About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
Core facilities
We offer specialist support for researchers, internal and external alike, ranging from specific services to preparing complete projects. All this, from a perspective of quality and speed of response.
News
We offer you a gateway for staying up to date on everything going on at the Vall d’Hebron Research Institute (VHIR), from the latest news to future solidarity activities and initiatives that we are organising.
The Liver Diseases group is a referent at the local, national and international level in research, and is one of the most active groups in clinical research at VHIR. The group's prominent involvement in clinical trials is a clear indication of our professionals' commitment to ensuring that patients have access to state-of-the-art therapies. Our participation and collaboration in international projects and consortiums are also a fundamental characteristic of the group. The main objective of the group is to become one of the best translational research groups in liver diseases. It is essential to be able to apply all the findings of basic research to clinical research to improve the health of patients with liver disease.
IP: Maria Buti Ferret Collaborators: Maria Jose Herrero Mata, Ana Barreira Diaz, Maria del Mar Riveiro Barciela, Jordi Llaneras Artigues, Adriana Palom Agusti Funding agency: Instituto de Salud Carlos III Funding: 117370 Reference: PI20/01692 Duration: 01/01/2021 - 30/06/2025
IP: Inmaculada Fuentes Camps Collaborators: Gemma Vona Giralt, Antonio Moreno Galdó, Rafael Simó Canonge, Núria Pérez Picazo, Tamara Del Rio Higueras, Ariadna Martín Balcells, Olga Sánchez- Maroto Carrizo, Angelica Valderrama Rodríguez, Joan Genescà Ferrer, Paula Isabel Roldan Caballero Funding agency: Instituto de Salud Carlos III Funding: 315150 Reference: PT20/00078 Duration: 01/01/2021 - 31/12/2024
IP: Joan Genescà Ferrer Collaborators: Immaculada Raurell Saborit, Maria Nieves Martell Pérez-Alcalde, Mònica Pons Delgado Funding agency: Instituto de Salud Carlos III Funding: 268620 Reference: PI21/00691 Duration: 01/01/2022 - 30/06/2026
IP: Macarena Simon-Talero Horga Collaborators: Joaquin Castillo Justribo, Mònica Pons Delgado Funding agency: Instituto de Salud Carlos III Funding: 60500 Reference: PI21/00312 Duration: 01/01/2022 - 31/12/2024
PMID: 37861218 Journal: NEW ENGLAND JOURNAL OF MEDICINE Year: 2023 Reference: N Engl J Med. 2023 Oct 20. doi: 10.1056/NEJMoa2307980. Impact factor: Publication type: Paper in international publication Authors: Abraldes, Juan Gonzalez; Ahn, Myung-Ju; Akamatsu, Hiroaki; Albillos, Agustin; Amitrano, Lucio; Anderson, Erik S; Balcar, Lorenz; Blackhall, Fiona; Borghaei, Hossein; Bosch, Jaime et al. DOI: 10.1056/NEJMoa2307980
PMID: 37870985 Journal: Hepatology Communications Year: 2023 Reference: Hepatol Commun. 2023 Oct 18;7(11):e0273. doi: 10.1097/HC9.0000000000000273. eCollection 2023 Nov 1. Impact factor: Publication type: Paper in international publication Authors: Albillos, Agustin; Ampuero, Javier; Andrade, Raul J; Angeli, Paolo; Arroyo, Vicente; Ballester, Maria Pilar; Belli, Luca; Berenguer, Marina; Berg, Thomas; Bongiovanni, Deborah et al. DOI: 10.1097/HC9.0000000000000273
PMID: 37871604 Journal: LANCET Year: 2023 Reference: Lancet. 2023 Oct 19:S0140-6736(23)02033-0. doi: 10.1016/S0140-6736(23)02033-0. Impact factor: Publication type: Paper in international publication Authors: Albillos, Agustin; Ampuero, Javier; Andrade, Raul J; Angeli, Paolo; Arroyo, Vicente; Bai, Yuxian; Ballester, Maria Pilar; Belli, Luca; Berenguer, Marina; Berg, Thomas et al. DOI: 10.1016/S0140-6736(23)02033-0
PMID: 37879444 Journal: ANNALS OF ONCOLOGY Year: 2023 Reference: Ann Oncol. 2023 Oct 17:S0923-7534(23)04281-3. doi: 10.1016/j.annonc.2023.10.117. Impact factor: Publication type: Paper in international publication Authors: Augustin, Salvador; Azuma, K; Baneras, Jordi; Barala, P; Bauml, J M; Bearz, A; Boixadera, Anna; Bourla, A B; Califano, R; Campelo, R G et al. DOI: 10.1016/j.annonc.2023.10.117
PMID: 35569541 Journal: Gastroenterologia y Hepatologia Year: 2022 Reference: Gastroenterol Hepatol. 2022 May 13. pii: S0210-5705(22)00137-6. doi: 10.1016/j.gastrohep.2022.04.001. Impact factor: 2.102 Publication type: Paper in national publication Authors: Romero-Gomez, Manuel, Aller, Rocio, Ampuero, Javier, Rodriguez, Conrado Fernandez, Augustin, Salvador, Latorre, Raquel, Rivera-Esteban, Jesus, Urroz, Belen Martinez, Garcia, Maria Luisa Gutierrez, Lopez, Sonia Alonso et al. DOI: 10.1016/j.gastrohep.2022.04.001
PMID: 35566592 Journal: Journal of Clinical Medicine Year: 2022 Reference: J Clin Med. 2022 Apr 27;11(9). pii: jcm11092466. doi: 10.3390/jcm11092466. Impact factor: 4.242 Publication type: Paper in international publication Authors: Banares, Juan, Bermudez, Maria, Vargas, Victor, Salcedo-Allende, Maria Teresa, Castells, Lluis, Augustin, Salvador, Minguez, Beatriz, Pericas, Juan M, Manzano, Ramiro, Rivera-Esteban, Jesus et al. DOI: 10.3390/jcm11092466
PMID: 35567756 Journal: LIVER INTERNATIONAL Year: 2022 Reference: Liver Int. 2022 Jul;42(7):1697. doi: 10.1111/liv.15291. Epub 2022 May 23. Impact factor: 5.828 Publication type: Letter or abstract Authors: Ventura-Cots, Meritxell, Bataller, Ramon, Vargas, Victor, Jimenez, Cesar et al. DOI: 10.1111/liv.15291
PMID: 35555847 Journal: JOURNAL OF VIRAL HEPATITIS Year: 2022 Reference: J Viral Hepat. 2022 Jul;29(7):579-583. doi: 10.1111/jvh.13686. Epub 2022 May 23. Impact factor: 3.728 Publication type: Paper in international publication Authors: Vargas-Accarino, Elena, Martinez-Camprecios, Joan, Dominguez-Hernandez, Raquel, Rando-Segura, Ariadna, Riveiro-Barciela, Mar, Rodriguez-Frias, Francisco, Barreira, Ana, Palom, Adriana, Casado, Miguel Angel, Esteban, Rafael et al. DOI: 10.1111/jvh.13686
PMID: 33720484 Journal: JOURNAL OF VIRAL HEPATITIS Year: 2021 Reference: J Viral Hepat. 2021 Sep;28(9):1319-1324. doi: 10.1111/jvh.13497. Epub 2021 Mar 22. Impact factor: 3.728 Publication type: Paper in international publication Authors: Buti, Maria, Esteban, Juan Ignacio, Quer, Josep, Campos, Carolina, Tabernero, David, Canizares, Angelina, Castro-Iglesias, Angeles, Garcia-Cehic, Damir, Rando, Ariadna, Rodriguez-Frias, Francisco et al. DOI: 10.1111/jvh.13497
PMID: 33614029 Journal: Therapeutic advances in infectious disease Year: 2021 Reference: Ther Adv Infect Dis. 2021 Feb 5;8:2049936120985954. doi: 10.1177/2049936120985954. eCollection 2021 Jan-Dec. Impact factor: 0 Publication type: Review in international publication Authors: Roade, Luisa, Riveiro-Barciela, Mar, Esteban, Rafael, Buti, Maria et al. DOI: 10.1177/2049936120985954
PMID: 33603102 Journal: Scientific Reports Year: 2021 Reference: Sci Rep. 2021 Feb 18;11(1):4215. doi: 10.1038/s41598-021-83762-4. Impact factor: 4.38 Publication type: Paper in international publication Authors: Pacin Ruiz, Beatriz, Garcia-Garcia, Selene, Esteban-Mur, Rafael, Tabernero, David, Buti, Maria, Rodriguez-Frias, Francisco, Lopez-Martinez, Rosa, Rando, Ariadna, Quer, Josep, Yll, Marcal et al. DOI: 10.1038/s41598-021-83762-4
PMID: 33317846 Journal: JOURNAL OF HEPATOLOGY Year: 2021 Reference: J Hepatol. 2021 Feb;74(2):491. doi: 10.1016/j.jhep.2020.11.020. Epub 2020 Dec 11. Impact factor: 25.083 Publication type: Letter or abstract Authors: Marino, Zoe, Darnell, Anna, Lens, Sabela, Sapena, Victor, Diaz, Alba, Belmonte, Ernest, Perello, Christie, Calleja, Jose Luis, Varela, Maria, Rodriguez, Manuel et al. DOI: 10.1016/j.jhep.2020.11.020
PMID: 31850577 Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS Year: 2020 Reference: Aliment Pharmacol Ther. 2020 Jan;51(1):174-175. doi: 10.1111/apt.15558. Impact factor: 7.515 Publication type: Editorail in international publication Authors: Palom, Adriana, Riveiro-Barciela, Mar, Buti, Maria et al. DOI: 10.1111/apt.15558
PMID: 31607677 Journal: Lancet Gastroenterology & Hepatology Year: 2020 Reference: Lancet Gastroenterol Hepatol. 2020 Jan;5(1):31-41. doi: 10.1016/S2468-1253(19)30320-6. Epub 2019 Oct 10. Impact factor: 14.789 Publication type: Paper in international publication Authors: Jimenez, Cesar, Pose, Elisa, Napoleone, Laura, Amin, Ahmed, Campion, Daniela, Sola, Elsa, Uschner, Frank Erhard, de Wit, Koos, Zaccherini, Giacomo, Alessandria, Carlo et al. DOI: 10.1016/S2468-1253(19)30320-6
PMID: 31721254 Journal: ALIMENTARY PHARMACOLOGY & THERAPEUTICS Year: 2020 Reference: Aliment Pharmacol Ther. 2020 Jan;51(1):158-166. doi: 10.1111/apt.15521. Epub 2019 Nov 13. Impact factor: 7.515 Publication type: Paper in international publication Authors: Esteban, Rafael, Buti, Maria, Rodriguez, Manuel, Lens, Sabela, Riveiro-Barciela, Mar, Garcia-Samaniego, Javier, Palom, Adriana, Rodriguez-Tajes, Sergio, Navascues, Carmen A et al. DOI: 10.1111/apt.15521
PMID: 27905173 Journal: JOURNAL OF VIRAL HEPATITIS Year: 2017 Reference: J Viral Hepat. 2017 Jan;24(1):4-12. doi: 10.1111/jvh.12620. Epub 2016 Dec 1. Impact factor: 4.122 Publication type: Review in international publication Authors: Esteban, R, Buti, M, Llaneras, J, Riveiro-Barciela, M et al. DOI: 10.1111/jvh.12620
PMID: 28192235 Journal: CLINICAL MICROBIOLOGY AND INFECTION Year: 2017 Reference: Clin Microbiol Infect. 2017 Oct;23(10):775.e1-775.e6. doi: 10.1016/j.cmi.2017.02.007. Epub 2017 Feb 10. Impact factor: 5.292 Publication type: Paper in international publication Authors: Ordeig, Laura, Rodriguez-Frias, Francisco, Nieto, Leonardo, Gregori, Josep, Garcia-Cehic, Damir, Casillas, Rosario, Tabernero, David, Homs, Maria, Blasi, Maria, Vila, Marta et al. DOI: 10.1016/j.cmi.2017.02.007
PMID: 28107169 Journal: CLINICAL CHEMISTRY AND LABORATORY MEDICINE Year: 2017 Reference: Clin Chem Lab Med. 2017 Aug 28;55(9):1276-1283. doi: 10.1515/cclm-2016-0842. Impact factor: 3.432 Publication type: Paper in international publication Authors: Belmonte, Irene, Barrecheguren, Miriam, Esquinas, Cristina, Rodriguez, Esther, Miravitlles, Marc, Rodriguez-Frias, Francisco et al. DOI: 10.1515/cclm-2016-0842
PMID: 28078526 Journal: DIGESTIVE DISEASES AND SCIENCES Year: 2017 Reference: Dig Dis Sci. 2017 Mar;62(3):784-793. doi: 10.1007/s10620-017-4448-7. Epub 2017 Jan 11. Impact factor: 2.875 Publication type: Paper in international publication Authors: Moreno-Palomares, J J, Esteban, Rafael, Buti, Maria, de Cuenca, Beatriz, Sanchez-Pobre, Pilar, Moreno, Diego, Fernandez-Bermejo, Miguel, Riveiro-Barciela, Mar, Tabernero, David, Calleja, Jose L et al. DOI: 10.1007/s10620-017-4448-7
Using computed tomography (CT), with or without contrast, it is possible to perform an accurate and safe detection of the disease without the need for biopsies and avoiding the limitations of other non-invasive diagnostic tools.
On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.
Preliminary study results confirm that the drug resmetirom reduces the presence of fat, inflammation, cell damage and fibrosis in the liver.
Des de Vall d'Hebron estem buscant 200 persones voluntàries sanes d'entre 18 i 30 anys per a participar en un estudi sobre els patrons de consum habitual de l'alcohol en població jove, en el marc del projecte StopALD.
