clinically Isolated Syndrome: A MAGNIMS Study.

PMID: 34716250
Journal: NEUROLOGY
Year: 2022
Reference: Neurology. 2022 Jan 4;98(1):e1-e14. doi: 10.1212/WNL.0000000000013016. Epub 2021 Oct 29.
Impact factor: 9.91
Publication type: Paper in international publication
Authors: Filippi, Massimo; Preziosa, Paolo; Meani, Alessandro; Costa, Gloria Dalla; Mesaros, Sarlota; Drulovic, Jelena; Ivanovic, Jovana; Rovira, Alex; Tintore, Mar; Montalban, Xavier et al.
DOI: 10.1212/WNL.0000000000013016

Treatment response scoring systems to assess long-term prognosis in self-injectable DMTs relapsing-remitting multiple sclerosis patients.

PMID: 34596743
Journal: JOURNAL OF NEUROLOGY
Year: 2022
Reference: J Neurol. 2022 Jan;269(1):452-459. doi: 10.1007/s00415-021-10823-z. Epub 2021 Oct 1.
Impact factor: 4.849
Publication type: Paper in international publication
Authors: Tur, Carmen; Auger, Cristina; Sastre-Garriga, Jaume; Montalban, Xavier; Cobo, Alvaro; Nos, Carlos; Arrambide, Georgina; Castillo, Joaquim; Rio, Jordi; Gasperini, Claudio et al.
DOI: 10.1007/s00415-021-10823-z

Herpes simplex encephalitis in the context of immune checkpoint inhibitors: a complex interplay.

PMID: 34988947
Journal: ACTA NEUROLOGICA BELGICA
Year: 2022
Reference: Acta Neurol Belg. 2022 Jun;122(3):823-825. doi: 10.1007/s13760-021-01864-2. Epub 2022 Jan 6.
Impact factor: 2.396
Publication type: Letter or abstract
Authors: Lallana, Sofia; Sanchez-Tejerina, Daniel; Auger, Cristina; Callejo, Ana; Rio, Jordi; Cobo-Calvo, Alvaro et al.
DOI: 10.1007/s13760-021-01864-2

Immunosenescence in multiple sclerosis: The identification of new therapeutic targets.

PMID: 34237417
Journal: AUTOIMMUNITY REVIEWS
Year: 2021
Reference: Autoimmun Rev. 2021 Sep;20(9):102893. doi: 10.1016/j.autrev.2021.102893. Epub 2021 Jul 5.
Impact factor: 9.754
Publication type: Review in international publication
Authors: Dema, Maria, Eixarch, Herena, Villar, Luisa M, Montalban, Xavier, Espejo, Carmen et al.
DOI: 10.1016/j.autrev.2021.102893

Adding brain volume measures into response criteria in multiple sclerosis: the Rio-4 score.

PMID: 33237430
Journal: NEURORADIOLOGY
Year: 2021
Reference: Neuroradiology. 2021 Jul;63(7):1031-1041. doi: 10.1007/s00234-020-02604-8. Epub 2020 Nov 25.
Impact factor: 2.804
Publication type: Paper in international publication
Authors: Perez-Miralles, Francisco Carlos, Rio, Jordi, Pareto, Deborah, Vidal-Jordana, Angela, Auger, Cristina, Arrambide, Georgina, Castillo, Joaquin, Tintore, Mar, Rovira, Alex, Montalban, Xavier et al.
DOI: 10.1007/s00234-020-02604-8

Quantitative comparison of subcortical and ventricular volumetry derived from MPRAGE and MP2RAGE images using different brain morphometry software.

PMID: 34052900
Journal: MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
Year: 2021
Reference: MAGMA. 2021 Dec;34(6):903-914. doi: 10.1007/s10334-021-00933-0. Epub 2021 May 29.
Impact factor: 2.31
Publication type: Paper in international publication
Authors: Alonso, Juli, Pareto, Deborah, Alberich, Manel, Kober, Tobias, Marechal, Benedicte, Llado, Xavier, Rovira, Alex et al.
DOI: 10.1007/s10334-021-00933-0

Scoring the 10-year risk of ambulatory disability in multiple sclerosis: the RoAD score.

PMID: 33786942
Journal: EUROPEAN JOURNAL OF NEUROLOGY
Year: 2021
Reference: Eur J Neurol. 2021 Aug;28(8):2533-2542. doi: 10.1111/ene.14845. Epub 2021 Apr 19.
Impact factor: 6.089
Publication type: Paper in international publication
Authors: Rovira, Alex, Tintore, Mar, Sastre-Garriga, Jaume, Tortorella, Carla, Haggiag, Shalom, Galgani, Simonetta, Capra, Ruggero, Pozzilli, Carlo, Montalban, Xavier, Rio, Jordi et al.
DOI: 10.1111/ene.14845

Using smartphones and wearable devices to monitor behavioural changes during COVID-19.

PMID: 32877352
Journal: JOURNAL OF MEDICAL INTERNET RESEARCH
Year: 2020
Reference: J Med Internet Res. 2020 Sep 25;22(9):e19992. doi: 10.2196/19992.
Impact factor: 5.034
Publication type: Paper in international publication
Authors: Lamers, Femke, Siddi, Sara, Haro, Josep Maria, Myin-Germeys, Inez, Rintala, Aki, Wykes, Til, Narayan, Vaibhav A, Comi, Giancarlo, Hotopf, Matthew, Dobson, Richard Jb et al.
DOI: 10.2196/19992

Multiple sclerosis management during the COVID-19 pandemic.

PMID: 32772807
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Sep;26(10):1163-1171. doi: 10.1177/1352458520948231. Epub 2020 Aug 10.
Impact factor: 5.412
Publication type: Paper in international publication
Authors: Moss, Brandon P, Mahajan, Kedar R, Bermel, Robert A, Hellisz, Kelsey, Hua, Le H, Hudec, Timothy, Husak, Scott, McGinley, Marisa P, Ontaneda, Daniel, Wang, Zhini et al.
DOI: 10.1177/1352458520948231

A pharmacogenetic study implicates NINJ2 in the response to Interferon-beta in multiple sclerosis.

PMID: 31221001
Journal: Multiple Sclerosis Journal
Year: 2020
Reference: Mult Scler. 2020 Aug;26(9):1074-1082. doi: 10.1177/1352458519851428. Epub 2019 Jun 21.
Impact factor: 5.412
Publication type: Paper in international publication
Authors: Peroni, Silvia, Sorosina, Melissa, Malhotra, Sunny, Clarelli, Ferdinando, Osiceanu, Ana Maria, Ferre, Laura, Roostaei, Tina, Rio, Jordi, Midaglia, Luciana, Villar, Luisa Maria et al.
DOI: 10.1177/1352458519851428

Endovascular management of internal carotid artery dissection with associated aneurysm using a multilayer flow modulator.

PMID: 32715174
Journal: Journal of vascular surgery cases and innovative techniques
Year: 2020
Reference: J Vasc Surg Cases Innov Tech. 2020 May 11;6(3):374-380. doi: 10.1016/j.jvscit.2020.04.006. eCollection 2020 Sep.
Impact factor: 0
Publication type: Paper in international publication
Authors: Lopez, Orlando, Pinana, Carlos, Gramegna, Laura Ludovica, Rodriguez, Jose, Hernandez, David, Tomasello, Alejandro et al.
DOI: 10.1016/j.jvscit.2020.04.006

A supervised framework with intensity subtraction and deformation field features for the detection of new T2-w lesions in multiple sclerosis.

PMID: 29234597
Journal: NeuroImage-Clinical
Year: 2018
Reference: Neuroimage Clin. 2017 Nov 20;17:607-615. doi: 10.1016/j.nicl.2017.11.015. eCollection 2018.
Impact factor: 3.869
Publication type: Paper in international publication
Authors: Salem, Mostafa, Cabezas, Mariano, Pareto, Deborah, Oliver, Arnau, Salvi, Joaquim, Rovira, Alex, Llado, Xavier, Valverde, Sergi et al.
DOI: 10.1016/j.nicl.2017.11.015

Blog

News

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

Dr. Carmen Espejo and Dr. Georgina Arrambide, researchers at Cemcat and Vall d'Hebron Research Institute, are the first authors of the article.

The research findings propose to modify the McDonald 2017 criteria, only in those in whom diagnosis using the current criteria is not possible.

Rates

Simoa HD1 equipment

We are seeking healthy volunteers for a study to find biomarkers of multiple sclerosis

We are looking for 100 healthy volunteers aged 18 or over to participate in a project where the usefulness of biomarkers in serum will be evaluated to predict the prognosis of the disease and the response to treatments.

More information