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Infection and Immunity in pediatric patients

The Infection and Immunity in pediatric patients research group is a multidisciplinary pediatric research group made up of health professionals involved in translational research in the field of pediatric infectious diseases and immunodeficiencies, two related fields in terms of pathophysiology and clinical implications. It is a consolidated research group recognized by the AGAUR and is the only one with the accreditation of the Jeffrey Modell Foundation in research in the field of primary immunodeficiencies throughout the state.

The group was officially created in 2010, belongs to the area of Infectious Diseases and participates in the transversal programs of Advanced Translational Immunology and Rare Diseases and actively participates in national and international competitive projects, carries out multiple academic and industry-linked clinical trials and has increased the number and quality in recent years. In addition, it has its own laboratory specially dedicated to advanced immune studies.

Publications

Human genetic and immunological determinants of critical COVID-19 pneumonia.

PMID: 35090163
Journal: NATURE
Year: 2022
Reference: Nature. 2022 Mar;603(7902):587-598. doi: 10.1038/s41586-022-04447-0. Epub 2022 Jan 28.
Impact factor:
Publication type: Review in international publication
Authors: Abel, Laurent; Aiuti, Alessandro; Akcan, Ozge Metin; Akcay, Nihal; Alexander, Natalie; Alkan, Gulsum; Allende, Luis M; Alsohime, Fahad; Anaya, Juan Manuel; Anderson, Mark S et al.
DOI: 10.1038/s41586-022-04447-0

Study protocol for monitoring SARS-CoV-2 infection and its determinants in Catalonia (Spain): an observational and participatory research approach in a Sentinel Network of Schools.

PMID: 35078847
Journal: BMJ Open
Year: 2022
Reference: BMJ Open. 2022 Jan 25;12(1):e055649. doi: 10.1136/bmjopen-2021-055649.
Impact factor:
Publication type: Paper in international publication
Authors: Aceiton, Jordi; Alonso, Lucia; Andres, Cristina; Anton, Andres; Anton, Andres; Aulet, Lidia; Basora, Josep; Blanco, Albert; Blanco, Ignacio; Blanco, Ignacio et al.
DOI: 10.1136/bmjopen-2021-055649

Dynamics of RT-PCR and Serologic Test Results in Children with SARS-CoV-2 Infection.

PMID: 34571020
Journal: JOURNAL OF PEDIATRICS
Year: 2022
Reference: J Pediatr. 2022 Feb;241:126-132.e3. doi: 10.1016/j.jpeds.2021.09.029. Epub 2021 Sep 25.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Cadenas, J A; Ballesteros, A; Baquero-Artigao, F; Bernardino, M; Calvo, C; Cava, F; Cobos, E; Dominguez-Rodriguez, S; Epalza, C; Fumado, V et al.
DOI: 10.1016/j.jpeds.2021.09.029

The risk of COVID-19 death is much greater and age-dependent with type I IFN autoantibodies.

PMID: 35043109
Journal:
Year: 2022
Reference: Res Sq. 2022 Jan 14. doi: 10.21203/rs.3.rs-1225906/v1.
Impact factor:
Publication type: Letter or abstract
Authors: Abel, Laurent; Aiuti, Alessandro; AlKhater, Suzan; Amador-Borrero, Blanca; Anaya, Juan-Manuel; Anderson, Mark; Andreakos, Evangelos; Anglicheau, Dany; Arias, Andres; Arrestier, Romain et al.
DOI: 10.21203/rs.3.rs-1225906/v1

Maternal Infection and Adverse Pregnancy Outcomes among Pregnant Travellers: Results of the International Zika Virus in Pregnancy Registry.

PMID: 33671742
Journal: Viruses-Basel
Year: 2021
Reference: Viruses. 2021 Feb 22;13(2). pii: v13020341. doi: 10.3390/v13020341.
Impact factor:
Publication type: Paper in international publication
Authors: Baud, David; Eggel, Beatrice; Eperon, Isabelle; Genton, Blaise; Gerardin, Patrick; Gonce, Anna; Gratacos, Eduard; Lambert, Veronique; Malvy, Denis; Martinez De Tejada, Begona et al.
DOI: 10.3390/v13020341

Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males.

PMID: 33647767
Journal: EBioMedicine
Year: 2021
Reference: EBioMedicine. 2021 Mar;65:103246. doi: 10.1016/j.ebiom.2021.103246. Epub 2021 Feb 26.
Impact factor:
Publication type: Paper in international publication
Authors: Amitrano, Sara; Baldassarri, Margherita; Benetti, Elisa; Bruttini, Mirella; Castagna, Maria Grazia; Colobran, Roger; Crawley, Francis P; Croci, Susanna; Daga, Sergio; Doddato, Gabriella et al.
DOI: 10.1016/j.ebiom.2021.103246

Safety of tocilizumab in COVID-19 pregnant women and their newborn: A retrospective study.

PMID: 33638257
Journal: JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
Year: 2021
Reference: J Clin Pharm Ther. 2021 Aug;46(4):1062-1070. doi: 10.1111/jcpt.13394. Epub 2021 Feb 26.
Impact factor:
Publication type: Paper in international publication
Authors: Batllori Badia, Emma; Cabanas Poy, Maria Josep; Camba-Longueira, Fatima; Caro-Teller, Jose Manuel; Fernandez-Hidalgo, Nuria; Frick, Marie Antoinette; Gorgas Torner, Maria Queralt; Jimenez-Lozano, Ines; Miarons, Marta; Moral-Pumarega, Maria Teresa et al.
DOI: 10.1111/jcpt.13394

Fever without source as the first manifestation of SARS-CoV-2 infection in infants less than 90 days old.

PMID: 33606120
Journal: EUROPEAN JOURNAL OF PEDIATRICS
Year: 2021
Reference: Eur J Pediatr. 2021 Jul;180(7):2099-2106. doi: 10.1007/s00431-021-03973-9. Epub 2021 Feb 19.
Impact factor:
Publication type: Paper in international publication
Authors: Blazquez-Gamero, Daniel; Cadenas, Jose Antonio Alonso; Calvo, Cristina; Cobo-Vazquez, Elvira; Delgado, Rafael; Epalza, Cristina; Fumado, Victoria; Gero, Lourdes Calleja; Guzman, Maria Fernanda; Jimenez, Ana B et al.
DOI: 10.1007/s00431-021-03973-9

Neuroinflammatory Disease as an Isolated Manifestation of Hemophagocytic Lymphohistiocytosis.

PMID: 32638196
Journal: JOURNAL OF CLINICAL IMMUNOLOGY
Year: 2020
Reference: J Clin Immunol. 2020 Aug;40(6):901-916. doi: 10.1007/s10875-020-00814-6. Epub 2020 Jul 7.
Impact factor: 6.78
Publication type: Paper in international publication
Authors: Ehl, Stephan, Elmaksoud, Marwa Abd, Astigarraga, Itziar, Kurjane, Natalja, Bulina, Inita, Kenina, Viktorija, Bryceson, Yenan, Rascon, Jelena, Lortie, Anne, Goldstein, Gal et al.
DOI: 10.1007/s10875-020-00814-6

[Tocilizumab in a child with acute lymphoblastic leukaemia and COVID-19-related cytokine release syndrome].

PMID: 32593520
Journal: ANALES DE PEDIATRIA
Year: 2020
Reference: An Pediatr (Barc). 2020 Aug;93(2):132-133. doi: 10.1016/j.anpedi.2020.05.002. Epub 2020 Jun 9.
Impact factor: 1.313
Publication type: Letter whit IF
Authors: Velasco Puyo, Pablo, Riviere, Jacques G, Soler Palacin, Pere, Diaz de Heredia, Cristina, Moreno, Lucas et al.
DOI: 10.1016/j.anpedi.2020.05.002

Long-term outcome of LRBA deficiency in 76 patients after various treatment modalities as evaluated by the immune deficiency and dysregulation activity (IDDA) score.

PMID: 31887391
Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Year: 2020
Reference: J Allergy Clin Immunol. 2020 May;145(5):1452-1463. doi: 10.1016/j.jaci.2019.12.896. Epub 2019 Dec 27.
Impact factor: 10.228
Publication type: Paper in international publication
Authors: Tesch, Victoria Katharina, Abolhassani, Hassan, Shadur, Bella, Zobel, Joachim, Mareika, Yuliya, Sharapova, Svetlana, Karakoc-Aydiner, Elif, Riviere, Jacques G, Garcia-Prat, Marina, Moes, Nicolette et al.
DOI: 10.1016/j.jaci.2019.12.896

Low-dose liposomal amphotericin B for antifungal prophylaxis in paediatric allogeneic haematopoietic stem cell transplantation.

PMID: 32335674
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2020
Reference: J Antimicrob Chemother. 2020 Aug 1;75(8):2264-2271. doi: 10.1093/jac/dkaa149.
Impact factor: 5.439
Publication type: Paper in international publication
Authors: Mendoza-Palomar, Natalia, Soques, Elena, Benitez-Carabante, Maria Isabel, Gonzalez-Amores, Miriam, Fernandez-Polo, Aurora, Renedo, Berta, Martin, Maria Teresa, Soler-Palacin, Pere, Diaz-de-Heredia, Cristina et al.
DOI: 10.1093/jac/dkaa149

Blog

News

The study seeks to better understand blood disorders in children and young people, analyzing the role of immunological alterations to improve diagnosis and treatment.

Members of the RBDCOV project, which involves VHIR, gathered at the Palau Macaya to review progress and achievements made during the final phase of the project.

During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.