About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
Medicine still has many challenges to solve specially on complex diseases were a large number of both, genetic and environmental factors are involved. Among them, neurodegenerative and autoimmune disorders affecting the central nervous system have attracted attention because CNS is difficult to access and to manipulate with classical pharmacological treatments and, in addition, there are no effective curative treatments for these diseases. To address these problems, we have focused our research interests in gene therapy strategies for autoimmune diseases and neurodegenerative disorders specially those associated to aging.
IP: Miguel Chillon Rodriguez Collaborators: - Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 0.01 Reference: RED2022-134221-T Duration: 01/06/2023 - 31/05/2025
IP: Jordi Barquinero Mañez Collaborators: Laia Perez Lasarte, Maria Pallares Masmitja Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 67400 Reference: JDC2022-049508-I Duration: 01/01/2024 - 31/12/2025
IP: Miguel Chillon Rodriguez Collaborators: Susana Miravet Delgado, Laia Rubio Ortega, Marina Tarrés Mercader, ESTUDIO Y DESARROLLO DE LA PRIMERA PLATAFORMA TECNOLÓGICA DE ENSAYOS PARA VIRUS ADENOASOCIADOS EN TERÁPIA GÉNICA, Almudena Sanchez Garcia Funding agency: Instituto de Salud Carlos III Funding: 296571 Reference: PMPTA22/00048 Duration: 01/01/2023 - 30/06/2025
IP: Jordi Barquinero Mañez Collaborators: Laura Costa Comellas, Francina Munell Casadesus, David Gómez Andrés, Rocío Piñera Moreno, Maria Pallares Masmitja Funding agency: Instituto de Salud Carlos III Funding: 117370 Reference: PI22/01027 Duration: 01/01/2023 - 31/12/2025
PMID: 35274439 Journal: AGING CELL Year: 2022 Reference: Aging Cell. 2022 Apr;21(4):e13581. doi: 10.1111/acel.13581. Epub 2022 Mar 10. Impact factor: 9.304 Publication type: Paper in international publication Authors: Bosch, A, Pallas, M, Chillon, Miguel, Abraham, C R, Espinosa-Parrilla, J F, Roig-Soriano, J, Grinan-Ferre, C et al. DOI: 10.1111/acel.13581
PMID: 34856394 Journal: Molecular Metabolism Year: 2022 Reference: Mol Metab. 2022 Jan;55:101408. doi: 10.1016/j.molmet.2021.101408. Epub 2021 Nov 30. Impact factor: 7.422 Publication type: Paper in international publication Authors: Leal-Julia, Marc, Vilches, Jorge J, Onieva, Andrea, Verdes, Sergi, Sanchez, Angela, Chillon, Miguel, Navarro, Xavier, Bosch, Assumpcio et al. DOI: 10.1016/j.molmet.2021.101408
PMID: 33786805 Journal: Neurotherapeutics Year: 2021 Reference: Neurotherapeutics. 2021 Apr;18(2):1113-1126. doi: 10.1007/s13311-021-01025-6. Epub 2021 Mar 30. Impact factor: Publication type: Paper in international publication Authors: Bosch, Assumpcio; Chillon, Miguel; Garcia-Lareu, Belen; Herrando-Grabulosa, Mireia; Lopez-Vales, Ruben; Modol-Caballero, Guillem; Navarro, Xavier; Pages, Gemma; Verdes, Sergi et al. DOI: 10.1007/s13311-021-01025-6
PMID: 33572045 Journal: Nutrients Year: 2021 Reference: Nutrients. 2021 Feb 9;13(2). pii: nu13020562. doi: 10.3390/nu13020562. Impact factor: Publication type: Paper in international publication Authors: Arnau-Barres, Isabel; Chillon, Miguel; Diez, Juana; Garcia-Giralt, Natalia; Gomez-Zorrilla, Silvia; Guerri-Fernandez, Robert; Herrera-Fernandez, Victor; Horcajada, Juan Pablo; Lopez-Montesinos, Inmaculada; Nogues, Xavier et al. DOI: 10.3390/nu13020562
PMID: 33571701 Journal: AGEING RESEARCH REVIEWS Year: 2021 Reference: Ageing Res Rev. 2021 May;67:101271. doi: 10.1016/j.arr.2021.101271. Epub 2021 Feb 8. Impact factor: Publication type: Review in international publication Authors: Andres-Lacueva, Cristina; Bellver-Sanchis, Aina; Chillon, Miguel; Corpas, Ruben; Grinan-Ferre, Christian; Izquierdo, Vanessa; Pallas, Merce; Roig-Soriano, Joan; Sanfeliu, Coral; Somogyvari, Milan et al. DOI: 10.1016/j.arr.2021.101271
PMID: 34944918 Journal: Cancers Year: 2021 Reference: Cancers (Basel). 2021 Dec 15;13(24). pii: cancers13246297. doi: 10.3390/cancers13246297. Impact factor: 6.639 Publication type: Paper in international publication Authors: Arbel Rubinstein, Tammi, Reuveni, Inbal, Hesin, Arkadi, Klein-Goldberg, Anat, Olauson, Hannes, Larsson, Tobias E, Abraham, Carmela R, Zeldich, Ella, Bosch, Assumpcio, Chillon, Miguel et al. DOI: 10.3390/cancers13246297
PMID: 33551753 Journal: Frontiers in Cellular Neuroscience Year: 2020 Reference: Front Cell Neurosci. 2021 Jan 22;14:627887. doi: 10.3389/fncel.2020.627887. eCollection 2020. Impact factor: 3.921 Publication type: Review in international publication Authors: Bosch, Assumpcio, Estevez, Raul et al. DOI: 10.3389/fncel.2020.627887
PMID: 32372403 Journal: Neurotherapeutics Year: 2020 Reference: Neurotherapeutics. 2020 Oct;17(4):2041-2053. doi: 10.1007/s13311-020-00865-y. Impact factor: 6.035 Publication type: Paper in international publication Authors: Bosch, Assumpcio, Estevez, Raul, Nunes, Virginia, Sanchez, Angela, Garcia-Lareu, Belen, Puig, Meritxell, Prat, Esther, Ruberte, Jesus, Chillon, Miguel et al. DOI: 10.1007/s13311-020-00865-y
PMID: 32032731 Journal: NEUROBIOLOGY OF DISEASE Year: 2020 Reference: Neurobiol Dis. 2020 Apr;137:104793. doi: 10.1016/j.nbd.2020.104793. Epub 2020 Feb 4. Impact factor: 5.332 Publication type: Paper in international publication Authors: Herrando-Grabulosa, Mireia, Garcia-Lareu, Belen, Solanes, Neus, Verdes, Sergi, Osta, Rosario, Francos-Quijorna, Isaac, Lopez-Vales, Ruben, Calvo, Ana Cristina, Bosch, Assumpcio, Navarro, Xavier et al. DOI: 10.1016/j.nbd.2020.104793
PMID: 28593439 Journal: Neurotherapeutics Year: 2017 Reference: Neurotherapeutics. 2017 Oct;14(4):1095-1106. doi: 10.1007/s13311-017-0545-8. Impact factor: 5.166 Publication type: Paper in international publication Authors: Eixarch, Herena, Tejero, Marcos, Costa, Carme, Hirota, Keiji, Castano, A Raul, Puig, Meritxell, Stockinger, Gitta, Montalban, Xavier, Bosch, Assumpcio, Espejo, Carmen et al. DOI: 10.1007/s13311-017-0545-8
PMID: 26491879 Journal: ACS NANO Year: 2015 Reference: ACS Nano. 2015 Nov 24;9(11):10826-33. doi: 10.1021/acsnano.5b03417. Epub 2015 Oct 28. Impact factor: Publication type: Paper in international publication Authors: Chillon, Miguel; Condezo, Gabriela N; de Pablo, Pedro J; Flint, S Jane; Ortega-Esteban, Alvaro; Perez-Berna, Ana J; Reguera, David; San Martin, Carmen et al. DOI: 10.1021/acsnano.5b03417
PMID: 25640021 Journal: Human Gene Therapy Methods Year: 2015 Reference: Hum Gene Ther Methods. 2015 Feb;26(1):35-42. doi: 10.1089/hgtb.2014.120. Impact factor: 2.436 Publication type: Paper in international publication Authors: Penalva, Cristina, Monfar, Merce, Chillon, Miguel, Miravet, Susana, Ontiveros, Maria, Piedra, Jose et al. DOI: 10.1089/hgtb.2014.120
PMID: 25410741 Journal: GENE THERAPY Year: 2015 Reference: Gene Ther. 2015 Feb;22(2):196-201. doi: 10.1038/gt.2014.103. Epub 2014 Nov 20. Impact factor: 3.104 Publication type: Paper in international publication Authors: Thwaite, R, Pages, G, Chillon, M, Bosch, A et al. DOI: 10.1038/gt.2014.103
PMID: 26599613 Journal: PLoS One Year: 2015 Reference: PLoS One. 2015 Nov 24;10(11):e0143623. doi: 10.1371/journal.pone.0143623. eCollection 2015. Impact factor: 3.234 Publication type: Paper in international publication Authors: Masso, Anna, Lizcano, Jose Miguel, Canete, Manuel, Garcia, Belen, Torres-Lista, Virginia, Puig, Meritxell, Bosch, Assumpcio, Chillon, Miguel, Gimenez-Llort, Lydia, Sanchez, Angela et al. DOI: 10.1371/journal.pone.0143623
PMID: 26015946 Journal: Molecular therapy. Methods & clinical developm Year: 2014 Reference: Mol Ther Methods Clin Dev. 2014 Jan 15;1:7. doi: 10.1038/mtm.2013.7. eCollection 2014. Impact factor: Publication type: Paper in international publication Authors: Ariza, Lorena; Bosch, Assumpcio; Casas, Caty; Chillon, Miguel; Homs, Judit; Navarro, Xavier; Pages, Gemma et al. DOI: 10.1038/mtm.2013.7
PMID: 24132485 Journal: Methods in molecular biology (Clifton, N.J.) Year: 2014 Reference: Methods Mol Biol. 2014;1089:159-73. doi: 10.1007/978-1-62703-679-5_12. Impact factor: Publication type: Paper in international publication Authors: Chillon, Miguel; Miravet, Susana; Monfar, Merce; Ontiveros, Maria; Penalva, Cristina; Piedra, Jose et al. DOI: 10.1007/978-1-62703-679-5_12
PMID: 24897304 Journal: J PROTEOME RES Year: 2014 Reference: J Proteome Res. 2014 Aug 1;13(8):3706-3721. doi: 10.1021/pr500304g. Epub 2014 Jul 15. Impact factor: 5.001 Publication type: Paper in international publication Authors: Gregori, Josep, Mendez, Olga, Katsila, Theodora, Pujals, Mireia, Salvans, Candida, Villarreal, Laura, Sanchez, Alex, Villanueva, Josep, Tabernero, Josep, Arribas, Joaquin et al. DOI: 10.1021/pr500304g
PMID: 24299455 Journal: HUM GENE THER Year: 2014 Reference: Hum Gene Ther. 2014 Mar;25(3):199-211. doi: 10.1089/hum.2013.152. Epub 2014 Jan 23. Impact factor: 3.623 Publication type: Paper in international publication Authors: Ariza, Lorena, Gimenez-Llort, Lydia, Pages, Gemma, Garcia-Lareu, Belen, Serratrice, Nicolas, Cots, Dan, Thwaite, Rosemary, Chillon, Miguel, Kremer, Eric J, Bosch, Assumpcio et al. DOI: 10.1089/hum.2013.152
PMID: 23922808 Journal: PLoS One Year: 2013 Reference: PLoS One. 2013 Jul 26;8(7):e69808. doi: 10.1371/journal.pone.0069808. Print 2013. Impact factor: Publication type: Paper in international publication Authors: Astrologo, Letizia; Chillon, Miguel; Costa, Rossella; Gennetier, Aurelie; Ibanes, Sandy; Kremer, Eric J; Licursi, Valerio; Negri, Rodolfo; Piersanti, Stefania; Roncaglia, Enrica et al. DOI: 10.1371/journal.pone.0069808
PMID: 24039890 Journal: PLoS One Year: 2013 Reference: PLoS One. 2013 Sep 11;8(9):e73227. doi: 10.1371/journal.pone.0073227. eCollection 2013. Impact factor: 3.73 Publication type: Paper in international publication Authors: Gil, Estel, Bosch, Assumpcio, Lampe, David, Lizcano, Jose M, Perales, Jose C, Danos, Olivier, Chillon, Miguel et al. DOI: 10.1371/journal.pone.0073227
PMID: 24369061 Journal: CURRENT GENE THERAPY Year: 2013 Reference: Curr Gene Ther. 2013 Oct;13(5):370-81. Impact factor: 5.318 Publication type: Review in national publication Authors: Cots, Dan, Bosch, Assumpcio, Chillon, Miguel et al. DOI:
PMID: 23746215 Journal: Human Gene Therapy Methods Year: 2013 Reference: Hum Gene Ther Methods. 2013 Aug;24(4):195-204. doi: 10.1089/hgtb.2012.096. Epub 2013 Jun 27. Impact factor: 0 Publication type: Paper in international publication Authors: Fernandez, Ester, Rodriguez, Ester, Romero, Carolina, Rio, Adolfo, Miralles, Marta, Raventos, Aida, Planells, Laura, Burgueno, Joan F, Hamada, Hirofumi, Perales, Jose Carlos et al. DOI: 10.1089/hgtb.2012.096
The European Rare Diseases Research Alliance (ERDERA) kicked off this September, with an estimated budget of 380 million euros and the aim of improving the lives of 30 million rare disease patients in Europe and beyond.
This gene therapy protects mice against cognitive deficits associated with aging, improves motor function, and delays the onset of diseases such as amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease.
Over the course of two days, experts presented the latest advances in vectors, different gene modification techniques and their transfer to clinical practice.
Check the current rates for the services offered by the Gene Therapy at Nervous System research group.
