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Kidney Physiopathology

Our main scientific interest is to understand, from a multidisciplinary and translational approach, the molecular and cellular processes leading to renal dysfunction in several kidney pathologies. Specifically, our research lines are

  • to study the pathophysiology of inherited rare renal tubulopathies
  • to understand the mechanisms of kidney injury and regeneration
  • to study the development of clear cell renal cell carcinoma (ccRCC)
  • the study the impact of androgens on those processes.

We are experts on the following areas:

  • the generation of cellular disease models carrying specific gene alterations,
  • genetically modified animal models and gene therapies,
  • life-imaging high-resolution microscopy
  • working with patients’ samples for translational research.

To sum up, our research main objective is to combine –omic data from cellular and animal models with patients’ data to identify novel biomarkers and possible treatments for several renal diseases.

Team

Gonzalo Fernández Miranda

Gonzalo Fernández Miranda

Senior researcher
Kidney Physiopathology
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Hector Rios Duro

Hector Rios Duro

Research technician
Kidney Physiopathology
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José Ramon Jarrín Luengo

José Ramon Jarrín Luengo

Research technician
Kidney Physiopathology
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Laura Nuñez Rodrigo

Laura Nuñez Rodrigo

Kidney Physiopathology
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Luis Enrique Lara Moctezuma

Luis Enrique Lara Moctezuma

Kidney Physiopathology
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Marina Muñoz López

Marina Muñoz López

Kidney Physiopathology
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Gonzalo Fernández Miranda

Gonzalo Fernández Miranda

Senior researcher
Kidney Physiopathology
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Hector Rios Duro

Hector Rios Duro

Research technician
Kidney Physiopathology
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José Ramon Jarrín Luengo

José Ramon Jarrín Luengo

Research technician
Kidney Physiopathology
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Laura Nuñez Rodrigo

Laura Nuñez Rodrigo

Kidney Physiopathology
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Luis Enrique Lara Moctezuma

Luis Enrique Lara Moctezuma

Kidney Physiopathology
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Marina Muñoz López

Marina Muñoz López

Kidney Physiopathology
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Projects

Rercerca biomèdica en urologia

IP: Joan Morote Robles
Collaborators: Fernando Lozano Palacio, Inés de Torres Ramirez, Enric Trilla Herrera, Olga Méndez Fernández, Ana Celma Domènech, Mercè Cuadras Solé, Carlos Serrano Burgos, Albert Carrión Puig , Enric Miret Alomar, Maria Eugenia Semidey Raven, Carles Xavier Raventós Busquets, David Ruiz Casajuana, Jacques Planas Morin, Richard Mast, Anna Santamaria Margalef
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 0.01
Reference: 2021 SGR 00858
Duration: 01/01/2022 - 30/06/2025

Biomarcadores, dianas y soluciones terapéuticas para mejorar el cuidado de pacientes afectados de Hipomagnesemia Familiar con Hipercalciuria y Nefrocalcinosis (HFHNC).

IP: Gema Ariceta Iraola
Collaborators: Hector Rios Duro, Gloria Mª Fraga Rodriguez, Julieta Torchia, Julieta Torchia
Funding agency: Instituto de Salud Carlos III
Funding: 202070
Reference: PI22/01946
Duration: 01/01/2023 - 31/12/2025

Papel del ClC-5 en la fibrosis renal. Identificación de posibles biomarcadores y dianas terapéuticas para la progresión de la enfermedad de Dent 1

IP: Gerard Cantero Recasens
Collaborators: Anna Meseguer Navarro, Hector Rios Duro, Gloria Mª Fraga Rodriguez, Julieta Torchia, Julieta Torchia
Funding agency: Instituto de Salud Carlos III
Funding: 123420
Reference: PI22/00741
Duration: 01/01/2023 - 31/12/2025

TRANS-GENE - Caracterización en Sangre Periférica de una Firma Génica de Rechazo Humoral Común en Trasplantes de Órganos Sólidos.

IP: Maria Antonia Emilia Meneghini
Collaborators: Lluis Castells Fusté, Joana Sellarés Roig, Jesús Quintero Bernabeu, Eva Maria Revilla Lopez, Marina Muñoz López, Meritxell Boada Perez, Laura Donadeu Casassas
Funding agency: Instituto de Salud Carlos III
Funding: 111320
Reference: PI22/00749
Duration: 01/01/2023 - 31/12/2025

Publications

Acute stress triggers sex-dependent rapid alterations in the human small intestine microbiota composition.

PMID: 39881982
Journal: Frontiers in Microbiology
Year: 2024
Reference: Front Microbiol. 2025 Jan 15;15:1441126. doi: 10.3389/fmicb.2024.1441126. eCollection 2024.
Impact factor:
Publication type: Paper in international publication
Authors: Albert-Bayo, Merce; Alonso-Cotoner, Carmen; Exposito, Elba; Fortea, Marina; Gabaldon, Toni; Gonzalez-Castro, Ana Maria; Guagnozzi, Danila; Khannous-Lleiffe, Olfat; Lobo, Beatriz; Martinez, Cristina et al.
DOI: 10.3389/fmicb.2024.1441126

Accurate diagnosis of prostate cancer by combining Proclarix with magnetic resonance imaging.

PMID: 36855895
Journal: BJU INTERNATIONAL
Year: 2023
Reference: BJU Int. 2023 Aug;132(2):188-195. doi: 10.1111/bju.15998. Epub 2023 Mar 21.
Impact factor:
Publication type: Paper in international publication
Authors: Ahmed, Hashim U; Athanasiou, Alcibiade; Campistol, Miriam; Celma, Anna; de Torres, Ines; Emberton, Mark; Freeman, Alex; Haider, Aiman; Heavey, Susan; Mast, Richard et al.
DOI: 10.1111/bju.15998

p27Kip1 V109G as a biomarker for CDK4/6 inhibitors indication in hormone receptor-positive breast cancer.

PMID: 36806942
Journal: JNCI cancer spectrum
Year: 2023
Reference: JNCI Cancer Spectr. 2023 Mar 1;7(2):pkad014. doi: 10.1093/jncics/pkad014.
Impact factor:
Publication type: Paper in international publication
Authors: Apala, Juan V; Bueno, Maria J; Guerra, Juan; Malon, Diego; Malumbres, Marcos; Manso, Luis; Mouron, Silvana; Munoz, Manuel; Quintela-Fandino, Miguel; Rodriguez, Sandra et al.
DOI: 10.1093/jncics/pkad014

Sodium intake and urinary losses in children on dialysis: a European multicenter prospective study.

PMID: 36988689
Journal: PEDIATRIC NEPHROLOGY
Year: 2023
Reference: Pediatr Nephrol. 2023 Oct;38(10):3389-3399. doi: 10.1007/s00467-023-05932-y. Epub 2023 Mar 29.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Aufricht, Christoph; Bakkaloglu, Sevcan A; Consolo, Silvia; Edefonti, Alberto; Grassi, Maria Rosa; Gual, Alejandro Cruz; Holtta, Tuula; Jankauskiene, Augustina; Klaus, Guenter et al.
DOI: 10.1007/s00467-023-05932-y

Clinical Profiles and Patterns of Kidney Disease Progression in C3 Glomerulopathy.

PMID: 36996481
Journal: Kidney360
Year: 2023
Reference: Kidney360. 2023 Mar 30. doi: 10.34067/KID.0000000000000115.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, Natalia; Ariceta, Gema; Avila, Ana; Barros, Xoana; Bravo, Luis; Cabello, Virginia; Caravaca-Fontan, Fernando; Cavero, Teresa; Cruz, Sonia; Da Silva, Iara et al.
DOI: 10.34067/KID.0000000000000115

Expert guidance on the multidisciplinary management of cystinosis in adolescent and adult patients.

PMID: 36003666
Journal: Clinical Kidney Journal
Year: 2022
Reference: Clin Kidney J. 2022 Apr 15;15(9):1675-1684. doi: 10.1093/ckj/sfac099. eCollection 2022 Sep.
Impact factor:
Publication type: Review in international publication
Authors: Ariceta, Gema; Das, Anibh M; Emma, Francesco; Game, David S; Hulton, Sally A; Lange, Karin; Lapatto, Risto; Levtchenko, Elena; Liang, Hong; Sberro-Soussan, Rebecca et al.
DOI: 10.1093/ckj/sfac099

Development and validation of a nomogram to predict kidney survival at baseline in patients with C3 glomerulopathy.

PMID: 36003665
Journal: Clinical Kidney Journal
Year: 2022
Reference: Clin Kidney J. 2022 Apr 28;15(9):1737-1746. doi: 10.1093/ckj/sfac108. eCollection 2022 Sep.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, Natalia; Alonso Titos, Juana; Ariceta, Gema; Avila, Ana; Barros, Xoana; Bravo, Luis; Cabello, Virginia; Caravaca-Fontan, Fernando; Cavero, Teresa; Cruz, Sonia et al.
DOI: 10.1093/ckj/sfac108

Health-related quality of life of X-linked hypophosphatemia in Spain.

PMID: 35906684
Journal: Orphanet Journal of Rare Diseases
Year: 2022
Reference: Orphanet J Rare Dis. 2022 Jul 29;17(1):298. doi: 10.1186/s13023-022-02452-0.
Impact factor:
Publication type: Paper in international publication
Authors: Arborio-Pinel, R; Ariceta, G; Broseta, J J; Calleja, M A; Diaz-Curiel, M; Espin, J; Espinosa, L; Hernandez, J; Marin, S; Martinez, V et al.
DOI: 10.1186/s13023-022-02452-0

Pediatric kidney retransplantation focused on surgical outcomes.

PMID: 35810139
Journal: Journal of Pediatric Urology
Year: 2022
Reference: J Pediatr Urol. 2022 Dec;18(6):847.e1-847.e9. doi: 10.1016/j.jpurol.2022.06.019. Epub 2022 Jun 25.
Impact factor:
Publication type: Paper in international publication
Authors: Andres Molino, Jose; Ariceta, Gema; Asensio, Marino; Fatou Royo, Gloria; Gander, Romy; Lopez, Manuel; Lopez, Manuel; Lopez-Gonzalez, Mercedes; Perez, Victor et al.
DOI: 10.1016/j.jpurol.2022.06.019

Multidimensional inflammatory and immunological endotypes of idiopathic focal segmental glomerulosclerosis and their association with treatment outcomes.

PMID: 34221390
Journal: Clinical Kidney Journal
Year: 2021
Reference: Clin Kidney J. 2020 Dec 14;14(7):1826-1834. doi: 10.1093/ckj/sfaa265. eCollection 2021 Jul.
Impact factor:
Publication type: Paper in international publication
Authors: Fraga, Gloria; Gonzalez, Jorge; Jatem, Elias; Lopez, Mercedes; Madrid, Alvaro; Martinez, Cristina; Roca, Neus; Segarra, Alfons et al.
DOI: 10.1093/ckj/sfaa265

Identification of a Locus on the X Chromosome Linked to Familial Membranous Nephropathy.

PMID: 34169208
Journal: Kidney International Reports
Year: 2021
Reference: Kidney Int Rep. 2021 Mar 3;6(6):1669-1676. doi: 10.1016/j.ekir.2021.02.025. eCollection 2021 Jun.
Impact factor:
Publication type: Paper in international publication
Authors: Al Attrach, Ibrahim; Aris, Alvaro Madrid; Arora, Steven; Bockenhauer, Detlef; Brenchley, Paul E; Cheshire, Chris; Downie, Mallory L; Gale, Daniel P; Gupta, Sanjana; Kleta, Robert et al.
DOI: 10.1016/j.ekir.2021.02.025

Long-Term Efficacy and Safety of the Long-Acting Complement C5 Inhibitor Ravulizumab for the Treatment of Atypical Hemolytic Uremic Syndrome in Adults.

PMID: 34169200
Journal: Kidney International Reports
Year: 2021
Reference: Kidney Int Rep. 2021 Mar 24;6(6):1603-1613. doi: 10.1016/j.ekir.2021.03.884. eCollection 2021 Jun.
Impact factor:
Publication type: Paper in international publication
Authors: Antognoli, Guilia; Arepally, Gowthami; Ariceta, Gema; Babu, Sunil; Barbour, Thomas; Boyer-Suavet, Sonia; Broeders, Nilufer; Brown, Fiona; Campbell, Philip; Campistol, Josep M et al.
DOI: 10.1016/j.ekir.2021.03.884

The long-acting C5 inhibitor, ravulizumab, is effective and safe in pediatric patients with atypical hemolytic uremic syndrome naive to complement inhibitor treatment.

PMID: 33307104
Journal: KIDNEY INTERNATIONAL
Year: 2021
Reference: Kidney Int. 2021 Jul;100(1):225-237. doi: 10.1016/j.kint.2020.10.046. Epub 2020 Dec 8.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Denker, Andrew E; Dixon, Bradley P; Greenbaum, Larry A; Kang, Hee Gyung; Kapur, Gaurav; Kim, Seong Heon; Mauch, Teri; Ortiz, Stephan; Vallee, Marc et al.
DOI: 10.1016/j.kint.2020.10.046

Severe neurological outcomes after very early bilateral nephrectomies in patients with autosomal recessive polycystic kidney disease (ARPKD).

PMID: 32994492
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Sep 29;10(1):16025. doi: 10.1038/s41598-020-71956-1.
Impact factor:
Publication type: Paper in international publication
Authors: Akinci, Nurver; Arbeiter, Klaus; Ariceta, Gema; Balasz-Chmielewska, Irena; Bald, Martin; Benz, Marcus; Bernhardt, Wanja; Boyer, Olivia; Buchholz, Bjorn; Buescher, Anja Katrin et al.
DOI: 10.1038/s41598-020-71956-1

Novel compound heterozygous mutations of CLDN16 in a patient with familial hypomagnesemia with hypercalciuria and nephrocalcinosis.

PMID: 32869508
Journal: Molecular Genetics & Genomic Medicine
Year: 2020
Reference: Mol Genet Genomic Med. 2020 Nov;8(11):e1475. doi: 10.1002/mgg3.1475. Epub 2020 Sep 1.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Claverie-Martin, Felix; Garcia-Castano, Alejandro; Madariaga, Leire; Perdomo-Ramirez, Ana; Ramos-Trujillo, Elena; Vall-Palomar, Monica et al.
DOI: 10.1002/mgg3.1475

Mycophenolate Mofetil in C3 Glomerulopathy and Pathogenic Drivers of the Disease.

PMID: 32816888
Journal: Clinical Journal of the American Society of Nephrology
Year: 2020
Reference: Clin J Am Soc Nephrol. 2020 Sep 7;15(9):1287-1298. doi: 10.2215/CJN.15241219. Epub 2020 Aug 19.
Impact factor:
Publication type: Paper in international publication
Authors: Allende, Natalia; Alonso Titos, Juana; Ariceta, Gema; Avila, Ana I; Barros, Xoana; Bravo, Luis; Cabello, Virginia; Cano-Megias, Marta; Caravaca-Fontan, Fernando; Cavero, Teresa et al.
DOI: 10.2215/CJN.15241219

Peripheral Corticotropin-Releasing Factor Triggers Jejunal Mast Cell Activation and Abdominal Pain in Patients With Diarrhea-Predominant Irritable Bowel Syndrome.

PMID: 32740086
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2020
Reference: Am J Gastroenterol. 2020 Dec;115(12):2047-2059. doi: 10.14309/ajg.0000000000000789.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Cotoner, Carmen; Antolin, Maria; Azpiroz, Fernando; de Torres, Ines; Fortea, Marina; Gonzalez-Castro, Ana; Guilarte, Mar; Lobo, Beatriz; Martinez, Cristina; Pardo-Camacho, Cristina et al.
DOI: 10.14309/ajg.0000000000000789

Clinical practice recommendations for growth hormone treatment in children with chronic kidney disease.

PMID: 31197263
Journal: Nature Reviews Nephrology
Year: 2019
Reference: Nat Rev Nephrol. 2019 Sep;15(9):577-589. doi: 10.1038/s41581-019-0161-4. Epub 2019 Jun 13.
Impact factor:
Publication type: Review in international publication
Authors: Ariceta Iraola, Gema; Bacchetta, Justine; Bonthuis, Marjolein; Drube, Jens; Edefonti, Alberto; Grenda, Ryszard; Haffner, Dieter; Harambat, Jerome; Santos, Fernando; Shroff, Rukshana et al.
DOI: 10.1038/s41581-019-0161-4

Variable phenotype in HNF1B mutations: extrarenal manifestations distinguish affected individuals from the population with congenital anomalies of the kidney and urinary tract.

PMID: 31198537
Journal: Clinical Kidney Journal
Year: 2019
Reference: Clin Kidney J. 2018 Nov 13;12(3):373-379. doi: 10.1093/ckj/sfy102. eCollection 2019 Jun.
Impact factor:
Publication type: Paper in international publication
Authors: Aguayo, Anibal; Ariceta, Gema; Castano, Luis; Garcia-Castano, Alejandro; Madariaga, Leire; Martinez-Salazar, Rosa et al.
DOI: 10.1093/ckj/sfy102

Management of bone disease in cystinosis: Statement from an international conference.

PMID: 31177550
Journal: JOURNAL OF INHERITED METABOLIC DISEASE
Year: 2019
Reference: J Inherit Metab Dis. 2019 Sep;42(5):1019-1029. doi: 10.1002/jimd.12134. Epub 2019 Aug 5.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Awan, Atif; Bacchetta, Justine; Bergmann, Carsten; Cassidy, Noelle; Deschenes, Geroges; Elenberg, Ewa; Gahl, William A; Greil, Oliver; Haffner, Dieter et al.
DOI: 10.1002/jimd.12134

Real-World Outcomes with Lomitapide Use in Paediatric Patients with Homozygous Familial Hypercholesterolaemia.

PMID: 31102204
Journal: ADVANCES IN THERAPY
Year: 2019
Reference: Adv Ther. 2019 Jul;36(7):1786-1811. doi: 10.1007/s12325-019-00985-8. Epub 2019 May 17.
Impact factor:
Publication type: Paper in international publication
Authors: Araujo, Maria; Ariceta, Gema; Ben-Omran, Tawfeg; Bogsrud, Martin P; Hussein, Osamah; Ibarretxe, Daiana; Kolovou, Genovefa; Lund, Allan M; Masana, Luis; Novoa, F Javier et al.
DOI: 10.1007/s12325-019-00985-8

Clinical and genetic predictors of atypical hemolytic uremic syndrome phenotype and outcome.

PMID: 29907460
Journal: KIDNEY INTERNATIONAL
Year: 2018
Reference: Kidney Int. 2018 Aug;94(2):408-418. doi: 10.1016/j.kint.2018.02.029. Epub 2018 Jun 19.
Impact factor:
Publication type: Paper in international publication
Authors: Ardissino, Gianluigi; Ariceta, Gema; Blasco, Miquel; Cresseri, Donata; Fakhouri, Fadi; Fremeaux-Bacchi, Veronique; Gasteyger, Christoph; Generolova, Galina; Greenbaum, Larry A; Hirt-Minkowski, Patricia et al.
DOI: 10.1016/j.kint.2018.02.029

Severe renal Fanconi and management strategies in Arthrogryposis-Renal dysfunction-Cholestasis syndrome: a case report.

PMID: 29907094
Journal: BMC Nephrology
Year: 2018
Reference: BMC Nephrol. 2018 Jun 15;19(1):144. doi: 10.1186/s12882-018-0926-1.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Gissen, Paul; Mhibik, Maissa; Redecillas, Susana; Rosales, Alejandra; Segarra, Oscar et al.
DOI: 10.1186/s12882-018-0926-1

A kidney-disease gene panel allows a comprehensive genetic diagnosis of cystic and glomerular inherited kidney diseases.

PMID: 29801666
Journal: KIDNEY INTERNATIONAL
Year: 2018
Reference: Kidney Int. 2018 Aug;94(2):363-371. doi: 10.1016/j.kint.2018.02.027. Epub 2018 May 22.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Ars, Elisabet; Ballarin, Jose; Ballesta-Martinez, Maria Juliana; Borregan, Mar; Bullich, Gemma; Domingo-Gallego, Andrea; Fraga, Gloria; Furlano, Monica; Llano-Rivas, Isabel et al.
DOI: 10.1016/j.kint.2018.02.027

Neutral pH and low-glucose degradation product dialysis fluids induce major early alterations of the peritoneal membrane in children on peritoneal dialysis.

PMID: 29776755
Journal: KIDNEY INTERNATIONAL
Year: 2018
Reference: Kidney Int. 2018 Aug;94(2):419-429. doi: 10.1016/j.kint.2018.02.022.
Impact factor:
Publication type: Paper in international publication
Authors: Arbeiter, Klaus; Ariceta, Gema; Bartosova, Maria; Bayazit, Aysun K; Bhayadia, Raj; Buscher, Rainer; Caliskan, Salim; Cerkauskiene, Rimante; Drozdz, Dorota; Fathallah-Shaykh, Sahar et al.
DOI: 10.1016/j.kint.2018.02.022

Kidney transplantation in children weighing 15 kg or less is challenging but associated with good outcome.

PMID: 28359777
Journal: Journal of Pediatric Urology
Year: 2017
Reference: J Pediatr Urol. 2017 Jun;13(3):279.e1-279.e7. doi: 10.1016/j.jpurol.2017.02.025. Epub 2017 Mar 18.
Impact factor:
Publication type: Editorail in international publication
Authors: Ariceta, Gema; Asensio, Marino; Gander, Romy; Lara, Luis Enrique; Lloret, Josep; Molino, Jose Andres; Royo, Gloria Fatou et al.
DOI: 10.1016/j.jpurol.2017.02.025

Efficacy and safety of paricalcitol in children with stages 3 to 5 chronic kidney disease.

PMID: 28332096
Journal: PEDIATRIC NEPHROLOGY
Year: 2017
Reference: Pediatr Nephrol. 2017 Jul;32(7):1221-1232. doi: 10.1007/s00467-017-3579-6. Epub 2017 Mar 22.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Dell, Katherine M; Dufek, Matthew B; Eldred, Ann; Greenbaum, Larry A; Hoppe, Bernd; Lee, Ho-Jin; Lerner, Gary; Linde, Peter; Warady, Bradley A et al.
DOI: 10.1007/s00467-017-3579-6

Poor phenotype-genotype association in a large series of patients with Type III Bartter syndrome.

PMID: 28288174
Journal: PLoS One
Year: 2017
Reference: PLoS One. 2017 Mar 13;12(3):e0173581. doi: 10.1371/journal.pone.0173581. eCollection 2017.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Mireia; Ariceta, Gema; Barajas de Frutos, David; Castano, Luis; Chocron, Sara; Espino, Mar; Espitaletta, Zilac; Fijo, Julia; Garcia Castano, Alejandro; Garcia Nieto, Victor et al.
DOI: 10.1371/journal.pone.0173581

Treatment of Post-Transplant Lymphocele in Children.

PMID: 28132852
Journal: UROLOGY
Year: 2017
Reference: Urology. 2017 May;103:218-223. doi: 10.1016/j.urology.2016.12.039. Epub 2017 Jan 26.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Asensio, Marino; Coma, Ana; Gander, Romy; Molino, Jose Andres; Perez, Mercedes; Royo, Gloria Fatou; Vilalta, Ramon et al.
DOI: 10.1016/j.urology.2016.12.039

A coordinated transition model for patients with cystinosis: from pediatrics to adult care.

PMID: 27595514
Journal: NEFROLOGIA
Year: 2016
Reference: Nefrologia. 2016 Nov - Dec;36(6):616-630. doi: 10.1016/j.nefro.2016.05.012. Epub 2016 Aug 30.
Impact factor:
Publication type: Paper in national publication
Authors: Ariceta, Gema; Camacho, Juan Antonio; Fernandez-Obispo, Matilde; Fernandez-Polo, Aurora; Gamez, Josep; Garcia-Villoria, Judit; Guell, Ana; Lara, Enrique; Leyes, Pere; Martin-Begue, Nieves et al.
DOI: 10.1016/j.nefro.2016.05.012

Considerable variations in growth hormone policy and prescription in paediatric end-stage renal disease across European countries-a report from the ESPN/ERA-EDTA registry.

PMID: 25925700
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2016
Reference: Nephrol Dial Transplant. 2016 Apr;31(4):609-19. doi: 10.1093/ndt/gfv105. Epub 2015 Apr 28.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, G; Baiko, S; Bjerre, A; Bohm, M; Bonthuis, M; Caldas-Afonso, A; Groothoff, J W; Jager, K J; Kolvek, G; Mencarelli, F et al.
DOI: 10.1093/ndt/gfv105

Hemodialysis in children with ventriculoperitoneal shunts: prevalence, management and outcomes.

PMID: 26386590
Journal: PEDIATRIC NEPHROLOGY
Year: 2016
Reference: Pediatr Nephrol. 2016 Jan;31(1):137-43. doi: 10.1007/s00467-015-3204-5. Epub 2015 Sep 19.
Impact factor:
Publication type: Paper in international publication
Authors: Ariceta, Gema; Aufricht, Christoph; Bakkaloglu, Sevcan; Dufek, Stephanie; Edefonti, Alberto; Ekim, Mesiha; Fischbach, Michel; Holtta, Tuula; Jankauskiene, Augustina; Klaus, Gunter et al.
DOI: 10.1007/s00467-015-3204-5

Exosome-like vesicles in uterine aspirates: a comparison of ultracentrifugation-based isolation protocols.

PMID: 27317346
Journal: Journal of Translational Medicine
Year: 2016
Reference: J Transl Med. 2016 Jun 18;14(1):180.
Impact factor:
Publication type: Paper in international publication
Authors: Altadill, Tatiana; Borros, Salvador; Cabrera, Silvia; Campoy, Irene; Colas, Eva; Cubo-Abert, Montserrat; Garcia, Angel; Gil-Moreno, Antonio; Lanau, Lucia; Matias-Guiu, Xavier et al.
DOI: 10.1186/s12967-016-0935-4

Pleuro-peritoneal or pericardio-peritoneal leak in children on chronic peritoneal dialysis-A survey from the European Paediatric Dialysis Working Group.

PMID: 26054713
Journal: PEDIATR NEPHROL
Year: 2015
Reference: Pediatr Nephrol. 2015 Nov;30(11):2021-7. doi: 10.1007/s00467-015-3137-z. Epub 2015 Jun 9.
Impact factor:
Publication type: Letter or abstract
Authors: Ariceta, Gema; Aufricht, Christoph; Bakkaloglu, Sevcan; Cerkauskiene, Rimante; Dufek, Stephanie; Edefonti, Alberto; Ekim, Mesiha; Fischbach, Michel; Holtta, Tuula; Jankauskiene, Augustina et al.
DOI: 10.1007/s00467-015-3137-z

Effectiveness of mycophenolate mofetil in C3 glomerulonephritis.

PMID: 26221755
Journal: KIDNEY INT
Year: 2015
Reference: Kidney Int. 2015 Nov;88(5):1153-60. doi: 10.1038/ki.2015.227. Epub 2015 Jul 29.
Impact factor:
Publication type: Letter or abstract
Authors: Alegre, Raquel; Anton, Monserrat; Ariceta, Gema; Avila, Ana; Baltar, Jose Maria; Barroso, Sergio; Bernis, Carmen; Blasco, Miguel; Cabello, Virginia; Campistol, Jose Maria et al.
DOI: 10.1038/ki.2015.227

Cystinosis in adult and adolescent patients: Recommendations for the comprehensive care of cystinosis.

PMID: 26523297
Journal: NEFROLOGIA
Year: 2015
Reference: Nefrologia. 2015;35(3):304-21.
Impact factor:
Publication type: Paper in national publication
Authors: Ariceta, Gema; Camacho, Juan Antonio; Fernandez-Obispo, Matilde; Fernandez-Polo, Aurora; Gamez, Josep; Garcia-Villoria, Judit; Guell, Ana; Lara Monteczuma, Enrique; Leyes, Pere; Martin-Begue, Nieves et al.
DOI: 10.1016/j.nefroe.2015.06.010

A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer.

PMID: 25902900
Journal: INVEST NEW DRUG
Year: 2015
Reference: Invest New Drugs. 2015 Jun;33(3):710-9. doi: 10.1007/s10637-015-0241-7. Epub 2015 Apr 24.
Impact factor:
Publication type: Paper in international publication
Authors: Azaro, Analia; Benhadji, Karim A; Brana, Irene; Bumgardner, William; Calles, Antonio; Calvo, Emiliano; Hidalgo, Manuel; Lopez-Casas, Pedro P; Miller, Joel; Moser, Brian A et al.
DOI: 10.1007/s10637-015-0241-7

HAVCR/KIM-1 activates the IL-6/STAT-3 Pathway in ccRCC and Determines Tumor Progression and Patient Outcome.

PMID: 24390735
Journal: CANCER RESEARCH
Year: 2014
Reference: Cancer Res. 2014 Mar 1;74(5):1416-28. doi: 10.1158/0008-5472.CAN-13-1671. Epub 2014 Jan 3.
Impact factor:
Publication type: Paper in international publication
Authors: Cuadros, Thais; de Torres, Ines; Itarte, Emilio; Lopez-Hellin, Joan; Meseguer, Anna; Morote, Juan; Ramon Y Cajal, Santiago; Salcedo, Mayte; Sanchez, Alex; Sarro, Eduard et al.
DOI: 10.1158/0008-5472.CAN-13-1671

Low serum mannose-binding lectin levels are associated with inflammation and apoptosis in early surveillance allograft biopsies.

PMID: 25073029
Journal: TRANSPL IMMUNOL
Year: 2014
Reference: Transpl Immunol. 2014 Sep;31(3):152-6. doi: 10.1016/j.trim.2014.07.001. Epub 2014 Jul 26.
Impact factor: 1.832
Publication type: Paper in international publication
Authors: Ibernon, M, Moreso, F, O'Valle, F, Grinyo, J M, Moral, R G, Seron, D et al.
DOI: 10.1016/j.trim.2014.07.001

Hypertension in chronic kidney disease: the influence of renal transplantation.

PMID: 24770618
Journal: TRANSPLANTATION
Year: 2014
Reference: Transplantation. 2014 Sep 15;98(5):537-42. doi: 10.1097/TP.0000000000000103.
Impact factor: 3.535
Publication type: Paper in international publication
Authors: Azancot, Maria A, Ramos, Natalia, Moreso, Francesc J, Ibernon, Meritxell, Espinel, Eugenia, Torres, Irina B, Fort, Joan, Seron, Daniel et al.
DOI: 10.1097/TP.0000000000000103

Innate immunity in renal transplantation: The role of mannose-binding lectin.

PMID: 24321303
Journal: TRANSPLANT REV-ORLAN
Year: 2014
Reference: Transplant Rev (Orlando). 2014 Jan;28(1):21-5. doi: 10.1016/j.trre.2013.10.006. Epub 2013 Oct 26.
Impact factor: 2.66
Publication type: Paper in international publication
Authors: Ibernon, Meritxell, Moreso, Francesc, Seron, Daniel et al.
DOI: 10.1016/j.trre.2013.10.006

Hepatitis A virus cellular receptor 1/kidney injury molecule-1 is a susceptibility gene for clear cell renal cell carcinoma and hepatitis A virus cellular receptor/kidney injury molecule-1 ectodomain shedding a predictive biomarker of tumour progression.

PMID: 23352434
Journal: EUROPEAN JOURNAL OF CANCER
Year: 2013
Reference: Eur J Cancer. 2013 May;49(8):2034-47. doi: 10.1016/j.ejca.2012.12.020. Epub 2013 Jan 23.
Impact factor:
Publication type: Paper in international publication
Authors: Blanco, Albert; Cuadros, Thais; de Torres, Ines; Itarte, Emilio; Lopez-Hellin, Joan; Meseguer, Anna; Messaoud, Nabil Ben; Mir, Carmen; Morote, Juan; Ramon Y Cajal, Santiago et al.
DOI: 10.1016/j.ejca.2012.12.020

Reversal of Hyperoxaluric Cardiomyopathy With Severe Cardiac Dysfunction After Combined Liver and Kidney Transplantation.

PMID: 23018040
Journal: REVISTA ESPANOLA DE CARDIOLOGIA
Year: 2013
Reference: Rev Esp Cardiol. 2013 Mar;66(3):224-5. doi: 10.1016/j.recesp.2012.06.028. Epub 2012 Sep 25.
Impact factor:
Publication type: Letter whit IF
Authors: Albert, Dimpna C; Betrian, Pedro; Garrido, Marta; Giralt, Gemma; Girona, Josep; Madrid, Alvaro et al.
DOI: 10.1016/j.recesp.2012.06.028

A Form of Apolipoprotein A-I Is Found Specifically in Relapses of Focal Segmental Glomerulosclerosis Following Transplantation.

PMID: 23205849
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2013
Reference: Am J Transplant. 2013 Feb;13(2):493-500. doi: 10.1111/j.1600-6143.2012.04338.x. Epub 2012 Dec 3.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, A; Burgos, D; Cantarell, C; Fernandez, A; Fernandez-Alvarez, P; Gonzalez-Roncero, F M; Guirado, L; Jacobs-Cacha, C; Jimenez, C; Jimeno, L et al.
DOI: 10.1111/j.1600-6143.2012.04338.x

The Jejunum of Diarrhea-Predominant Irritable Bowel Syndrome Shows Molecular Alterations in the Tight Junction Signaling Pathway That Are Associated With Mucosal Pathobiology and Clinical Manifestations.

PMID: 22415197
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2012
Reference: Am J Gastroenterol. 2012 May;107(5):736-46. doi: 10.1038/ajg.2011.472. Epub 2012 Mar 13.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1038/ajg.2011.472

A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.

PMID: 22155090
Journal: TOXICOLOGY AND APPLIED PHARMACOLOGY
Year: 2012
Reference: Toxicol Appl Pharmacol. 2012 Jan 15;258(2):275-87. doi: 10.1016/j.taap.2011.11.007. Epub 2011 Dec 3.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; et al.
DOI: 10.1016/j.taap.2011.11.007

Chronic psychosocial stress induces reversible mitochondrial damage and corticotropin-releasing factor receptor type-1 upregulation in the rat intestine and IBS-like gut dysfunction.

PMID: 21641728
Journal: PSYCHONEUROENDOCRINOLOGY
Year: 2012
Reference: Psychoneuroendocrinology. 2012 Jan;37(1):65-77. Epub 2011 Jun 8.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1016/j.psyneuen.2011.05.005

Eccrine porocarcinoma presenting with scrotal lymphedema: a case report and review of systemic treatment.

PMID: 20089564
Journal: ANNALS OF ONCOLOGY
Year: 2010
Reference: Ann Oncol. 2010 Apr;21(4):907. Epub 2010 Jan 20.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; ; ; ; ; ; et al.
DOI: 10.1093/annonc/mdp601

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The communication is part of a study aimed at identifying the mechanisms of progression of Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis, a rare disease that affects the kidneys.

"Patients with familial hypomagnesemia with hypercalciuria and nephrocalcinosis present miRNA profiles in urinary extracellular vesicles associated with disease progression" was the awarded work.

Researchers at the VHIR have carried out a study showing that the ClC-5 protein regulates collagen levels through the β-catenin pathway and lysosomal degradation.