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Infection and Immunity in pediatric patients

The Infection and Immunity in pediatric patients research group is a multidisciplinary pediatric research group made up of health professionals involved in translational research in the field of pediatric infectious diseases and immunodeficiencies, two related fields in terms of pathophysiology and clinical implications. It is a consolidated research group recognized by the AGAUR and is the only one with the accreditation of the Jeffrey Modell Foundation in research in the field of primary immunodeficiencies throughout the state.

The group was officially created in 2010, belongs to the area of Infectious Diseases and participates in the transversal programs of Advanced Translational Immunology and Rare Diseases and actively participates in national and international competitive projects, carries out multiple academic and industry-linked clinical trials and has increased the number and quality in recent years. In addition, it has its own laboratory specially dedicated to advanced immune studies.

Publications

JAK-inhibitor treatment for inborn errors of JAK/STAT signaling: An ESID and EBMT IEWP retrospective study.

PMID: 37935260
Journal: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Year: 2023
Reference: J Allergy Clin Immunol. 2023 Nov 5:S0091-6749(23)01390-8. doi: 10.1016/j.jaci.2023.10.018.
Impact factor:
Publication type: Paper in international publication
Authors: Albert, Michael H; Andersson, Tommy; Aumann, Volker; Bakhtiar, Shahrzad; Barlogis, Vincent; Booth, Claire; Buddingh, Emmeline P; Cagdas, Deniz; Castelle, Martin; Chan, Alice Y et al.
DOI: 10.1016/j.jaci.2023.10.018

Reporting reimbursement price decisions for onco-hematology drugs in Spain.

PMID: 37942255
Journal: Frontiers in Public Health
Year: 2023
Reference: Front Public Health. 2023 Oct 24;11:1265323. doi: 10.3389/fpubh.2023.1265323. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Aixut, Sandra; Aixut, Sandra; Bargues, Ma Dolores; Bocanegra, Cristina; de Pando, Thais; Elvira, David; Espiau, Maria; Gay, Daniel; Martinez-Camprecios, Joan; Mas-Coma, Santiago et al.
DOI: 10.3389/fpubh.2023.1265323

Slaying the "Troll of Transplantation"-new frontiers in cytomegalovirus management. A report from the CMV International Symposium 2023.

PMID: 37942955
Journal: Transplant Infectious Disease
Year: 2023
Reference: Transpl Infect Dis. 2023 Nov 9:e14183. doi: 10.1111/tid.14183.
Impact factor:
Publication type: Paper in international publication
Authors: Albert, Michael H; Aumann, Volker; Bakhtiar, Shahrzad; Barlogis, Vincent; Booth, Claire; Buddingh, Emmeline P; Cagdas, Deniz; Castelle, Martin; Chan, Alice Y; Chandrakasan, Shanmuganathan et al.
DOI: 10.1111/tid.14183

Isavuconazole use and TDM in real-world pediatric practice.

PMID: 37962334
Journal: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Year: 2023
Reference: Antimicrob Agents Chemother. 2023 Nov 14:e0082923. doi: 10.1128/aac.00829-23.
Impact factor:
Publication type: Paper in international publication
Authors: Benitez-Carbante, Maria Isabel; Di Masso, Andres; Diaz de Heredia, Cristina; Fernandez Ledesma, Berta; Fernandez-Polo, Aurora; Grau Cerrato, Santiago; Luque Pardos, Sonia; Martin-Gomez, Maria Teresa; Melendo Perez, Susana; Mendoza-Palomar, Natalia et al.
DOI: 10.1128/aac.00829-23

Impact of the COVID-19 Pandemic on the Diagnosis of Congenital Cytomegalovirus Infection in Spain.

PMID: 35363648
Journal: PEDIATRIC INFECTIOUS DISEASE JOURNAL
Year: 2022
Reference: Pediatr Infect Dis J. 2022 Jul 1;41(7):590-592. doi: 10.1097/INF.0000000000003532. Epub 2022 Jun 7.
Impact factor:
Publication type: Paper in international publication
Authors: Baquero-Artigao, Fernando; Blazquez-Gamero, Daniel; Esquivel, Estrella; Frick, Marie Antoinette; Noguera-Julian, Antoni; Rojo, Pablo; Villaverde, Serena et al.
DOI: 10.1097/INF.0000000000003532

SARS-CoV-2 PCR negativization in respiratory sample in patients with need for recurring assistance.

PMID: 35305952
Journal: ANALES DE PEDIATRIA
Year: 2022
Reference: An Pediatr (Engl Ed). 2022 Apr;96(4):357-359. doi: 10.1016/j.anpede.2021.01.008. Epub 2022 Mar 3.
Impact factor:
Publication type: Letter whit IF
Authors: Bassets-Bosch, Alba; Gonzalez-Peris, Sebastia; Melendo-Perez, Susana; Raya-Munoz, Judith; Worner-Tomasa, Nuria et al.
DOI: 10.1016/j.anpede.2021.01.008

Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis.

PMID: 35255197
Journal: Journal of the International AIDS Society
Year: 2022
Reference: J Int AIDS Soc. 2022 Mar;25(3):e25871. doi: 10.1002/jia2.25871.
Impact factor:
Publication type: Paper in international publication
Authors: Abrams, Elaine J; Abzug, Mark J; Ake-Assi, Marie-Helene; Bekker, Linda-Gail; Ben-Farhat, Jihane; Bolton, Carolyn; Chappell, Elizabeth; Chokephaibulkit, Kulkanya; Collins, Intira Jeannie; Crichton, Siobhan et al.
DOI: 10.1002/jia2.25871

Clinical spectrum of COVID-19 and risk factors associated with severity in Spanish children.

PMID: 34738173
Journal: EUROPEAN JOURNAL OF PEDIATRICS
Year: 2022
Reference: Eur J Pediatr. 2022 Mar;181(3):1105-1115. doi: 10.1007/s00431-021-04306-6. Epub 2021 Nov 5.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Cadenas, Jose-Antonio; Astigarraga, Itziar; Ballesteros, Alvaro; Batista, Rosa; Bernardino, Maria; Berzosa, Arantxa; Calleja, Lourdes; Calvo, Cristina; Carrasco-Colom, Jaime; Cobos-Carrascosa, Elena et al.
DOI: 10.1007/s00431-021-04306-6

Epigenome-wide association study of COVID-19 severity with respiratory failure.

PMID: 33867313
Journal: EBioMedicine
Year: 2021
Reference: EBioMedicine. 2021 Apr;66:103339. doi: 10.1016/j.ebiom.2021.103339. Epub 2021 Apr 15.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera-Albesa, Sergio; Albu, Sergiu; Alvarez-Errico, Damiana; Arranz, Maria J; Arribas, Carles; Casasnovas, Carlos; Castro de Moura, Manuel; Colobran, Roger; Dalmau, David; Davalos, Veronica et al.
DOI: 10.1016/j.ebiom.2021.103339

Three-Year Clinical Follow-Up of Children Intrauterine Exposed to Zika Virus.

PMID: 33810110
Journal: Viruses-Basel
Year: 2021
Reference: Viruses. 2021 Mar 22;13(3). pii: v13030523. doi: 10.3390/v13030523.
Impact factor:
Publication type: Paper in international publication
Authors: Almeida, Juliana Paula Gomes de; Bertozzi, Ana Paula Antunes Pascalicchio; Catalan, Daniel T; Clemente, Nuria Sanchez; Damico, Francisco Max; Dezena, Rita de Cassia de Aguirre Bernardes; Fajardo, Thamirys Cosmo Gillo; Franca, Valtenice de Cassia Rodrigues de Matos; Gazeta, Rosa Estela; Jundiai, Cohort Zika Virus et al.
DOI: 10.3390/v13030523

[SARS-CoV-2 PCR negativization in respiratory sample in patients with need for recurring assistance].

PMID: 33775582
Journal: ANALES DE PEDIATRIA
Year: 2021
Reference: An Pediatr (Engl Ed). 2021 Jan 27. pii: S1695-4033(21)00012-6. doi: 10.1016/j.anpedi.2021.01.006.
Impact factor:
Publication type: Letter whit IF
Authors: Bassets-Bosch, Alba; Gonzalez-Peris, Sebastia; Melendo-Perez, Susana; Raya-Munoz, Judith; Worner-Tomasa, Nuria et al.
DOI: 10.1016/j.anpedi.2021.01.006

Vertical transmission of Zika virus and its outcomes: a Bayesian synthesis of prospective studies.

PMID: 33068528
Journal: LANCET INFECTIOUS DISEASES
Year: 2021
Reference: Lancet Infect Dis. 2021 Apr;21(4):537-545. doi: 10.1016/S1473-3099(20)30432-1. Epub 2020 Oct 14.
Impact factor:
Publication type: Paper in international publication
Authors: Ades, A E; Alarcon, Ana; Bonfante, Francesco; Giaquinto, Carlo; Peckham, Catherine S; Soriano-Arandes, Antoni; Thorne, Claire et al.
DOI: 10.1016/S1473-3099(20)30432-1

Detection of Zika virus in paired urine and amniotic fluid samples from symptomatic and asymptomatic women and their babies during a disease outbreak: association with neurological symptoms in newborns.

PMID: 31502209
Journal: JOURNAL OF NEUROVIROLOGY
Year: 2020
Reference: J Neurovirol. 2020 Feb;26(1):70-76. doi: 10.1007/s13365-019-00797-0. Epub 2019 Sep 9.
Impact factor:
Publication type: Paper in international publication
Authors: Bertozzi, Ana Paula Antunes Pascalicchio; da Silva, Alify Bertoldo; Fajardo, Thamirys Cosmo Gillo; Filho, Nemesio Florence Vieira; Gazeta, Rosa Estela; Mello, Alexandra Siqueira; Moron, Antonio Fernandes; Passos, Saulo Duarte; Rodrigues, Maria Manoela Duarte; Sarmento, Stephanno Gomes Pereira et al.
DOI: 10.1007/s13365-019-00797-0

Uncovering Low-Level Maternal Gonosomal Mosaicism in X-Linked Agammaglobulinemia: Implications for Genetic Counseling.

PMID: 32117230
Journal: Frontiers in Immunology
Year: 2020
Reference: Front Immunol. 2020 Feb 12;11:46. doi: 10.3389/fimmu.2020.00046. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilo-Cucurull, Aina; Antolin, Maria; Blasco-Perez, Laura; Colobran, Roger; Franco-Jarava, Clara; Martin-Nalda, Andrea; Martinez-Gallo, Monica; Paramonov, Ida; Riviere, Jacques G; Soler-Palacin, Pere et al.
DOI: 10.3389/fimmu.2020.00046

Researching Zika in pregnancy: lessons for global preparedness.

PMID: 32085848
Journal: LANCET INFECTIOUS DISEASES
Year: 2020
Reference: Lancet Infect Dis. 2020 Apr;20(4):e61-e68. doi: 10.1016/S1473-3099(20)30021-9. Epub 2020 Feb 19.
Impact factor:
Publication type: Review in international publication
Authors: Ades, A E; Brown, David W; Christie, Celia D C; Giaquinto, Carlo; Lang, Daniel; Morris, J Glenn; Peckham, Catherine S; Soriano-Arandes, Antoni; Thorne, Claire et al.
DOI: 10.1016/S1473-3099(20)30021-9

FHLdb: A Comprehensive Database on the Molecular Basis of Familial Hemophagocytic Lymphohistiocytosis.

PMID: 32076423
Journal: Frontiers in Immunology
Year: 2020
Reference: Front Immunol. 2020 Jan 31;11:107. doi: 10.3389/fimmu.2020.00107. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Batlle-Maso, Laura; Casals, Ferran; Colobran, Roger; de la Cruz, Xavier; Martinez-Gallo, Monica; Padilla, Natalia; Riviere, Jacques G; Vinas-Gimenez, Laura et al.
DOI: 10.3389/fimmu.2020.00107

Blog

News

The study seeks to better understand blood disorders in children and young people, analyzing the role of immunological alterations to improve diagnosis and treatment.

Members of the RBDCOV project, which involves VHIR, gathered at the Palau Macaya to review progress and achievements made during the final phase of the project.

During the meeting, the role of the Vall d'Hebron Paediatric Research Hub in promoting research on children and adolescents was highlighted.