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Clinical Biochemistry, Drug Delivery & Therapy

The Clinical Biochemistry, Drug Delivery & Therapy (CB-DDT) group arises from the merger of two VHIR groups, the Clinical Biochemistry group and the Drug Delivery and Targeting group, which they develop preclinical and clinical research in the diagnosis and therapy of different diseases.

With a direct link to the Clinical Biochemistry service of the Vall d'Hebron Hospital, our scope of action ranges from the analysis of massive data coming from the service, the development of diagnostic and prognostic biomarkers, evaluation of existing therapies and the development of new therapeutic strategies based on nanotechnology.

In terms of specific pathologies or indications, the group has an extensive track record in basic and applied research in cancer (new biomarkers, therapeutic targets and new treatments), metabolopathies (biomarkers and improvements in enzyme replacement therapy), kidney disease and liver disease.

Projects

EVERETT: Engineered mesenchymal stromal cell Extracellular Vesicles for immunomodulatory biotherapy and Enzyme REplacemenT Therapy

IP: Ibane Abasolo Olaortua
Collaborators: -
Funding agency: Agence Nationale de la Recherche
Funding: 0.01
Reference: EVERETT_ANR-BIOPNSE2020
Duration: 01/11/2022 - 31/10/2025

Vesículas extracelulares para el tratamiento de enfermeades lisosomales (Título provisional)

IP: Ibane Abasolo Olaortua
Collaborators: Laura García Latorre, Guillem Pintos Morell, Sandra Mancilla Zamora, Zamira Vanessa Diaz Riascos, Marc Miquel Moltó Abad
Funding agency: Instituto de Salud Carlos III
Funding: 153670
Reference: PI21/00936
Duration: 01/01/2022 - 31/12/2024

Desentrañando las vías protectoras de los SGLT2i y GLP-1RA en la enfermedad renal diabética: papel de las proteínas adaptadoras MAP17 y D-AKAP-2 en ratones db/db y organoides renales humanos.

IP: Maria Jose Soler Romeo
Collaborators: Mario Alonso Narvaez Barros, Pamela Dominguez Baez, Vergara Arana, Ander, Sheila Bermejo Garcia, Alejandra Planas Vilaseca, Concepció Jacobs Cachá, Juan Carlos León Román
Funding agency: Instituto de Salud Carlos III
Funding: 122210
Reference: PI21/01292
Duration: 01/01/2022 - 31/12/2024

Publications

In-Host HEV Quasispecies Evolution Shows the Limits of Mutagenic Antiviral Treatments.

PMID: 38139013
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2023
Reference: Int J Mol Sci. 2023 Dec 6;24(24):17185. doi: 10.3390/ijms242417185.
Impact factor:
Publication type: Paper in international publication
Authors: Adombi, Caroline Melanie; Buti, Maria; Campos, Carolina; Colomer-Castell, Sergi; Cortese, Maria Francesca; Esteban, Juan Ignacio; Garcia-Cehic, Damir; Gregori, Josep; Ibanez-Lligona, Marta; Quer, Josep et al.
DOI: 10.3390/ijms242417185

Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit.

PMID: 38188336
Journal: Frontiers in Medicine
Year: 2023
Reference: Front Med (Lausanne). 2023 Dec 20;10:1301001. doi: 10.3389/fmed.2023.1301001. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Bajana, Ivan; Camos, Silvia; Chiscano-Camon, Luis; Ferrer, Ricard; Ferrer-Costa, Roser; Martin, Laura; Martin-Rodriguez, Cristina; Palmada, Clara; Perez-Carrasco, Marcos; Plata-Menchaca, Erika P et al.
DOI: 10.3389/fmed.2023.1301001

Blog

News

The European project, in which Vall d'Hebron participates, will favor personalized diagnosis and innovative therapeutic strategies in patients with the disease.

In total, different projects of six research groups will be promoted, focusing on precision medicine and advanced therapies.

During the last year, the collaboration between Vall d’Hebron and ZeClinics has found three nanobody candidates with potent anticancer properties in zebrafish model.