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Gene Therapy at Nervous System

Medicine still has many challenges to solve specially on complex diseases were a large number of both, genetic and environmental factors are involved. Among them, neurodegenerative and autoimmune disorders affecting the central nervous system have attracted attention because CNS is difficult to access and to manipulate with classical pharmacological treatments and, in addition, there are no effective curative treatments for these diseases. To address these problems, we have focused our research interests in gene therapy strategies for autoimmune diseases and neurodegenerative disorders specially those associated to aging.
 

Team

Miguel Chillon Rodriguez

Miguel Chillon Rodriguez

Head of group
Gene Therapy at Nervous System
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Anna Jeanne Behr

Anna Jeanne Behr

Predoctoral researcher
Gene Therapy at Nervous System
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David Ramirez Gomez

David Ramirez Gomez

Predoctoral researcher
Gene Therapy at Nervous System
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Edo Salvador, Angel

Edo Salvador, Angel

Research technician
Gene Therapy at Nervous System
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Jiménez Hernández, Nerea

Jiménez Hernández, Nerea

Research technician
Gene Therapy at Nervous System
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Joan Roig Soriano

Joan Roig Soriano

Main researcher
Gene Therapy at Nervous System
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Miguel Chillon Rodriguez

Miguel Chillon Rodriguez

Head of group
Gene Therapy at Nervous System
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Anna Jeanne Behr

Anna Jeanne Behr

Predoctoral researcher
Gene Therapy at Nervous System
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David Ramirez Gomez

David Ramirez Gomez

Predoctoral researcher
Gene Therapy at Nervous System
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Edo Salvador, Angel

Edo Salvador, Angel

Research technician
Gene Therapy at Nervous System
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Jiménez Hernández, Nerea

Jiménez Hernández, Nerea

Research technician
Gene Therapy at Nervous System
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Joan Roig Soriano

Joan Roig Soriano

Main researcher
Gene Therapy at Nervous System
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Research lines

Gene Therapy Strategies for Esclerosis Multiple, an autoimmune disease affecting the nervous system

IP: -

Generation and development of more selective and less immunogenic viral vectors

IP: -

Molecular mechanisms involved in memory formation: Study of altered signaling pathways in CNS in non-pathogenic aging and in Alzheimer's Disease

IP: -

Projects

Bringing Klotho protein as a new therapy against age-associated muscle degeneration

IP: Joan Roig Soriano
Collaborators: Miguel Chillon Rodriguez, Elsa Ibarrola Carrasco, David Ramirez Gomez
Funding agency: Fundació Institut de Recerca HUVH
Funding: 10000
Reference: VHIR-FIT-24-002
Duration: 13/12/2024 - 12/12/2025

Towards an effective and safe therapy for hormonal-deficiency osteoporosis based on klotho protein

IP: Joan Roig Soriano
Collaborators: Miguel Chillon Rodriguez
Funding agency: Fundació "La Caixa"
Funding: 64450
Reference: CI24-20581
Duration: 15/10/2024 - 14/10/2026

ERDERA: European Rare Disease Research Alliance

IP: M Mar Mañu Pereira
Collaborators: Augusto Cesar Sao Aviles, Patricia González Ruiz, ERDERA: European Rare Disease Research Alliance, Miguel Chillon Rodriguez, Simon Schwartz Navarro
Funding agency: EUROPEAN COMMISSION
Funding: 1080135.58
Reference: ERDERA/EC/HLTH-2023-DISEASE-07-01/2023/MAÑU
Duration: 01/09/2024 - 31/08/2031

Use of chimeric chronokines for neurodegenerative diseases and cognitive impairments associated with aging

IP: Miguel Chillon Rodriguez
Collaborators: Laia Perez Lasarte, David Ramirez Gomez
Funding agency: Fundació Institut de Recerca HUVH
Funding: 102820.06
Reference: VHIR-PHD-2023-007
Duration: 01/02/2024 - 30/01/2028

Publications

HEBE: A novel chimeric chronokine for ameliorating memory deficits in Alzheimer's disease.

PMID: 39818099
Journal: BIOMEDICINE & PHARMACOTHERAPY
Year: 2025
Reference: Biomed Pharmacother. 2025 Jan 15;183:117815. doi: 10.1016/j.biopha.2025.117815.
Impact factor:
Publication type: Paper in international publication
Authors: Almolda, Beatriz; Blanch, Rebeca; Bosch, Assumpcio; Capilla-Lopez, Maria Dolores; Chillon, Miguel; Edo, Angel; Esandi, Jon; Giraldo, Jesus; Ramirez-Gomez, David; Renault, Pedro et al.
DOI: 10.1016/j.biopha.2025.117815

Long-term effects of s-KL treatment in wild-type mice: enhancing longevity, physical well-being, and neurological resilience.

PMID: 39988871
Journal: MOLECULAR THERAPY
Year: 2025
Reference: Mol Ther. 2025 Feb 22:S1525-0016(25)00120-0. doi: 10.1016/j.ymthe.2025.02.030.
Impact factor:
Publication type: Paper in international publication
Authors: Abraham, Carmela R; Bosch, Assumpcio; Chillon, Miguel; Edo, Angel; Jordan, Bryen A; Martin-Alonso, Carlos; Munoz-Canoves, Pura; Rodriguez-Estevez, Laura; Roig-Soriano, Joan; Sanchez-de-Diego, Cristina et al.
DOI: 10.1016/j.ymthe.2025.02.030

Gene therapy rescues brain edema and motor function in a mouse model of megalencephalic leukoencephalopathy with subcortical cysts.

PMID: 40051162
Journal: MOLECULAR THERAPY
Year: 2025
Reference: Mol Ther. 2025 Mar 5:S1525-0016(25)00173-X. doi: 10.1016/j.ymthe.2025.02.046.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Assumpcio; Brao, Alejandro; Chillon, Miguel; Del Rey, Javier; Estevez, Raul; Lope-Piedrafita, Silvia; Nunes, Virginia; Prat, Esther; Rodriguez, Irina; Sanchez, Angela et al.
DOI: 10.1016/j.ymthe.2025.02.046

Rituximab maintenance after bendamustine-based treatment for follicular lymphoma and mantle cell lymphoma may exert a negative influence on SARS-CoV-2 infection outcomes.

PMID: 38988269
Journal: HAEMATOLOGICA
Year: 2024
Reference: Haematologica. 2024 Jul 11. doi: 10.3324/haematol.2024.285219.
Impact factor:
Publication type: Paper in international publication
Authors: Abrisqueta, Pau; Bosch, Francesc; Bosch, Marc; Cabirta, Alba; Cordoba, Raul; Ferrero, Ainara; Garcia, Cristina; Garcia, Tomas; Gonzalez-Barca, Eva; Iacoboni, Gloria et al.
DOI: 10.3324/haematol.2024.285219

An in vitro and in vivo efficacy evaluation of gene therapy candidate SBT101 in mouse models of adrenomyeloneuropathy and in NHPs.

PMID: 39524975
Journal: Molecular Therapy Methods & Clinical Development
Year: 2024
Reference: Mol Ther Methods Clin Dev. 2024 Oct 9;32(4):101354. doi: 10.1016/j.omtm.2024.101354. eCollection 2024 Dec 12.
Impact factor:
Publication type: Paper in international publication
Authors: Anderson, David W; Bosch, Assumpcio; Clark, Sean W; Dijkstra, Inge M E; Eichler, Florian; Fourcade, Stephane; Gong, Yi; Guilera, Cristina; Kemp, Stephan; Kozarsky, Karen et al.
DOI: 10.1016/j.omtm.2024.101354

Differential toxicity profile of secreted and processed alpha-Klotho expression over mineral metabolism and bone microstructure.

PMID: 36918615
Journal: Scientific Reports
Year: 2023
Reference: Sci Rep. 2023 Mar 14;13(1):4211. doi: 10.1038/s41598-023-31117-6.
Impact factor:
Publication type: Paper in international publication
Authors: Abraham, Carmela R; Bosch, Assumpcio; Chillon, Miguel; Esandi-Jauregui, Jon; Roig-Soriano, Joan; Sanchez-de-Diego, Cristina; Ventura, Francesc; Verdes, Sergi et al.
DOI: 10.1038/s41598-023-31117-6

Optimized N-methyl-D-aspartate receptor antagonist exhibits hippocampal proneurogenic effects in aged senescence-accelerated mouse prone 8 mice.

PMID: 36062512
Journal: NEUROREPORT
Year: 2022
Reference: Neuroreport. 2022 Oct 5;33(14):623-628. doi: 10.1097/WNR.0000000000001825. Epub 2022 Aug 20.
Impact factor:
Publication type: Paper in international publication
Authors: Chillon, Miguel; Companys-Alemany, Julia; Grinan-Ferre, Christian; Pallas, Merce; Roig-Soriano, Joan; Turcu, Andreea L; Vazquez, Santiago et al.
DOI: 10.1097/WNR.0000000000001825

Therapeutic Effect of IL-21 Blockage by Gene Therapy in Experimental Autoimmune Encephalomyelitis.

PMID: 35902536
Journal: Neurotherapeutics
Year: 2022
Reference: Neurotherapeutics. 2022 Sep;19(5):1617-1633. doi: 10.1007/s13311-022-01279-8. Epub 2022 Jul 28.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Assumpcio; Calvo-Barreiro, Laura; Chillon, Miguel; Edo, Angel; Eixarch, Herena; Espejo, Carmen et al.
DOI: 10.1007/s13311-022-01279-8

AAV-mediated expression of secreted and transmembrane alphaKlotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice.

PMID: 35274439
Journal: AGING CELL
Year: 2022
Reference: Aging Cell. 2022 Apr;21(4):e13581. doi: 10.1111/acel.13581. Epub 2022 Mar 10.
Impact factor:
Publication type: Paper in international publication
Authors: Abraham, C R; Bosch, A; Chillon, Miguel; Espinosa-Parrilla, J F; Grinan-Ferre, C; Pallas, M; Roig-Soriano, J et al.
DOI: 10.1111/acel.13581

PROTEOMIC QUANTITATIVE STUDY OF DORSAL ROOT GANGLIA AND SCIATIC NERVE IN TYPE 2 DIABETIC MICE.

PMID: 34856394
Journal: Molecular Metabolism
Year: 2022
Reference: Mol Metab. 2022 Jan;55:101408. doi: 10.1016/j.molmet.2021.101408. Epub 2021 Nov 30.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Assumpcio; Chillon, Miguel; Leal-Julia, Marc; Navarro, Xavier; Onieva, Andrea; Sanchez, Angela; Verdes, Sergi; Vilches, Jorge J et al.
DOI: 10.1016/j.molmet.2021.101408

A Transgenic Model Reveals the Role of Klotho in Pancreatic Cancer Development and Paves the Way for New Klotho-Based Therapy.

PMID: 34944918
Journal: Cancers
Year: 2021
Reference: Cancers (Basel). 2021 Dec 15;13(24). pii: cancers13246297. doi: 10.3390/cancers13246297.
Impact factor:
Publication type: Paper in international publication
Authors: Abraham, Carmela R; Arbel Rubinstein, Tammi; Bosch, Assumpcio; Chillon, Miguel; Hesin, Arkadi; Hollander, Kenneth Samuel; Klein-Goldberg, Anat; Larsson, Tobias E; Olauson, Hannes; Reuveni, Inbal et al.
DOI: 10.3390/cancers13246297

Efficacy of AAV serotypes to target Schwann cells after intrathecal and intravenous delivery.

PMID: 34857831
Journal: Scientific Reports
Year: 2021
Reference: Sci Rep. 2021 Dec 2;11(1):23358. doi: 10.1038/s41598-021-02694-1.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, A; Christodoulou, C; Kagiava, A; Kleopa, K A; Leal-Julia, M; Richter, J; Sargiannidou, I; Tryfonos, C et al.
DOI: 10.1038/s41598-021-02694-1

Gene Therapy Overexpressing Neuregulin 1 Type I in Combination With Neuregulin 1 Type III Promotes Functional Improvement in the SOD1(G93A) ALS Mice.

PMID: 34630277
Journal: Frontiers in Neurology
Year: 2021
Reference: Front Neurol. 2021 Sep 22;12:693309. doi: 10.3389/fneur.2021.693309. eCollection 2021.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Assumpcio; Francos-Quijorna, Isaac; Garcia-Lareu, Belen; Hernandez, Neus; Herrando-Grabulosa, Mireia; Lopez-Vales, Ruben; Modol-Caballero, Guillem; Navarro, Xavier; Verdes, Sergi et al.
DOI: 10.3389/fneur.2021.693309

PolyPurine Reverse Hoogsteen Hairpins Work as RNA Species for Gene Silencing.

PMID: 34576188
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2021
Reference: Int J Mol Sci. 2021 Sep 16;22(18). pii: ijms221810025. doi: 10.3390/ijms221810025.
Impact factor:
Publication type: Paper in international publication
Authors: Aubets, Eva; Chillon, Miguel; Ciudad, Carlos J; Noe, Veronique et al.
DOI: 10.3390/ijms221810025

Chapter 10 - Gene therapy approaches in central nervous system regenerative medicine

PMID: NOPMID0091
Journal: Handbook of Innovations in Central Nervous System Regenerative Medicine
Year: 2020
Reference: In: Handbook of Innovations in Central Nervous System Regenerative Medicine. Elsevier; 2020. p. 375-98.
Impact factor:
Publication type: Letter or abstract
Authors: Bosch, Assumpció ; Chillon, Miguel et al.
DOI: 10.1016/B978-0-12-818084-6.00010-6

Megalencephalic Leukoencephalopathy: Insights Into Pathophysiology and Perspectives for Therapy.

PMID: 33551753
Journal: Frontiers in Cellular Neuroscience
Year: 2020
Reference: Front Cell Neurosci. 2021 Jan 22;14:627887. doi: 10.3389/fncel.2020.627887. eCollection 2020.
Impact factor:
Publication type: Review in international publication
Authors: Bosch, Assumpcio; Estevez, Raul et al.
DOI: 10.3389/fncel.2020.627887

Cerebellar Astrocyte Transduction as Gene Therapy for Megalencephalic Leukoencephalopathy.

PMID: 32372403
Journal: Neurotherapeutics
Year: 2020
Reference: Neurotherapeutics. 2020 Oct;17(4):2041-2053. doi: 10.1007/s13311-020-00865-y.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Assumpcio; Chillon, Miguel; Estevez, Raul; Garcia-Lareu, Belen; Nunes, Virginia; Prat, Esther; Puig, Meritxell; Ruberte, Jesus; Sanchez, Angela et al.
DOI: 10.1007/s13311-020-00865-y

Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1(G93A) ALS mice.

PMID: 32032731
Journal: NEUROBIOLOGY OF DISEASE
Year: 2020
Reference: Neurobiol Dis. 2020 Apr;137:104793. doi: 10.1016/j.nbd.2020.104793. Epub 2020 Feb 4.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Assumpcio; Calvo, Ana Cristina; Francos-Quijorna, Isaac; Garcia-Lareu, Belen; Herrando-Grabulosa, Mireia; Lopez-Vales, Ruben; Modol-Caballero, Guillem; Navarro, Xavier; Osta, Rosario; Solanes, Neus et al.
DOI: 10.1016/j.nbd.2020.104793

Intrathecal AAVrh10 corrects Biochemical and Histological Hallmarks of Mucopolysaccharidosis VII Mice and Improves Behavior and Survival.

PMID: 31511867
Journal: HUMAN MOLECULAR GENETICS
Year: 2019
Reference: Hum Mol Genet. 2019 Nov 1;28(21):3610-3624. doi: 10.1093/hmg/ddz220.
Impact factor:
Publication type: Paper in international publication
Authors: Ariza, L; Bosch, A; Casas, C; Chillon, M; Garcia-Lareu, B; Gimenez-Llort, L; Navarro, M; Pages, G et al.
DOI: 10.1093/hmg/ddz220

Intrathecal AAVrh10 corrects Biochemical and Histological Hallmarks of Mucopolysaccharidosis VII Mice and Improves Behavior and Survival.

PMID: 31511867
Journal: HUMAN MOLECULAR GENETICS
Year: 2019
Reference: Hum Mol Genet. 2019 Nov 1;28(21):3610-3624. doi: 10.1093/hmg/ddz220.
Impact factor: 4.544
Publication type: Paper in international publication
Authors: Pages, G, Gimenez-Llort, L, Garcia-Lareu, B, Ariza, L, Navarro, M, Casas, C, Chillon, M, Bosch, A et al.
DOI: 10.1093/hmg/ddz220

Secreted alphaKlotho isoform protects against age-dependent memory deficits.

PMID: 29086766
Journal: MOLECULAR PSYCHIATRY
Year: 2018
Reference: Mol Psychiatry. 2018 Sep;23(9):1-11. doi: 10.1038/mp.2017.211. Epub 2017 Oct 31.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, A; Chillon, M; Gimenez-Llort, L; Masso, A; Sanchez, A et al.
DOI: 10.1038/mp.2017.211

Effects of Low Phytanic Acid-Concentrated DHA on Activated Microglial Cells: Comparison with a Standard Phytanic Acid-Concentrated DHA.

PMID: 29846873
Journal: NEUROMOLECULAR MEDICINE
Year: 2018
Reference: Neuromolecular Med. 2018 Sep;20(3):328-342. doi: 10.1007/s12017-018-8496-8. Epub 2018 May 30.
Impact factor:
Publication type: Paper in international publication
Authors: Ballesteros, Sandra; de Las Heras, Natalia; Espinosa-Parrilla, Juan F; Lahera, Vicente; Martin-Fernandez, Beatriz; Olivares-Alvaro, Elena; Quintela, Jose Carlos; Ruiz-Roso, Baltasar; Ruiz-Roso, Maria Belen et al.
DOI: 10.1007/s12017-018-8496-8

Secreted alphaKlotho isoform protects against age-dependent memory deficits.

PMID: 29086766
Journal: MOLECULAR PSYCHIATRY
Year: 2018
Reference: Mol Psychiatry. 2018 Sep;23(9):1-11. doi: 10.1038/mp.2017.211. Epub 2017 Oct 31.
Impact factor: 13.204
Publication type: Paper in international publication
Authors: Masso, A, Sanchez, A, Bosch, A, Gimenez-Llort, L, Chillon, M et al.
DOI: 10.1038/mp.2017.211

Effects of Low Phytanic Acid-Concentrated DHA on Activated Microglial Cells: Comparison with a Standard Phytanic Acid-Concentrated DHA.

PMID: 29846873
Journal: NEUROMOLECULAR MEDICINE
Year: 2018
Reference: Neuromolecular Med. 2018 Sep;20(3):328-342. doi: 10.1007/s12017-018-8496-8. Epub 2018 May 30.
Impact factor: 2.952
Publication type: Paper in international publication
Authors: Ruiz-Roso, Maria Belen, Olivares-Alvaro, Elena, Quintela, Jose Carlos, Ballesteros, Sandra, Espinosa-Parrilla, Juan F, Ruiz-Roso, Baltasar, Lahera, Vicente, de Las Heras, Natalia, Martin-Fernandez, Beatriz et al.
DOI: 10.1007/s12017-018-8496-8

Soluble interleukin 23 receptor gene therapy with adeno-associated vectors for the treatment of multiple sclerosis.

PMID: 29171419
Journal: Neural Regeneration Research
Year: 2017
Reference: Neural Regen Res. 2017 Oct;12(10):1605-1606. doi: 10.4103/1673-5374.217327.
Impact factor:
Publication type: Editorail in international publication
Authors: Edo, Angel; Espinosa-Parrilla, Juan Francisco et al.
DOI: 10.4103/1673-5374.217327

Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor.

PMID: 28593439
Journal: Neurotherapeutics
Year: 2017
Reference: Neurotherapeutics. 2017 Oct;14(4):1095-1106. doi: 10.1007/s13311-017-0545-8.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Assumpcio; Castano, A Raul; Chillon, Miguel; Costa, Carme; Eixarch, Herena; Espejo, Carmen; Hirota, Keiji; Miralles, Marta; Montalban, Xavier; Puig, Meritxell et al.
DOI: 10.1007/s13311-017-0545-8

Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice.

PMID: 28665331
Journal: Nutrients
Year: 2017
Reference: Nutrients. 2017 Jun 30;9(7):681. doi: 10.3390/nu9070681.
Impact factor:
Publication type: Paper in international publication
Authors: Cordobilla, Begona; Domingo, Joan C; Espinosa-Parrilla, Juan F; Mancera, Pilar; Pugliese, Marco; Rueda, Felix; Virgili, Noemi; Wappenhans, Blanca et al.
DOI: 10.3390/nu9070681

Soluble interleukin 23 receptor gene therapy with adeno-associated vectors for the treatment of multiple sclerosis.

PMID: 29171419
Journal: Neural Regeneration Research
Year: 2017
Reference: Neural Regen Res. 2017 Oct;12(10):1605-1606. doi: 10.4103/1673-5374.217327.
Impact factor: 1.769
Publication type: Editorail in international publication
Authors: Edo, Angel, Espinosa-Parrilla, Juan Francisco et al.
DOI: 10.4103/1673-5374.217327

Structures of Adenovirus Incomplete Particles Clarify Capsid Architecture and Show Maturation Changes of Packaging Protein L1 52/55k.

PMID: 26178997
Journal: J VIROL
Year: 2015
Reference: J Virol. 2015 Sep;89(18):9653-64. doi: 10.1128/JVI.01453-15. Epub 2015 Jul 15.
Impact factor:
Publication type: Paper in international publication
Authors: Alba, Raul; Ayora, Silvia; Carazo, Jose M; Chillon, Miguel; Condezo, Gabriela N; Marabini, Roberto; San Martin, Carmen et al.
DOI: 10.1128/JVI.01453-15

Development of a rapid, robust, and universal picogreen-based method to titer adeno-associated vectors.

PMID: 25640021
Journal: HUM GENE THER METHOD
Year: 2015
Reference: Hum Gene Ther Methods. 2015 Feb;26(1):35-42. doi: 10.1089/hgtb.2014.120.
Impact factor:
Publication type: Paper in international publication
Authors: Chillon, Miguel; Miravet, Susana; Monfar, Merce; Ontiveros, Maria; Penalva, Cristina; Piedra, Jose et al.
DOI: 10.1089/hgtb.2014.120

AAVrh.10 immunogenicity in mice and humans. Relevance of antibody cross-reactivity in human gene therapy.

PMID: 25410741
Journal: GENE THER
Year: 2015
Reference: Gene Ther. 2015 Feb;22(2):196-201. doi: 10.1038/gt.2014.103. Epub 2014 Nov 20.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, A; Chillon, M; Pages, G; Thwaite, R et al.
DOI: 10.1038/gt.2014.103

Secreted and Transmembrane alphaKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression.

PMID: 26599613
Journal: PLOS ONE
Year: 2015
Reference: PLoS One. 2015 Nov 24;10(11):e0143623. doi: 10.1371/journal.pone.0143623. eCollection 2015.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Assumpcio; Canete, Manuel; Chillon, Miguel; Garcia, Belen; Gimenez-Llort, Lydia; Lizcano, Jose Miguel; Masso, Anna; Puig, Meritxell; Sanchez, Angela; Torres-Lista, Virginia et al.
DOI: 10.1371/journal.pone.0143623

Enhancing the Biological Relevance of Secretome-Based Proteomics by Linking Tumor Cell Proliferation and Protein Secretion.

PMID: 24897304
Journal: JOURNAL OF PROTEOME RESEARCH
Year: 2014
Reference: J Proteome Res. 2014 Aug 1;13(8):3706-3721. doi: 10.1021/pr500304g. Epub 2014 Jul 15.
Impact factor:
Publication type: Paper in international publication
Authors: Arribas, Joaquin; Gregori, Josep; Katsila, Theodora; Mendez, Olga; Pujals, Mireia; Salvans, Candida; Sanchez, Alex; Tabernero, Josep; Villanueva, Josep; Villarreal, Laura et al.
DOI: 10.1021/pr500304g

Production of chimeric adenovirus.

PMID: 24132489
Journal: Methods in molecular biology (Clifton, N.J.)
Year: 2014
Reference: Methods Mol Biol. 2014;1089:231-43. doi: 10.1007/978-1-62703-679-5_16.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Assumpcio; Chillon, Miguel; Garcia, Marc; Miralles, Marta; Tejero, Marcos et al.
DOI: 10.1007/978-1-62703-679-5_16

Central nervous system delivery of helper-dependent canine adenovirus corrects neuropathology and behavior in mucopolysaccharidosis type VII mice.

PMID: 24299455
Journal: HUMAN GENE THERAPY
Year: 2014
Reference: Hum Gene Ther. 2014 Mar;25(3):199-211. doi: 10.1089/hum.2013.152. Epub 2014 Jan 23.
Impact factor:
Publication type: Paper in international publication
Authors: Ariza, Lorena; Bosch, Assumpcio; Chillon, Miguel; Cots, Dan; Cubizolle, Aurelie; Garcia-Lareu, Belen; Gimenez-Llort, Lydia; Kremer, Eric J; Pages, Gemma; Serratrice, Nicolas et al.
DOI: 10.1089/hum.2013.152

Experimental diabetes in neonatal mice induces early peripheral sensorimotor neuropathy.

PMID: 24846610
Journal: NEUROSCIENCE
Year: 2014
Reference: Neuroscience. 2014 Aug 22;274:250-9. doi: 10.1016/j.neuroscience.2014.05.015. Epub 2014 May 15.
Impact factor:
Publication type: Paper in international publication
Authors: Ariza, L; Bosch, A; Chillon, M; Cobianchi, S; Garcia-Lareu, B; Navarro, X; Otaegui, P J; Pages, G; Ruberte, J et al.
DOI: 10.1016/j.neuroscience.2014.05.015

Adeno-associated virus enhances wild-type and oncolytic adenovirus spread.

PMID: 24020980
Journal: Human gene therapy methods
Year: 2013
Reference: Hum Gene Ther Methods. 2013 Dec;24(6):372-80. doi: 10.1089/hgtb.2013.124. Epub 2013 Oct 8.
Impact factor:
Publication type: Paper in international publication
Authors: Alemany, Ramon; Cascallo, Manel; Chillon, Miguel; Laborda, Eduardo; Puig-Saus, Cristina et al.
DOI: 10.1089/hgtb.2013.124

Functional characterization of the human mariner transposon Hsmar2.

PMID: 24039890
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Sep 11;8(9):e73227. doi: 10.1371/journal.pone.0073227. eCollection 2013.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Assumpcio; Chillon, Miguel; Danos, Olivier; Gil, Estel; Lampe, David; Lizcano, Jose M; Perales, Jose C et al.
DOI: 10.1371/journal.pone.0073227

Helper dependent adenovirus vectors: progress and future prospects.

PMID: 24369061
Journal: CURRENT GENE THERAPY
Year: 2013
Reference: Curr Gene Ther. 2013 Oct;13(5):370-81.
Impact factor:
Publication type: Review in national publication
Authors: Bosch, Assumpcio; Chillon, Miguel; Cots, Dan et al.
DOI:

Short-fiber protein of ad40 confers enteric tropism and protection against acidic gastrointestinal conditions.

PMID: 23746215
Journal: Human gene therapy methods
Year: 2013
Reference: Hum Gene Ther Methods. 2013 Aug;24(4):195-204. doi: 10.1089/hgtb.2012.096. Epub 2013 Jun 27.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Assumpcio; Burgueno, Joan F; Chillon, Miguel; Fernandez, Ester; Gassull, Miguel Angel; Hamada, Hirofumi; Miralles, Marta; Perales, Jose Carlos; Planells, Laura; Raventos, Aida et al.
DOI: 10.1089/hgtb.2012.096

Efficient amplification of chimeric adenovirus 5/40S vectors carrying the short fiber protein of Ad40 in suspension cell cultures.

PMID: 22860056
Journal: PLoS One
Year: 2012
Reference: PLoS One. 2012;7(7):e42073. doi: 10.1371/journal.pone.0042073. Epub 2012 Jul 31.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Assumpcio; Chillon, Miguel; Miralles, Marta; Puig, Meritxell; Segura, Maria Mercedes et al.
DOI: 10.1371/journal.pone.0042073

Efficient amplification of chimeric adenovirus 5/40S vectors carrying the short fiber protein of Ad40 in suspension cell cultures.

PMID: 22860056
Journal: PLoS One
Year: 2012
Reference: PLoS One. 2012;7(7):e42073. doi: 10.1371/journal.pone.0042073. Epub 2012 Jul 31.
Impact factor: 4.092
Publication type: Paper in international publication
Authors: Miralles, Marta, Segura, Maria Mercedes, Puig, Meritxell, Bosch, Assumpcio, Chillon, Miguel et al.
DOI: 10.1371/journal.pone.0042073

Thesis

AAV-mediated expression of Secreted Klotho as a therapeutic strategy for Alzheimer’s disease

PhD student: Rebeca Blanch Garcia
Director/s: Miguel Chillon Rodriguez
University: Universitat Autònoma de Barcelona
Year: 2023

Safety and therapeutical efficacy of the antiageing protein klotho for treating age-associated deficits and increasing longevity

PhD student: Joan Roig Soriano, Joan Roig Soriano
Director/s: Miguel Chillon Rodriguez
University: Universitat Autònoma de Barcelona
Year: 2023

Desarrollo de nuevas estrategias de terapia génica como tratamiento inmunomodulador de la esclerosis múltiple

PhD student: Angel Edo Salvador
Director/s: Miguel Chillon Rodriguez, Xavier Montalban Gairín
University:
Year: 2020

Generación de un adenovirus quimérico Ad5/52s pseudotipado con la proteína fiber corta del Ad52 para su caracterización in vitro e in vivo como vector de terapia génica

PhD student: Marc García Moure
Director/s: Miguel Chillon Rodriguez
University: Universidad Autònoma de Barcelona
Year: 2016

Blog

News

The European Rare Diseases Research Alliance (ERDERA) kicked off this September, with an estimated budget of 380 million euros and the aim of improving the lives of 30 million rare disease patients in Europe and beyond.

This gene therapy protects mice against cognitive deficits associated with aging, improves motor function, and delays the onset of diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease.

Over the course of two days, experts presented the latest advances in vectors, different gene modification techniques and their transfer to clinical practice.

Rates

Check the current rates for the services offered by the Gene Therapy at Nervous System research group.