About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
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People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
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The Microbiome Research’s group seeks to investigate the role of the microbiota in health and disease. Its secondary objectives include developing molecular as well as bioinformatics tools to characterize the microbiome structure and function, discovering micro-biomarkers for diagnosis and prognosis, investigating how fecal microbiota transplantation could be used as a therapeutic strategy, and evaluating the impact of diet on the gut microbial ecosystem The Microbiome Lab is a multidisciplinary team, composed of molecular biologists, bioinformaticians, and physicians. The group tackles several clinical fields including inflammatory bowel diseases, diabetes, liver diseases, pre-term birth, and critical illness.
The Microbiome Research Group seeks to investigate the role of the microbiota in health and disease. Its secondary objectives include:
1. Role of the microbiota in health and disease
2. Tools to characterize the microbiome structure and function
3. Micro-biomarkers for diagnosis and prognosis
4. Fecal microbiota transplantation as a therapeutic strategy
5. Impact of diet on the gut microbial ecosystem
IP: Chaysavanh Manichanh
IP: Chaysavanh Manichanh Collaborators: Zaida Soler Luque, Laura Campderros Traver, Sara Vega Abellaneda, Luis Fernando Mayorga Ayala Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 237500 Reference: PID2023-147387OB-I00 Duration: 01/09/2024 - 31/08/2028
IP: Chaysavanh Manichanh Collaborators: Itxarone Izaskun Bilbao Aguirre, Zaida Soler Luque, Jordi Barquinero Mañez, Oscar Segarra Canton, Gerard Serrano Gomez, Cristina Dopazo Taboada, Rocío Piñera Moreno Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 40000 Reference: 2021 SGR 00459 Duration: 01/01/2022 - 30/06/2025
IP: Fco Javier Santos Vicente Collaborators: Beatriz Lobo Alvarez, Fisiologia i fisiopatologia digestiva, Merce Albert Bayo, Natalia Borruel Sainz, Francesc Casellas Jordá, Carmen Alonso Cotoner, Carolina Malagelada Prats, Jorge Serra Pueyo, Ana Maria Gonzalez Castro, Ariadna Aguilar Cayuelas, Elba Exposito Fernandez, Laura Campderros Traver, Blanca Grases Pintó, Virginia Robles Alonso, Adoración Nieto Ruiz, Claudia Barber Caselles, Elena Céspedes Martínez, Danila Guagnozzi, Ronald Benjamin Llerena Castro, Consuelo Cammarota Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 40000 Reference: 2021 SGR 00766 Duration: 01/01/2022 - 30/06/2025
IP: Chaysavanh Manichanh Collaborators: Laura Campderros Traver, Judit Álvarez González Funding agency: Instituto de Salud Carlos III Funding: 95000 Reference: CD22/00177 Duration: 01/03/2023 - 28/02/2025
PMID: 38556088 Journal: AMERICAN JOURNAL OF TRANSPLANTATION Year: 2024 Reference: Am J Transplant. 2024 Mar 29:S1600-6135(24)00248-X. doi: 10.1016/j.ajt.2024.03.038. Impact factor: Publication type: Paper in international publication Authors: Bilbao, Itxarone; Canalda Baltrons, Aleix; Dopazo, Cristina; Manichanh, Chaysavanh; Pons, Marc; Soler, Zaida; Vega-Abellaneda, Sara; Xie, Zixuan; Yanez, Francisca et al. DOI: 10.1016/j.ajt.2024.03.038
PMID: 38189256 Journal: mSystems Year: 2024 Reference: mSystems. 2024 Jan 8:e0095023. doi: 10.1128/msystems.00950-23. Impact factor: Publication type: Paper in international publication Authors: Manichanh, Chaysavanh; Molano, Leidy-Alejandra G; Vega-Abellaneda, Sara et al. DOI: 10.1128/msystems.00950-23
PMID: 37026745 Journal: Hepatology Communications Year: 2023 Reference: Hepatol Commun. 2023 Apr 4;7(4):e0072. doi: 10.1097/HC9.0000000000000072. eCollection 2023 Apr 1. Impact factor: Publication type: Paper in international publication Authors: Alvarado, Edilmar; Canalda-Baltrons, Aleix; Claria, Joan; Cuyas, Berta; Escorsell, Angels; Guarner, Carlos; Laghi, Luca; Lan, Qiuyu; Manichanh, Chaysavanh; Nieto, Juan Camilo et al. DOI: 10.1097/HC9.0000000000000072
PMID: 37170542 Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS Year: 2023 Reference: Rev Esp Enferm Dig. 2023 May 12. doi: 10.17235/reed.2023.9436/2022. Impact factor: Publication type: Paper in international publication Authors: Borruel, Natalia; Borruel, Natalia; Casellas, Francesc; Casellas, Francesc; Cespedes Martinez, Elena; Cespedes Martinez, Elena; Herrera-De Guise, Claudia; Herrera-De Guise, Claudia; Mayorga, Luis; Mayorga, Luis et al. DOI: 10.17235/reed.2023.9436/2022
PMID: 37342265 Journal: Frontiers in Endocrinology Year: 2023 Reference: Front Endocrinol (Lausanne). 2023 Jun 5;14:1074757. doi: 10.3389/fendo.2023.1074757. eCollection 2023. Impact factor: Publication type: Paper in international publication Authors: Amodru, Vincent; Fernandez, Pedro Gonzalez; Gaztambide, Sonia; Manichanh, Chaysavanh; Martel-Duguech, Luciana; Puig-Domingo, Manel; Valassi, Elena; Webb, Susan M; Yanez, Francisca et al. DOI: 10.3389/fendo.2023.1074757
PMID: 37655859 Journal: INFLAMMATORY BOWEL DISEASES Year: 2023 Reference: Inflamm Bowel Dis. 2023 Sep 1;29(9):1362-1369. doi: 10.1093/ibd/izad058. Impact factor: Publication type: Paper in international publication Authors: Alonso, Virginia Robles; Casellas, Francesc; Casellas, Francesc; Guarner, Francisco; Herrera-deGuise, Claudia; Herrera-deGuise, Claudia; Manichanh, Chaysavanh; Mayorga, Luis Fernando; Mayorga, Luis Fernando; Pozuelo Del Rio, Marta et al. DOI: 10.1093/ibd/izad058
PMID: 36555453 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2022 Reference: Int J Mol Sci. 2022 Dec 13;23(24):15808. doi: 10.3390/ijms232415808. Impact factor: Publication type: Paper in international publication Authors: Barquinero, Jordi; Cuenca, Silvia; Manichanh, Chaysavanh; Roca, Joaquim; Serrano-Gomez, Gerard; Sirvent, Jose-Maria; Soler, Zaida; Xie, Zixuan et al. DOI: 10.3390/ijms232415808
PMID: 36168933 Journal: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA Year: 2022 Reference: Acta Obstet Gynecol Scand. 2022 Dec;101(12):1403-1413. doi: 10.1111/aogs.14460. Epub 2022 Sep 28. Impact factor: Publication type: Paper in international publication Authors: Bernabeu, Andrea; Blasquez, Carlos; Brik, Maia; Carreras, Elena; Elias, Andrea; Farras, Alba; Goya, Maria; Manichanh, Chaysavanh; Munoz, Begona; Olivella, Anna et al. DOI: 10.1111/aogs.14460
PMID: 36142786 Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Year: 2022 Reference: Int J Mol Sci. 2022 Sep 17;23(18). pii: ijms231810868. doi: 10.3390/ijms231810868. Impact factor: Publication type: Paper in international publication Authors: Borruel, Natalia; Manichanh, Chaysavanh; Mayorga, Luis; Serrano-Gomez, Gerard; Xie, Zixuan et al. DOI: 10.3390/ijms231810868
PMID: 35891785 Journal: Computational and Structural Biotechnology Journal Year: 2022 Reference: Comput Struct Biotechnol J. 2022 Jul 11;20:3685-3694. doi: 10.1016/j.csbj.2022.07.010. eCollection 2022. Impact factor: Publication type: Paper in international publication Authors: Manichanh, Chaysavanh; Xie, Zixuan et al. DOI: 10.1016/j.csbj.2022.07.010
The study also linked improved microbiota diversity to better liver function.
This work sets the basis for future research aimed at a deeper understanding of the microbiota and the effect of nutrition.
These are the results of a study published in Nature Communications and led by the Vall d'Hebron Research Institute (VHIR), the University of Lleida (UdL) and the Biomedical Research Institute of Lleida (IRBLleida).
Check the current rates of the services offered by the Microbiome Research group
We are looking for approximately 1,000 volunteers who will have to answer a very simple questionnaire about their eating habits and provide a stool sample, 3 times over the course of a year.
