Kidney Physiopathology
Our main scientific interest is to understand, from a multidisciplinary and translational approach, the molecular and cellular processes leading to renal dysfunction in several kidney pathologies. Specifically, our research lines are
- to study the pathophysiology of inherited rare renal tubulopathies
- to understand the mechanisms of kidney injury and regeneration
- to study the development of clear cell renal cell carcinoma (ccRCC)
- the study the impact of androgens on those processes.
We are experts on the following areas:
- the generation of cellular disease models carrying specific gene alterations,
- genetically modified animal models and gene therapies,
- life-imaging high-resolution microscopy
- working with patients’ samples for translational research.
To sum up, our research main objective is to combine –omic data from cellular and animal models with patients’ data to identify novel biomarkers and possible treatments for several renal diseases.
Publications
Correction to: Impact of coronavirus disease-2019 on pediatric nephrology practice and education: an ESPN survey.
PMID: 35211799
Journal: PEDIATRIC NEPHROLOGY
Year: 2022
Reference: Pediatr Nephrol. 2022 Feb 24. pii: 10.1007/s00467-022-05473-w. doi: 10.1007/s00467-022-05473-w.
Impact factor:
Publication type: Letter or abstract
Authors: Abranches, M; Akman, S; Alpay, H; Ariceta, G; Atmis, B; Bael, A; Bakkaloglu, S A; Bakkaloglu, Sevcan A; Bayrakci, U S; Bhimma, R et al.
DOI: 10.1007/s00467-022-05473-w
CD44-negative parietal-epithelial cell staining in minimal change disease: association with clinical features, response to corticosteroids and kidney outcome.
PMID: 35211308
Journal: Clinical Kidney Journal
Year: 2022
Reference: Clin Kidney J. 2021 Nov 15;15(3):545-552. doi: 10.1093/ckj/sfab215. eCollection 2022 Mar.
Impact factor:
Publication type: Paper in international publication
Authors: Abo, Anabel; Balius, Anna; Cruz, Alejandro; Fraga, Gloria; Gonzalez, Jorge; Jatem, Elias; Madrid, Alvaro; Martin, Marisa; Martinez, Cristina; Roca, Neus et al.
DOI: 10.1093/ckj/sfab215
Who with suspected prostate cancer can benefit from Proclarix after multiparametric magnetic resonance imaging?
PMID: 35200058
Journal: INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
Year: 2022
Reference: Int J Biol Markers. 2022 Jun;37(2):218-223. doi: 10.1177/03936155221081537. Epub 2022 Feb 24.
Impact factor:
Publication type: Paper in international publication
Authors: Campistol, Miriam; Celma, Anna; de Torres, Ines; Mast, Richard; Morote, Juan; Planas, Jacques; Regis, Lucas; Roche, Sarai; Santamaria, Anna; Semidey, Maria E et al.
DOI: 10.1177/03936155221081537
Kidney Transplantation in Small Children: Association Between Body Weight and Outcome - A Report From the ESPN/ERA-EDTA Registry.
PMID: 33795596
Journal: TRANSPLANTATION
Year: 2022
Reference: Transplantation. 2022 Mar 1;106(3):607-614. doi: 10.1097/TP.0000000000003771.
Impact factor:
Publication type: Paper in international publication
Authors: Aufricht, Christoph; Battelino, Nina; Bjerre, Anna; Boehm, Michael; Bonthuis, Marjolein; de Jong, Huib; Edvardsson, Vidar O; Groothoff, Jaap; Harambat, Jerome; Herthelius, Maria et al.
DOI: 10.1097/TP.0000000000003771
Phenotypic characterization of X-linked hypophosphatemia in pediatric Spanish population.
PMID: 33639975
Journal: Orphanet Journal of Rare Diseases
Year: 2021
Reference: Orphanet J Rare Dis. 2021 Feb 27;16(1):104. doi: 10.1186/s13023-021-01729-0.
Impact factor:
Publication type: Paper in international publication
Authors: Anton-Gamero, Montserrat; Ariceta, Gema; Carrasco Hidalgo-Barquero, Marta; Chocron, Sara; de la Cerda-Ojeda, Francisco; de Lucas-Collantes, Carmen; Espinosa, Laura; Fernandez-Escribano, Angustias; Fernandez-Fernandez, Marta; Fernandez-Maseda, M masculine Angeles et al.
DOI: 10.1186/s13023-021-01729-0
Relationship between soluble urokinase-type plasminogen activator receptor and serum biomarkers of endothelial activation in patients with idiopathic nephrotic syndrome.
PMID: 33623677
Journal: Clinical Kidney Journal
Year: 2021
Reference: Clin Kidney J. 2020 Jan 17;14(2):543-549. doi: 10.1093/ckj/sfz173. eCollection 2021 Feb.
Impact factor:
Publication type: Paper in international publication
Authors: Jatem, Elias; Martin, Maria Luisa; Martinez, Cristina; Molina, Maria; Munoz, Marina; Roca, Neus; Segarra, Alfons et al.
DOI: 10.1093/ckj/sfz173
Challenges in primary focal segmental glomerulosclerosis diagnosis: from the diagnostic algorithm to novel biomarkers.
PMID: 33623672
Journal: Clinical Kidney Journal
Year: 2021
Reference: Clin Kidney J. 2020 Aug 11;14(2):482-491. doi: 10.1093/ckj/sfaa110. eCollection 2021 Feb.
Impact factor:
Publication type: Review in international publication
Authors: Agraz, Irene; Ariceta, Gema; Garcia-Carro, Clara; Jacobs-Cacha, Conxita; Lopez-Hellin, Joan; Moreso, Francesc; Seron, Daniel; Soler, Maria Jose; Toapanta-Gaibor, Nestor; Vergara, Ander et al.
DOI: 10.1093/ckj/sfaa110
Countermeasures against COVID-19: how to navigate medical practice through a nascent, evolving evidence base - a European multicentre mixed methods study.
PMID: 33597140
Journal: BMJ Open
Year: 2021
Reference: BMJ Open. 2021 Feb 17;11(2):e043015. doi: 10.1136/bmjopen-2020-043015.
Impact factor:
Publication type: Paper in international publication
Authors: Alper, Seth L; Ariceta, Gema; Aufricht, Christoph; Bakkaloglu, Sevcan; Cetin, Asil; Edefonti, Alberto; Eibensteiner, Fabian; Jankauskiene, Augustina; Klaus, Gunter; Paglialonga, Fabio et al.
DOI: 10.1136/bmjopen-2020-043015
Characterization of two novel mutations in the claudin-16 and claudin-19 genes that cause familial hypomagnesemia with hypercalciuria and nephrocalcinosis.
PMID: 30576809
Journal: GENE
Year: 2019
Reference: Gene. 2019 Mar 20;689:227-234. doi: 10.1016/j.gene.2018.12.024. Epub 2018 Dec 18.
Impact factor:
Publication type: Paper in international publication
Authors: Aguirre, Mireia; Ariceta, Gema; Claverie-Martin, Felix; Davitaia, Tinatin; Perdomo-Ramirez, Ana; Ramos-Trujillo, Elena et al.
DOI: 10.1016/j.gene.2018.12.024
Risk of cardiovascular involvement in pediatric patients with X-linked hypophosphatemia.
PMID: 30607568
Journal: PEDIATRIC NEPHROLOGY
Year: 2019
Reference: Pediatr Nephrol. 2019 Jun;34(6):1077-1086. doi: 10.1007/s00467-018-4180-3. Epub 2019 Jan 4.
Impact factor:
Publication type: Paper in international publication
Authors: Anton-Gamero, Montserrat; Ariceta, Gema; Chocron, Sara; de la Cerda Ojeda, Francisco; Fernandez-Fernandez, Marta; Fernandez-Maseda, Angeles; Ferrando-Monleon, Susana; Gil-Pena, Helena; Gonzalez-Sanchez, Susana; Hernandez-Frias, Olaya et al.
DOI: 10.1007/s00467-018-4180-3
Long-term outcome in a case series of Denys-Drash syndrome.
PMID: 31807296
Journal: Clinical Kidney Journal
Year: 2019
Reference: Clin Kidney J. 2019 Mar 16;12(6):836-839. doi: 10.1093/ckj/sfz022. eCollection 2019 Dec.
Impact factor: 2.975
Publication type: Paper in international publication
Authors: Roca, Neus, Munoz, Marina, Cruz, Alejandro, Vilalta, Ramon, Lara, Enrique, Ariceta, Gema et al.
DOI: 10.1093/ckj/sfz022
Prediabetes is a risk factor for cardiovascular disease following renal transplantation.
PMID: 31611066
Journal: KIDNEY INTERNATIONAL
Year: 2019
Reference: Kidney Int. 2019 Dec;96(6):1374-1380. doi: 10.1016/j.kint.2019.06.026. Epub 2019 Aug 14.
Impact factor: 8.306
Publication type: Paper in international publication
Authors: Porrini, Esteban, Diaz, Juan Manuel, Moreso, Francesc, Lauzurrica, Ricardo, Ibernon, Meritxel, Torres, Irene Silva, Ruiz, Rocio Benitez, Rodriguez Rodriguez, Ana Elena, Mallen, Patricia Delgado, Bayes-Genis, Beatriz et al.
DOI: 10.1016/j.kint.2019.06.026
News
The communication is part of a study aimed at identifying the mechanisms of progression of Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis, a rare disease that affects the kidneys.
"Patients with familial hypomagnesemia with hypercalciuria and nephrocalcinosis present miRNA profiles in urinary extracellular vesicles associated with disease progression" was the awarded work.
Researchers at the VHIR have carried out a study showing that the ClC-5 protein regulates collagen levels through the β-catenin pathway and lysosomal degradation.