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Liver Diseases

The Liver Diseases group is a referent at the local, national and international level in research, and is one of the most active groups in clinical research at VHIR. The group's prominent involvement in clinical trials is a clear indication of our professionals' commitment to ensuring that patients have access to state-of-the-art therapies. Our participation and collaboration in international projects and consortiums are also a fundamental characteristic of the group. The main objective of the group is to become one of the best translational research groups in liver diseases. It is essential to be able to apply all the findings of basic research to clinical research to improve the health of patients with liver disease.

Publications

Comparison of Nanopore and Synthesis-Based Next-Generation Sequencing Platforms for SARS-CoV-2 Variant Monitoring in Wastewater.

PMID: 38139015
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2023
Reference: Int J Mol Sci. 2023 Dec 6;24(24):17184. doi: 10.3390/ijms242417184.
Impact factor:
Publication type: Paper in international publication
Authors: Abid, Islem; Bosch, Albert; Carcereny, Albert; Cereto-Massague, Adria; Costafreda, Maria Isabel; Garcia-Cehic, Damir; Garcia-Pedemonte, David; Gregori, Josep; Guerrero, Laura; Guix, Susana et al.
DOI: 10.3390/ijms242417184

Isatuximab Monotherapy for Desensitization in Highly Sensitized Patients Awaiting Kidney Transplant.

PMID: 38147137
Journal: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Year: 2023
Reference: J Am Soc Nephrol. 2023 Dec 26. doi: 10.1681/ASN.0000000000000287.
Impact factor:
Publication type: Paper in international publication
Authors: Abbadessa, Giovanni; Adombi, Caroline Melanie; Ali, Nicole; Bestard, Oriol; Brar, Amarpali; Buti, Maria; Campos, Carolina; Colomer-Castell, Sergi; Cortese, Maria Francesca; Cruzado, Josep M et al.
DOI: 10.1681/ASN.0000000000000287

Crossing barriers: the burden of inflammatory bowel disease across Western Europe.

PMID: 38144422
Journal: Therapeutic Advances in Gastroenterology
Year: 2023
Reference: Therap Adv Gastroenterol. 2023 Dec 22;16:17562848231218615. doi: 10.1177/17562848231218615. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Abid, Islem; Avellaneda, Nicolas; Bellato, Vittoria; Bettenworth, Dominik; Bosch, Albert; Brookes, Matthew J; Carcereny, Albert; Catalan-Serra, Ignacio; Cereto-Massague, Adria; Costafreda, Maria Isabel et al.
DOI: 10.1177/17562848231218615

The EASL-Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality.

PMID: 34863359
Journal: LANCET
Year: 2022
Reference: Lancet. 2022 Jan 1;399(10319):61-116. doi: 10.1016/S0140-6736(21)01701-3. Epub 2021 Dec 2.
Impact factor:
Publication type: Review in international publication
Authors: Barrett, Damon; Belloni, Annalisa; Bugianesi, Elisabetta; Burra, Patrizia; Burton, Robyn; Buti, Maria; Byrne, Chris D; Carrieri, Patrizia; Cecchini, Michele; Cortez-Pinto, Helena et al.
DOI: 10.1016/S0140-6736(21)01701-3

Advancing the global public health agenda for NAFLD: a consensus statement.

PMID: 34707258
Journal: Nature Reviews Gastroenterology & Hepatology
Year: 2022
Reference: Nat Rev Gastroenterol Hepatol. 2022 Jan;19(1):60-78. doi: 10.1038/s41575-021-00523-4. Epub 2021 Oct 27.
Impact factor:
Publication type: Review in international publication
Authors: Aberg, Fredrik; Adams, Leon; Allen, Alina M; Alnaser, Faisal; Alqahtani, Saleh A; Alswat, Khalid; Alvares-da-Silva, Mario Reis; Alvaro, Domenico; Andrade, Raul J; Anstee, Quentin M et al.
DOI: 10.1038/s41575-021-00523-4

Spontaneous Portosystemic Shunt Embolization in Liver Transplant Recipients with Recurrent Hepatic Encephalopathy.

PMID: 35192963
Journal: Annals of Hepatology
Year: 2022
Reference: Ann Hepatol. 2022 May-Jun;27(3):100687. doi: 10.1016/j.aohep.2022.100687. Epub 2022 Feb 19.
Impact factor:
Publication type: Paper in international publication
Authors: Campos-Varela, Isabel; Castells, Lluis; Charco, Ramon; Diez, Iratxe; Patricia, Alvarez-Lopez; Quiroga, Sergi; Simon-Talero, Macarena et al.
DOI: 10.1016/j.aohep.2022.100687

The impact of COVID-19 on the cascade of care of HCV in the US and China.

PMID: 35192964
Journal: Annals of Hepatology
Year: 2022
Reference: Ann Hepatol. 2022 May-Jun;27(3):100685. doi: 10.1016/j.aohep.2022.100685. Epub 2022 Feb 19.
Impact factor:
Publication type: Paper in international publication
Authors: Ayoub, Walid S; Buti, Maria; Gao, Xu; Geng, Yu; Huang, Rui; Ji, Fanpu; Li, Qingyu; Noureddin, Mazen; Su, Xingyang; Sundaram, Vinay et al.
DOI: 10.1016/j.aohep.2022.100685

Radiological response to nivolumab in patients with hepatocellular carcinoma: A multicenter analysis of real-life practice.

PMID: 33383399
Journal: EUROPEAN JOURNAL OF RADIOLOGY
Year: 2021
Reference: Eur J Radiol. 2021 Feb;135:109484. doi: 10.1016/j.ejrad.2020.109484. Epub 2020 Dec 17.
Impact factor:
Publication type: Paper in international publication
Authors: Ayuso, Carmen; Bruix, Jordi; Calleja, Jose Luis; Da Fonseca, Leonardo G; De La Torre-Alaez, Manuel; Guerrero, Antonio; Lledo, Jose Luis; Marquez, Laura; Matilla, Ana; Minguez, Beatriz et al.
DOI: 10.1016/j.ejrad.2020.109484

Clinical features and evolution of bacterial infection-related acute-on-chronic liver failure.

PMID: 32781201
Journal: JOURNAL OF HEPATOLOGY
Year: 2021
Reference: J Hepatol. 2021 Feb;74(2):330-339. doi: 10.1016/j.jhep.2020.07.046. Epub 2020 Aug 8.
Impact factor:
Publication type: Paper in international publication
Authors: Alessandria, Carlo; Angeli, Paolo; Bartoletti, Michele; Bruns, Tony; Colombato, Luis; de Cassia Ribeiro Barea, Rita; Durand, Francois; Elkrief, Laure; Fernandez, Javier; Gadano, Adrian et al.
DOI: 10.1016/j.jhep.2020.07.046

Corrigendum to "Time association between hepatitis C therapy and hepatocellular carcinoma emergence in cirrhosis: Relevance of non-characterized nodules" [J Hepatol (2019) 874-884].

PMID: 33317846
Journal: JOURNAL OF HEPATOLOGY
Year: 2021
Reference: J Hepatol. 2021 Feb;74(2):491. doi: 10.1016/j.jhep.2020.11.020. Epub 2020 Dec 11.
Impact factor:
Publication type: Letter or abstract
Authors: Ayuso, Carmen; Belmonte, Ernest; Bruix, Jordi; Calleja, Jose Luis; Carrion, Jose Antonio; Coll, Susana; Darnell, Anna; Diaz, Alba; Forns, Xavier; Gallego, Adolfo et al.
DOI: 10.1016/j.jhep.2020.11.020

Diagnosis and treatment of hepatocellular carcinoma. Update of the consensus document of the AEEH, AEC, SEOM, SERAM, SERVEI, and SETH.

PMID: 33461840
Journal: MEDICINA CLINICA
Year: 2021
Reference: Med Clin (Barc). 2021 May 7;156(9):463.e1-463.e30. doi: 10.1016/j.medcli.2020.09.022. Epub 2021 Jan 16.
Impact factor:
Publication type: Paper in national publication
Authors: Avila, Matias A; Ayuso, Carmen; Bilbao, Itxarone; Bilbao, Jose Ignacio; Bruix, Jordi; Burrel, Marta; Bustamante, Javier; De la Mata, Manuel; Ferrer, Joana; Forner, Alejandro et al.
DOI: 10.1016/j.medcli.2020.09.022

Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis (LIVERHOPE-SAFETY): a randomised, double-blind, placebo-controlled, phase 2 trial.

PMID: 31607677
Journal: Lancet Gastroenterology & Hepatology
Year: 2020
Reference: Lancet Gastroenterol Hepatol. 2020 Jan;5(1):31-41. doi: 10.1016/S2468-1253(19)30320-6. Epub 2019 Oct 10.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes, Juan G; Alessandria, Carlo; Amin, Ahmed; Andrade, Raul J; Angeli, Paolo; Bernardi, Mauro; Beuers, Ulrich; Campion, Daniela; Caraceni, Paolo; Carol, Marta et al.
DOI: 10.1016/S2468-1253(19)30320-6

Pneumococcal superinfection in COVID-19 patients: A series of 5 cases.

PMID: 33521301
Journal:
Year: 2020
Reference: Med Clin (Engl Ed). 2020 Dec 11;155(11):502-505. doi: 10.1016/j.medcle.2020.05.028. Epub 2020 Dec 14.
Impact factor:
Publication type: Other (letters to the editor, abstracts, corrigendum, etc.)
Authors: Cucchiari, David; Gumucio, Roberto; Md, Emmanuel Coloma; Nicolas, David; Pericas, Juan M; Riera, Josep et al.
DOI: 10.1016/j.medcle.2020.05.028

Trends in Diagnosis of Alpha-1 Antitrypsin Deficiency Between 2015 and 2019 in a Reference Laboratory.

PMID: 33116457
Journal: International Journal of Chronic Obstructive Pulmonary Disease
Year: 2020
Reference: Int J Chron Obstruct Pulmon Dis. 2020 Oct 7;15:2421-2431. doi: 10.2147/COPD.S269641. eCollection 2020.
Impact factor: 2.772
Publication type: Paper in international publication
Authors: Belmonte, Irene, Nunez, Alexa, Barrecheguren, Miriam, Esquinas, Cristina, Pons, Monica, Lopez-Martinez, Rosa M, Ruiz, Gerard, Blanco-Grau, Albert, Genesca, Joan, Ferrer, Roser et al.
DOI: 10.2147/COPD.S269641

VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage.

PMID: 33076429
Journal: Cancers
Year: 2020
Reference: Cancers (Basel). 2020 Oct 15;12(10). pii: cancers12102986. doi: 10.3390/cancers12102986.
Impact factor: 6.126
Publication type: Paper in international publication
Authors: Garcia-Gonzalez, Raul, Morejon-Garcia, Patricia, Campillo-Marcos, Ignacio, Salzano, Marcella, Lazo, Pedro A et al.
DOI: 10.3390/cancers12102986

Prevalence and distribution of hepatitis C virus genotypes in Spain during the 2000-2015 period (The GEHEP 005 study).

PMID: 28248445
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2017
Reference: J Viral Hepat. 2017 Sep;24(9):725-732. doi: 10.1111/jvh.12700. Epub 2017 Apr 10.
Impact factor: 4.122
Publication type: Paper in international publication
Authors: Navarro, Daniel, Rodriguez Frias, Francisco, Viciana, Isabel, Martinez-Sapina, Ana Maria, Rodriguez, Mario Jose, Martro, Elisa, Del Carmen Lozano, Maria, Coletta, Eleda, Cardenoso, Laura, Suarez, Avelina et al.
DOI: 10.1111/jvh.12700

Hepatitis C virus genotype 4: Genotype 1's little brother.

PMID: 27905173
Journal: JOURNAL OF VIRAL HEPATITIS
Year: 2017
Reference: J Viral Hepat. 2017 Jan;24(1):4-12. doi: 10.1111/jvh.12620. Epub 2016 Dec 1.
Impact factor: 4.122
Publication type: Review in international publication
Authors: Esteban, R, Buti, M, Llaneras, J, Riveiro-Barciela, M et al.
DOI: 10.1111/jvh.12620

High Hcv subtype heterogeneity in a chronically infected general population Revealed by high-Resolution Hcv subtyping.

PMID: 28192235
Journal: CLINICAL MICROBIOLOGY AND INFECTION
Year: 2017
Reference: Clin Microbiol Infect. 2017 Oct;23(10):775.e1-775.e6. doi: 10.1016/j.cmi.2017.02.007. Epub 2017 Feb 10.
Impact factor: 5.292
Publication type: Paper in international publication
Authors: Ordeig, Laura, Rodriguez-Frias, Francisco, Nieto, Leonardo, Gregori, Josep, Garcia-Cehic, Damir, Casillas, Rosario, Tabernero, David, Homs, Maria, Blasi, Maria, Vila, Marta et al.
DOI: 10.1016/j.cmi.2017.02.007

Genetic diagnosis of alpha1-antitrypsin deficiency using DNA from buccal swab and serum samples.

PMID: 28107169
Journal: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Year: 2017
Reference: Clin Chem Lab Med. 2017 Aug 28;55(9):1276-1283. doi: 10.1515/cclm-2016-0842.
Impact factor: 3.432
Publication type: Paper in international publication
Authors: Belmonte, Irene, Barrecheguren, Miriam, Esquinas, Cristina, Rodriguez, Esther, Miravitlles, Marc, Rodriguez-Frias, Francisco et al.
DOI: 10.1515/cclm-2016-0842

Blog

News

The consensus establishes recommendations that could correct the current disparities related to muscle mass, weight and height and would allow for more precise prioritization of patients who require transplants more urgently.

Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.

On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.

Estudi sobre els patrons de consum habitual de l'alcohol en població jove

Des de Vall d'Hebron estem buscant 200 persones voluntàries sanes d'entre 18 i 30 anys per a participar en un estudi sobre els patrons de consum habitual de l'alcohol en població jove, en el marc del projecte StopALD.

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