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Microbiome Research

The Microbiome Research’s group seeks to investigate the role of the microbiota in health and disease. Its secondary objectives include developing molecular as well as bioinformatics tools to characterize the microbiome structure and function, discovering micro-biomarkers for diagnosis and prognosis, investigating how fecal microbiota transplantation could be used as a therapeutic strategy, and evaluating the impact of diet on the gut microbial ecosystem The Microbiome Lab is a multidisciplinary team, composed of molecular biologists, bioinformaticians, and physicians. The group tackles several clinical fields including inflammatory bowel diseases, diabetes, liver diseases, pre-term birth, and critical illness.

Team

Zaida Soler Luque

Zaida Soler Luque

Predoctoral researcher
Microbiome Research
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Gerard Serrano Gomez

Gerard Serrano Gomez

Predoctoral researcher
Microbiome Research
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Ana Mimic

Ana Mimic

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Arnau Noguera Segura

Arnau Noguera Segura

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Isaac Manjon Fernández

Isaac Manjon Fernández

Research technician
Microbiome Research
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Marc Pons Tarín

Marc Pons Tarín

Research technician
Microbiome Research
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Zaida Soler Luque

Zaida Soler Luque

Predoctoral researcher
Microbiome Research
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Gerard Serrano Gomez

Gerard Serrano Gomez

Predoctoral researcher
Microbiome Research
Read more
Ana Mimic

Ana Mimic

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Arnau Noguera Segura

Arnau Noguera Segura

Read more
Isaac Manjon Fernández

Isaac Manjon Fernández

Research technician
Microbiome Research
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Marc Pons Tarín

Marc Pons Tarín

Research technician
Microbiome Research
Read more

Research lines

The Human Microbiome

The Microbiome Research Group seeks to investigate the role of the microbiota in health and disease. Its secondary objectives include:

1. Role of the microbiota in health and disease

2. Tools to characterize the microbiome structure and function

3. Micro-biomarkers for diagnosis and prognosis

4. Fecal microbiota transplantation as a therapeutic strategy

5. Impact of diet on the gut microbial ecosystem


IP: Chaysavanh Manichanh

Projects

Modulación de la microbiota intestinal y el sistema inmunológicoModulación de la microbiota intestinal y el sistema inmunológico (MICROBIMM)

IP: Chaysavanh Manichanh
Collaborators: Zaida Soler Luque, Laura Campderros Traver, Sara Vega Abellaneda, Luis Fernando Mayorga Ayala
Funding agency: Ministerio de Ciencia e Innovación-MICINN
Funding: 237500
Reference: PID2023-147387OB-I00
Duration: 01/09/2024 - 31/08/2027

Ministerio de Ciencia

Fisiologia i fisiopatologia digestiva

IP: Chaysavanh Manichanh
Collaborators: Itxarone Izaskun Bilbao Aguirre, Zaida Soler Luque, Jordi Barquinero Mañez, Oscar Segarra Canton, Gerard Serrano Gomez, Cristina Dopazo Taboada, Rocío Piñera Moreno
Funding agency: Agència Gestió Ajuts Universitaris i de Recerca
Funding: 40000
Reference: 2021 SGR 00459
Duration: 01/01/2022 - 30/06/2025

El déficit de CFTR facilita la carcinogénesis pancreática y potencia el crecimiento, la agresividad tumoral y las metástasis

IP: Chaysavanh Manichanh
Collaborators: Laura Campderros Traver, Judit Álvarez González
Funding agency: Instituto de Salud Carlos III
Funding: 95000
Reference: CD22/00177
Duration: 01/03/2023 - 28/02/2025

X

IP: Laia Perez Lasarte
Collaborators: Gerard Serrano Gomez, Chaysavanh Manichanh, Judit Álvarez González
Funding agency: Fundació Institut de Recerca HUVH
Funding: 56357.41
Reference: VHIR/PHDPROGRAMME/2022/SERRANO
Duration: 01/07/2022 - 30/09/2025

Publications

GSR-DB: a manually curated and optimized taxonomical database for 16S rRNA amplicon analysis.

PMID: 38189256
Journal: mSystems
Year: 2024
Reference: mSystems. 2024 Jan 8:e0095023. doi: 10.1128/msystems.00950-23.
Impact factor:
Publication type: Paper in international publication
Authors: Manichanh, Chaysavanh; Molano, Leidy-Alejandra G; Vega-Abellaneda, Sara et al.
DOI: 10.1128/msystems.00950-23

A multistrain probiotic increases the serum glutamine/glutamate ratio in patients with cirrhosis: a metabolomic analysis.

PMID: 37026745
Journal: Hepatology Communications
Year: 2023
Reference: Hepatol Commun. 2023 Apr 4;7(4):e0072. doi: 10.1097/HC9.0000000000000072. eCollection 2023 Apr 1.
Impact factor:
Publication type: Paper in international publication
Authors: Alvarado, Edilmar; Canalda-Baltrons, Aleix; Claria, Joan; Cuyas, Berta; Escorsell, Angels; Guarner, Carlos; Laghi, Luca; Lan, Qiuyu; Manichanh, Chaysavanh; Nieto, Juan Camilo et al.
DOI: 10.1097/HC9.0000000000000072

Gut microbial dysbiosis in patients with Cushing's disease in long-term remission. Relationship with cardiometabolic risk.

PMID: 37342265
Journal: Frontiers in Endocrinology
Year: 2023
Reference: Front Endocrinol (Lausanne). 2023 Jun 5;14:1074757. doi: 10.3389/fendo.2023.1074757. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Amodru, Vincent; Fernandez, Pedro Gonzalez; Gaztambide, Sonia; Manichanh, Chaysavanh; Martel-Duguech, Luciana; Puig-Domingo, Manel; Valassi, Elena; Webb, Susan M; Yanez, Francisca et al.
DOI: 10.3389/fendo.2023.1074757

Gut Microbiota Composition in Long-Remission Ulcerative Colitis is Close to a Healthy Gut Microbiota.

PMID: 37655859
Journal: INFLAMMATORY BOWEL DISEASES
Year: 2023
Reference: Inflamm Bowel Dis. 2023 Sep 1;29(9):1362-1369. doi: 10.1093/ibd/izad058.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Virginia Robles; Casellas, Francesc; Casellas, Francesc; Guarner, Francisco; Herrera-deGuise, Claudia; Herrera-deGuise, Claudia; Manichanh, Chaysavanh; Mayorga, Luis Fernando; Pozuelo Del Rio, Marta; Pozuelo Del Rio, Marta et al.
DOI: 10.1093/ibd/izad058

Mutual modulation of gut microbiota and the immune system in type 1 diabetes models.

PMID: 38012160
Journal: Nature Communications
Year: 2023
Reference: Nat Commun. 2023 Nov 27;14(1):7770. doi: 10.1038/s41467-023-43652-x.
Impact factor:
Publication type: Paper in international publication
Authors: Alonso, Fabiola; Arpa, Berta; Aunon, Pilar; Corral-Pujol, Marta; Cosovanu, Catalina; Egia-Mendikute, Leire; Garcia, Patricia; Garcia-Carro, Clara; Gutierrez, Eduardo; Manichanh, Chaysavanh et al.
DOI: 10.1038/s41467-023-43652-x

Colonic bacterial diversity and dysbiosis in active microscopic colitis as compared to chronic diarrhoea and healthy controls: effect of polyethylene glycol after bowel lavage for colonoscopy.

PMID: 35764931
Journal: BMC GASTROENTEROLOGY
Year: 2022
Reference: BMC Gastroenterol. 2022 Jun 28;22(1):320. doi: 10.1186/s12876-022-02392-w.
Impact factor: 3.067
Publication type: Paper in international publication
Authors: Batista, Lissette; Robles, Virginia; Manichanh, Chaysavanh; Ruiz, Laura; Pinsach, Ferran; Guarner, Francisco; Fernandez-Banares, Fernando; Guagnozzi, Danila et al.
DOI: 10.1186/s12876-022-02392-w

Blog

News

The study also linked improved microbiota diversity to better liver function.

This work sets the basis for future research aimed at a deeper understanding of the microbiota and the effect of nutrition.

These are the results of a study published in Nature Communications and led by the Vall d'Hebron Research Institute (VHIR), the University of Lleida (UdL) and the Biomedical Research Institute of Lleida (IRBLleida).

Rates

Check the current rates of the services offered by the Microbiome Research group

We are looking for healthy volunteers for a study on the microbiota and eating habits

We are looking for approximately 1,000 volunteers who will have to answer a very simple questionnaire about their eating habits and provide a stool sample, 3 times over the course of a year.

More information