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Kidney Physiopathology

Our main scientific interest is to understand, from a multidisciplinary and translational approach, the molecular and cellular processes leading to renal dysfunction in several kidney pathologies. Specifically, our research lines are

  • to study the pathophysiology of inherited rare renal tubulopathies
  • to understand the mechanisms of kidney injury and regeneration
  • to study the development of clear cell renal cell carcinoma (ccRCC)
  • the study the impact of androgens on those processes.

We are experts on the following areas:

  • the generation of cellular disease models carrying specific gene alterations,
  • genetically modified animal models and gene therapies,
  • life-imaging high-resolution microscopy
  • working with patients’ samples for translational research.

To sum up, our research main objective is to combine –omic data from cellular and animal models with patients’ data to identify novel biomarkers and possible treatments for several renal diseases.

Team

Gonzalo Fernández Miranda

Gonzalo Fernández Miranda

Senior researcher
Kidney Physiopathology
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Hector Rios Duro

Hector Rios Duro

Research technician
Kidney Physiopathology
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José Ramon Jarrín Luengo

José Ramon Jarrín Luengo

Research technician
Kidney Physiopathology
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Julieta Torchia

Julieta Torchia

Predoctoral researcher
Kidney Physiopathology
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Laura Nuñez Rodrigo

Laura Nuñez Rodrigo

Kidney Physiopathology
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Luis Enrique Lara Moctezuma

Luis Enrique Lara Moctezuma

Kidney Physiopathology
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Gonzalo Fernández Miranda

Gonzalo Fernández Miranda

Senior researcher
Kidney Physiopathology
Read more
Hector Rios Duro

Hector Rios Duro

Research technician
Kidney Physiopathology
Read more
José Ramon Jarrín Luengo

José Ramon Jarrín Luengo

Research technician
Kidney Physiopathology
Read more
Julieta Torchia

Julieta Torchia

Predoctoral researcher
Kidney Physiopathology
Read more
Laura Nuñez Rodrigo

Laura Nuñez Rodrigo

Kidney Physiopathology
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Luis Enrique Lara Moctezuma

Luis Enrique Lara Moctezuma

Kidney Physiopathology
Read more

Projects

Biomarcadores, dianas y soluciones terapéuticas para mejorar el cuidado de pacientes afectados de Hipomagnesemia Familiar con Hipercalciuria y Nefrocalcinosis (HFHNC).

IP: Gema Ariceta Iraola
Collaborators: Hector Rios Duro, Mónica Durán Fernández, Gloria Mª Fraga Rodriguez, Julieta Torchia
Funding agency: Instituto de Salud Carlos III
Funding: 202070
Reference: PI22/01946
Duration: 01/01/2023 - 31/12/2025

Papel del ClC-5 en la fibrosis renal. Identificación de posibles biomarcadores y dianas terapéuticas para la progresión de la enfermedad de Dent 1

IP: Gerard Cantero Recasens
Collaborators: Anna Meseguer Navarro, Hector Rios Duro, Mónica Durán Fernández, Gloria Mª Fraga Rodriguez, Julieta Torchia
Funding agency: Instituto de Salud Carlos III
Funding: 123420
Reference: PI22/00741
Duration: 01/01/2023 - 31/12/2025

TRANS-GENE - Caracterización en Sangre Periférica de una Firma Génica de Rechazo Humoral Común en Trasplantes de Órganos Sólidos.

IP: Maria Antonia Emilia Meneghini
Collaborators: Lluis Castells Fusté, Joana Sellarés Roig, Jesús Quintero Bernabeu, Eva Maria Revilla Lopez, Marina Muñoz López, Meritxell Boada Perez, Laura Donadeu Casassas, Mercedes López González
Funding agency: Instituto de Salud Carlos III
Funding: 111320
Reference: PI22/00749
Duration: 01/01/2023 - 31/12/2025

Radiogenomics for the prediction of prostate cancer aggressiveness through artificial intelligence.

IP: Joan Morote Robles
Collaborators: Inés de Torres Ramirez, Marta Barber Servera, Ana Celma Domènech, Jacques Planas Morin, Richard Mast, Lucas Regis Plácido
Funding agency: Instituto de Salud Carlos III
Funding: 159720
Reference: PI20/01666
Duration: 01/01/2021 - 30/06/2025

Publications

The International X-Linked Hypophosphatemia (XLH) Registry: first interim analysis of baseline demographic, genetic and clinical data.

PMID: 37752558
Journal: Orphanet Journal of Rare Diseases
Year: 2023
Reference: Orphanet J Rare Dis. 2023 Sep 27;18(1):304. doi: 10.1186/s13023-023-02882-4.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Ariceta, Gema; Beck-Nielsen, Signe Sparre; Boot, Annemieke M; Brandi, Maria Luisa; Briot, Karine; de Lucas Collantes, Carmen; Emma, Francesco; Giannini, Sandro; Haffner, Dieter et al.
DOI: 10.1186/s13023-023-02882-4

The coexistence of diabetic retinopathy and diabetic nephropathy is associated with worse kidney outcomes.

PMID: 37779839
Journal: Clinical Kidney Journal
Year: 2023
Reference: Clin Kidney J. 2023 Jul 6;16(10):1656-1663. doi: 10.1093/ckj/sfad142. eCollection 2023 Oct.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz, Irene; Agraz, Irene; Barros, Xoana; Bermejo, Sheila; Bestard, Oriol; Bonet, Josep; Calero, Francesca; Coloma, Ana; Diaz, Montserrat; Diaz, Montserrat et al.
DOI: 10.1093/ckj/sfad142

Assessment of obesity stigma and discrimination among Spanish subjects with a wide weight range: the OBESTIGMA study.

PMID: 37799531
Journal: Frontiers in Psychology
Year: 2023
Reference: Front Psychol. 2023 Sep 18;14:1209245. doi: 10.3389/fpsyg.2023.1209245. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Canizares, Silvia; Ciudin, Andreea; Ciudin, Andreea; Comas, Marta; Comas, Marta; Cuatrecasas, Guillem; Diaz-Trastoy, Olaia; Flores, Lilliam; Goni, Fernando; Gutierrez-Medina, Sonsoles et al.
DOI: 10.3389/fpsyg.2023.1209245

Real-World Experience with Vismodegib on Advanced and Multiple BCCs: Data from the RELIVIS Study.

PMID: 37257423
Journal: DERMATOLOGY
Year: 2023
Reference: Dermatology. 2023;239(5):685-693. doi: 10.1159/000530813. Epub 2023 May 31.
Impact factor:
Publication type: Paper in international publication
Authors: Aguayo-Ortiz, Rafael; Ariceta, Gema; Bassas-Freixas, Patricia; Bernia-Petit, Eduardo; Bonfill-Orti, Montserrat; Canueto, Javier; Comas, Jordi; Cruz, Alejandro; Deza, Gustavo; Florez-Menendez, Angeles et al.
DOI: 10.1159/000530813

The True Utility of Predictive Models Based on Magnetic Resonance Imaging in Selecting Candidates for Prostate Biopsy.

PMID: 35795075
Journal: European Urology Open Science
Year: 2022
Reference: Eur Urol Open Sci. 2022 Jul 1;42:40-41. doi: 10.1016/j.euros.2022.06.002. eCollection 2022 Aug.
Impact factor: 0
Publication type: Letter whit IF
Authors: Trilla, Enrique; Esteban, Luis M; Triquell, Marina; Morote, Juan; Borque-Fernando, Angel et al.
DOI: 10.1016/j.euros.2022.06.002

Pediatric kidney retransplantation focused on surgical outcomes.

PMID: 35810139
Journal: Journal of Pediatric Urology
Year: 2022
Reference: J Pediatr Urol. 2022 Jun 25. pii: S1477-5131(22)00288-1. doi: 10.1016/j.jpurol.2022.06.019.
Impact factor: 1.83
Publication type: Paper in international publication
Authors: Gander, Romy; Asensio, Marino; Andres Molino, Jose; Fatou Royo, Gloria; Lopez-Gonzalez, Mercedes; Perez, Victor; Lopez, Manuel; Ariceta, Gema et al.
DOI: 10.1016/j.jpurol.2022.06.019

Clinical Factors and Adverse Kidney Outcomes in Children With ANCA-Associated Glomerulonephritis.

PMID: 35810826
Journal: AMERICAN JOURNAL OF KIDNEY DISEASES
Year: 2022
Reference: Am J Kidney Dis. 2022 Jul 7. pii: S0272-6386(22)00772-7. doi: 10.1053/j.ajkd.2022.05.013.
Impact factor: 8.86
Publication type: Letter or abstract
Authors: Forero-Delgadillo, Jessica, Sanchez-Kazi, Cheryl, Principi, Iliana, Pecoraro, Carmine, Parolin, Mattia, Nastausheva, Tatiana, Muller, Rebekka, Moczulska, Anna, Maxted, Andrew, Marks, Stephen et al.
DOI: 10.1053/j.ajkd.2022.05.013

ePHex: a phase 3, double-blind, placebo-controlled, randomized study to evaluate long-term efficacy and safety of Oxalobacter formigenes in patients with primary hyperoxaluria.

PMID: 35552824
Journal: PEDIATRIC NEPHROLOGY
Year: 2022
Reference: Pediatr Nephrol. 2022 May 12. pii: 10.1007/s00467-022-05591-5. doi: 10.1007/s00467-022-05591-5.
Impact factor: 3.714
Publication type: Paper in international publication
Authors: Ariceta, Gema, Collard, Laure, Abroug, Saoussen, Moochhala, Shabbir H, Gould, Edward, Boussetta, Abir, Ben Hmida, Mohamed, Hunley, Tracy E, Jarraya, Faical, Fraga, Gloria et al.
DOI: 10.1007/s00467-022-05591-5

Blog

News

The project, which has received funding from the Association for Genetic Kidney Disease Information and Research, aims to help develop new therapies for familial hypomagnesemia with hypercalciuria and nephrocalcinosis.

The association supports the Kidney Pathophysiology group at VHIR since 2015 to investigate familial hypomagnesemia with hypercalciuria and nephrocalcinosis.

Dr. Conxita Jacobs' research has been awarded in the clinical project category, while Dr. Anna Meseguer's research has been recognised in the basic research category.

Job offers

The Renal Physiopathology Research Group.
Start date:
14/06/2021
End date:
28/06/2021
Document: Download
Clinical trial data entry
Start date:
19/02/2021
End date:
05/03/2021
Document: Download
Study Coordinator: Kidney Physiopathology Group
Start date:
09/11/2020
End date:
23/11/2020
Document: Download