About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
Medicine still has many challenges to solve specially on complex diseases were a large number of both, genetic and environmental factors are involved. Among them, neurodegenerative and autoimmune disorders affecting the central nervous system have attracted attention because CNS is difficult to access and to manipulate with classical pharmacological treatments and, in addition, there are no effective curative treatments for these diseases. To address these problems, we have focused our research interests in gene therapy strategies for autoimmune diseases and neurodegenerative disorders specially those associated to aging.
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IP: Miguel Chillon Rodriguez Collaborators: Laia Perez Lasarte, David Ramirez Gomez Funding agency: Fundació Institut de Recerca HUVH Funding: 102820.06 Reference: VHIR-PHD-2023-007 Duration: 01/02/2024 - 30/01/2028
IP: Miguel Chillon Rodriguez Collaborators: - Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 0.01 Reference: RED2022-134221-T Duration: 01/06/2023 - 31/05/2025
IP: Jordi Barquinero Mañez Collaborators: Laia Perez Lasarte, Maria Pallares Masmitja Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 67400 Reference: JDC2022-049508-I Duration: 01/01/2024 - 31/12/2025
IP: Miguel Chillon Rodriguez Collaborators: Susana Miravet Delgado, Laia Rubio Ortega, Marina Tarrés Mercader Funding agency: Instituto de Salud Carlos III Funding: 296571 Reference: PMPTA22/00048 Duration: 01/01/2023 - 31/12/2024
PMID: 36918615 Journal: Scientific Reports Year: 2023 Reference: Sci Rep. 2023 Mar 14;13(1):4211. doi: 10.1038/s41598-023-31117-6. Impact factor: Publication type: Paper in international publication Authors: Abraham, Carmela R; Bosch, Assumpcio; Chillon, Miguel; Esandi-Jauregui, Jon; Roig-Soriano, Joan; Sanchez-de-Diego, Cristina; Ventura, Francesc; Verdes, Sergi et al. DOI: 10.1038/s41598-023-31117-6
PMID: 35274439 Journal: AGING CELL Year: 2022 Reference: Aging Cell. 2022 Apr;21(4):e13581. doi: 10.1111/acel.13581. Epub 2022 Mar 10. Impact factor: 9.304 Publication type: Paper in international publication Authors: Bosch, A, Pallas, M, Chillon, Miguel, Abraham, C R, Espinosa-Parrilla, J F, Roig-Soriano, J, Grinan-Ferre, C et al. DOI: 10.1111/acel.13581
PMID: 34856394 Journal: Molecular Metabolism Year: 2022 Reference: Mol Metab. 2022 Jan;55:101408. doi: 10.1016/j.molmet.2021.101408. Epub 2021 Nov 30. Impact factor: 7.422 Publication type: Paper in international publication Authors: Leal-Julia, Marc, Vilches, Jorge J, Onieva, Andrea, Verdes, Sergi, Sanchez, Angela, Chillon, Miguel, Navarro, Xavier, Bosch, Assumpcio et al. DOI: 10.1016/j.molmet.2021.101408
PMID: 34944918 Journal: Cancers Year: 2021 Reference: Cancers (Basel). 2021 Dec 15;13(24). pii: cancers13246297. doi: 10.3390/cancers13246297. Impact factor: 6.639 Publication type: Paper in international publication Authors: Arbel Rubinstein, Tammi, Reuveni, Inbal, Hesin, Arkadi, Klein-Goldberg, Anat, Olauson, Hannes, Larsson, Tobias E, Abraham, Carmela R, Zeldich, Ella, Bosch, Assumpcio, Chillon, Miguel et al. DOI: 10.3390/cancers13246297
PMID: 34857831 Journal: Scientific Reports Year: 2021 Reference: Sci Rep. 2021 Dec 2;11(1):23358. doi: 10.1038/s41598-021-02694-1. Impact factor: 4.38 Publication type: Paper in international publication Authors: Kagiava, A, Richter, J, Tryfonos, C, Leal-Julia, M, Sargiannidou, I, Christodoulou, C, Bosch, A, Kleopa, K A et al. DOI: 10.1038/s41598-021-02694-1
PMID: 34576188 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2021 Reference: Int J Mol Sci. 2021 Sep 16;22(18). pii: ijms221810025. doi: 10.3390/ijms221810025. Impact factor: 5.924 Publication type: Paper in international publication Authors: Aubets, Eva, Chillon, Miguel, Ciudad, Carlos J, Noe, Veronique et al. DOI: 10.3390/ijms221810025
PMID: 33786805 Journal: Neurotherapeutics Year: 2021 Reference: Neurotherapeutics. 2021 Apr;18(2):1113-1126. doi: 10.1007/s13311-021-01025-6. Epub 2021 Mar 30. Impact factor: 7.62 Publication type: Paper in international publication Authors: Modol-Caballero, Guillem, Garcia-Lareu, Belen, Herrando-Grabulosa, Mireia, Verdes, Sergi, Lopez-Vales, Ruben, Pages, Gemma, Chillon, Miguel, Navarro, Xavier, Bosch, Assumpcio et al. DOI: 10.1007/s13311-021-01025-6
PMID: 33551753 Journal: Frontiers in Cellular Neuroscience Year: 2020 Reference: Front Cell Neurosci. 2021 Jan 22;14:627887. doi: 10.3389/fncel.2020.627887. eCollection 2020. Impact factor: 3.921 Publication type: Review in international publication Authors: Bosch, Assumpcio, Estevez, Raul et al. DOI: 10.3389/fncel.2020.627887
PMID: 32372403 Journal: Neurotherapeutics Year: 2020 Reference: Neurotherapeutics. 2020 Oct;17(4):2041-2053. doi: 10.1007/s13311-020-00865-y. Impact factor: 6.035 Publication type: Paper in international publication Authors: Bosch, Assumpcio, Estevez, Raul, Nunes, Virginia, Sanchez, Angela, Garcia-Lareu, Belen, Puig, Meritxell, Prat, Esther, Ruberte, Jesus, Chillon, Miguel et al. DOI: 10.1007/s13311-020-00865-y
PMID: 32032731 Journal: NEUROBIOLOGY OF DISEASE Year: 2020 Reference: Neurobiol Dis. 2020 Apr;137:104793. doi: 10.1016/j.nbd.2020.104793. Epub 2020 Feb 4. Impact factor: 5.332 Publication type: Paper in international publication Authors: Herrando-Grabulosa, Mireia, Garcia-Lareu, Belen, Solanes, Neus, Verdes, Sergi, Osta, Rosario, Francos-Quijorna, Isaac, Lopez-Vales, Ruben, Calvo, Ana Cristina, Bosch, Assumpcio, Navarro, Xavier et al. DOI: 10.1016/j.nbd.2020.104793
PMID: 31511867 Journal: HUMAN MOLECULAR GENETICS Year: 2019 Reference: Hum Mol Genet. 2019 Nov 1;28(21):3610-3624. doi: 10.1093/hmg/ddz220. Impact factor: 4.544 Publication type: Paper in international publication Authors: Pages, G, Gimenez-Llort, L, Garcia-Lareu, B, Ariza, L, Navarro, M, Casas, C, Chillon, M, Bosch, A et al. DOI: 10.1093/hmg/ddz220
PMID: 29086766 Journal: MOLECULAR PSYCHIATRY Year: 2018 Reference: Mol Psychiatry. 2018 Sep;23(9):1-11. doi: 10.1038/mp.2017.211. Epub 2017 Oct 31. Impact factor: 13.204 Publication type: Paper in international publication Authors: Masso, A, Sanchez, A, Bosch, A, Gimenez-Llort, L, Chillon, M et al. DOI: 10.1038/mp.2017.211
PMID: 29846873 Journal: NEUROMOLECULAR MEDICINE Year: 2018 Reference: Neuromolecular Med. 2018 Sep;20(3):328-342. doi: 10.1007/s12017-018-8496-8. Epub 2018 May 30. Impact factor: 2.952 Publication type: Paper in international publication Authors: Ruiz-Roso, Maria Belen, Olivares-Alvaro, Elena, Quintela, Jose Carlos, Ballesteros, Sandra, Espinosa-Parrilla, Juan F, Ruiz-Roso, Baltasar, Lahera, Vicente, de Las Heras, Natalia, Martin-Fernandez, Beatriz et al. DOI: 10.1007/s12017-018-8496-8
PMID: 28665331 Journal: Nutrients Year: 2017 Reference: Nutrients. 2017 Jun 30;9(7):681. doi: 10.3390/nu9070681. Impact factor: Publication type: Paper in international publication Authors: Cordobilla, Begona; Domingo, Joan C; Espinosa-Parrilla, Juan F; Mancera, Pilar; Pugliese, Marco; Rueda, Felix; Virgili, Noemi; Wappenhans, Blanca et al. DOI: 10.3390/nu9070681
PMID: 29171419 Journal: Neural Regeneration Research Year: 2017 Reference: Neural Regen Res. 2017 Oct;12(10):1605-1606. doi: 10.4103/1673-5374.217327. Impact factor: 1.769 Publication type: Editorail in international publication Authors: Edo, Angel, Espinosa-Parrilla, Juan Francisco et al. DOI: 10.4103/1673-5374.217327
PMID: 28593439 Journal: Neurotherapeutics Year: 2017 Reference: Neurotherapeutics. 2017 Oct;14(4):1095-1106. doi: 10.1007/s13311-017-0545-8. Impact factor: 5.166 Publication type: Paper in international publication Authors: Eixarch, Herena, Tejero, Marcos, Costa, Carme, Hirota, Keiji, Castano, A Raul, Puig, Meritxell, Stockinger, Gitta, Montalban, Xavier, Bosch, Assumpcio, Espejo, Carmen et al. DOI: 10.1007/s13311-017-0545-8
PMID: 25640021 Journal: Human Gene Therapy Methods Year: 2015 Reference: Hum Gene Ther Methods. 2015 Feb;26(1):35-42. doi: 10.1089/hgtb.2014.120. Impact factor: 2.436 Publication type: Paper in international publication Authors: Penalva, Cristina, Monfar, Merce, Chillon, Miguel, Miravet, Susana, Ontiveros, Maria, Piedra, Jose et al. DOI: 10.1089/hgtb.2014.120
PMID: 25410741 Journal: GENE THERAPY Year: 2015 Reference: Gene Ther. 2015 Feb;22(2):196-201. doi: 10.1038/gt.2014.103. Epub 2014 Nov 20. Impact factor: 3.104 Publication type: Paper in international publication Authors: Thwaite, R, Pages, G, Chillon, M, Bosch, A et al. DOI: 10.1038/gt.2014.103
PMID: 26599613 Journal: PLoS One Year: 2015 Reference: PLoS One. 2015 Nov 24;10(11):e0143623. doi: 10.1371/journal.pone.0143623. eCollection 2015. Impact factor: 3.234 Publication type: Paper in international publication Authors: Masso, Anna, Lizcano, Jose Miguel, Canete, Manuel, Garcia, Belen, Torres-Lista, Virginia, Puig, Meritxell, Bosch, Assumpcio, Chillon, Miguel, Gimenez-Llort, Lydia, Sanchez, Angela et al. DOI: 10.1371/journal.pone.0143623
PMID: 26491879 Journal: ACS Nano Year: 2015 Reference: ACS Nano. 2015 Nov 24;9(11):10826-33. doi: 10.1021/acsnano.5b03417. Epub 2015 Oct 28. Impact factor: 12.881 Publication type: Paper in international publication Authors: Ortega-Esteban, Alvaro, Condezo, Gabriela N, Perez-Berna, Ana J, Chillon, Miguel, Flint, S Jane, Reguera, David, San Martin, Carmen, de Pablo, Pedro J et al. DOI: 10.1021/acsnano.5b03417
PMID: 24897304 Journal: J PROTEOME RES Year: 2014 Reference: J Proteome Res. 2014 Aug 1;13(8):3706-3721. doi: 10.1021/pr500304g. Epub 2014 Jul 15. Impact factor: 5.001 Publication type: Paper in international publication Authors: Gregori, Josep, Mendez, Olga, Katsila, Theodora, Pujals, Mireia, Salvans, Candida, Villarreal, Laura, Sanchez, Alex, Villanueva, Josep, Tabernero, Josep, Arribas, Joaquin et al. DOI: 10.1021/pr500304g
PMID: 24299455 Journal: HUM GENE THER Year: 2014 Reference: Hum Gene Ther. 2014 Mar;25(3):199-211. doi: 10.1089/hum.2013.152. Epub 2014 Jan 23. Impact factor: 3.623 Publication type: Paper in international publication Authors: Ariza, Lorena, Gimenez-Llort, Lydia, Pages, Gemma, Garcia-Lareu, Belen, Serratrice, Nicolas, Cots, Dan, Thwaite, Rosemary, Chillon, Miguel, Kremer, Eric J, Bosch, Assumpcio et al. DOI: 10.1089/hum.2013.152
PMID: 24846610 Journal: NEUROSCIENCE Year: 2014 Reference: Neuroscience. 2014 Aug 22;274:250-9. doi: 10.1016/j.neuroscience.2014.05.015. Epub 2014 May 15. Impact factor: 3.327 Publication type: Paper in international publication Authors: Ariza, L, Pages, G, Garcia-Lareu, B, Cobianchi, S, Ruberte, J, Otaegui, P J, Chillon, M, Navarro, X, Bosch, A et al. DOI: 10.1016/j.neuroscience.2014.05.015
PMID: 26015946 Journal: Molecular therapy. Methods & clinical developm Year: 2014 Reference: Mol Ther Methods Clin Dev. 2014 Jan 15;1:7. doi: 10.1038/mtm.2013.7. eCollection 2014. Impact factor: 0 Publication type: Paper in international publication Authors: Homs, Judit, Pages, Gemma, Ariza, Lorena, Casas, Caty, Chillon, Miguel, Navarro, Xavier, Bosch, Assumpcio et al. DOI: 10.1038/mtm.2013.7
PMID: 24039890 Journal: PLoS One Year: 2013 Reference: PLoS One. 2013 Sep 11;8(9):e73227. doi: 10.1371/journal.pone.0073227. eCollection 2013. Impact factor: 3.73 Publication type: Paper in international publication Authors: Gil, Estel, Bosch, Assumpcio, Lampe, David, Lizcano, Jose M, Perales, Jose C, Danos, Olivier, Chillon, Miguel et al. DOI: 10.1371/journal.pone.0073227
PMID: 24369061 Journal: CURRENT GENE THERAPY Year: 2013 Reference: Curr Gene Ther. 2013 Oct;13(5):370-81. Impact factor: 5.318 Publication type: Review in national publication Authors: Cots, Dan, Bosch, Assumpcio, Chillon, Miguel et al. DOI:
PMID: 23746215 Journal: Human Gene Therapy Methods Year: 2013 Reference: Hum Gene Ther Methods. 2013 Aug;24(4):195-204. doi: 10.1089/hgtb.2012.096. Epub 2013 Jun 27. Impact factor: 0 Publication type: Paper in international publication Authors: Fernandez, Ester, Rodriguez, Ester, Romero, Carolina, Rio, Adolfo, Miralles, Marta, Raventos, Aida, Planells, Laura, Burgueno, Joan F, Hamada, Hirofumi, Perales, Jose Carlos et al. DOI: 10.1089/hgtb.2012.096
PMID: 23922808 Journal: PLoS One Year: 2013 Reference: PLoS One. 2013 Jul 26;8(7):e69808. doi: 10.1371/journal.pone.0069808. Print 2013. Impact factor: 3.73 Publication type: Paper in international publication Authors: Licursi, Valerio, Costa, Rossella, Roncaglia, Enrica, Gennetier, Aurelie, Ibanes, Sandy, Chillon, Miguel, Negri, Rodolfo, Tagliafico, Enrico, Kremer, Eric J, Saggio, Isabella et al. DOI: 10.1371/journal.pone.0069808
PMID: 22860056 Journal: PLoS One Year: 2012 Reference: PLoS One. 2012;7(7):e42073. doi: 10.1371/journal.pone.0042073. Epub 2012 Jul 31. Impact factor: 4.092 Publication type: Paper in international publication Authors: Miralles, Marta, Segura, Maria Mercedes, Puig, Meritxell, Bosch, Assumpcio, Chillon, Miguel et al. DOI: 10.1371/journal.pone.0042073
PhD student: Rebeca Blanch Garcia Director/s: Miguel Chillon Rodriguez University: Universitat Autònoma de Barcelona Year: 2023
PhD student: Joan Roig Soriano, Joan Roig Soriano Director/s: Miguel Chillon Rodriguez University: Universitat Autònoma de Barcelona Year: 2023
PhD student: Angel Edo Salvador Director/s: Miguel Chillon Rodriguez, Xavier Montalban Gairín University: Year: 2020
PhD student: Marc García Moure Director/s: Miguel Chillon Rodriguez University: Universidad Autònoma de Barcelona Year: 2016
This gene therapy protects mice against cognitive deficits associated with aging, improves motor function, and delays the onset of diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease.
Over the course of two days, experts presented the latest advances in vectors, different gene modification techniques and their transfer to clinical practice.
Check the current rates for the services offered by the Gene Therapy at Nervous System research group.
