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Clinical Research/Innovation in Pneumonia & Sepsis (CRIPS)

CRIPS is a research group focusing on severe acute respiratory infections and sepsis. 

The objective is to develop projects on clinical and translational research in hospital-acquired pneumonia, community-acquired pneumonia, and severe viral respiratory infections, such as influenza and COVID-19. CRIPS also develop epidemiological studies focused on risk and prognostic factors for multi-resistant pathogens, validation of ventilator-associated events in ventilated adult and pediatric patients, incorporating artificial intelligence techniques. It also highlights evidence-based medicine (EBM) research, evaluating therapies and prevention strategies and participating in the formulation of clinical practice guidelines, as part of CIBERES and the European Society for Clinical Microbiology and Infections. The EBM research focuses on knowledge translation to get research findings to the point of decision making, providing health-related recommendations, focusing on clinical research and relevance of care. 

CRIPS collaborate on a Local (UIC, IDIAP), National (CIBERES), and International level (CHU Nimes, Uolo University, ISARIC and Pneumo-Inspire Networks).

Publications

Clinical characteristics, risk factors and outcomes in patients with severe COVID-19 registered in the International Severe Acute Respiratory and Emerging Infection Consortium WHO clinical characterisation protocol: a prospective, multinational, multicentre, observational study.

PMID: 35169585
Journal: ERJ open research
Year: 2022
Reference: ERJ Open Res. 2022 Feb 14;8(1). pii: 00552-2021. doi: 10.1183/23120541.00552-2021. eCollection 2022 Jan.
Impact factor: 0
Publication type: Paper in international publication
Authors: Kartsonaki, Christiana, Aragao, Irene, Barrett, Peter W, Beane, Abigail, Burrell, Aidan, Cheng, Matthew Pellan, Christian, Michael D, Cidade, Jose Pedro, Citarella, Barbara Wanjiru, Donnelly, Christl A et al.
DOI: 10.1183/23120541.00552-2021

Plasma Levels of Mid-Regional Proadrenomedullin Accurately Identify H1N1pdm09 Influenza Virus Patients with Risk of Intensive Care Admission and Mortality in the Emergency Department.

PMID: 35055399
Journal: Journal of Personalized Medicine
Year: 2022
Reference: J Pers Med. 2022 Jan 10;12(1). pii: jpm12010084. doi: 10.3390/jpm12010084.
Impact factor: 4.945
Publication type: Paper in international publication
Authors: Valenzuela-Mendez, Blanca, Valenzuela-Sanchez, Francisco, Rodriguez-Gutierrez, Juan Francisco, Bohollo-de-Austria, Rafael, Estella, Angel, Martinez-Garcia, Pilar, Gonzalez-Garcia, Maria Angela, Rello, Jordi et al.
DOI: 10.3390/jpm12010084

Critical appraisal of international adult bronchiectasis guidelines using the AGREE II tool.

PMID: 35074245
Journal: European Journal of Internal Medicine
Year: 2022
Reference: Eur J Intern Med. 2022 Apr;98:4-11. doi: 10.1016/j.ejim.2022.01.023. Epub 2022 Jan 21.
Impact factor: 4.624
Publication type: Paper in international publication
Authors: Tejada, Sofia, Ramirez-Estrada, Sergio, Tejo, Alexandre M, Forero, Carlos G, Pomares, Xavier, Gallego, Miguel, Soriano, Joan B, Chalmers, James D, Rello, Jordi et al.
DOI: 10.1016/j.ejim.2022.01.023

Nebulized Antibiotics for Healthcare- and Ventilator-Associated Pneumonia.

PMID: 35042259
Journal: SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
Year: 2022
Reference: Semin Respir Crit Care Med. 2022 Apr;43(2):255-270. doi: 10.1055/s-0041-1740340. Epub 2022 Jan 18.
Impact factor: 3.119
Publication type: Paper in international publication
Authors: Boisson, Matthieu, Bougle, Adrien, Sole-Lleonart, Candela, Dhanani, Jayesh, Arvaniti, Kostoula, Rello, Jordi, Rouby, Jean-Jacques, Mimoz, Olivier et al.
DOI: 10.1055/s-0041-1740340

Short-Acting Sedative-Analgesic Drugs Protect Against Development of Ventilator-Associated Events in Children: Secondary Analysis of the EUVAE Study.

PMID: 33688086
Journal: Respiratory Care
Year: 2021
Reference: Respir Care. 2021 May;66(5):798-805. doi: 10.4187/respcare.08597. Epub 2021 Mar 9.
Impact factor: 2.258
Publication type: Paper in international publication
Authors: Rello, Jordi, Lagunes, Leonel, Serrano-Megias, Marta, Ramirez-Estrada, Sergio, Pena-Lopez, Yolanda et al.
DOI: 10.4187/respcare.08597

Performance of Existing Definitions and Tests for the Diagnosis of Invasive Fungal Diseases other than Invasive Candidiasis and Invasive Aspergillosis in Critically Ill, Adult Patients: A Systematic Review with Qualitative Evidence Synthesis.

PMID: 33670864
Journal: Journal of Fungi
Year: 2021
Reference: J Fungi (Basel). 2021 Feb 28;7(3). pii: jof7030176. doi: 10.3390/jof7030176.
Impact factor: 5.816
Publication type: Review in international publication
Authors: Zuccaro, Valentina, Giacobbe, Daniele R, Cortegiani, Andrea, Karaiskos, Ilias, Mercier, Toine, Tejada, Sofia, Peghin, Maddalena, Grecchi, Cecilia, Rebuffi, Chiara, Asperges, Erika et al.
DOI: 10.3390/jof7030176

Percutaneous atrioseptostomy for left ventricular unloading in pediatric patients in cardiogenic shock on venoarterial ECMO support.

PMID: 33632636
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2021
Reference: Rev Esp Cardiol. 2021 Aug;74(8):710-712. doi: 10.1016/j.rec.2021.01.010. Epub 2021 Feb 23.
Impact factor: 4.753
Publication type: Letter whit IF
Authors: Dolader, Paola, Betrian Blasco, Pedro, Balcells, Joan, Izquierdo-Blasco, Jaume, Gran, Ferran, Marti Aguasca, Gerard et al.
DOI: 10.1016/j.rec.2021.01.010

Omalizumab outcomes for up to 6 years in pediatric patients with severe persistent allergic asthma.

PMID: 33619748
Journal: PEDIATRIC ALLERGY AND IMMUNOLOGY
Year: 2021
Reference: Pediatr Allergy Immunol. 2021 Jul;32(5):980-991. doi: 10.1111/pai.13484. Epub 2021 Mar 20.
Impact factor: 6.377
Publication type: Paper in international publication
Authors: Valdesoiro Navarrete, Laura, Ballester Asensio, Esther, Sanz Santiago, Veronica, Romero Garcia, Raquel, Gimeno Diaz de Atauri, Alvaro, Valenzuela Soria, Alfredo, Sanchez Mateos, Mercedes, Batlles Garrido, Jose, Andres Martin, Anselmo, Campos Alonso, Elena et al.
DOI: 10.1111/pai.13484

Cutaneous manifestations in COVID-19: the experiences of Barcelona and Rome.

PMID: 32330340
Journal: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
Year: 2020
Reference: J Eur Acad Dermatol Venereol. 2020 Jul;34(7):e306-e307. doi: 10.1111/jdv.16530.
Impact factor: 5.248
Publication type: Letter or abstract
Authors: Tammaro, A, Adebanjo, G A R, Parisella, F R, Pezzuto, A, Rello, J et al.
DOI: 10.1111/jdv.16530

SARS-CoV-2: First Do No Harm.

PMID: 32311297
Journal: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Year: 2020
Reference: Am J Respir Crit Care Med. 2020 Jun 1;201(11):1324-1325. doi: 10.1164/rccm.202004-1153ED.
Impact factor: 17.452
Publication type: Editorail in international publication
Authors: Waterer, Grant W, Rello, Jordi, Wunderink, Richard G et al.
DOI: 10.1164/rccm.202004-1153ED

Pneumocystis jirovecii pneumonia in children. A retrospective study in a single center over three decades.

PMID: 31272810
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2020
Reference: Enferm Infecc Microbiol Clin. 2020 Mar;38(3):111-118. doi: 10.1016/j.eimc.2019.05.005. Epub 2019 Jul 1.
Impact factor: 1.654
Publication type: Paper in national publication
Authors: Garcia-Moreno, Jorge, Melendo-Perez, Susana, Martin-Gomez, Maria Teresa, Frick, Marie Antoinette, Balcells-Ramirez, Joan, Pujol-Jover, Montserrat, Martin-Nalda, Andrea, Mendoza-Palomar, Natalia, Soler-Palacin, Pere et al.
DOI: 10.1016/j.eimc.2019.05.005

SARS-Cov-2 in Spanish Intensive Care: Early Experience with 15-day Survival In Vitoria.

PMID: 32278670
Journal: Anaesthesia Critical Care & Pain Medicine
Year: 2020
Reference: Anaesth Crit Care Pain Med. 2020 Oct;39(5):553-561. doi: 10.1016/j.accpm.2020.04.001. Epub 2020 Apr 9.
Impact factor: 2.707
Publication type: Paper in international publication
Authors: Barrasa, Helena, Rello, Jordi, Tejada, Sofia, Martin, Alejandro, Balziskueta, Goiatz, Vinuesa, Cristina, Fernandez-Miret, Borja, Villagra, Ana, Vallejo, Ana, Sebastian, Ana San et al.
DOI: 10.1016/j.accpm.2020.04.001

Ten tips for the intensive care management of transplanted lung patients.

PMID: 30840123
Journal: INTENSIVE CARE MEDICINE
Year: 2019
Reference: Intensive Care Med. 2019 Mar;45(3):371-373. doi: 10.1007/s00134-019-05578-1. Epub 2019 Mar 6.
Impact factor: 18.967
Publication type: Editorail in international publication
Authors: Welte, Tobias, Ingels, Catherine, Rello, Jordi et al.
DOI: 10.1007/s00134-019-05578-1

Correction to: The relationship between ventilator-associated pneumonia and chronic obstructive pulmonary disease: What is the current evidence?

PMID: 30820839
Journal: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Year: 2019
Reference: Eur J Clin Microbiol Infect Dis. 2019 Apr;38(4):649. doi: 10.1007/s10096-019-03518-x.
Impact factor: 2.591
Publication type: Letter or abstract
Authors: Koulenti, Despoina, Parisella, Francesca Romana, Xu, Elena, Lipman, Jeffrey, Rello, Jordi et al.
DOI: 10.1007/s10096-019-03518-x

Ventilator-Associated Pneumonia due to Drug-Resistant Acinetobacter baumannii: Risk Factors and Mortality Relation with Resistance Profiles, and Independent Predictors of In-Hospital Mortality.

PMID: 30781896
Journal: Medicina-Lithuania
Year: 2019
Reference: Medicina (Kaunas). 2019 Feb 13;55(2). pii: medicina55020049. doi: 10.3390/medicina55020049.
Impact factor: 1.467
Publication type: Paper in international publication
Authors: Adukauskiene, Dalia, Rello, Jordi, Ciginskiene, Ausra, Dambrauskiene, Asta et al.
DOI: 10.3390/medicina55020049

Infectious diseases: the 10 common truths I never believed.

PMID: 29934924
Journal: INTENSIVE CARE MEDICINE
Year: 2019
Reference: Intensive Care Med. 2019 Feb;45(2):243-245. doi: 10.1007/s00134-018-5272-z. Epub 2018 Jun 22.
Impact factor: 18.967
Publication type: Editorail in international publication
Authors: Rello, Jordi, Alp, Emine, Vandana, Kalwaje Eshwara et al.
DOI: 10.1007/s00134-018-5272-z

Severe community-acquired pneumonia: optimal management.

PMID: 28067676
Journal: CURRENT OPINION IN INFECTIOUS DISEASES
Year: 2017
Reference: Curr Opin Infect Dis. 2017 Apr;30(2):240-247. doi: 10.1097/QCO.0000000000000349.
Impact factor: 4.242
Publication type: Review in international publication
Authors: Rello, Jordi, Leoni, Davide et al.
DOI: 10.1097/QCO.0000000000000349

Pseudomonas aeruginosa ventilator-associated pneumonia management.

PMID: 26855594
Journal: Phytotaxa
Year: 2016
Reference: Infect Drug Resist. 2016 Jan 20;9:7-18. doi: 10.2147/IDR.S50669. eCollection 2016.
Impact factor: 1.087
Publication type: Review in national publication
Authors: Ramirez-Estrada, Sergio, Borgatta, Barbara, Rello, Jordi et al.
DOI: 10.2147/IDR.S50669

Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DALI) cohort.

PMID: 26433783
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2016
Reference: J Antimicrob Chemother. 2016 Jan;71(1):196-207. doi: 10.1093/jac/dkv288. Epub 2015 Oct 3.
Impact factor: 4.919
Publication type: Paper in international publication
Authors: Dupont, Herve, Abdul-Aziz, Mohd H, Lipman, Jeffrey, Akova, Murat, Bassetti, Matteo, De Waele, Jan J, Dimopoulos, George, Dulhunty, Joel, Kaukonen, Kirsi-Maija, Koulenti, Despoina et al.
DOI: 10.1093/jac/dkv288

Complications in the immediate postoperatory of lung transplantation: three years of practice at a high-experienced center.

PMID: 24638776
Journal: CHEST
Year: 2014
Reference: Chest. 2014 Mar 1;145(3 Suppl):631A. doi: 10.1378/chest.1799525.
Impact factor: 7.132
Publication type: Paper in international publication
Authors: Riera, Jordi, Caralt, Berta, Augustin, Salvador, Masclans, Joan Ramon, Canela, Merce, Roman, Antonio, Rello, Jordi et al.
DOI: 10.1378/chest.1799525

ICU readmission of a lung transplant recipient with acute respiratory failure.

PMID: 24638713
Journal: CHEST
Year: 2014
Reference: Chest. 2014 Mar 1;145(3 Suppl):563A. doi: 10.1378/chest.1823743.
Impact factor: 7.132
Publication type: Paper in international publication
Authors: Acuna, Mauricio, Riera, Jordi, Rello, Jordi, Roman, Antonio et al.
DOI: 10.1378/chest.1823743

FLOR Index to Predict the Need of Mechanical Ventilation in Patients With Pneumonia Treated With High Flow Nasal Cannula.

PMID: 24638346
Journal: CHEST
Year: 2014
Reference: Chest. 2014 Mar 1;145(3 Suppl):180A. doi: 10.1378/chest.1823812.
Impact factor: 7.132
Publication type: Paper in international publication
Authors: Caralt Ramisa, Berta, Roca, Oriol, Masclans, Joan Ramon, Garcia de Acilu, Marina, Rello, Jordi et al.
DOI: 10.1378/chest.1823812

Plasma ST2 Predicts Mortality in Patients With Acute Respiratory Distress Syndrome.

PMID: 24638340
Journal: CHEST
Year: 2014
Reference: Chest. 2014 Mar 1;145(3 Suppl):174A. doi: 10.1378/chest.1822406.
Impact factor: 7.132
Publication type: Paper in international publication
Authors: Garcia de Acilu, Marina, Roca, Oriol, Masclans, Joan Ramon, Ruano, Laura, Rello, Jordi et al.
DOI: 10.1378/chest.1822406

[Incident reporting system and management of incidents. Implementation and improvement actions derived for patient safety. One year experience.]

PMID: 23246168
Journal: MEDICINA CLINICA
Year: 2013
Reference: Med Clin (Barc). 2013 Apr 15;140(7):320-4. doi: 10.1016/j.medcli.2012.09.038. Epub 2012 Dec 13.
Impact factor: 1.399
Publication type: Paper in national publication
Authors: Angles, Roser, Llinas, Montserrat, Alerany, Carme, Garcia, Maria Victoria et al.
DOI: 10.1016/j.medcli.2012.09.038

Antifungal prophylaxis in the postoperative period of lung transplant surgery in Spain.

PMID: 23260267
Journal: Medicina Intensiva
Year: 2013
Reference: Med Intensiva. 2013 Apr;37(3):201-205. doi: 10.1016/j.medin.2012.10.003. Epub 2012 Dec 20.
Impact factor: 1.323
Publication type: Paper in national publication
Authors: Sacanell, J, Rey, T, Lopez, E, Vicente, R, Ballesteros, M A, Iranzo, R, Robles, J C, Restrepo, M I, Rello, J et al.
DOI: 10.1016/j.medin.2012.10.003

Patients with New York Heart Association class III heart failure may benefit with high flow nasal cannula supportive therapy: High flow nasal cannula in heart failure.

PMID: 23602035
Journal: JOURNAL OF CRITICAL CARE
Year: 2013
Reference: J Crit Care. 2013 Oct;28(5):741-6. doi: 10.1016/j.jcrc.2013.02.007. Epub 2013 Apr 16.
Impact factor: 2.498
Publication type: Paper in international publication
Authors: Roca, Oriol, Perez-Teran, Purificacion, Masclans, Joan R, Perez, Lourdes, Galve, Enrique, Evangelista, Arturo, Rello, Jordi et al.
DOI: 10.1016/j.jcrc.2013.02.007

Epidemiology, Clinical Features, and Prognosis of Elderly Adults with Severe Forms of Influenza A (H1N1).

PMID: 23496351
Journal: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
Year: 2013
Reference: J Am Geriatr Soc. 2013 Mar;61(3):350-6.
Impact factor: 3.978
Publication type: Paper in international publication
Authors: Gutierrez-Pizarraya, Antonio, Marquez, Juan A, Zaragoza, Rafael, Granada, Rosa, Ruiz-Santana, Sergio, Rello, Jordi, Rodriguez, Alejandro, Garnacho-Montero, Jose et al.
DOI: 10.1111/jgs.12152

Usefulness of procalcitonin clearance as a prognostic biomarker in septic shock. A prospective pilot study.

PMID: 22257436
Journal: Medicina Intensiva
Year: 2012
Reference: Med Intensiva. 2012 Oct;36(7):475-80. doi: 10.1016/j.medin.2011.11.024. Epub 2012 Jan 16.
Impact factor: 1.072
Publication type: Paper in national publication
Authors: , , , , , , et al.
DOI: 10.1016/j.medin.2011.11.024

E. coli O104:H4 outbreak and haemolytic-uraemic syndrome.

PMID: 22244215
Journal: Medicina Intensiva
Year: 2012
Reference: Med Intensiva. 2012 Nov;36(8):576-83. doi: 10.1016/j.medin.2011.11.022. Epub 2012 Jan 13.
Impact factor: 1.072
Publication type: Review in national publication
Authors: , , et al.
DOI: 10.1016/j.medin.2011.11.022

Impact of obesity in patients infected with 2009 influenza A(H1N1)..

PMID: 20688928
Journal: CHEST
Year: 2011
Reference: Chest. 2011 Feb;139(2):382-6. Epub 2010 Aug 5.
Impact factor: 6.519
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1378/chest.10-1160

Management of community-acquired pneumonia in adults.

PMID: 20693379
Journal: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Year: 2011
Reference: Am J Respir Crit Care Med. 2011 Jan 15;183(2):157-64. Epub 2010 Aug 6.
Impact factor: 10.191
Publication type: Review in international publication
Authors: Wunderink, Richard G, Rello, Jordi, Waterer, Grant W et al.
DOI: 10.1164/rccm.201002-0272CI

[Southern European Intensive Care Nurses' Knowledge of Evidence-Based Guidelines for Preventing Ventilator-Associated Pneumonia.]

PMID: 21122950
Journal: Medicina Intensiva
Year: 2011
Reference: Med Intensiva. 2011 January - February;35(1):6-12. Epub 2010 Nov 30.
Impact factor: 1.496
Publication type: Paper in national publication
Authors: , , , , , , , , , et al.
DOI: 10.1016/j.medin.2010.07.012

Acute kidney injury in critical ill patients affected by influenza A (H1N1) v infection.

PMID: 21342489
Journal: CRITICAL CARE
Year: 2011
Reference: Crit Care. 2011 Feb 22;15(1):R66.
Impact factor: 4.595
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1186/cc10046

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A study, in which Vall d'Hebron has participated, has analysed all the interventions of this type carried out between 2006 and 2020.

The work of the multinational team, which has reviewed the records of more than one million patients who have received a new organ, has found significant differences between women and men

The scientific review reports that changes in the respiratory system flora due to pollution increase the risk of suffering a hospital infection caused by multidrug-resistant organisms.