Microbiome Research
The Microbiome Research’s group seeks to investigate the role of the microbiota in health and disease. Its secondary objectives include developing molecular as well as bioinformatics tools to characterize the microbiome structure and function, discovering micro-biomarkers for diagnosis and prognosis, investigating how fecal microbiota transplantation could be used as a therapeutic strategy, and evaluating the impact of diet on the gut microbial ecosystem The Microbiome Lab is a multidisciplinary team, composed of molecular biologists, bioinformaticians, and physicians. The group tackles several clinical fields including inflammatory bowel diseases, diabetes, liver diseases, pre-term birth, and critical illness.
Research lines
The Human Microbiome
The Microbiome Research Group seeks to investigate the role of the microbiota in health and disease. Its secondary objectives include:
1. Role of the microbiota in health and disease
2. Tools to characterize the microbiome structure and function
3. Micro-biomarkers for diagnosis and prognosis
4. Fecal microbiota transplantation as a therapeutic strategy
5. Impact of diet on the gut microbial ecosystem
IP: Chaysavanh Manichanh
Publications
Microbiome Composition Recovery after Liver Transplantation Correlates with Initial Liver Disease Severity and Antibiotics Treatment.
PMID: 38556088
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2024
Reference: Am J Transplant. 2024 Mar 29:S1600-6135(24)00248-X. doi: 10.1016/j.ajt.2024.03.038.
Impact factor:
Publication type: Paper in international publication
Authors: Bilbao, Itxarone; Canalda Baltrons, Aleix; Dopazo, Cristina; Manichanh, Chaysavanh; Pons, Marc; Soler, Zaida; Vega-Abellaneda, Sara; Xie, Zixuan; Yanez, Francisca et al.
DOI: 10.1016/j.ajt.2024.03.038
GSR-DB: a manually curated and optimized taxonomical database for 16S rRNA amplicon analysis.
PMID: 38189256
Journal: mSystems
Year: 2024
Reference: mSystems. 2024 Jan 8:e0095023. doi: 10.1128/msystems.00950-23.
Impact factor:
Publication type: Paper in international publication
Authors: Manichanh, Chaysavanh; Molano, Leidy-Alejandra G; Vega-Abellaneda, Sara et al.
DOI: 10.1128/msystems.00950-23
A multistrain probiotic increases the serum glutamine/glutamate ratio in patients with cirrhosis: a metabolomic analysis.
PMID: 37026745
Journal: Hepatology Communications
Year: 2023
Reference: Hepatol Commun. 2023 Apr 4;7(4):e0072. doi: 10.1097/HC9.0000000000000072. eCollection 2023 Apr 1.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarado, Edilmar; Canalda-Baltrons, Aleix; Claria, Joan; Cuyas, Berta; Escorsell, Angels; Guarner, Carlos; Laghi, Luca; Lan, Qiuyu; Manichanh, Chaysavanh; Nieto, Juan Camilo et al.
DOI: 10.1097/HC9.0000000000000072
Severe and refractory gastrointestinal toxicity due to immune checkpoint inhibitors: clinical experience in a tertiary referral hospital.
PMID: 37170542
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2023
Reference: Rev Esp Enferm Dig. 2023 May 12. doi: 10.17235/reed.2023.9436/2022.
Impact factor:
Publication type: Paper in international publication
Authors: Borruel, Natalia; Borruel, Natalia; Casellas, Francesc; Casellas, Francesc; Cespedes Martinez, Elena; Cespedes Martinez, Elena; Herrera-De Guise, Claudia; Herrera-De Guise, Claudia; Mayorga, Luis; Mayorga, Luis et al.
DOI: 10.17235/reed.2023.9436/2022
Gut microbial dysbiosis in patients with Cushing's disease in long-term remission. Relationship with cardiometabolic risk.
PMID: 37342265
Journal: Frontiers in Endocrinology
Year: 2023
Reference: Front Endocrinol (Lausanne). 2023 Jun 5;14:1074757. doi: 10.3389/fendo.2023.1074757. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Amodru, Vincent; Fernandez, Pedro Gonzalez; Gaztambide, Sonia; Manichanh, Chaysavanh; Martel-Duguech, Luciana; Puig-Domingo, Manel; Valassi, Elena; Webb, Susan M; Yanez, Francisca et al.
DOI: 10.3389/fendo.2023.1074757
Gut Microbiota Composition in Long-Remission Ulcerative Colitis is Close to a Healthy Gut Microbiota.
PMID: 37655859
Journal: INFLAMMATORY BOWEL DISEASES
Year: 2023
Reference: Inflamm Bowel Dis. 2023 Sep 1;29(9):1362-1369. doi: 10.1093/ibd/izad058.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Virginia Robles; Casellas, Francesc; Casellas, Francesc; Guarner, Francisco; Herrera-deGuise, Claudia; Herrera-deGuise, Claudia; Manichanh, Chaysavanh; Mayorga, Luis Fernando; Mayorga, Luis Fernando; Pozuelo Del Rio, Marta et al.
DOI: 10.1093/ibd/izad058
Dysbiosis: An Indicator of COVID-19 Severity in Critically Ill Patients.
PMID: 36555453
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 Dec 13;23(24):15808. doi: 10.3390/ijms232415808.
Impact factor:
Publication type: Paper in international publication
Authors: Barquinero, Jordi; Cuenca, Silvia; Manichanh, Chaysavanh; Roca, Joaquim; Serrano-Gomez, Gerard; Sirvent, Jose-Maria; Soler, Zaida; Xie, Zixuan et al.
DOI: 10.3390/ijms232415808
Cervical pessary and cerclage placement for preterm birth prevention and cervicovaginal microbiome changes.
PMID: 36168933
Journal: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
Year: 2022
Reference: Acta Obstet Gynecol Scand. 2022 Dec;101(12):1403-1413. doi: 10.1111/aogs.14460. Epub 2022 Sep 28.
Impact factor:
Publication type: Paper in international publication
Authors: Bernabeu, Andrea; Blasquez, Carlos; Brik, Maia; Carreras, Elena; Elias, Andrea; Farras, Alba; Goya, Maria; Manichanh, Chaysavanh; Munoz, Begona; Olivella, Anna et al.
DOI: 10.1111/aogs.14460
Intercontinental Gut Microbiome Variances in IBD.
PMID: 36142786
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2022
Reference: Int J Mol Sci. 2022 Sep 17;23(18). pii: ijms231810868. doi: 10.3390/ijms231810868.
Impact factor:
Publication type: Paper in international publication
Authors: Borruel, Natalia; Manichanh, Chaysavanh; Mayorga, Luis; Serrano-Gomez, Gerard; Xie, Zixuan et al.
DOI: 10.3390/ijms231810868
FunOMIC: Pipeline with built-in fungal taxonomic and functional databases for human mycobiome profiling.
PMID: 35891785
Journal: Computational and Structural Biotechnology Journal
Year: 2022
Reference: Comput Struct Biotechnol J. 2022 Jul 11;20:3685-3694. doi: 10.1016/j.csbj.2022.07.010. eCollection 2022.
Impact factor:
Publication type: Paper in international publication
Authors: Manichanh, Chaysavanh; Xie, Zixuan et al.
DOI: 10.1016/j.csbj.2022.07.010
News
The study also linked improved microbiota diversity to better liver function.
This work sets the basis for future research aimed at a deeper understanding of the microbiota and the effect of nutrition.
These are the results of a study published in Nature Communications and led by the Vall d'Hebron Research Institute (VHIR), the University of Lleida (UdL) and the Biomedical Research Institute of Lleida (IRBLleida).
We are looking for healthy volunteers for a study on the microbiota and eating habits
We are looking for approximately 1,000 volunteers who will have to answer a very simple questionnaire about their eating habits and provide a stool sample, 3 times over the course of a year.