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Kidney Physiopathology

Our main scientific interest is to understand, from a multidisciplinary and translational approach, the molecular and cellular processes leading to renal dysfunction in several kidney pathologies. Specifically, our research lines are

  • to study the pathophysiology of inherited rare renal tubulopathies
  • to understand the mechanisms of kidney injury and regeneration
  • to study the development of clear cell renal cell carcinoma (ccRCC)
  • the study the impact of androgens on those processes.

We are experts on the following areas:

  • the generation of cellular disease models carrying specific gene alterations,
  • genetically modified animal models and gene therapies,
  • life-imaging high-resolution microscopy
  • working with patients’ samples for translational research.

To sum up, our research main objective is to combine –omic data from cellular and animal models with patients’ data to identify novel biomarkers and possible treatments for several renal diseases.

Team

Alejandro Cruz Gual

Alejandro Cruz Gual

Research technician
Kidney Physiopathology
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Alvaro Domingo Madrid Aris

Alvaro Domingo Madrid Aris

Kidney Physiopathology
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Cristina Cea Arestín

Cristina Cea Arestín

Predoctoral researcher
Kidney Physiopathology
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Cristina Martínez Martínez

Cristina Martínez Martínez

Main researcher
Kidney Physiopathology
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Gema Ariceta Iraola

Gema Ariceta Iraola

Head of group
Kidney Physiopathology
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Gloria Mª Fraga Rodriguez

Gloria Mª Fraga Rodriguez

Senior researcher
Kidney Physiopathology
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Alejandro Cruz Gual

Alejandro Cruz Gual

Research technician
Kidney Physiopathology
Read more
Alvaro Domingo Madrid Aris

Alvaro Domingo Madrid Aris

Kidney Physiopathology
Read more
Cristina Cea Arestín

Cristina Cea Arestín

Predoctoral researcher
Kidney Physiopathology
Read more
Cristina Martínez Martínez

Cristina Martínez Martínez

Main researcher
Kidney Physiopathology
Read more
Gema Ariceta Iraola

Gema Ariceta Iraola

Head of group
Kidney Physiopathology
Read more
Gloria Mª Fraga Rodriguez

Gloria Mª Fraga Rodriguez

Senior researcher
Kidney Physiopathology
Read more

Projects

TRANS-GENE - Caracterización en Sangre Periférica de una Firma Génica de Rechazo Humoral Común en Trasplantes de Órganos Sólidos.

IP: Maria Antonia Emilia Meneghini
Collaborators: Saskia Natali Agámez Luengas, Lluis Castells Fusté, Joana Sellarés Roig, Jesús Quintero Bernabeu, Eva Maria Revilla Lopez, Marina Muñoz López, Meritxell Boada Perez, Laura Donadeu Casassas, Mercedes López González
Funding agency: Instituto de Salud Carlos III
Funding: 111320
Reference: PI22/00749
Duration: 01/01/2023 - 31/12/2026

Blog

News

The team has discovered that a protein called SEC22B acts as a phenotype modifier and could be used as a potential urinary marker of the disease.

Funding has been obtained for 43 projects under the calls for Health R&D&I Projects, Health Technology Development, and Independent Clinical Research

The aim of the project is to establish kidney organoids derived from patients with familial hypomagnesaemia with hypercalciuria and nephrocalcinosis, which will be essential tools for studying the disease and testing new treatments.