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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Team

Francisco Torralba Saban

Francisco Torralba Saban

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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JAUME VIMA BOFARULL

JAUME VIMA BOFARULL

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Joaquin Ruiz Altarejo

Joaquin Ruiz Altarejo

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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José Antonio Arranz  Amo

José Antonio Arranz Amo

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura Castellote Bellés

Laura Castellote Bellés

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Laura Castillo Ribelles

Laura Castillo Ribelles

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Francisco Torralba Saban

Francisco Torralba Saban

Research technician
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
JAUME VIMA BOFARULL

JAUME VIMA BOFARULL

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Joaquin Ruiz Altarejo

Joaquin Ruiz Altarejo

Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
José Antonio Arranz  Amo

José Antonio Arranz Amo

Postdoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Laura Castellote Bellés

Laura Castellote Bellés

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
Read more
Laura Castillo Ribelles

Laura Castillo Ribelles

Predoctoral researcher
Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT)
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Projects

Impacto y valor pronóstico de vesículas extracelulares tumorales provenientes de células madre cancerígenas en tumores de mama triple negativo.

IP: Joaquin Seras Franzoso
Collaborators: Laura García Latorre, Diego Baranda Martínez-Abasca, Sandra Mancilla Zamora, Zamira Vanessa Diaz Riascos, Belen Garcia Prats
Funding agency: Instituto de Salud Carlos III
Funding: 99220
Reference: PI22/01301
Duration: 01/01/2023 - 31/12/2025

RICORS2040 - Inflamación e inmunopatología de órganos y sistemas

IP: Maria Jose Soler Romeo
Collaborators: Francesc Moreso Mateos, Oriol Bestard Matamoros, Joana Sellarés Roig, Irina Betsabe Torres Rodriguez, Concepció Jacobs Cachá, Maria Antonia Emilia Meneghini
Funding agency: Instituto de Salud Carlos III
Funding: 105765
Reference: RD21/0005/0016
Duration: 01/01/2022 - 31/12/2024

Estudio de la quasiespecies del gen X en ARN circulante del virus de la hepatitis B (ARN-VHB): en búsqueda de nuevos factores pronósticos y dianas para terapia génica.

IP: Francisco Rodríguez Frias
Collaborators: -
Funding agency: Instituto de Salud Carlos III
Funding: 82400
Reference: FI19/00025
Duration: 23/01/2020 - 22/01/2024

Design of Nanoparticles for Blood-Brain-Barrier Crossing and Glioblastoma Multiforme Cancer Stem Cells Targeting (NanoGlio)

IP: Ibane Abasolo Olaortua
Collaborators: Fernanda Raquel Da Silva Andrade, Miriam Izquierdo Sans
Funding agency: Asociación Española Contra el Cáncer
Funding: 100000
Reference: INVES211530DASI
Duration: 01/09/2021 - 31/08/2025

Publications

Accuracy of a sequential algorithm based on FIB-4 and ELF to identify high-risk advanced liver fibrosis at the primary care level.

PMID: 37952070
Journal: Internal and Emergency Medicine
Year: 2023
Reference: Intern Emerg Med. 2023 Nov 11. doi: 10.1007/s11739-023-03441-2.
Impact factor:
Publication type: Paper in international publication
Authors: Abrisqueta, Pau; Augustin, Salvador; Campo, Elias; Casanueva-Eliceiry, Sebastian; Ciudin, Andreea; Correa, Juan Gonzalo; Delgado, Julio; Ferrer-Costa, Roser; Gabriel-Medina, Pablo; Gine, Eva et al.
DOI: 10.1007/s11739-023-03441-2

Olaparib for the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer and Alterations in BRCA1 and/or BRCA2 in the PROfound Trial.

PMID: 37963304
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2023
Reference: J Clin Oncol. 2023 Nov 14:JCO2300339. doi: 10.1200/JCO.23.00339.
Impact factor:
Publication type: Paper in international publication
Authors: Agarwal, Neeraj; Augustin, Salvador; Barnicle, Alan; Chi, Kim N; Ciudin, Andreea; de Bono, Johann S; Ferrer-Costa, Roser; Fizazi, Karim; Gabriel-Medina, Pablo; Hussain, Maha et al.
DOI: 10.1200/JCO.23.00339

Formation of an invasion-permissive matrix requires TGFbeta/SNAIL1-regulated alternative splicing of fibronectin.

PMID: 37964360
Journal: BREAST CANCER RESEARCH
Year: 2023
Reference: Breast Cancer Res. 2023 Nov 14;25(1):143. doi: 10.1186/s13058-023-01736-y.
Impact factor:
Publication type: Paper in international publication
Authors: Baulida, Josep; Benitez-Carbante, Maria Isabel; Diaz de Heredia, Cristina; Eyras, Eduardo; Fernandez Ledesma, Berta; Fernandez-Polo, Aurora; Franco-Valls, Hector; Garcia de Herreros, Antonio; Grau Cerrato, Santiago; Iaconcig, Alessandra et al.
DOI: 10.1186/s13058-023-01736-y

Reference ranges of thyroid hormones during the first trimester in Catalan women using the Atellica(R) IM Solution Immunoassay Analyzer.

PMID: 37996255
Journal: ANNALS OF CLINICAL BIOCHEMISTRY
Year: 2023
Reference: Ann Clin Biochem. 2023 Nov 23:45632231219387. doi: 10.1177/00045632231219387.
Impact factor:
Publication type: Paper in international publication
Authors: Andrade, Monica Viegas; Blanco, Albert; Bracarense, Henrique; Braga, Paulo Estevao Franco; Comas, Immaculada; Conesa, Laura; de Miranda, Maria Carolina Correa; de Souza, Aline; Diaz-Troyano, Noelia; Ferrer, Roser et al.
DOI: 10.1177/00045632231219387

Blog

News

The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

During the last year, the collaboration between Vall d’Hebron and ZeClinics has found three nanobody candidates with potent anticancer properties in zebrafish model.