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Nephrology and kidney transplantation

Our research group is accredited by the Agency for Management of University and Research Grants (AGAUR) in Catalonia, and focuses on two main areas of interest which are related to Solid Organ Transplantation and especially Kidney, and in clinical Nephrology. We tackle these areas from an innovative perspective, both basic-experimental and mechanistic, always with a translational goal. On the one hand, we investigate, develop, and use novel diagnostic and therapeutic technologies to decipher and target main molecular and immune mechanisms of transplant rejection as well as the immune susceptibility to opportunistic infections and malignancies. Also, a main task force of the group is devoted to better understand the main mechanisms involved in certain autoimmune glomerular diseases and idiopathic nephrotic syndrome as well as in diabetic kidney disease, having a specific interest in the role of the renin-angiotensin system. Our ultimate goal is to improve the management and care of patients suffering from kidney diseases as well as their quality of life, reducing associated morbidity and mortality.

Team

Jordi Vilardell Vilà

Jordi Vilardell Vilà

Postdoctoral researcher
Nephrology and kidney transplantation
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Juan Carlos León Ramón

Juan Carlos León Ramón

Nephrology and kidney transplantation
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Muñoz Vaño, Vicent

Muñoz Vaño, Vicent

Research technician
Nephrology and kidney transplantation
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Alba Torija Recasens

Alba Torija Recasens

Predoctoral researcher
Nephrology and kidney transplantation
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Carmen Llorens Cebriá

Carmen Llorens Cebriá

Research technician
Nephrology and kidney transplantation
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Cristina Guirao Martinez

Cristina Guirao Martinez

Research technician
Nephrology and kidney transplantation
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Jordi Vilardell Vilà

Jordi Vilardell Vilà

Postdoctoral researcher
Nephrology and kidney transplantation
Read more
Juan Carlos León Ramón

Juan Carlos León Ramón

Nephrology and kidney transplantation
Read more
Muñoz Vaño, Vicent

Muñoz Vaño, Vicent

Research technician
Nephrology and kidney transplantation
Read more
Alba Torija Recasens

Alba Torija Recasens

Predoctoral researcher
Nephrology and kidney transplantation
Read more
Carmen Llorens Cebriá

Carmen Llorens Cebriá

Research technician
Nephrology and kidney transplantation
Read more
Cristina Guirao Martinez

Cristina Guirao Martinez

Research technician
Nephrology and kidney transplantation
Read more

Projects

Disección y promoción de inmunidad adaptativa específica frente al poliomavirus (BKV) para prevenir la infección viral tras el trasplante renal (proyecto BK-VAX).

IP: Oriol Bestard Matamoros
Collaborators: Juliana Esperalba Esquerra, Joana Sellarés Roig, Emma Pardo De los Santos, Elena Isabel Crespo Gimeno, Laura Donadeu Casassas, Narcís Saubí Roca
Funding agency: Instituto de Salud Carlos III
Funding: 174240
Reference: PI22/01019
Duration: 01/01/2023 - 31/12/2025

CONNECT

IP: Maria Jose Soler Romeo
Collaborators: -
Funding agency: EUROPEAN COMMISSION
Funding: 0.01
Reference: EC / COST-ACTION / 2020 / SOLER
Duration: 12/10/2020 - 11/10/2024

RICORS2040 - Inflamación e inmunopatología de órganos y sistemas

IP: Maria Jose Soler Romeo
Collaborators: Francesc Moreso Mateos, Oriol Bestard Matamoros, Joana Sellarés Roig, Irina Betsabe Torres Rodriguez, Concepció Jacobs Cachá, Maria Antonia Emilia Meneghini
Funding agency: Instituto de Salud Carlos III
Funding: 105765
Reference: RD21/0005/0016
Duration: 01/01/2022 - 31/12/2024

Mecanismos y dianas terapéuticas de la respuesta Inmunológica Humoral de Memoria facilitando el rechazo del injerto en el trasplante renal

IP: Oriol Bestard Matamoros
Collaborators: Nuria Bolaños Peruga
Funding agency: Instituto de Salud Carlos III
Funding: 158886.66
Reference: PI19/01710
Duration: 01/04/2021 - 30/06/2024

Publications

The coexistence of diabetic retinopathy and diabetic nephropathy is associated with worse kidney outcomes.

PMID: 37779839
Journal: Clinical Kidney Journal
Year: 2023
Reference: Clin Kidney J. 2023 Jul 6;16(10):1656-1663. doi: 10.1093/ckj/sfad142. eCollection 2023 Oct.
Impact factor:
Publication type: Paper in international publication
Authors: Agraz, Irene; Agraz, Irene; Barros, Xoana; Bermejo, Sheila; Bestard, Oriol; Bonet, Josep; Calero, Francesca; Coloma, Ana; Diaz, Montserrat; Diaz, Montserrat et al.
DOI: 10.1093/ckj/sfad142

Mayo Clinic consensus report on membranous nephropathy: proposal for a novel classification.

PMID: 37795587
Journal: KIDNEY INTERNATIONAL
Year: 2023
Reference: Kidney Int. 2023 Sep 6:S0085-2538(23)00490-8. doi: 10.1016/j.kint.2023.06.032.
Impact factor:
Publication type: Paper in international publication
Authors: Alexander, Mariam P; Amer, Hatem; Appel, Gerald B; Barbour, Sean J; Beck, Laurence H Jr; Caravaca-Fontan, Fernando; Casal Moura, Marta; Cattran, Daniel C; Caza, Tiffany N; D'Agati, Vivette D et al.
DOI: 10.1016/j.kint.2023.06.032

Mayo Clinic Consensus Report on Membranous Nephropathy: Proposal for a Novel Classification.

PMID: 37804268
Journal: MAYO CLINIC PROCEEDINGS
Year: 2023
Reference: Mayo Clin Proc. 2023 Sep 29:S0025-6196(23)00372-5. doi: 10.1016/j.mayocp.2023.08.006.
Impact factor:
Publication type: Paper in international publication
Authors: Alexander, Mariam P; Amer, Hatem; Appel, Gerald B; Barbour, Sean J; Beck, Laurence H Jr; Caravaca-Fontan, Fernando; Casal Moura, Marta; Cattran, Daniel C; Caza, Tiffany N; D'Agati, Vivette D et al.
DOI: 10.1016/j.mayocp.2023.08.006

Finerenone: towards a holistic therapeutic approach to patients with diabetic kidney disease.

PMID: 37813743
Journal: Nefrologia
Year: 2023
Reference: Nefrologia (Engl Ed). 2023 Oct 7:S2013-2514(23)00146-3. doi: 10.1016/j.nefroe.2023.09.002.
Impact factor:
Publication type: Review in international publication
Authors: Facila, Lorenzo; Gonzalez-Juanatey, Jose Ramon; Gorriz, Jose Luis; Ortiz, Alberto; Soler, Maria Jose; Valle, Alfonso et al.
DOI: 10.1016/j.nefroe.2023.09.002

Alloimmune Risk Stratification for Kidney Transplant Rejection.

PMID: 35669972
Journal: TRANSPLANT INTERNATIONAL
Year: 2022
Reference: Transpl Int. 2022 May 20;35:10138. doi: 10.3389/ti.2022.10138. eCollection 2022.
Impact factor: 3.782
Publication type: Editorail in international publication
Authors: Oberbauer, Rainer, Pengel, Liset, Schneeberger, Stefan, Naesens, Maarten, Mamode, Nizam, Heemann, Uwe, Furian, Lucrezia, Couzi, Lionel, Claas, Frans, Budde, Klemens et al.
DOI: 10.3389/ti.2022.10138

Evolution of the Definition of Rejection in Kidney Transplantation and Its Use as an Endpoint in Clinical Trials.

PMID: 35669978
Journal: TRANSPLANT INTERNATIONAL
Year: 2022
Reference: Transpl Int. 2022 May 20;35:10141. doi: 10.3389/ti.2022.10141. eCollection 2022.
Impact factor: 3.782
Publication type: Editorail in international publication
Authors: Rabant, Marion, Roufosse, Candice, Naesens, Maarten, Seron, Daniel, Becker, Jan Ulrich et al.
DOI: 10.3389/ti.2022.10141

Proposed Definitions of T Cell-Mediated Rejection and Tubulointerstitial Inflammation as Clinical Trial Endpoints in Kidney Transplantation.

PMID: 35669975
Journal: TRANSPLANT INTERNATIONAL
Year: 2022
Reference: Transpl Int. 2022 May 20;35:10135. doi: 10.3389/ti.2022.10135. eCollection 2022.
Impact factor: 3.782
Publication type: Review in international publication
Authors: Bellini, Maria Irene, Seron, Daniel, Rabant, Marion, Becker, Jan Ulrich, Roufosse, Candice, Diekmann, Fritz, Glotz, Denis, Hilbrands, Luuk, Loupy, Alexandre, Oberbauer, Rainer et al.
DOI: 10.3389/ti.2022.10135

Welcome editorial by the new CKJ Editor-in-Chief: Facing the future of CKJ with enthusiasm!

PMID: 35664277
Journal: Clinical Kidney Journal
Year: 2022
Reference: Clin Kidney J. 2022 May 30;15(6):1029-1033. doi: 10.1093/ckj/sfac121. eCollection 2022 Jun.
Impact factor: 4.452
Publication type: Editorail in international publication
Authors: Soler, Maria Jose et al.
DOI: 10.1093/ckj/sfac121

Crystal-Induced Podocytopathy Producing Collapsing Focal Segmental Glomerulosclerosis in Monoclonal Gammopathy of Renal Significance: A Case Report.

PMID: 34401732
Journal: Kidney medicine
Year: 2021
Reference: Kidney Med. 2021 May 14;3(4):659-664. doi: 10.1016/j.xkme.2021.03.007. eCollection 2021 Jul-Aug.
Impact factor: 0
Publication type: Letter or abstract
Authors: Buxeda, Anna, Said, Samar, Nasr, Samih H, Soler, Maria Jose, Howard, Mathew T, Maguire, Leo J, Fervenza, Fernando C et al.
DOI: 10.1016/j.xkme.2021.03.007

Live donor kidney transplantation. Situation analysis and roadmap.

PMID: 34294484
Journal: NEFROLOGIA
Year: 2021
Reference: Nefrologia (Engl Ed). 2021 Jul 19. pii: S0211-6995(21)00113-2. doi: 10.1016/j.nefro.2021.03.008.
Impact factor: 2.033
Publication type: Paper in national publication
Authors: Martinez, Itziar, Valentin, Maria de la Oliva, Hernandez, Domingo, Crespo, Marta, Mahillo, Beatriz, Beneyto, Isabel, Ramos-Verde, Ana, Revuelta, Ignacio, Rodriguez-Ferrero, Maria Luisa, Ruiz, Juan Carlos et al.
DOI: 10.1016/j.nefro.2021.03.008

Diabetes and renal disease-should we biopsy?

PMID: 31883322
Journal: NEPHROLOGY DIALYSIS TRANSPLANTATION
Year: 2021
Reference: Nephrol Dial Transplant. 2021 Jul 23;36(8):1384-1386. doi: 10.1093/ndt/gfz248.
Impact factor: 5.992
Publication type: Paper in international publication
Authors: Bermejo, Sheila, Garcia-Carro, Clara, Soler, Maria Jose et al.
DOI: 10.1093/ndt/gfz248

The Impact of Age on Mortality in Chronic Haemodialysis Popu-Lation with COVID-19.

PMID: 34300188
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Jul 7;10(14). pii: jcm10143022. doi: 10.3390/jcm10143022.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Vergara, Ander, Molina-Van den Bosch, Mireia, Toapanta, Nestor, Villegas, Andres, Sanchez-Camara, Luis, Sequera, Patricia de, Manrique, Joaquin, Shabaka, Amir, Aragoncillo, Ines, Ruiz, Maria Carmen et al.
DOI: 10.3390/jcm10143022

The Banff 2019 Kidney Meeting Report (I): Updates on and clarification of criteria for T cell- and antibody-mediated rejection.

PMID: 32463180
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2020
Reference: Am J Transplant. 2020 Sep;20(9):2318-2331. doi: 10.1111/ajt.15898. Epub 2020 May 28.
Impact factor: 7.338
Publication type: Paper in international publication
Authors: Sapir-Pichhadze, Ruth, Duong van Huyen, Jean-Paul, Farris, Alton B, Fogo, Agnes B, Gibson, Ian W, Glotz, Denis, Gueguen, Juliette, Kikic, Zeljko, Kozakowski, Nicolas, Kraus, Edward et al.
DOI: 10.1111/ajt.15898

Revisiting Experimental Models of Diabetic Nephropathy.

PMID: 32438732
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2020
Reference: Int J Mol Sci. 2020 May 19;21(10). pii: ijms21103587. doi: 10.3390/ijms21103587.
Impact factor: 4.556
Publication type: Review in international publication
Authors: Giralt-Lopez, Anna, Molina-Van den Bosch, Mireia, Vergara, Ander, Garcia-Carro, Clara, Seron, Daniel, Jacobs-Cacha, Conxita, Soler, Maria Jose et al.
DOI: 10.3390/ijms21103587

Glomerular endothelial cells and podocytes can express CD80 in patients with minimal change disease during relapse.

PMID: 32399663
Journal: PEDIATRIC NEPHROLOGY
Year: 2020
Reference: Pediatr Nephrol. 2020 Oct;35(10):1887-1896. doi: 10.1007/s00467-020-04541-3. Epub 2020 May 12.
Impact factor: 2.676
Publication type: Paper in international publication
Authors: Garg, Puneet, Cara-Fuentes, Gabriel, Venkatareddy, Madhusudan, Verma, Rakesh, Segarra, Alfons, Cleuren, Audrey C, Martinez-Ramos, Alfonso, Johnson, Richard J et al.
DOI: 10.1007/s00467-020-04541-3

Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology.

PMID: 32366514
Journal: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Year: 2020
Reference: J Am Soc Nephrol. 2020 Jul;31(7):1380-1383. doi: 10.1681/ASN.2020040419. Epub 2020 May 4.
Impact factor: 9.274
Publication type: Review in international publication
Authors: Batlle, Daniel, Soler, Maria Jose, Sparks, Matthew A, Hiremath, Swapnil, South, Andrew M, Welling, Paul A, Swaminathan, Sundararaman et al.
DOI: 10.1681/ASN.2020040419

Anti-phospholipase A2 receptor antibody and spontaneous remission in membranous nephropathy.

PMID: 30747149
Journal: Clinical Kidney Journal
Year: 2019
Reference: Clin Kidney J. 2019 Feb;12(1):33-35. doi: 10.1093/ckj/sfy079. Epub 2018 Oct 3.
Impact factor: 2.975
Publication type: Paper in international publication
Authors: Diaz, Montserrat, Agraz, Irene, Soler, Maria Jose et al.
DOI: 10.1093/ckj/sfy079

Apolipoprotein A-Ib as a biomarker of FSGS recurrence after kidney transplantation: Diagnostic performance and assessment of its prognostic value - a multi-centre cohort study.

PMID: 30411406
Journal: TRANSPLANT INTERNATIONAL
Year: 2019
Reference: Transpl Int. 2019 Mar;32(3):313-322. doi: 10.1111/tri.13372. Epub 2018 Nov 28.
Impact factor: 3.526
Publication type: Paper in international publication
Authors: Puig-Gay, Natalia, Jacobs-Cacha, Conxita, Sellares, Joana, Guirado, Lluis, Gonzalez Roncero, Francisco, Jimenez, Carlos, Zarraga, Sofia, Paul, Javier, Lauzurica, Ricardo, Angel, Alonso et al.
DOI: 10.1111/tri.13372

Vitamin D deficiency in solid-organ transplant recipients from a Spanish Mediterranean population.

PMID: 30701578
Journal: CLINICAL AND EXPERIMENTAL DERMATOLOGY
Year: 2019
Reference: Clin Exp Dermatol. 2019 Jun;44(4):e103-e109. doi: 10.1111/ced.13915. Epub 2019 Jan 30.
Impact factor: 1.771
Publication type: Paper in international publication
Authors: Ferrandiz-Pulido, C, Torres, I B, Juarez-Dobjanschi, C, Zarzoso-Munoz, I, Berastegui, C, Castells, L, Garcia-Patos, V, Moreso, F et al.
DOI: 10.1111/ced.13915

Cutaneous infections by dematiaceous opportunistic fungi: diagnosis and management in 11 solid organ transplant recipients.

PMID: 30230044
Journal: MYCOSES
Year: 2019
Reference: Mycoses. 2019 Feb;62(2):121-127. doi: 10.1111/myc.12853. Epub 2018 Oct 17.
Impact factor: 3.065
Publication type: Paper in international publication
Authors: Ferrandiz-Pulido, C, Martin-Gomez, M T, Repiso, T, Juarez, C, Ferrer, B, Lopez-Lerma, I, Gonzalez-Cruz, C, Moreso, F, Roman, A, Garcia-Patos, V et al.
DOI: 10.1111/myc.12853

Management of multidrug resistant Gram-negative bacilli infections in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations.

PMID: 28811074
Journal: Transplantation Reviews
Year: 2018
Reference: Transplant Rev (Orlando). 2018 Jan;32(1):36-57. doi: 10.1016/j.trre.2017.07.001. Epub 2017 Jul 26.
Impact factor: 2.364
Publication type: Clinical guide
Authors: Martin-Davila, P, Montejo, M, Moreno, A, Oliver, A, Pascual, A, Perez-Nadales, E, Roman-Broto, A, San-Juan, R, Seron, D, Sole-Jover, A et al.
DOI: 10.1016/j.trre.2017.07.001

Clinical Trials for Immunosuppression in Transplantation; The Case for Reform and Change in Direction.

PMID: 28207630
Journal: TRANSPLANTATION
Year: 2017
Reference: Transplantation. 2017 Jul;101(7):1527-1534. doi: 10.1097/TP.0000000000001648.
Impact factor: 3.678
Publication type: Review in international publication
Authors: Woodle, E Steve, Kuypers, Dirk, Mannon, Roslyn R, Abecassis, Michael, Chadban, Stephen, Gill, John S, Murphy, Barbara, Nickerson, Peter W, Schold, Jesse D, Stock, Peter et al.
DOI: 10.1097/TP.0000000000001648

[Adherence to treatment after kidney transplantation as quality indicator of the information received: Longitudinal study of 2 years follow-up].

PMID: 27425627
Journal: Revista de calidad asistencial : organo de la Soci
Year: 2017
Reference: Rev Calid Asist. 2017 Jan - Feb;32(1):33-39. doi: 10.1016/j.cali.2016.05.004. Epub 2016 Jul 15.
Impact factor: 0
Publication type: Paper in national publication
Authors: Costa-Requena, G, Cantarell, M C, Moreso, F, Parramon, G, Seron, D et al.
DOI: 10.1016/j.cali.2016.05.004

The Banff 2015 Kidney Meeting Report: Current Challenges in Rejection Classification and Prospects for Adopting Molecular Pathology.

PMID: 27862883
Journal: AMERICAN JOURNAL OF TRANSPLANTATION
Year: 2017
Reference: Am J Transplant. 2017 Jan;17(1):28-41. doi: 10.1111/ajt.14107.
Impact factor: 6.165
Publication type: Editorail in international publication
Authors: Alachkar, N, Bagnasco, S, Becker, J U, Cornell, L, Drachenberg, C, Dragun, D, de Kort, H, Gibson, I W, Kraus, E S, Lefaucheur, C et al.
DOI: 10.1111/ajt.14107

Advancing Transplantation: New Questions, New Possibilities in Kidney and Liver Transplantation.

PMID: 28125449
Journal: TRANSPLANTATION
Year: 2017
Reference: Transplantation. 2017 Feb;101 Suppl 2S:S1-S41. doi: 10.1097/TP.0000000000001563.
Impact factor: 3.678
Publication type: Editorail in international publication
Authors: Grinyo, Josep, Loupy, Alexandre, Kuypers, Dirk, Mariat, Christophe, Clancy, Marc, Jardine, Alan G, Guirado, Lluis, Fellstrom, Bengt, O'Grady, John, Pirenne, Jacques et al.
DOI: 10.1097/TP.0000000000001563

Dispositional optimism and coping strategies in patients with a kidney transplant.

PMID: 25259815
Journal: NEFROLOGIA
Year: 2014
Reference: Nefrologia. 2014 Sep 26;34(5):605-10. doi: 10.3265/Nefrologia.pre2014.Jun.11881.
Impact factor: 1.442
Publication type: Paper in national publication
Authors: Costa-Requena, Gemma, Cantarell-Aixendri, M Carmen, Parramon-Puig, Gemma, Seron-Micas, Daniel et al.
DOI: 10.3265/Nefrologia.pre2014.Jun.11881

Cirrhosis, liver transplantation and HIV infection are risk factors associated with hepatitis E virus infection.

PMID: 25068388
Journal: PLOS ONE
Year: 2014
Reference: PLoS One. 2014 Jul 28;9(7):e103028. doi: 10.1371/journal.pone.0103028. eCollection 2014.
Impact factor: 3.534
Publication type: Paper in international publication
Authors: Riveiro-Barciela, Mar, Buti, Maria, Homs, Maria, Campos-Varela, Isabel, Cantarell, Carmen, Crespo, Manuel, Castells, Lluis, Tabernero, David, Quer, Josep, Esteban, Rafael et al.
DOI: 10.1371/journal.pone.0103028

The Interplay between inflammation and fibrosis in kidney transplantation.

PMID: 24991565
Journal: BIOMED RES INT
Year: 2014
Reference: Biomed Res Int. 2014;2014:750602. doi: 10.1155/2014/750602. Epub 2014 Jun 4.
Impact factor: 2.134
Publication type: Paper in international publication
Authors: Torres, Irina B, Moreso, Francesc, Sarro, Eduard, Meseguer, Anna, Seron, Daniel et al.
DOI: 10.1155/2014/750602

Antibody-mediated rejection: analyzing the risk, proposing solutions.

PMID: 25093441
Journal: TRANSPLANTATION
Year: 2014
Reference: Transplantation. 2014 Aug 15;98 Suppl 3:S3-21. doi: 10.1097/TP.0000000000000218.
Impact factor: 3.535
Publication type: Paper in international publication
Authors: Schwaiger, Elisabeth, Arias, Manuel, Rush, David N, Wiebe, Chris, Gibson, Ian W, Blydt-Hansen, Tom D, Nickerson, Peter W, Sellares, Joana, Lopez-Hoyos, Marcos, San Segundo, David et al.
DOI: 10.1097/TP.0000000000000218

Early Subclinical Rejection as a Risk Factor for Late Chronic Humoral Rejection.

PMID: 22094957
Journal: TRANSPLANTATION
Year: 2012
Reference: Transplantation. 2012 Jan 15;93(1):41-6.
Impact factor: 4.003
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1097/TP.0b013e31823bb647

Histology and proteinuria after renal transplantation.

PMID: 22137728
Journal: Transplantation reviews (Orlando, Fla.)
Year: 2012
Reference: Transplant Rev (Orlando). 2012 Jan;26(1):20-6.
Impact factor:
Publication type: Letter or abstract
Authors: Seron, Daniel, Burgos, Dolores, Alonso, Angel et al.
DOI: 10.1016/j.trre.2011.07.009

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News

An international study involving the Hospital del Mar Research Institute and VHIR shows that there are substantial differences between men and women in the energy metabolism of of renal tubular cells.

Dr. Conxita Jacobs' research has been awarded in the clinical project category, while Dr. Anna Meseguer's research has been recognised in the basic research category.

This initiative of the ”la Caixa” Foundation offers the selected entrepreneurial scientists financial support and support through individual mentoring and training.

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Pre-doctoral Student - Nephrology and Transplantation
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