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Liver Diseases

The Liver Diseases group is a referent at the local, national and international level in research, and is one of the most active groups in clinical research at VHIR. The group's prominent involvement in clinical trials is a clear indication of our professionals' commitment to ensuring that patients have access to state-of-the-art therapies. Our participation and collaboration in international projects and consortiums are also a fundamental characteristic of the group. The main objective of the group is to become one of the best translational research groups in liver diseases. It is essential to be able to apply all the findings of basic research to clinical research to improve the health of patients with liver disease.

Team

Clara Sabiote Cartes

Clara Sabiote Cartes

Research technician
Liver Diseases
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Adriana Palom Agusti

Adriana Palom Agusti

Postdoctoral researcher
Liver Diseases
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Agnès Soriano Varela

Agnès Soriano Varela

Predoctoral researcher
Liver Diseases
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Alba Maria Jiménez Masip

Alba Maria Jiménez Masip

Predoctoral researcher
Liver Diseases
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Cespedes Guachamboza, Carlos Milton

Cespedes Guachamboza, Carlos Milton

Predoctoral researcher
Liver Diseases
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Claudia Ana Burillo Vargas

Claudia Ana Burillo Vargas

Liver Diseases
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Clara Sabiote Cartes

Clara Sabiote Cartes

Research technician
Liver Diseases
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Adriana Palom Agusti

Adriana Palom Agusti

Postdoctoral researcher
Liver Diseases
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Agnès Soriano Varela

Agnès Soriano Varela

Predoctoral researcher
Liver Diseases
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Alba Maria Jiménez Masip

Alba Maria Jiménez Masip

Predoctoral researcher
Liver Diseases
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Cespedes Guachamboza, Carlos Milton

Cespedes Guachamboza, Carlos Milton

Predoctoral researcher
Liver Diseases
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Claudia Ana Burillo Vargas

Claudia Ana Burillo Vargas

Liver Diseases
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Research lines

Malaltia hepàtica crònica avançada

Tractaments combinats per prevenir les lesions o fibrosis hepàtica en malaltia hepàtica crònica/NASH

Tractaments dirigits a cèl·lules sinusoïdals hepàtiques a través de nanopartícules biodegradables

Desenvolupament de models animals experimentals translacionals a la patologia en humans de NASH i malaltia hepàtica per alcohol

Mètodes no invasius per malaltia hepàtica crònica avançada

Hipertensió portal


Serveis o tecnologies rellevants:


Models animals de malaltia hepàtica crònica: PVL; BDL; CCL4; TAA; NAFLD; NASH; MAFLD

Determinació de paràmetres hemodinàmics en models animals: PP; MAP; SMABF; SMAR, PF; IHVR

Aïllament de cèl·lules primàries de fetge: hepatòcits; LSEC; KC; HSC

Tincions histològiques

Cultius cel·lulars

Citometria de flux

Anàlisis de proteïnes: Wb, IIHC, IF, Proteòmica diferencial

Anàlisis d'expressió gènica: RT-qPCR, ISH, Microarrays

Microscòpia confocal i Microscòpia electrònica

Administració de fàrmacs en nanopartícules: Internalizació; direccionament; biodistribució; efectivitat; assaigs MTT y MTD

IP: Maria Nieves Martell Pérez-Alcalde, Joan Genescà Ferrer

Malaltia hepàtica relacionada amb l'alcohol

Malaltia avançada: hepatitis alcohòlica, cirrosis i malaltia hepàtica crònica per alcohol (cALD)

Salut pública

Insuficiència hepàtica aguda sobre crònica (ACLF)

IP: Meritxell Ventura Cots

Malalties hepàtiques cròniques

Malalties colestàsiques

Complicacions de la cirrosi hepàtica

Insuficiència hepàtica aguda sobre crònica (ACLF)

IP: Malalties hepàtiques cròniques

Metabolisme hepàtic i infeccions (LivMI)

Epidemiologia del fetge gras no alcohòlic, biomarcadors i nous tractament

Infeccions malaltia hepàtica avançada

IP: Juan Manuel Pericàs Pulido

Projects

Application of bioinformatic tools in the diagnosis of infectious diseases through metagenomics and deep-sequencing

IP: Josep Quer Sivila
Collaborators: Marta Ibañez Lligoña, Miriam Izquierdo Sans
Funding agency: Fundació "La Caixa"
Funding: 117900
Reference: 132074
Duration: 01/09/2023 - 31/08/2026

Búsqueda de biomarcadores (inmunológicos y/o celulares) predictivos de respuesta virológica o de control de la infección en la hepatitis crónica D.

IP: Maria Buti Ferret
Collaborators: Maria Francesca Cortese
Funding agency: Instituto de Salud Carlos III
Funding: 220000
Reference: PI23/01065
Duration: 01/01/2024 - 31/12/2026

Proyecto de formación integral en enfermedad hepática crónica avanzada

IP: Juan Manuel Pericàs Pulido
Collaborators: Miriam Izquierdo Sans
Funding agency: Instituto de Salud Carlos III
Funding: 65000
Reference: CM23/00251
Duration: 02/01/2024 - 01/01/2026

Beca VHIR PhD

IP: Josep Quer Sivila
Collaborators: Beca VHIR PhD, Laia Perez Lasarte, Carolina Campos Martinez
Funding agency: Fundació Institut de Recerca HUVH
Funding: 69188.74
Reference: VPHD/CAROLINA_C
Duration: 01/04/2023 - 31/03/2026

Publications

Utility of mobile applications in the management of hepatitis B: A systematic review.

PMID: 39983899
Journal: Gastroenterologia y Hepatologia
Year: 2025
Reference: Gastroenterol Hepatol. 2025 Feb 19:502395. doi: 10.1016/j.gastrohep.2025.502395.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Fabrellas, Nuria; Palom, Adriana; Romero-Vico, Judit; Vargas-Accarino, Elena et al.
DOI: 10.1016/j.gastrohep.2025.502395

Impact of zinc on hepatocellular carcinoma cell behavior and metallothionein expression: Insights from preclinical models.

PMID: 40048869
Journal: BIOMEDICINE & PHARMACOTHERAPY
Year: 2025
Reference: Biomed Pharmacother. 2025 Mar 5;185:117918. doi: 10.1016/j.biopha.2025.117918.
Impact factor:
Publication type: Paper in international publication
Authors: Bermudez-Ramos, Maria; Higuera, Monica; Minguez, Beatriz; Salcedo, Maria Teresa; Soriano-Varela, Agnes; Torrens, Maria; Vargas-Accarino, Elena et al.
DOI: 10.1016/j.biopha.2025.117918

Editorial: Virology today in Spain. Selected topics from Spanish virology.

PMID: 38333036
Journal: Frontiers in Cellular and Infection Microbiology
Year: 2024
Reference: Front Cell Infect Microbiol. 2024 Jan 25;14:1367322. doi: 10.3389/fcimb.2024.1367322. eCollection 2024.
Impact factor:
Publication type: Editorail in international publication
Authors: Alonso, Covadonga; Garcia-Dorival, Isabel; Quer, Josep et al.
DOI: 10.3389/fcimb.2024.1367322

Serum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis.

PMID: 38377466
Journal: HEPATOLOGY
Year: 2024
Reference: Hepatology. 2024 Feb 20. doi: 10.1097/HEP.0000000000000777.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes, Juan G; Altamirano, Jose; Bataller, Ramon; Bosques-Padilla, Francisco; Brown, Robert S Jr; Caballeria, Juan; Garcia-Tsao, Guadalupe; Hartmann, Phillipp; Hsu, Cynthia L; Kouno, Tetsuya et al.
DOI: 10.1097/HEP.0000000000000777

Complete Genome Sequences of Four Mycobacteriophages Involved in Directed Evolution against Undisputed Mycobacterium abscessus Clinical Strains.

PMID: 38399778
Journal: Microorganisms
Year: 2024
Reference: Microorganisms. 2024 Feb 11;12(2):374. doi: 10.3390/microorganisms12020374.
Impact factor:
Publication type: Paper in international publication
Authors: Cao Yao, Juan Carlos; Fernandez, Maria Teresa Tortola; Garcia Cehic, Damir; Gorrin, Alexis Dorta; Hevia, Lorena Garcia; Mendez, Jesus Navas; Quer, Josep et al.
DOI: 10.3390/microorganisms12020374

Impact of percutaneous mitral paravalvular leak closure on the natural history of recurrent gastrointestinal bleeding.

PMID: 38436370
Journal: EuroIntervention
Year: 2024
Reference: EuroIntervention. 2024 Mar 4;20(5):e329-e331. doi: 10.4244/EIJ-D-23-00703.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso-Cotoner, Carmen; Belahnech, Yassin; Bermudez-Ramos, Maria; Ferreira-Gonzalez, Ignacio; Galian-Gay, Laura; Garcia Del Blanco, Bruno; Marti-Aguasca, Gerard; Rodenas-Alesina, Eduard; Vila-Olives, Rosa et al.
DOI: 10.4244/EIJ-D-23-00703

Liver steatosis induces portal hypertension regardless of fibrosis in patients with NAFLD: A proof of concept case report.

PMID: 36478872
Journal: JHEP Reports
Year: 2023
Reference: JHEP Rep. 2022 Oct 29;5(1):100618. doi: 10.1016/j.jhepr.2022.100618. eCollection 2023 Jan.
Impact factor:
Publication type: Paper in international publication
Authors: Barbera, Aurora; Genesca, Joan; Martell, Maria; Pericas, Juan M; Rivera-Esteban, Jesus; Salcedo, Maria Teresa et al.
DOI: 10.1016/j.jhepr.2022.100618

msmsEDA & msmsTests: Label-Free Differential Expression by Spectral Counts.

PMID: 36308691
Journal: Methods in molecular biology (Clifton, N.J.)
Year: 2023
Reference: Methods Mol Biol. 2023;2426:197-242. doi: 10.1007/978-1-0716-1967-4_10.
Impact factor:
Publication type: Paper in international publication
Authors: Gregori, Josep; Sanchez, Alex; Villanueva, Josep et al.
DOI: 10.1007/978-1-0716-1967-4_10

Oportunistic diagnosis based on age and hepatitis C virus clearance: an essential step to improve the overall health of the liver.

PMID: 36514974
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2023
Reference: Rev Esp Enferm Dig. 2023 Mar;115(3):128-132. doi: 10.17235/reed.2022.9325/2022.
Impact factor:
Publication type: Paper in international publication
Authors: A Serra, Miguel; Aguilera, Antonio; Albillos, Agustin; Buti, Maria; Cabezas, Joaquin; Calleja, Jose Luis; Calvo Montes, Jorge; Casado Martin, Marta; Crespo, Javier; Diago Madrid, Moises et al.
DOI: 10.17235/reed.2022.9325/2022

Platform trials as the way forward in infectious disease' clinical research: the case of COVID-19.

PMID: 36462745
Journal: CLINICAL MICROBIOLOGY AND INFECTION
Year: 2023
Reference: Clin Microbiol Infect. 2023 Mar;29(3):277-280. doi: 10.1016/j.cmi.2022.11.022. Epub 2022 Dec 1.
Impact factor:
Publication type: Letter or abstract
Authors: Berry, Scott M; Derde, Lennie Pg; Pericas, Juan M et al.
DOI: 10.1016/j.cmi.2022.11.022

Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experiencing Mental Health Disorders.

PMID: 36423102
Journal: Viruses-Basel
Year: 2022
Reference: Viruses. 2022 Nov 11;14(11):2493. doi: 10.3390/v14112493.
Impact factor:
Publication type: Paper in international publication
Authors: Acosta-Lopez, Silvia; Borgia, Sergio M; Buti, Maria; Di Marco, Vito; Fenech, Mary; Fraser, Chris; Garcia-Retortillo, Montserrat; Guerra-Veloz, Maria Fernanda; Hernandez, Candido; Martins, Alexandra et al.
DOI: 10.3390/v14112493

Outcomes of Patients with Severe Obesity and Cirrhosis with Portal Hypertension Undergoing Bariatric Surgery: a Systematic Review.

PMID: 36422758
Journal: OBESITY SURGERY
Year: 2022
Reference: Obes Surg. 2022 Nov 24. doi: 10.1007/s11695-022-06362-9.
Impact factor:
Publication type: Review in international publication
Authors: Angel, Mariana; Banares, Juan; Ciudin, Andreea; Comas, Marta; Flores, Vanesa; Manzano-Nunez, Ramiro; Pericas, Juan M; Rivera-Esteban, Jesus; Vilallonga, Ramon et al.
DOI: 10.1007/s11695-022-06362-9

Liver diseases: a sanitary and social challenge for Europe in the XXI Century. Results of EASL-Lancet Comission.

PMID: 36041936
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin (Barc). 2022 Dec 23;159(12):598-603. doi: 10.1016/j.medcli.2022.07.010. Epub 2022 Aug 27.
Impact factor:
Publication type: Paper in national publication
Authors: Buti, Maria; Gines, Pere; Lazarus, Jeffrey V; Sangro, Bruno et al.
DOI: 10.1016/j.medcli.2022.07.010

hbsag levels can be used to rule out cirrhosis in hbeag positive chronic hepatitis b: results from the sonic-b study.

PMID: 32318704
Journal: JOURNAL OF INFECTIOUS DISEASES
Year: 2022
Reference: J Infect Dis. 2022 Jun 1;225(11):1967-1973. doi: 10.1093/infdis/jiaa192.
Impact factor:
Publication type: Paper in international publication
Authors: Brouwer, Willem P; Buti, Maria; Chan, Henry L-Y; Chien, R N; de Knegt, R J; de Man, R A; Gaggar, Anuj; Hansen, Bettina E; Janssen, Harry L A; Jia, Ji-Dong et al.
DOI: 10.1093/infdis/jiaa192

The impact of direct acting antivirals on hepatitis C virus disease burden and associated costs in four european countries.

PMID: 33529499
Journal: LIVER INTERNATIONAL
Year: 2021
Reference: Liver Int. 2021 May;41(5):934-948. doi: 10.1111/liv.14808. Epub 2021 Feb 24.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Craxi, Antonio; Gheorghe, Liana; Kondili, Loreta A; Marcellusi, Andrea; Mennini, Francesco S; Montilla, Simona; Robbins Scott, Sarah; Ryder, Stephen et al.
DOI: 10.1111/liv.14808

EASL position paper on the use of COVID-19 vaccines in patients with chronic liver diseases, hepatobiliary cancer and liver transplant recipients.

PMID: 33563499
Journal: JOURNAL OF HEPATOLOGY
Year: 2021
Reference: J Hepatol. 2021 Apr;74(4):944-951. doi: 10.1016/j.jhep.2021.01.032. Epub 2021 Feb 6.
Impact factor:
Publication type: Review in international publication
Authors: Buti, Maria; Cornberg, Markus; Eberhardt, Christiane S; Grossi, Paolo Antonio; Shouval, Daniel et al.
DOI: 10.1016/j.jhep.2021.01.032

Assessing Liver Fibrosis Using the FIB4 Index in the Community Setting.

PMID: 34943471
Journal: Diagnostics
Year: 2021
Reference: Diagnostics (Basel). 2021 Nov 29;11(12). pii: diagnostics11122236. doi: 10.3390/diagnostics11122236.
Impact factor:
Publication type: Paper in international publication
Authors: Augustin, Salvador; Blanco-Grau, Albert; Buti, Maria; Casis, Ernesto; Cruz, Luz-Maria; Enfedaque, Belen; Ferrer-Costa, Roser; Gabriel-Medina, Pablo; Lopez-Martinez, Rosa; Pons, Monica et al.
DOI: 10.3390/diagnostics11122236

Microorganisms as Shapers of Human Civilization, from Pandemics to Even Our Genomes: Villains or Friends? A Historical Approach.

PMID: 34946123
Journal: Microorganisms
Year: 2021
Reference: Microorganisms. 2021 Dec 6;9(12). pii: microorganisms9122518. doi: 10.3390/microorganisms9122518.
Impact factor:
Publication type: Review in international publication
Authors: Cortese, Maria Francesca; Garcia-Garcia, Selene; Pumarola, Tomas; Quer, Josep; Rando-Segura, Ariadna; Rodriguez-Frias, Francisco; Tabernero, David et al.
DOI: 10.3390/microorganisms9122518

Risk of Secondary Infection Waves of COVID-19 in an Insular Region: The Case of the Balearic Islands, Spain

PMID: NOPMID0081
Journal: Frontiers in Medicine
Year: 2020
Reference: Frontiers in Medicine. 2020;7:905. doi: 10.3389/fmed.2020.563455
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; et al.
DOI: 10.3389/fmed.2020.563455

Simple predictive models identify patients with COVID-19 pneumonia and poor prognosis.

PMID: 33370397
Journal: PLoS One
Year: 2020
Reference: PLoS One. 2020 Dec 28;15(12):e0244627. doi: 10.1371/journal.pone.0244627. eCollection 2020.
Impact factor:
Publication type: Paper in international publication
Authors: Anton, Andres; Camps-Relats, Laura; Gonzalez, Antonio; Gonzalez-Sans, Didac; Hernandez, Manuel; Labrador-Horrillo, Moises; Martinez-Gallo, Monica; Martinez-Valle, Fernando; Nunez-Conde, Andrea; Pujol-Borrell, Ricardo et al.
DOI: 10.1371/journal.pone.0244627

Treatment duration of enterococcal intravascular catheter-related infections - Author's reply.

PMID: 33340670
Journal: CLINICAL MICROBIOLOGY AND INFECTION
Year: 2020
Reference: Clin Microbiol Infect. 2020 Dec 16. pii: S1198-743X(20)30730-8. doi: 10.1016/j.cmi.2020.11.034.
Impact factor:
Publication type: Letter or abstract
Authors: Bartoletti, Michele; Cervera, Carlos; Dahl, Anders; Del Turco, Elena Rosselli; Pericas, Juan M et al.
DOI: 10.1016/j.cmi.2020.11.034

Hepatocellular carcinoma with tumor thrombus extends to the right atrium and portal vein: A case report.

PMID: 33312435
Journal: World journal of hepatology
Year: 2020
Reference: World J Hepatol. 2020 Nov 27;12(11):1128-1135. doi: 10.4254/wjh.v12.i11.1128.
Impact factor:
Publication type: Letter or abstract
Authors: Gomez-Puerto, Diego; Mirallas, Oriol; Vargas, Victor; Vidal-Gonzalez, Judit et al.
DOI: 10.4254/wjh.v12.i11.1128

HEVnet: a One Health, collaborative, interdisciplinary network and sequence data repository for enhanced hepatitis E virus molecular typing, characterisation and epidemiological investigations.

PMID: 30862334
Journal: Eurosurveillance
Year: 2019
Reference: Euro Surveill. 2019 Mar;24(10). doi: 10.2807/1560-7917.ES.2019.24.10.1800407.
Impact factor:
Publication type: Paper in international publication
Authors: Aberle, Stephan; Adlhoch, Cornelia; Avellon, Ana; Bachofen, Claudia; Baechlein, Christine; Baylis, Sally A.; Boxman, Ingeborg; Bruni, Roberto; Buti, Maria; Ciccaglione, Anna Rita et al.
DOI: 10.2807/1560-7917.ES.2019.24.10.1800407

Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease.

PMID: 31723265
Journal: NATURE
Year: 2019
Reference: Nature. 2019 Nov;575(7783):505-511. doi: 10.1038/s41586-019-1742-x. Epub 2019 Nov 13.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes, Juan G; Altamirano, Jose; Bataller, Ramon; Bosques-Padilla, Francisco; Brandl, Katharina; Brown, Robert S Jr; Caballeria, Juan; Chu, Huikuan; Clarke, Thomas H; Duan, Yi et al.
DOI: 10.1038/s41586-019-1742-x

Factors Associated with Rates of HBsAg Seroclearance in Adults with Chronic HBV Infection: A systematic review and meta-analysis.

PMID: 30342034
Journal: GASTROENTEROLOGY
Year: 2019
Reference: Gastroenterology. 2019 Feb;156(3):635-646.e9. doi: 10.1053/j.gastro.2018.10.027. Epub 2018 Oct 17.
Impact factor:
Publication type: Review in international publication
Authors: Buti, Maria; Charatcharoenwitthaya, Phunchai; Chien, Nicholas; Chong, Yutian; Fung, James Yan Yue; Ho, Hsiu J; Hosaka, Tetsuya; Istratescu, Doina; Jeong, Donghak; Kam, Leslie et al.
DOI: 10.1053/j.gastro.2018.10.027

Risk Stratification in Acute Variceal Bleeding: Child-Pugh Versus Model for End-stage Liver Disease.

PMID: 28445236
Journal: JOURNAL OF CLINICAL GASTROENTEROLOGY
Year: 2019
Reference: J Clin Gastroenterol. 2019 Aug;53(7):549. doi: 10.1097/MCG.0000000000000815.
Impact factor:
Publication type: Letter or abstract
Authors: Abraldes, Juan G; Augustin, Salvador; Genesca, Joan; Reverter, Enric et al.
DOI: 10.1097/MCG.0000000000000815

Complete response under sorafenib in patients with hepatocellular carcinoma. Relationship with dermatologic adverse events.

PMID: 28898447
Journal: HEPATOLOGY
Year: 2018
Reference: Hepatology. 2018 Feb;67(2):612-622. doi: 10.1002/hep.29515. Epub 2018 Jan 2.
Impact factor:
Publication type: Paper in international publication
Authors: Ayuso, Carmen; Bruix, Jordi; Castroagudin, Javier; Darnell, Anna; de Lope, Carlos Rodriguez; Delgado, Manuel; Diaz-Gonzalez, Alvaro; Gonzalez, Carmen; Hernandez-Guerra, Manuel; Huertas, Carlos et al.
DOI: 10.1002/hep.29515

Minimal hepatic encephalopathy identifies patients at risk of faster cirrhosis progression.

PMID: 28768371
Journal: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Year: 2018
Reference: J Gastroenterol Hepatol. 2018 Mar;33(3):718-725. doi: 10.1111/jgh.13917.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, Virginia; Ampuero, Javier; Jover, Rodrigo; Marquez, Celina; Millan, Raquel; Montoliu, Carmina; Rico, Maria Carmen; Romero-Gomez, Manuel; Sendra, Carmen; Serra, Miguel Angel et al.
DOI: 10.1111/jgh.13917

Baseline hepatitis C virus resistance-associated substitutions present at frequencies lower than 15% may be clinically significant.

PMID: 30519058
Journal: Infection and Drug Resistance
Year: 2018
Reference: Infect Drug Resist. 2018 Nov 8;11:2207-2210. doi: 10.2147/IDR.S172226. eCollection 2018.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Castells, Lluis; Chen, Qian; Domingo, Esteban; Esteban, Juan Ignacio; Garcia-Cehic, Damir; Gregori, Josep; Imaz, Arkaitz; Llorens-Revull, Meritxell; Nieto-Aponte, Leonardo et al.
DOI: 10.2147/IDR.S172226

Healthcare value of implementing hepatitis C screening in the adult general population in Spain.

PMID: 30485377
Journal: PLoS One
Year: 2018
Reference: PLoS One. 2018 Nov 28;13(11):e0208036. doi: 10.1371/journal.pone.0208036. eCollection 2018.
Impact factor:
Publication type: Paper in international publication
Authors: Buti, Maria; Casado, Miguel Angel; Dominguez-Hernandez, Raquel; Esteban, Rafael; Sabater, Eliazar et al.
DOI: 10.1371/journal.pone.0208036

Efficacy and tolerability of interferon-free antiviral therapy in kidney transplant recipients with chronic hepatitis c.

PMID: 28039098
Journal: JOURNAL OF HEPATOLOGY
Year: 2017
Reference: J Hepatol. 2017 Apr;66(4):718-723. doi: 10.1016/j.jhep.2016.12.020. Epub 2016 Dec 28.
Impact factor:
Publication type: Paper in international publication
Authors: Arias, Ana; Baliellas, Carme; Calleja, Jose L; Castells, Lluis; Crespo, Javier; Cuervas-Mons, Valentin; Esforzado, Nuria; Fernandez, Inmaculada; Forns, Xavier; Hernandez, Olga et al.
DOI: 10.1016/j.jhep.2016.12.020

Deep sequencing in the management of hepatitis virus infections.

PMID: 28040474
Journal: VIRUS RESEARCH
Year: 2017
Reference: Virus Res. 2017 Jul 15;239:115-125. doi: 10.1016/j.virusres.2016.12.020. Epub 2016 Dec 28.
Impact factor:
Publication type: Review in national publication
Authors: Bosch, Albert; Domingo, Esteban; Esteban, Juan Ignacio; Garcia-Cehic, Damir; Gregori, Josep; Homs, Maria; Perales, Celia; Pinto, Rosa Maria; Quer, Josep; Rodriguez-Frias, Francisco et al.
DOI: 10.1016/j.virusres.2016.12.020

Effects of an intensive lifestyle intervention program on portal hypertension in patients with cirrhosis and obesity: The sportdiet study.

PMID: 27997989
Journal: HEPATOLOGY
Year: 2017
Reference: Hepatology. 2017 Apr;65(4):1293-1305. doi: 10.1002/hep.28992. Epub 2017 Mar 6.
Impact factor:
Publication type: Paper in international publication
Authors: Albillos, Agustin; Ardevol, Alba; Augustin, Salvador; Banares, Rafael; Berzigotti, Annalisa; Bosch, Jaime; Calleja, Jose Luis; Garcia-Pagan, Juan Carlos; Genesca, Joan; Mesonero, Francisco et al.
DOI: 10.1002/hep.28992

Left pleural effusion secondary to splenic infarctions in a patient with liver cirrhosis.

PMID: 27939683
Journal: MEDICINA CLINICA
Year: 2017
Reference: Med Clin (Barc). 2017 Feb 9;148(3):144-145. doi: 10.1016/j.medcli.2016.09.048. Epub 2016 Dec 6.
Impact factor:
Publication type: Paper in national publication
Authors: Castells, Lluis; Riveiro-Barciela, Mar; Vidal-Gonzalez, Judit et al.
DOI: 10.1016/j.medcli.2016.09.048

Treatment of severe recurrent hepatitis C after liver transplantation in HIV infected patients using sofosbuvir-based therapy.

PMID: 27098374
Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year: 2016
Reference: Aliment Pharmacol Ther. 2016 Jun;43(12):1319-29. doi: 10.1111/apt.13629. Epub 2016 Apr 21.
Impact factor:
Publication type: Paper in international publication
Authors: Banos, I; Bellot, P; Bhamidimarri, K R; Brainard, D M; Campos-Varela, I; Castells, L; Grewal, P; Guaraldi, G; Hasson, H; McHutchison, J G et al.
DOI: 10.1111/apt.13629

[Management and treatment of patients with hepatitis B].

PMID: 27474247
Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
Year: 2016
Reference: Enferm Infecc Microbiol Clin. 2016 Jul;34 Suppl 3:47-51. doi: 10.1016/S0213-005X(16)30219-1.
Impact factor:
Publication type: Review in national publication
Authors: den Eynde, Eva Van; Riveiro-Barciela, Mar et al.
DOI: 10.1016/S0213-005X(16)30219-1

New findings in HCV genotype distribution in selected West European, Russian and Israeli regions.

PMID: 27367545
Journal: JOURNAL OF CLINICAL VIROLOGY
Year: 2016
Reference: J Clin Virol. 2016 Aug;81:82-9. doi: 10.1016/j.jcv.2016.05.010. Epub 2016 May 24.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilera, A; Alados, J C; Araujo, F; Barreca, G S; Benitez-Gutierrez, L; Bernal, S; Blas-Espada, J; Braun, P; Cabanas, J; Cardenoso, L et al.
DOI: 10.1016/j.jcv.2016.05.010

[Hiccups as an onset form of aortic dissection].

PMID: 27143531
Journal: MEDICINA CLINICA
Year: 2016
Reference: Med Clin (Barc). 2016 Aug 5;147(3):e13. doi: 10.1016/j.medcli.2016.03.014. Epub 2016 Apr 30.
Impact factor:
Publication type: Letter or abstract
Authors: Callejas-Moraga, Eduardo L; Mestre-Torres, Jaume; Riveiro-Barciela, Mar et al.
DOI: 10.1016/j.medcli.2016.03.014

Grazoprevir and elbasvir plus ribavirin for chronic HCV genotype-1 infection after failure of combination therapy containing a direct-acting antiviral agent.

PMID: 25895428
Journal: J HEPATOL
Year: 2015
Reference: J Hepatol. 2015 Sep;63(3):564-72. doi: 10.1016/j.jhep.2015.04.009. Epub 2015 Apr 18.
Impact factor:
Publication type: Paper in international publication
Authors: Barr, Eliav; Buti, Maria; Calleja, Jose L; DiNubile, Mark J; Forns, Xavier; Gilbert, Christopher; Gordon, Stuart C; Hofer, Harald; Howe, Anita Y M; Lawitz, Eric et al.
DOI: 10.1016/j.jhep.2015.04.009

Clonality and intracellular polyploidy in virus evolution and pathogenesis.

PMID: 26195777
Journal: P NATL ACAD SCI USA
Year: 2015
Reference: Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):8887-92. doi: 10.1073/pnas.1501715112. Epub 2015 Jul 20.
Impact factor:
Publication type: Paper in international publication
Authors: Domingo, Esteban; Moreno, Elena; Perales, Celia et al.
DOI: 10.1073/pnas.1501715112

Minimal hepatic encephalopathy and critical flicker frequency are associated with survival of patients with cirrhosis.

PMID: 26299413
Journal: GASTROENTEROLOGY
Year: 2015
Reference: Gastroenterology. 2015 Nov;149(6):1483-9. doi: 10.1053/j.gastro.2015.07.067. Epub 2015 Aug 21.
Impact factor:
Publication type: Paper in international publication
Authors: Ampuero, Javier; Cordoba, Juan; Jover, Rodrigo; Montoliu, Carmina; Romero-Gomez, Manuel; Serra, Miguel Angel; Simon, Macarena et al.
DOI: 10.1053/j.gastro.2015.07.067

Resistance of Hepatitis C Virus to Inhibitors: Complexity and Clinical Implications.

PMID: 26561827
Journal: VIRUSES-BASEL
Year: 2015
Reference: Viruses. 2015 Nov 6;7(11):5746-66. doi: 10.3390/v7112902.
Impact factor:
Publication type: Review in international publication
Authors: Domingo, Esteban; Esteban, Juan Ignacio; Gregori, Josep; Perales, Celia; Quer, Josep et al.
DOI: 10.3390/v7112902

Heterotopic ossification after surgery for distal humeral fractures.

PMID: 25452373
Journal: Bone & Joint Journal
Year: 2014
Reference: Bone Joint J. 2014 Dec;96-B(12):1681-7. doi: 10.1302/0301-620X.96B12.34091.
Impact factor:
Publication type: Letter or abstract
Authors: Augustin, S; Foruria, A M; Lawrence, T M; Morrey, B F; Sanchez-Sotelo, J et al.
DOI: 10.1302/0301-620X.96B12.34091

Immunosuppression Based on Everolimus in Liver Transplant Recipients With Severe Early Post-transplantation Neurotoxicity.

PMID: 25420835
Journal: TRANSPLANTATION PROCEEDINGS
Year: 2014
Reference: Transplant Proc. 2014;46(9):3104-7. doi: 10.1016/j.transproceed.2014.10.001.
Impact factor:
Publication type: Paper in international publication
Authors: Bilbao, I; Caralt, M; Castells, L; Charco, R; Dopazo, C; Lazaro, J; Sapisochin, G et al.
DOI: 10.1016/j.transproceed.2014.10.001

Multiple indications for everolimus after liver transplantation in current clinical practice.

PMID: 25032101
Journal: World journal of transplantation
Year: 2014
Reference: World J Transplant. 2014 Jun 24;4(2):122-32. doi: 10.5500/wjt.v4.i2.122.
Impact factor:
Publication type: Letter or abstract
Authors: Bilbao, Itxarone; Caralt, Mireia; Castells, Lluis; Charco, Ramon; Dopazo, Cristina; Lazaro, Jose; Sapisochin, Gonzalo et al.
DOI: 10.5500/wjt.v4.i2.122

Increased replicative fitness can lead to decreased drug sensitivity of hepatitis C virus.

PMID: 25122776
Journal: JOURNAL OF VIROLOGY
Year: 2014
Reference: J Virol. 2014 Oct;88(20):12098-111. doi: 10.1128/JVI.01860-14. Epub 2014 Aug 13.
Impact factor:
Publication type: Paper in international publication
Authors: Beach, Nathan M; Domingo, Esteban; Esteban, Juan Ignacio; Gallego, Isabel; Gregori, Josep; Martinez-Salas, Encarnacion; Moreno, Elena; Perales, Celia; Pineiro, David; Quer, Josep et al.
DOI: 10.1128/JVI.01860-14

Once-daily simeprevir (TMC435) with pegylated interferon and ribavirin in treatment-naive genotype 1 hepatitis C: the randomized PILLAR study.

PMID: 23907700
Journal: HEPATOLOGY
Year: 2013
Reference: Hepatology. 2013 Dec;58(6):1918-29. doi: 10.1002/hep.26641. Epub 2013 Oct 11.
Impact factor:
Publication type: Paper in international publication
Authors: Beumont-Mauviel, Maria; Buti, Maria; De Smedt, Goedele; Dore, Gregory J; Ferenci, Peter; Flisiak, Robert; Fried, Michael W; Gilles, Leen; Jacobson, Ira; Lenz, Oliver et al.
DOI: 10.1002/hep.26641

Multicenter evaluation of the Elecsys(R) anti-HCV II assay for the diagnosis of hepatitis C virus infection.

PMID: 23765774
Journal: JOURNAL OF MEDICAL VIROLOGY
Year: 2013
Reference: J Med Virol. 2013 Aug;85(8):1362-8. doi: 10.1002/jmv.23536.
Impact factor:
Publication type: Paper in international publication
Authors: Alborino, Flora; Burgisser, Philippe; Cellerai, Cristina; Eiras, Adolfo; Esteban, Juan I; Ghisetti, Valeria; Gleich, Michael; Imdahl, Roland; Kaiser, Claudia; Moller, Petra et al.
DOI: 10.1002/jmv.23536

Ultra-Deep Pyrosequencing (UDPS) Data Treatment to Study Amplicon HCV Minor Variants.

PMID: 24391758
Journal: PLoS One
Year: 2013
Reference: PLoS One. 2013 Dec 31;8(12):e83361. doi: 10.1371/journal.pone.0083361.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarez-Tejado, Miguel; Casillas, Rosario; Cubero, Maria; Domingo, Esteban; Esteban, Juan I; Garcia-Cehic, Damir; Gregori, Josep; Guardia, Jaume; Perales, Celia; Quer, Josep et al.
DOI: 10.1371/journal.pone.0083361

Preparing the patient for success: Treat or wait?

PMID: 24091112
Journal: DIGESTIVE AND LIVER DISEASE
Year: 2013
Reference: Dig Liver Dis. 2013 Sep 30;45S5:S332-S336. doi: 10.1016/j.dld.2013.07.013.
Impact factor:
Publication type: Review in international publication
Authors: Buti, Maria; Esteban, Rafael et al.
DOI: 10.1016/j.dld.2013.07.013

Considerations for the long-term treatment of chronic hepatitis B with nucleos(t)ide analogs.

PMID: 23237254
Journal: Expert review of gastroenterology & hepatology
Year: 2012
Reference: Expert Rev Gastroenterol Hepatol. 2012 Dec;6(6):683-93; quiz 694. doi: 10.1586/egh.12.52.
Impact factor:
Publication type: Letter or abstract
Authors: Buti, Maria; Petersen, Jorg et al.
DOI: 10.1586/egh.12.52

IL28B genetic variation and hepatitis C virus-specific CD4(+) T-cell responses in anti-HCV-positive blood donors.

PMID: 23121365
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2012
Reference: J Viral Hepat. 2012 Dec;19(12):867-71. doi: 10.1111/j.1365-2893.2012.01631.x. Epub 2012 Jul 4.
Impact factor:
Publication type: Paper in international publication
Authors: Bes, M; Campos-Varela, I; Casamitjana, N; Esteban, J I; Guardia, J; Homs, M; Piron, M; Puig, L; Quer, J; Rodriguez-Frias, F et al.
DOI: 10.1111/j.1365-2893.2012.01631.x

alpha1-Antitrypsin in Fibromyalgia: Results of a Randomized, Placebo-Controlled, Double-Blind and Crossover Pilot Trial.

PMID: 22190533
Journal: Musculoskeletal care
Year: 2012
Reference: Musculoskeletal Care. 2012 Sep;10(3):178-83. doi: 10.1002/msc.1000. Epub 2011 Dec 22.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; et al.
DOI: 10.1002/msc.1000

Genetic-based reference values for angiotensin-converting enzyme (ACE) according to I/D polymorphism in a Spanish population sample.

PMID: 23089703
Journal: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Year: 2012
Reference: Clin Chem Lab Med. 2012 Oct 1;50(10):1749-53. doi: 10.1515/cclm-2012-0042.
Impact factor:
Publication type: Paper in international publication
Authors: Camos, Silvia; Cruz, M Jesus; Morell, Ferran; Sole, Esther et al.
DOI: 10.1515/cclm-2012-0042

Prognostic evaluation of patients with acute variceal bleeding.

PMID: 22045401
Journal: DISEASE MARKERS
Year: 2011
Reference: Dis Markers. 2011 Jan 1;31(3):155-164.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; et al.
DOI: 10.3233/DMA-2011-0838

Diagnostic and prognostic molecular markers in hepatocellular carcinoma.

PMID: 22045404
Journal: DISEASE MARKERS
Year: 2011
Reference: Dis Markers. 2011 Jan 1;31(3):181-190.
Impact factor:
Publication type: Paper in international publication
Authors: ; et al.
DOI: 10.3233/DMA-2011-0841

Prognostic assessment in patients with hepatic encephalopathy.

PMID: 22045403
Journal: DISEASE MARKERS
Year: 2011
Reference: Dis Markers. 2011 Jan 1;31(3):171-179.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; et al.
DOI: 10.3233/DMA-2011-0840

Long-Term outcome of hepatitis c infection acquired following pediatric liver transplantation.

PMID: 21932378
Journal: LIVER TRANSPLANTATION
Year: 2011
Reference: Liver Transpl. 2011 Dec;17(12):1474-80. doi: 10.1002/lt.22439.
Impact factor:
Publication type: Paper in international publication
Authors: ; ; ; ; ; ; ; et al.
DOI: 10.1002/lt.22439

Physiopathology of splanchnic vasodilation in portal hypertension.

PMID: 21160999
Journal: World journal of hepatology
Year: 2010
Reference: World J Hepatol. 2010 Jun 27;2(6):208-20.
Impact factor:
Publication type: Letter or abstract
Authors: Coll, Mar; Ezkurdia, Nahia; Genesca, Joan; Martell, Maria; Raurell, Imma et al.
DOI: 10.4254/wjh.v2.i6.208

Infrequent detection of hepatitis E virus RNA in pregnant women with hepatitis E virus antibodies in Spain.

PMID: 20629948
Journal: LIVER INTERNATIONAL
Year: 2010
Reference: Liver Int. 2010 Nov;30(10):1549-51. doi: 10.1111/j.1478-3231.2010.02304.x.
Impact factor:
Publication type: Letter or abstract
Authors: ; ; ; ; ; ; ; ; et al.
DOI: 10.1111/j.1478-3231.2010.02304.x

Atrophy of mesenteric sympathetic innervation may contribute to splanchnic vasodilation in rat portal hypertension.

PMID: 19968782
Journal: LIVER INTERNATIONAL
Year: 2010
Reference: Liver Int. 2010 Apr;30(4):593-602. Epub 2009 Nov 30.
Impact factor:
Publication type: Paper in international publication
Authors: Bosch, Jaume; Coll, Mar; Cuenca, Silvia; Esteban, Rafael; Ezkurdia, Nahia; Genesca, Joan; Guardia, Jaume; Hernandez-Losa, Javier; Martell, Maria; Raurell, Imma et al.
DOI: 10.1111/j.1478-3231.2009.02176.x

Randomized trial of peginterferon alfa-2b and ribavirin for 48 or 72 weeks in patients with hepatitis C virus genotype 1 and slow virologic response.

PMID: 20683847
Journal: HEPATOLOGY
Year: 2010
Reference: Hepatology. 2010 Oct;52(4):1201-7.
Impact factor:
Publication type: Paper in international publication
Authors: Aguilar Reina, J; Anderson, F; Arnold, J; Balciuniene, Ligita; Bar-Meir, S; Barcena Marugan, R; Bassaris, H; Berg, T; Berr, F; Bilodeau, M et al.
DOI: 10.1002/hep.23816

Predicting 6-week mortality after acute variceal bleeding: role of classification and regression tree analysis.

PMID: 20009129
Journal: Annals of Hepatology
Year: 2009
Reference: Ann Hepatol. 2009 Oct-Dec;8(4):308-15.
Impact factor:
Publication type: Letter or abstract
Authors: Agustin, Salvador; Altamirano, Jose; Camargo, Leonardo; Degiau, Louis; Genesca, Joan; Gonzalez-Angulo, Alberto; Muntaner, Laura; Ortiz, Ana Laura; Zapata, Laura et al.
DOI:

Evaluation of Anti-HBs serum levels and pharmacokinetic profile after intravenous administration of Niuliva, a new hepatitis B immunoglobulin, following liver transplantation.

PMID: 20005379
Journal: TRANSPLANTATION PROCEEDINGS
Year: 2009
Reference: Transplant Proc. 2009 Dec;41(10):4253-8.
Impact factor:
Publication type: Paper in international publication
Authors: Abradelo, M; Bernardos, A; Castells, L; Mas, A; Paez, A; Sousa, J M; Woodward, M K et al.
DOI: 10.1016/j.transproceed.2009.09.083

Indications and management of everolimus after liver transplantation.

PMID: 19715864
Journal: TRANSPLANTATION PROCEEDINGS
Year: 2009
Reference: Transplant Proc. 2009 Jul-Aug;41(6):2172-6.
Impact factor:
Publication type: Paper in international publication
Authors: Bilbao, I; Blanco, L; Caralt, M; Castells, L; Charco, R; Dopazo, C; Gantxegi, A; Lazaro, J L; Margarit, C; Pou, L et al.
DOI: 10.1016/j.transproceed.2009.06.087

Modeling the cost-effectiveness of different oral antiviral therapies in patients with chronic hepatitis B.

PMID: 19576651
Journal: JOURNAL OF HEPATOLOGY
Year: 2009
Reference: J Hepatol. 2009 Oct;51(4):640-6.
Impact factor:
Publication type: Paper in international publication
Authors: Brosa, Max; Buti, Maria; Casado, Miguel A; Esteban, Rafael; Rueda, Magdalena et al.
DOI: 10.1016/j.jhep.2009.04.013

Thesis

Impacto de la enfermedad hepática grasa no alcohólica a nivel poblacional y en grupos de riesgo. Papel de la elastografía de transición en el diagnóstico, estadiaje y predicción de eventos clínicos.

PhD student: Jesus Manuel Rivera Esteban
Director/s: Salvador Augustin Recio
University:
Year: 2023

Blog

News

The consensus establishes recommendations that could correct the current disparities related to muscle mass, weight and height and would allow for more precise prioritization of patients who require transplants more urgently.

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.

On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.

Estudi sobre els patrons de consum habitual de l'alcohol en població jove

Des de Vall d'Hebron estem buscant 200 persones voluntàries sanes d'entre 18 i 30 anys per a participar en un estudi sobre els patrons de consum habitual de l'alcohol en població jove, en el marc del projecte StopALD.

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