About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Liver Diseases group is a referent at the local, national and international level in research, and is one of the most active groups in clinical research at VHIR. The group's prominent involvement in clinical trials is a clear indication of our professionals' commitment to ensuring that patients have access to state-of-the-art therapies. Our participation and collaboration in international projects and consortiums are also a fundamental characteristic of the group. The main objective of the group is to become one of the best translational research groups in liver diseases. It is essential to be able to apply all the findings of basic research to clinical research to improve the health of patients with liver disease.
Sarcopènia i fragilitat
Malaltia metabòlica i NASH pre-transplantament
Nutrició en el trasplantament
Serveis o tecnologies rellevants:
Bioimpedància
IP: Isabel Campos Varela
IP: - Collaborators: David Tabernero Caellas Funding agency: GILEAD SCIENCES SLU Funding: 49961.71 Reference: GLD22/00080 Duration: 28/02/2023 - 27/02/2025
IP: Josep Quer Sivila Collaborators: Sergi Colomer Castell Funding agency: Ministerio de Universidades Funding: 73389.26 Reference: FPU21/04150 Duration: 16/12/2022 - 15/05/2025
IP: Joan Genescà Ferrer Collaborators: Beatriz Minguez Rosique, Sergi Colomer Castell, Elena Vargas Accarino, Immaculada Raurell Saborit, Lluís Viladomiu Catà, Lluis Castells Fusté, Maria del Mar Riveiro Barciela, Maria Buti Ferret, Montserrat Gomez Perez, Judit Romero Vico, Josep Quer Sivila, Adriana Palom Agusti, Juan Manuel Pericàs Pulido, Maria Nieves Martell Pérez-Alcalde, Damir Garcia Cehic, Daniel Martinez Vazquez, Laura Puente Ramo, Isabel Campos Varela, María Bermúdez Ramos, Juan Ignacio Esteban Mur, Ester Palacio Gutierrez, Susana Anton Calvo, Monica Higuera Urbano, Meritxell Ventura Cots, Ares Aurora Villagrasa Vilella, Emma Bigas Alsina, Carolina Campos Martinez, Macarena Simon-Talero Horga, David Tabernero Caellas, Mònica Pons Delgado, Marcella Salzano Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 60000 Reference: 2021 SGR 00462 Duration: 01/01/2022 - 30/06/2025
IP: Meritxell Ventura Cots Collaborators: Juan Manuel Pericàs Pulido, Sonia Carramiñana Mayor, Juan Bañares Sanchez Funding agency: Ajuntament Barcelona Funding: 119700 Reference: AJUNT.BCN/CIENCIA_INNOV/2022/VENTURA Duration: 08/12/2022 - 07/06/2024
PMID: 37572680 Journal: LANCET Year: 2023 Reference: Lancet. 2023 Aug 9:S0140-6736(23)01174-1. doi: 10.1016/S0140-6736(23)01174-1. Impact factor: Publication type: Paper in international publication Authors: Allen, Alina; Alvarez, Marife; Andersen, Peter; Angeli, Paolo; Angeli, Paolo; Ardevol, Alba; Arslanow, Anita; Arslanow, Anita; Beggiato, Luca; Ben Abdesselam, Zahia et al. DOI: 10.1016/S0140-6736(23)01174-1
PMID: 37569568 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2023 Reference: Int J Mol Sci. 2023 Jul 29;24(15):12183. doi: 10.3390/ijms241512183. Impact factor: Publication type: Paper in international publication Authors: Bes, Marta; Borras, Francesc E; Burgui, Idoia; Camos, Silvia; Corrales, Irene; Costafreda, Maria Isabel; Domingo, Esteban; Esteban, Juan Ignacio; Llorens-Revull, Meritxell; Martinez-Gonzalez, Brenda et al. DOI: 10.3390/ijms241512183
PMID: 37695530 Journal: JOURNAL OF NEUROLOGY Year: 2023 Reference: J Neurol. 2023 Sep 11. doi: 10.1007/s00415-023-11973-y. Impact factor: Publication type: Paper in international publication Authors: Buti, Maria; Buti, Maria; Castillo, Joaquin; Marzo, Blanca; Montalban, Xavier; Otero-Romero, Susana; Otero-Romero, Susana; Riveiro-Barciela, Mar; Riveiro-Barciela, Mar; Robles-Sanchez, Miguel-Angel et al. DOI: 10.1007/s00415-023-11973-y
PMID: 37691049 Journal: Expert Review of Anti-Infective Therapy Year: 2023 Reference: Expert Rev Anti Infect Ther. 2023 Sep 10. doi: 10.1080/14787210.2023.2257392. Impact factor: Publication type: Review in international publication Authors: Cilloniz, Catia; Curioso, Walter H; Pericas, Juan Manuel; Pericas, Juan Manuel et al. DOI: 10.1080/14787210.2023.2257392
PMID: 35743358 Journal: Journal of Clinical Medicine Year: 2022 Reference: J Clin Med. 2022 Jun 8;11(12). pii: jcm11123286. doi: 10.3390/jcm11123286. Impact factor: 4.242 Publication type: Review in international publication Authors: Rojano-Toimil, Alba; Rivera-Esteban, Jesus; Banares, Juan; Ciudin, Andreea; Pericas, Juan M; Ferrer, Roser; Gabriel-Medina, Pablo; Martinez Selva, David; Manzano-Nunez, Ramiro et al. DOI: 10.3390/jcm11123286
PMID: 35755602 Journal: MEDICINA CLINICA Year: 2022 Reference: Med Clin. 2022 Jun 10;158(11):509-518. doi: 10.1016/j.medcle.2021.06.023. Epub 2022 Jun 18. Impact factor: 1.725 Publication type: Paper in international publication Authors: Sellares-Nadal, Julia; Almirante, Benito; Guillen-Del-Castillo, Alfredo; Sampol, Julia; Augustin, Salvador; Bosch-Nicolau, Pau; Monforte-Pallares, Arnau; Sempere-Gonzalez, Abiu; Eremiev-Eremiev, Simeon; Miarons, Marta et al. DOI: 10.1016/j.medcle.2021.06.023
PMID: 35775000 Journal: Frontiers in Medicine Year: 2022 Reference: Front Med (Lausanne). 2022 Jun 14;9:906565. doi: 10.3389/fmed.2022.906565. eCollection 2022. Impact factor: 5.093 Publication type: Review in international publication Authors: Riveiro-Barciela, Mar; Bolufer, Monica; Bermejo, Sheila; Soler, Maria Jose et al. DOI: 10.3389/fmed.2022.906565
PMID: 35780057 Journal: Journal of healthcare quality research Year: 2022 Reference: J Healthc Qual Res. 2022 Mar 10. pii: S2603-6479(22)00012-4. doi: 10.1016/j.jhqr.2022.02.006. Impact factor: 0 Publication type: Paper in international publication Authors: Rodriguez, I; Barba, M-A; Cebrian, R; Abadias, M-J; Aller, M-B; Cossio-Gil, Y; Roman, A; Dominguez, J-M; Campins, M; Martinez, J et al. DOI: 10.1016/j.jhqr.2022.02.006
PMID: 34433852 Journal: Scientific Reports Year: 2021 Reference: Sci Rep. 2021 Aug 25;11(1):17063. doi: 10.1038/s41598-021-96350-3. Impact factor: 4.38 Publication type: Paper in international publication Authors: Picchio, Camila A, Nomah, Daniel K, Araujo, Silvia G, Rando-Segura, Ariadna, Fernandez, Emma, Buti, Maria, Rodriguez-Tajes, Sergio, Lens, Sabela, Rodriguez-Frias, Francisco, Lazarus, Jeffrey V et al. DOI: 10.1038/s41598-021-96350-3
PMID: 34402744 Journal: Emerging Microbes & Infections Year: 2021 Reference: Emerg Microbes Infect. 2021 Dec;10(1):1777-1789. doi: 10.1080/22221751.2021.1969868. Impact factor: 7.163 Publication type: Paper in international publication Authors: Quer, Josep, Anton, Andres, Rodriguez-Frias, Francisco, Esteban, Juan Ignacio, Gregori, Josep, Cortese, Maria Francesca, Pinana, Maria, Campos, Carolina, Garcia-Cehic, Damir, Andres, Cristina et al. DOI: 10.1080/22221751.2021.1969868
PMID: 34242466 Journal: LIVER INTERNATIONAL Year: 2021 Reference: Liver Int. 2021 Sep;41(9):1999-2008. doi: 10.1111/liv.15013. Epub 2021 Jul 21. Impact factor: 5.828 Publication type: Review in international publication Authors: Rivera-Esteban, Jesus, Armandi, Angelo, Augustin, Salvador, Bugianesi, Elisabetta et al. DOI: 10.1111/liv.15013
PMID: 34242330 Journal: PLoS One Year: 2021 Reference: PLoS One. 2021 Jul 9;16(7):e0254243. doi: 10.1371/journal.pone.0254243. eCollection 2021. Impact factor: 3.24 Publication type: Paper in international publication Authors: Llorens-Revull, Meritxell, Costafreda, Maria Isabel, Rico, Angie, Guerrero-Murillo, Mercedes, Soria, Maria Eugenia, Piriz-Ruzo, Sofia, Vargas-Accarino, Elena, Gabriel-Medina, Pablo, Rodriguez-Frias, Francisco, Riveiro-Barciela, Mar et al. DOI: 10.1371/journal.pone.0254243
PMID: 32711039 Journal: JOURNAL OF INFECTION Year: 2020 Reference: J Infect. 2020 Oct;81(4):600-606. doi: 10.1016/j.jinf.2020.07.019. Epub 2020 Jul 22. Impact factor: 4.842 Publication type: Paper in international publication Authors: Fernandez-Cuenca, Felipe, Garcia-Arata, Isabel, Reina, Gabriel, Ocete, Maria Dolores, Fuentes, Ana, de la Cruz, Daniel Navarro, Nieto, Leonardo, de Castro, Ana Blazquez, Buti, Maria, Alvarez, Marta et al. DOI: 10.1016/j.jinf.2020.07.019
PMID: 32703729 Journal: DIGESTIVE AND LIVER DISEASE Year: 2020 Reference: Dig Liver Dis. 2020 Oct;52(10):1164-1169. doi: 10.1016/j.dld.2020.06.037. Epub 2020 Jul 20. Impact factor: 3.57 Publication type: Paper in international publication Authors: Roade, Luisa, Loglio, Alessandro, Borghi, Marta, Riveiro-Barciela, Mar, Soffredini, Roberta, Facchetti, Floriana, di Paolo, Dhanai, Tabernero, David, Lunghi, Giovanna, Esteban, Rafael et al. DOI: 10.1016/j.dld.2020.06.037
PMID: 32697274 Journal: Revista espanola de sanidad penitenciaria Year: 2020 Reference: Rev Esp Sanid Penit. 2020 May-Aug;22(2):55-57. doi: 10.18176/resp.00010. Impact factor: 0 Publication type: Editorail in international publication Authors: Rivera Esteban, J M, Augustin Recio, S et al. DOI: 10.18176/resp.00010
PMID: 32681987 Journal: Nanomedicine-Nanotechnology Biology and Medicine Year: 2020 Reference: Nanomedicine. 2020 Oct;29:102267. doi: 10.1016/j.nano.2020.102267. Epub 2020 Jul 15. Impact factor: 5.182 Publication type: Paper in international publication Authors: Hide, Diana, Gil, Mar, Andrade, Fernanda, Rafael, Diana, Raurell, Imma, Bravo, Miren, Barbera, Aurora, Gracia-Sancho, Jordi, Vargas, Victor, Augustin, Salvador et al. DOI: 10.1016/j.nano.2020.102267
PMID: 30815504 Journal: Open Forum Infectious Diseases Year: 2019 Reference: Open Forum Infect Dis. 2019 Jan 16;6(2):ofz036. doi: 10.1093/ofid/ofz036. eCollection 2019 Feb. Impact factor: 3.371 Publication type: Paper in international publication Authors: Gimeno, A, Benito, R, Algarate, S, Gil, J, Ortiz de Lejarazu, R, Rojo, S, Eiros, J M, San Miguel, A, Manzardo, C, Miro, J M et al. DOI: 10.1093/ofid/ofz036
PMID: 30768983 Journal: GASTROENTEROLOGY Year: 2019 Reference: Gastroenterology. 2019 May;156(6):1820-1833. doi: 10.1053/j.gastro.2019.02.003. Epub 2019 Feb 12. Impact factor: 19.233 Publication type: Paper in international publication Authors: Hoffmann, Daniel, Wedemeyer, Heiner, Cornberg, Markus, Krawczyk, Adalbert, Rashidi-Alavijeh, Jassin, Rodriguez-Frias, Francisco, Casillas, Rosario, Buti, Maria, Smedile, Antonina, Alavian, Seyed Moayed et al. DOI: 10.1053/j.gastro.2019.02.003
PMID: 30684506 Journal: JOURNAL OF HEPATOLOGY Year: 2019 Reference: J Hepatol. 2019 May;70(5):874-884. doi: 10.1016/j.jhep.2019.01.005. Epub 2019 Jan 24. Impact factor: 18.946 Publication type: Paper in international publication Authors: Ayuso, Carmen, Rios, Jose, Forns, Xavier, Bruix, Jordi, Reig, Maria, Sole, Manel, Vilana, Ramon, Inarrairaegui, Mercedes, Marino, Zoe, Darnell, Anna et al. DOI: 10.1016/j.jhep.2019.01.005
PMID: 30103740 Journal: RESPIRATORY RESEARCH Year: 2018 Reference: Respir Res. 2018 Aug 13;19(1):151. doi: 10.1186/s12931-018-0826-8. Impact factor: 3.751 Publication type: Paper in international publication Authors: Greulich, Timm, Rodriguez-Frias, Francisco, Belmonte, Irene, Miravitlles, Marc, Vogelmeier, Claus F, Klemmer, Andreas et al. DOI: 10.1186/s12931-018-0826-8
PMID: 30059722 Journal: ANTIVIRAL RESEARCH Year: 2018 Reference: Antiviral Res. 2018 Oct;158:34-44. doi: 10.1016/j.antiviral.2018.07.019. Epub 2018 Jul 29. Impact factor: 4.307 Publication type: Review in international publication Authors: Rodriguez-Frias, Francisco, Tabernero, David, Caballero, Andrea, Buti, Maria et al. DOI: 10.1016/j.antiviral.2018.07.019
PMID: 29887482 Journal: Gastroenterologia y Hepatologia Year: 2018 Reference: Gastroenterol Hepatol. 2018 Oct;41(8):510-511. doi: 10.1016/j.gastrohep.2018.05.006. Epub 2018 Jun 7. Impact factor: 1.078 Publication type: Paper in national publication Authors: Roade Tato, Luisa, Ventura Cots, Meritxell, Riveiro-Barciela, Mar et al. DOI: 10.1016/j.gastrohep.2018.05.006
PMID: 29785078 Journal: WORLD JOURNAL OF GASTROENTEROLOGY Year: 2018 Reference: World J Gastroenterol. 2018 May 21;24(19):2095-2107. doi: 10.3748/wjg.v24.i19.2095. Impact factor: 3.3 Publication type: Paper in international publication Authors: Rodriguez-Frias, Francisco, Buti, Maria, Esteban, Rafael, Quer, Josep, Lopez-Martinez, Rosa, Gonzalez, Carolina, Tabernero, David, Cortese, Maria Francesca, Gregori, Josep, Casillas, Rosario et al. DOI: 10.3748/wjg.v24.i19.2095
PMID: 28982120 Journal: PLoS One Year: 2017 Reference: PLoS One. 2017 Oct 5;12(10):e0185911. doi: 10.1371/journal.pone.0185911. eCollection 2017. Impact factor: 2.806 Publication type: Paper in international publication Authors: Gonzales-Gustavson, Eloy, Timoneda, N, Fernandez-Cassi, X, Caballero, A, Abril, J F, Buti, M, Rodriguez-Frias, F, Girones, R et al. DOI: 10.1371/journal.pone.0185911
PMID: 28939495 Journal: ACTA TROPICA Year: 2017 Reference: Acta Trop. 2017 Dec;176:412-414. doi: 10.1016/j.actatropica.2017.09.018. Epub 2017 Sep 20. Impact factor: 2.218 Publication type: Paper in international publication Authors: Salvador, Fernando, Sulleiro, Elena, Piron, Maria, Sanchez-Montalva, Adrian, Sauleda, Silvia, Molina, Israel et al. DOI: 10.1016/j.actatropica.2017.09.018
PMID: 28869694 Journal: TROPICAL MEDICINE & INTERNATIONAL HEALTH Year: 2017 Reference: Trop Med Int Health. 2017 Nov;22(11):1436-1441. doi: 10.1111/tmi.12970. Epub 2017 Sep 20. Impact factor: 2.85 Publication type: Paper in international publication Authors: Salvador, Fernando, Sulleiro, Elena, Piron, Maria, Sanchez-Montalva, Adrian, Sauleda, Silvia, Molina-Morant, Daniel, Moure, Zaira, Molina, Israel et al. DOI: 10.1111/tmi.12970
PMID: 28842296 Journal: JOURNAL OF HEPATOLOGY Year: 2017 Reference: J Hepatol. 2017 Dec;67(6):1168-1176. doi: 10.1016/j.jhep.2017.08.008. Epub 2017 Aug 24. Impact factor: 12.486 Publication type: Paper in international publication Authors: Nogueras, Flor, Giraldez, Alvaro, Prieto, Martin, Forns, Xavier, Londono, Maria-Carlota, Narvaez, Isidoro, Sanchez-Antolin, Gloria, Salcedo, Magdalena, Pascasio, Juan Manuel, Vinaixa, Carmen et al. DOI: 10.1016/j.jhep.2017.08.008
PMID: 27037760 Journal: Transplant Infectious Disease Year: 2016 Reference: Transpl Infect Dis. 2016 Jun;18(3):442-445. doi: 10.1111/tid.12538. Epub 2016 Jun 9. Impact factor: 1.459 Publication type: Paper in international publication Authors: Crespo, M, Puig, T, Esteban, J I, Esteban, R, Santos, B, Castells, L, Llaneras, J et al. DOI: 10.1111/tid.12538
PMID: 25378574 Journal: JOURNAL OF CLINICAL MICROBIOLOGY Year: 2015 Reference: J Clin Microbiol. 2015 Jan;53(1):219-26. doi: 10.1128/JCM.02093-14. Epub 2014 Nov 5. Impact factor: 3.993 Publication type: Paper in international publication Authors: Quer, Josep, Gregori, Josep, Rodriguez-Frias, Francisco, Buti, Maria, Madejon, Antonio, Perez-Del-Pulgar, Sofia, Garcia-Cehic, Damir, Casillas, Rosario, Blasi, Maria, Homs, Maria et al. DOI: 10.1128/JCM.02093-14
PMID: 24637729 Journal: JOURNAL OF CLINICAL GASTROENTEROLOGY Year: 2015 Reference: J Clin Gastroenterol. 2015 Feb;49(2):165-8. doi: 10.1097/MCG.0000000000000113. Impact factor: 3.498 Publication type: Paper in international publication Authors: Riveiro-Barciela, Mar, Minguez, Beatriz, Girones, Rosa, Rodriguez-Frias, Francisco, Quer, Josep, Buti, Maria et al. DOI: 10.1097/MCG.0000000000000113
PMID: 24620835 Journal: J VIRAL HEPATITIS Year: 2014 Reference: J Viral Hepat. 2014 Oct;21(10):e118-28. doi: 10.1111/jvh.12246. Epub 2014 Mar 12. Impact factor: 3.307 Publication type: Paper in international publication Authors: Campos-Varela, I, Esteban, J I, Bes, M, Caralt, M, Allende, H, Rodriguez-Frias, F, Salcedo, M T, Sauleda, S, Charco, R, Guardia, J et al. DOI: 10.1111/jvh.12246
PMID: 24552864 Journal: ANN HEPATOL Year: 2014 Reference: Ann Hepatol. 2014 Mar-Apr;13(2):219-30. Impact factor: 2.193 Publication type: Paper in international publication Authors: Campos-Varela, Isabel, Esteban, Juan Ignacio, Bes, Marta, Dopazo, Cristina, Allende, Helena, Rodriguez-Frias, Francisco, Salcedo, Maria Teresa, Sauleda, Silvia, Charco, Ramon, Guardia, Jaime et al. DOI:
PMID: 24389655 Journal: BIOINFORMATICS Year: 2014 Reference: Bioinformatics. 2014 Apr 15;30(8):1104-1111. doi: 10.1093/bioinformatics/btt768. Epub 2014 Jan 2. Impact factor: 4.621 Publication type: Paper in international publication Authors: Quer, Josep, Sanchez, Alex, Gregori, Josep, Salicru, Miquel, Domingo, Esteban, Rodriguez-Frias, Francisco et al. DOI: 10.1093/bioinformatics/btt768
PMID: 22386306 Journal: ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA Year: 2012 Reference: Enferm Infecc Microbiol Clin. 2012 Dec;30(10):624-34. doi: 10.1016/j.eimc.2012.01.014. Epub 2012 Mar 3. Impact factor: 1.491 Publication type: Review in national publication Authors: , , et al. DOI: 10.1016/j.eimc.2012.01.014
PMID: 22291048 Journal: Therapeutic advances in respiratory disease Year: 2012 Reference: Ther Adv Respir Dis. 2012 Apr;6(2):79-85. doi: 10.1177/1753465811434320. Epub 2012 Jan 30. Impact factor: Publication type: Letter or abstract Authors: , , , , et al. DOI: 10.1177/1753465811434320
PMID: 22257075 Journal: HIV MEDICINE Year: 2012 Reference: HIV Med. 2012 Jul;13(6):379-83. doi: 10.1111/j.1468-1293.2011.00985.x. Epub 2012 Jan 18. Impact factor: 3.006 Publication type: Paper in international publication Authors: , , , , , , , , , et al. DOI: 10.1111/j.1468-1293.2011.00985.x
PMID: 22262129 Journal: TRANSPLANTATION Year: 2012 Reference: Transplantation. 2012 Feb 27;93(4):450-3. doi: 10.1097/TP.0b013e318240e9dd. Impact factor: 4.003 Publication type: Paper in international publication Authors: , , , , , , , , et al. DOI: 10.1097/TP.0b013e318240e9dd
Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.
On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.
Preliminary study results confirm that the drug resmetirom reduces the presence of fat, inflammation, cell damage and fibrosis in the liver.
Des de Vall d'Hebron estem buscant 200 persones voluntàries sanes d'entre 18 i 30 anys per a participar en un estudi sobre els patrons de consum habitual de l'alcohol en població jove, en el marc del projecte StopALD.
