About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
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People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
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Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
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The research conducted in our group is geared toward elucidating the cause and molecular mechanisms of neurodegeneration in Parkinson's disease (PD), a disabling, currently incurable common neurodegenerative disorder. To this end, we perform clinical and pre-clinical translational research in both PD patients and in human-relevant experimental in vitro and in vivo PD-related models.
Elucidating the molecular mechanisms underlying neurodegeneration in PD should allow to:
Formation and accumulation of abnormal protein aggregates are a central hallmark of several neurodegenerative diseases. In Parkinson’s disease (PD), the aggregation-prone protein á-synuclein accumulates in several areas of the central and peripheral nervous system. Pathological á-synuclein accumulation in PD can result from (i) abnormally increased á-synuclein expression, (ii) defective intracellular clearance of á-synuclein protein, (iii) progressive self-propagation and spreading of pathological á-synuclein between interconnected brain areas. Targeting á-synuclein pathological changes may provide therapeutic benefit to delay, halt or prevent neuronal dysfunction and degeneration in PD.
IP: Miquel Vila Bover
Despite intensive efforts towards understanding the aetiology/pathogenesis of Parkinson's disease (PD) and the development of novel therapeutic approaches for this neurodegenerative condition, the current treatment for PD remains symptomatic and yet far from modifying disease onset or progression. Before the manifestation of the classical motor symptoms, PD patients present with non-motor symptoms in a prodromal phase. The identification of deregulated molecular pathways or genes in peripheral blood and/or cerebrospinal fluid from these prodromal patients may help develop potential biomarkers for the early detection, diagnosis, risk assessment and/or progression of PD, which are currently lacking, as well as to stratify patients at very early stages to apply more specific, personalized disease-modifying treatments.
IP: Miquel Vila Bover, Ariadna Laguna Tuset
Defective lysosomal-mediated turnover of mitochondria may play a pathogenic role in Huntington’s disease neurodegeneration.
IP: Marta Martínez Vicente
In Parkinson's disease (PD), there is a selective degeneration of neurons that contain a dark-brown pigment called neuromelanin, especially dopaminergic neurons of the substantia nigra, which leads to the classical motor symptoms of the disease. However, the physiological significance of neuromelanin and its potential contribution to PD pathogenesis remain unknown.
IP: Marta Martínez Vicente Collaborators: José Antonio Arranz Amo, Mercedes Arrúe Gonzalo, Silvia Enriquez Calzada, Jorge Hernández Vara, Pau Sarle Valles, Eddie Pradas Gracia, Maria Camprodon Gomez, Laura Castillo Ribelles, Clara Carnicer Cáceres, Jordi Riera Heredia, Pablo Castillo Sánchez Funding agency: Instituto de Salud Carlos III Funding: 265000 Reference: PI24/00062 Duration: 01/01/2025 - 31/12/2027
IP: Jordi Bove Badell Collaborators: Oscar Len Abad, Jordi Mollet Sánchez, Xavier Serres Créixams, Oriol de Fabregues-Boixar Nebot, Maria Piñana Moro Funding agency: Instituto de Salud Carlos III Funding: 221250 Reference: PI24/01820 Duration: 01/01/2025 - 31/12/2027
IP: Marta Martínez Vicente Collaborators: Mercedes Arrúe Gonzalo, Jorge Hernández Vara, Maria Camprodon Gomez, Jordi Riera Heredia, Pablo Castillo Sánchez Funding agency: Fundació "La Caixa" Funding: 24440 Reference: CI24-20222 Duration: 01/10/2024 - 30/09/2026
IP: Miquel Vila Bover Collaborators: - Funding agency: Fundació Institut de Recerca HUVH Funding: 160000 Reference: VILA/BOOST/2024 Duration: 15/11/2024 - 14/11/2028
PMID: 39814268 Journal: JOURNAL OF INFECTION Year: 2025 Reference: J Infect. 2025 Jan 13:106411. doi: 10.1016/j.jinf.2025.106411. Impact factor: Publication type: Paper in international publication Authors: Almansa, Raquel; Alvarez-Napagao, Sergio; Amaya-Villar, Rosario; Anon, Jose M; Barbe, Ferran; Barbera, Carme; Barberan, Jose; Barral-Segade, Patricia; Blandino-Ortiz, Aaron; Bustamante-Munguira, Elena et al. DOI: 10.1016/j.jinf.2025.106411
PMID: 39829033 Journal: JOURNAL OF CHEMOTHERAPY Year: 2025 Reference: J Chemother. 2025 Jan 19:1-7. doi: 10.1080/1120009X.2025.2452694. Impact factor: Publication type: Paper in international publication Authors: Cruz Lopez, Ivan; Diez Poch, Monica; Domenech Moral, Laura; Domenech Vila, Josep Maria; Ferrer, Ricard; Gallart, Elisabet; Garcia-Garcia, Sonia; Gorgas Torner, Maria Queralt; Lalueza Broto, Pilar; Martinez Pla, Maria et al. DOI: 10.1080/1120009X.2025.2452694
PMID: 39883803 Journal: ASAIO JOURNAL Year: 2025 Reference: ASAIO J. 2025 Jan 28. doi: 10.1097/MAT.0000000000002375. Impact factor: Publication type: Paper in international publication Authors: Brodie, Daniel; Broman, Lars; Cruz, Sherene; Diaz, Rodrigo; Herr, Daniel; Hodgson, Carol; O'Neil, Erika; Peek, Giles; Ramanan, Raj; Ramanathan, Kollengode et al. DOI: 10.1097/MAT.0000000000002375
PMID: 39998658 Journal: INTENSIVE CARE MEDICINE Year: 2025 Reference: Intensive Care Med. 2025 Feb 25. doi: 10.1007/s00134-025-07805-4. Impact factor: Publication type: Paper in international publication Authors: Adler, Christoph; Billig, Hannah; Binzenhofer, Leonhard; Borst, Oliver; Camboni, Daniele; Chiscano-Camon, Luis; Combes, Alain; Crusius, Lisa; De Roeck, Frederic; El-Essawi, Aschraf et al. DOI: 10.1007/s00134-025-07805-4
PMID: 38237635 Journal: ASAIO JOURNAL Year: 2024 Reference: ASAIO J. 2024 Jan 19. doi: 10.1097/MAT.0000000000002132. Impact factor: Publication type: Paper in international publication Authors: Barbaro, Ryan P; Bellani, Giacomo; Brochard, Laurent; Brodie, Daniel; Combes, Alain; Foti, Giuseppe; Giani, Marco; Rezoagli, Emanuele; Riera, Jordi et al. DOI: 10.1097/MAT.0000000000002132
PMID: 38311960 Journal: EUROPEAN JOURNAL OF NEUROSCIENCE Year: 2024 Reference: Eur J Neurosci. 2024 Feb 4. doi: 10.1111/ejn.16262. Impact factor: Publication type: Editorail in international publication Authors: Binder, Luisa B; Castany, Silvia; Chagas, Luana S; Choconta, Jeiny L; Compagnion, Anne-Claire; de Sousa, Barbara M; Dubljevic, Olga; Krstanovic, Fran; Lepiarz-Raba, Izabela; Lorente-Picon, Marina et al. DOI: 10.1111/ejn.16262
PMID: 38391573 Journal: Antibiotics-Basel Year: 2024 Reference: Antibiotics (Basel). 2024 Feb 15;13(2):187. doi: 10.3390/antibiotics13020187. Impact factor: Publication type: Paper in international publication Authors: Bajana, Ivan; Bastidas, Juliana; Chiscano-Camon, Luis; Ferrer, Ricard; Franco-Jarava, Clara; Gonzalez-Lopez, Juan Jose; Larrosa, Nieves; Lopez-Martinez, Rocio; Maldonado, Carolina; Martin, Laura et al. DOI: 10.3390/antibiotics13020187
PMID: 38397859 Journal: Biomedicines Year: 2024 Reference: Biomedicines. 2024 Jan 23;12(2):257. doi: 10.3390/biomedicines12020257. Impact factor: Publication type: Paper in international publication Authors: Martinez-Vicente, Marta; Valdor, Rut et al. DOI: 10.3390/biomedicines12020257
PMID: 36265282 Journal: BLOOD CELLS MOLECULES AND DISEASES Year: 2023 Reference: Blood Cells Mol Dis. 2023 Jan;98:102704. doi: 10.1016/j.bcmd.2022.102704. Epub 2022 Oct 5. Impact factor: Publication type: Paper in international publication Authors: Agraz-Pamplona, Irene; Arranz-Amo, Jose Antonio; Barquin-Del-Pino, Raquel; Camprodon-Gomez, Maria; Carnicer-Caceres, Clara; Castillo-Ribelles, Laura; Del-Toro-Riera, Mireia; Felipe-Rucian, Ana; Garcia-Serra, Anna; Hernandez-Vara, Jorge et al. DOI: 10.1016/j.bcmd.2022.102704
PMID: 33843696 Journal: Journal of Parkinsons Disease Year: 2023 Reference: J Parkinsons Dis. 2023;13(1):105-124. doi: 10.3233/JPD-212539. Impact factor: Publication type: Paper in international publication Authors: Alonso Losada, Maria Gema; Alvarez Sauco, Maria; Avila Rivera, Maria Asuncion; Bernardo, Noemi; Blazquez Estrada, Marta; Borrue, Carmen; Caballol, Nuria; Cabo, Iria; Caldentey, Juan Garcia; Carlos Martinez Castrillo, Juan et al. DOI: 10.3233/JPD-212539
PMID: 36611984 Journal: Cells Year: 2023 Reference: Cells. 2023 Jan 3;12(1):191. doi: 10.3390/cells12010191. Impact factor: Publication type: Review in international publication Authors: Martinez-Vicente, Marta; Pradas, Eddie et al. DOI: 10.3390/cells12010191
PMID: 36690515 Journal: ARCHIVOS DE BRONCONEUMOLOGIA Year: 2023 Reference: Arch Bronconeumol. 2023 Apr;59(4):205-215. doi: 10.1016/j.arbres.2022.12.017. Epub 2023 Jan 7. Impact factor: Publication type: Paper in national publication Authors: Abril Palomares, Elena; Adrio, Sabela Vara; Aguila, Maria; Aguilera, Luciano; Albaiceta, Guillermo M; Alcaraz-Serrano, Victoria; Aldecoa, Cesar; Alegre, Cynthia; Alvarez, Juan I Lazo; Alvarez, Sergio et al. DOI: 10.1016/j.arbres.2022.12.017
PMID: 35364453 Journal: PARKINSONISM & RELATED DISORDERS Year: 2022 Reference: Parkinsonism Relat Disord. 2022 Apr;97:79-83. doi: 10.1016/j.parkreldis.2022.03.005. Epub 2022 Mar 24. Impact factor: Publication type: Paper in international publication Authors: Adarmes-Gomez, Astrid D; Aguilar, Miquel; Alvarez, Ignacio; Alvarez, Victoria; Alvarez-Santullano, Marina Mata; Bandres-Ciga, Sara; Barrero, Francisco Javier; Bergareche Yarza, Jesus Alberto; Blazquez-Estrada, Marta; Bonilla-Toribio, Marta et al. DOI: 10.1016/j.parkreldis.2022.03.005
PMID: 36202848 Journal: npj Parkinsons Disease Year: 2022 Reference: NPJ Parkinsons Dis. 2022 Oct 6;8(1):126. doi: 10.1038/s41531-022-00397-6. Impact factor: Publication type: Paper in international publication Authors: Albert-Bayo, Merce; Arranz-Amo, Jose Antonio; Carnicer-Caceres, Clara; Casas, Josefina; Castillo-Ribelles, Laura; Castillo-Sanchez, Pablo; Fernandez-Gonzalez, Irene; Lopez-Royo, Tresa; Martinez-Vicente, Marta; Montpeyo, Marta et al. DOI: 10.1038/s41531-022-00397-6
PMID: 36118514 Journal: Movement Disorders Clinical Practice Year: 2022 Reference: Mov Disord Clin Pract. 2022 Sep 11;9(Suppl 2):S17-S20. doi: 10.1002/mdc3.13526. eCollection 2022 Sep. Impact factor: Publication type: Letter or abstract Authors: Gabaldon Dominguez, Maria Alejandra; Gonzalez, Victoria; Hernandez-Vara, Jorge; Llaurado Gayete, Arnau; Samaniego-Toro, Daniela et al. DOI: 10.1002/mdc3.13526
PMID: 36078975 Journal: Journal of Clinical Medicine Year: 2022 Reference: J Clin Med. 2022 Aug 28;11(17). pii: jcm11175045. doi: 10.3390/jcm11175045. Impact factor: Publication type: Paper in international publication Authors: Barrio-Carreras, Delia; Bellusci, Marcello; Blasco-Alonso, Javier; Camprodon Gomez, Maria; Canedo, Elvira; Correcher, Patricia; Couce, Maria L; de Las Heras Montero, Javier; de Los Santos, Mariela; Del Toro, Mireia et al. DOI: 10.3390/jcm11175045
PMID: 33873000 Journal: PARKINSONISM & RELATED DISORDERS Year: 2021 Reference: Parkinsonism Relat Disord. 2021 May;86:78-80. doi: 10.1016/j.parkreldis.2021.03.021. Epub 2021 Mar 29. Impact factor: Publication type: Letter whit IF Authors: Ahuir, Maribel; Baixauli, Montserrat; Buongiorno, Mariateresa; Caballol, Nuria; Camara, Ana; Compta, Yaroslau; de Fabregues, Oriol; Fernandez, Noemi; Garrido, Alicia; Giraldo, Darly M et al. DOI: 10.1016/j.parkreldis.2021.03.021
PMID: 33492245 Journal: Journal of Parkinsons Disease Year: 2021 Reference: J Parkinsons Dis. 2021;11(2):685-694. doi: 10.3233/JPD-202332. Impact factor: Publication type: Paper in international publication Authors: Avila, Asuncion; Bayes, Angels; Caballol, Nuria; Calopa, Matilde; Camara, Ana; Campdelacreu, Jaume; Classen, Serge Jauma; Compta, Yaroslau; de Fabregues, Oriol; Gaig, Carles et al. DOI: 10.3233/JPD-202332
PMID: 34943619 Journal: Diagnostics Year: 2021 Reference: Diagnostics (Basel). 2021 Dec 17;11(12). pii: diagnostics11122380. doi: 10.3390/diagnostics11122380. Impact factor: Publication type: Paper in international publication Authors: Aguilar, Miquel; Alonso Losada, Maria G; Alonso Redondo, Ruben; Alvarez Sauco, Maria; Avila Rivera, Maria A; Blazquez Estrada, Marta; Borrue, Carmen; Caballol, Nuria; Cabo, Iria; Canfield, Hector et al. DOI: 10.3390/diagnostics11122380
PMID: 34916528 Journal: npj Parkinsons Disease Year: 2021 Reference: NPJ Parkinsons Dis. 2021 Dec 16;7(1):118. doi: 10.1038/s41531-021-00256-w. Impact factor: Publication type: Paper in international publication Authors: Adarmes, Daniela A; Aguilar, Miquel; Almeria, Marta; Alonso Canovas, Araceli; Alonso Frech, F; Alonso Losada, Maria G; Alonso Redondo, Ruben; Alvarez Sauco, Maria; Alvarez, Ignacio; Aneiros Diaz, Angel et al. DOI: 10.1038/s41531-021-00256-w
PMID: 33358530 Journal: NEUROLOGIA Year: 2020 Reference: Neurologia. 2020 Dec 24. pii: S0213-4853(20)30339-X. doi: 10.1016/j.nrl.2020.10.013. Impact factor: Publication type: Paper in national publication Authors: Alonso-Frech, F; Alvarez Fernandez, I; Alvarez Sauco, M; Avila Rivera, M A; Barrios-Lopez, J M; Borrue, C; Buongiorno, M T; Caballol, N; Cabo, I; Cubo, E et al. DOI: 10.1016/j.nrl.2020.10.013
PMID: 33147750 Journal: Cells Year: 2020 Reference: Cells. 2020 Nov 2;9(11). pii: cells9112399. doi: 10.3390/cells9112399. Impact factor: Publication type: Review in international publication Authors: Martinez-Vicente, Marta; Montpeyo, Marta; Navarro-Romero, Alba et al. DOI: 10.3390/cells9112399
PMID: 33118032 Journal: BRAIN Year: 2020 Reference: Brain. 2020 Dec 1;143(12):3717-3733. doi: 10.1093/brain/awaa269. Impact factor: Publication type: Paper in international publication Authors: Bove, Jordi; Galiano-Landeira, Jordi; Torra, Albert; Vila, Miquel et al. DOI: 10.1093/brain/awaa269
PMID: 33022436 Journal: PARKINSONISM & RELATED DISORDERS Year: 2020 Reference: Parkinsonism Relat Disord. 2020 Nov;80:165-174. doi: 10.1016/j.parkreldis.2020.09.023. Epub 2020 Sep 21. Impact factor: Publication type: Paper in international publication Authors: Aguilera-Albesa, Sergio; Baide-Mairena, Heidy; Cabrera, Jose Carlos; Cazurro, Anna; Correa-Vela, Marta; De Fabregues, Oriol; Eiris, Jesus; Espinos, Carmen; Fernandez-Ramos, Joaquin Alejandro; Garriz-Luis, Maite et al. DOI: 10.1016/j.parkreldis.2020.09.023
PMID: 31211166 Journal: Annals of Clinical and Translational Neurology Year: 2019 Reference: Ann Clin Transl Neurol. 2019 May 9;6(6):1024-1032. doi: 10.1002/acn3.772. eCollection 2019 Jun. Impact factor: Publication type: Paper in international publication Authors: Barcelona LRRK2 Study Grp; de Fabregues-Boixar Nebot, Oriol; Fairfoul, Graham; Garrido, Alicia; Green, Alison; Hernández Vara, Jorge; Marti, Maria Jose; Tolosa, Eduardo S et al. DOI: 10.1002/acn3.772
PMID: 31731485 Journal: Cells Year: 2019 Reference: Cells. 2019 Oct 25;8(11). pii: cells8111317. doi: 10.3390/cells8111317. Impact factor: Publication type: Review in international publication Authors: Laguna, Ariadna; Penuelas, Nuria; Vila, Miquel; Xicoy, Helena et al. DOI: 10.3390/cells8111317
PMID: 31178335 Journal: PARKINSONISM & RELATED DISORDERS Year: 2019 Reference: Parkinsonism Relat Disord. 2019 Aug;65:3-12. doi: 10.1016/j.parkreldis.2019.05.040. Epub 2019 Jun 3. Impact factor: Publication type: Paper in international publication Authors: Aguilar, Miquel; Avila, Asuncion; Bayes, Angels; Botta, Teresa; Bravo, Paloma; Caballol, Nuria; Calopa, Matilde; Camara, Ana; Campdelacreu, Jaume; Classen, Serge Jauma et al. DOI: 10.1016/j.parkreldis.2019.05.040
PMID: 31673927 Journal: JOURNAL OF NEURAL TRANSMISSION Year: 2019 Reference: J Neural Transm (Vienna). 2019 Dec;126(12):1599-1608. doi: 10.1007/s00702-019-02096-8. Epub 2019 Oct 31. Impact factor: Publication type: Paper in international publication Authors: Adarmes Astrid, D; Aguilar, M; Almeria, M; Alonso Canovas, A; Alonso Frech, F; Alonso Losada, M G; Alvarez Sauco, M; Aneiros Diaz, A; Arnaiz, S; Arribas, S et al. DOI: 10.1007/s00702-019-02096-8
PMID: 30637289 Journal: Movement disorders clinical practice Year: 2018 Reference: Mov Disord Clin Pract. 2018 Nov 6;5(6):649-652. doi: 10.1002/mdc3.12670. eCollection 2018 Nov-Dec. Impact factor: Publication type: Letter or abstract Authors: Avila, Asuncion; Balague-Marmana, Marta; Caballol, Nuria; de Fabregas, Oriol; Gelpi, Ellen; Martinez-Fernandez, Raul; Navarro-Otano, Judith; Tolosa, Eduardo; Valls-Sole, Josep et al. DOI: 10.1002/mdc3.12670
PMID: 30618654 Journal: Frontiers in Neuroanatomy Year: 2018 Reference: Front Neuroanat. 2018 Dec 14;12:113. doi: 10.3389/fnana.2018.00113. eCollection 2018. Impact factor: Publication type: Review in international publication Authors: Blanco-Prieto, Maria J; Blesa, Javier; Carballo-Carbajal, Iria; Del Rey, Natalia Lopez-Gonzalez; Fernandez-Santiago, Ruben; Garbayo, Elisa; Monje, Mariana H G; Quiroga-Varela, Ana; Trigo-Damas, Ines et al. DOI: 10.3389/fnana.2018.00113
PMID: 28229331 Journal: MOLECULAR NEUROBIOLOGY Year: 2018 Reference: Mol Neurobiol. 2018 Mar;55(3):1847-1860. doi: 10.1007/s12035-017-0451-4. Epub 2017 Feb 22. Impact factor: Publication type: Paper in international publication Authors: Aznar, Jose Manuel Garcia; Del Rio, Jose Antonio; Ferrer, Isidro; Gavin, Rosalina; Hagesawa, Masato; Hervera, Arnau; Masuda-Suzukake, Masami; Pedraz, Lucas; Samitier, Josep; Segura-Feliu, Miriam et al. DOI: 10.1007/s12035-017-0451-4
PMID: 30515291 Journal: Parkinsons Disease Year: 2018 Reference: Parkinsons Dis. 2018 Nov 1;2018:8691495. doi: 10.1155/2018/8691495. eCollection 2018. Impact factor: Publication type: Paper in international publication Authors: Alvarez-Sabin, Jose; De Fabregues, Oriol; Ferre, Alex; Quintana, Manuel; Romero, Odile et al. DOI: 10.1155/2018/8691495
PMID: 29260038 Journal: eNeurologicalSci Year: 2017 Reference: eNeurologicalSci. 2017 Jul 2;8:44-53. doi: 10.1016/j.ensci.2017.06.004. eCollection 2017 Sep. Impact factor: Publication type: Review in international publication Authors: Antonini, Angelo; Bajenaru, Ovidiu; Calopa, Matilde; Catalan, Maria Jose; de Fabregues, Oriol; Garcia-Moreno, Jose Manuel; Kulisevsky, Jaime; Minguez-Castellanos, Adolfo; Odin, Per; Pedersen, Stephen W et al. DOI: 10.1016/j.ensci.2017.06.004
PMID: 29071698 Journal: REVISTA DE NEUROLOGIA Year: 2017 Reference: Rev Neurol. 2017 Nov 1;65(9):396-404. Impact factor: Publication type: Paper in national publication Authors: de Fabregues, O; Gironell, A; Regueras, E; Rossello-Jimenez, D et al. DOI: 10.33588/rn.6509.2017106
PMID: 28828219 Journal: Brain and Behavior Year: 2017 Reference: Brain Behav. 2017 Jul 7;7(8):e00758. doi: 10.1002/brb3.758. eCollection 2017 Aug. Impact factor: Publication type: Paper in international publication Authors: Abu-Suboh, Monder; Alvarez-Sabin, Jose; Armengol, Josep Ramon; De Fabregues, Oriol; Dot, Joan; Ferre, Alex; Gomez, Maria Rosa; Hernandez-Vara, Jorge; Ibarria, Marta; Puiggros, Carolina et al. DOI: 10.1002/brb3.758
PMID: 28631218 Journal: ADVANCES IN THERAPY Year: 2017 Reference: Adv Ther. 2017 Jul;34(7):1741-1752. doi: 10.1007/s12325-017-0571-2. Epub 2017 Jun 19. Impact factor: Publication type: Paper in international publication Authors: Antonini, Angelo; Danielsen, Erik H; de Fabregues, Oriol; Doskas, Triantafyllos; Henselmans, Johanna M L; Kruger, Rejko; Lingor, Paul; Onuk, Koray; Parra, Juan Carlos; Sensken, Sven-Christian et al. DOI: 10.1007/s12325-017-0571-2
PMID: 27653520 Journal: MOVEMENT DISORDERS Year: 2016 Reference: Mov Disord. 2016 Dec;31(12):1820-1828. doi: 10.1002/mds.26799. Epub 2016 Sep 21. Impact factor: Publication type: Paper in international publication Authors: Aguilar, Miquel; Baggio, Hugo C; Bayes, Angels; Calopa, Matilde; Compta, Yaroslau; Hernandez-Vara, Jorge; Jose Marti, Maria; Junque, Carme; Pont-Sunyer, Claustre; Quintana, Maria et al. DOI: 10.1002/mds.26799
PMID: 25761946 Journal: NEUROSCIENTIST Year: 2016 Reference: Neuroscientist. 2016 Jun;22(3):266-77. doi: 10.1177/1073858415574600. Epub 2015 Mar 11. Impact factor: Publication type: Paper in international publication Authors: Franco-Iborra, Sandra; Perier, Celine; Vila, Miquel et al. DOI: 10.1177/1073858415574600
PMID: 26799652 Journal: Autophagy Year: 2016 Reference: Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. Impact factor: Publication type: Paper in international publication Authors: Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Acevedo Arozena, Abraham; Adachi, Hiroaki; Adams, Christopher M; Adams, Peter D; Adeli, Khosrow; Adhihetty, Peter J et al. DOI: 10.1080/15548627.2015.1100356
PMID: 27917109 Journal: Frontiers in Molecular Neuroscience Year: 2016 Reference: Front Mol Neurosci. 2016 Nov 21;9:128. eCollection 2016. Impact factor: Publication type: Review in national publication Authors: Perier, Celine; Recasens, Ariadna; Sue, Carolyn M et al. DOI: 10.3389/fnmol.2016.00128
PMID: 26177462 Journal: PLOS ONE Year: 2015 Reference: PLoS One. 2015 Jul 15;10(7):e0132368. doi: 10.1371/journal.pone.0132368. eCollection 2015. Impact factor: Publication type: Paper in international publication Authors: Bayes, Angels; Calopa, Matilde; Casquero, Pilar; Compta, Yaroslau; de Fabregues, Oriol; Fernandez, Manel; Fernandez-Arcos, Ana; Fernandez-Santiago, Ruben; Gaig, Carles; Iranzo, Alex et al. DOI: 10.1371/journal.pone.0132368
PMID: 26003410 Journal: PARKINSONISM RELAT D Year: 2015 Reference: Parkinsonism Relat Disord. 2015 Aug;21(8):871-6. doi: 10.1016/j.parkreldis.2015.05.014. Epub 2015 May 19. Impact factor: Publication type: Paper in international publication Authors: Antonelli, Francesca; Buongiorno, Mariateresa; Calopa, Matilde; Camara, Ana; Campolongo, Antonia; de Fabregues-Nebot, Oriol; Hernandez-Vara, Jorge; Kulisevsky, Jaime; Marti, Maria Jose; Pascual-Sedano, Berta et al. DOI: 10.1016/j.parkreldis.2015.05.014
PMID: 26306001 Journal: PARKINSONISM RELAT D Year: 2015 Reference: Parkinsonism Relat Disord. 2015 Oct;21(10):1170-6. doi: 10.1016/j.parkreldis.2015.08.007. Epub 2015 Aug 12. Impact factor: Publication type: Paper in international publication Authors: Aguilar, Miquel; Alvarez, Ramiro; Calopa, Matilde; Campdelacreu, Jaume; Casquero, Pilar; Compta, Yaroslau; de Fabregues, Oriol; Hernandez-Vara, Jorge; Ispierto, Lourdes; Jauma, Serge et al. DOI: 10.1016/j.parkreldis.2015.08.007
PMID: 26516212 Journal: EMBO MOL MED Year: 2015 Reference: EMBO Mol Med. 2015 Oct 29;7(12):1529-46. doi: 10.15252/emmm.201505439. Impact factor: Publication type: Paper in international publication Authors: Alberch, Jordi; Canals, Josep M; Carballo-Carbajal, Iria; Castellano, Giancarlo; Consiglio, Antonella; Ezquerra, Mario; Fernandez-Santiago, Ruben; Lopez-Barneo, Jose; Martin-Subero, Jose I; Mosquera, Jose Luis et al. DOI: 10.15252/emmm.201505439
PMID: 25330404 Journal: PLoS One Year: 2014 Reference: PLoS One. 2014 Oct 17;9(10):e108982. doi: 10.1371/journal.pone.0108982. eCollection 2014. Impact factor: Publication type: Paper in international publication Authors: Aguilar, Miquel; Buongiorno, Mariateresa; Calopa, Matilde; Ezquerra, Mario; Gaig, Carles; Garcia-Gorostiaga, Ines; Hernandez-Vara, Jorge; Infante, Jon; Marti, Maria Jose; Sierra, Maria et al. DOI: 10.1371/journal.pone.0108982
PMID: 25565982 Journal: Frontiers in Neuroanatomy Year: 2014 Reference: Front Neuroanat. 2014 Dec 18;8:159. doi: 10.3389/fnana.2014.00159. eCollection 2014. Impact factor: Publication type: Review in international publication Authors: Dehay, Benjamin; Recasens, Ariadna et al. DOI: 10.3389/fnana.2014.00159
PMID: 24922073 Journal: CELL DEATH AND DIFFERENTIATION Year: 2014 Reference: Cell Death Dis. 2014 Jun 12;5:e1289. doi: 10.1038/cddis.2014.253. Impact factor: Publication type: Paper in international publication Authors: Arbones, M L; Barallobre, M J; Bove, J; Delabar, J M; Laguna, A; Perier, C; Vila, M et al. DOI: 10.1038/cddis.2014.253
PMID: 24686337 Journal: Autophagy Year: 2014 Reference: Autophagy. 2014 May 1;10(5):889-900. doi: 10.4161/auto.28286. Epub 2014 Mar 26. Impact factor: Publication type: Paper in international publication Authors: Antonsson, Bruno; Bombrun, Agnes; Bove, Jordi; Dehay, Benjamin; Martinez-Vicente, Marta ; Perier, Celine; Recasens, Ariadna; Vila, Miquel et al. DOI: 10.4161/auto.28286
PMID: 23580333 Journal: MOVEMENT DISORDERS Year: 2013 Reference: Mov Disord. 2013 Jun;28(6):725-32. doi: 10.1002/mds.25462. Epub 2013 Apr 11. Impact factor: Publication type: Review in international publication Authors: Bezard, Erwan; Caldwell, Guy A; Caldwell, Kim A; Cookson, Mark R; Dehay, Benjamin; Klein, Christine; Martinez-Vicente, Marta; Vila, Miquel; Yue, Zhenyue et al. DOI: 10.1002/mds.25462
PMID: 23884809 Journal: BRAIN Year: 2013 Reference: Brain. 2013 Aug;136(Pt 8):2369-78. doi: 10.1093/brain/awt196. Impact factor: Publication type: Paper in international publication Authors: Andreu, Antoni L; Bender, Andreas; Bove, Jordi; Elstner, Matthias; Garcia-Arumi, Elena; Klopstock, Thomas; Laub, Christoph; Melia, M Jesus; Mounsey, Ross B; Perier, Celine et al. DOI: 10.1093/brain/awt196
PMID: 23658034 Journal: Revista de neurologia Year: 2013 Reference: Rev Neurol. 2013 May 16;56(10):515-20. Impact factor: Publication type: Review in national publication Authors: Alvarez-Sabin, J; Boronat-Guerrero, S; Hernandez-Vara, J; Salvado, M et al. DOI:
PMID: 23499831 Journal: EXPERIMENTAL NEUROLOGY Year: 2013 Reference: Exp Neurol. 2013 Sep;247:308-13. doi: 10.1016/j.expneurol.2013.03.005. Epub 2013 Mar 13. Impact factor: Publication type: Paper in international publication Authors: Martinez-Vicente, Marta; Vila, Miquel et al. DOI: 10.1016/j.expneurol.2013.03.005
PMID: 22976778 Journal: MOVEMENT DISORDERS Year: 2012 Reference: Mov Disord. 2012 Sep 1;27(10):1220-1. doi: 10.1002/mds.25049. Impact factor: Publication type: Editorail in international publication Authors: Castell-Conesa, Joan; Cuberas-Borros, Gemma; Franquet, Elisa; Hernandez-Vara, Jorge; Lorenzo-Bosquet, Carlos; Rovira, Alex; Salvado-Figueres, Maria et al. DOI: 10.1002/mds.25049
PMID: 22966490 Journal: Autophagy Year: 2012 Reference: Autophagy. 2012 Apr;8(4):445-544. Impact factor: Publication type: Review in international publication Authors: ; Abdalla, Fabio C; Abeliovich, Hagai; Abraham, Robert T; Acevedo-Arozena, Abraham; Adeli, Khosrow; Agholme, Lotta; Agnello, Maria; Agostinis, Patrizia; Aguirre-Ghiso, Julio A et al. DOI:
PMID: 22885599 Journal: Autophagy Year: 2012 Reference: Autophagy. 2012 Sep;8(9):1389-91. doi: 10.4161/auto.21011. Epub 2012 Aug 13. Impact factor: Publication type: Paper in international publication Authors: Bezard, Erwan; Dehay, Benjamin; Klein, Christine; Martinez-Vicente, Marta; Perier, Celine; Ramirez, Alfredo; Vila, Miquel et al. DOI:
PMID: 22108613 Journal: NEUROSCIENCE Year: 2012 Reference: Neuroscience. 2012 Jun 1;211:51-76. Epub 2011 Nov 10. Impact factor: Publication type: Review in international publication Authors: ; et al. DOI: 10.1016/j.neuroscience.2011.10.057
PMID: 22171050 Journal: JOURNAL OF NEUROSCIENCE Year: 2011 Reference: J Neurosci. 2011 Dec 14;31(50):18492-505. Impact factor: Publication type: Paper in international publication Authors: Arias, Esperanza; Cuervo, Ana Maria; Kaushik, Susmita; Koga, Hiroshi; Martinez-Vicente, Marta; Sulzer, David et al. DOI: 10.1523/JNEUROSCI.3219-11.2011
PMID: 21975386 Journal: CLINICAL NUCLEAR MEDICINE Year: 2011 Reference: Clin Nucl Med. 2011 Nov;36(11):991-6. Impact factor: Publication type: Paper in international publication Authors: Aguade-Bruix, Santiago; Alvarez-Sabin, Jose; Castell-Conesa, Joan; Cuberas-Borros, Gemma; Hernandez-Vara, Jorge; Lorenzo-Bosquet, Carles; Miquel, Francesc; Pifarre-Montaner, Paloma et al. DOI: 10.1097/RLU.0b013e3182291a7b
PMID: 21938766 Journal: MOVEMENT DISORDERS Year: 2011 Reference: Mov Disord. 2011 Aug 1;26(9):1616. Impact factor: Publication type: Editorail in international publication Authors: Vila, Miquel et al. DOI:
PMID: 21772323 Journal: NATURE REVIEWS NEUROSCIENCE Year: 2011 Reference: Nat Rev Neurosci. 2011 Jul 20;12(8):437-52. doi: 10.1038/nrn3068. Impact factor: Publication type: Review in international publication Authors: Bove, Jordi; Martinez-Vicente, Marta; Vila, Miquel et al. DOI: 10.1038/nrn3068
PMID: 19152986 Journal: NEUROBIOLOGY OF AGING Year: 2010 Reference: Neurobiol Aging. 2010 Dec;31(12):2103-14. Epub 2009 Jan 18. Impact factor: Publication type: Paper in international publication Authors: ; ; ; et al. DOI: 10.1016/j.neurobiolaging.2008.11.010
PMID: 20925027 Journal: REVISTA DE NEUROLOGIA Year: 2010 Reference: Rev Neurol. 2010 Oct 16;51(8):460-4. Impact factor: Publication type: Paper in national publication Authors: Alvarez-Sabin, J; Hernandez-Vara, J; Parees, I et al. DOI:
PMID: 20023429 Journal: Autophagy Year: 2010 Reference: Autophagy. 2010 Jan;6(1):182-3. Epub 2010 Jan 1. Impact factor: Publication type: Review in national publication Authors: Cuervo, Ana Maria; Kaushik, Susmita; Kruger, Ulrike; Mandelkow, Eckhard; Mandelkow, Eva-Maria; Martinez-Vicente, Marta; Wang, Yipeng; Wong, Esther et al. DOI:
PMID: 20695011 Journal: ANNALS OF NEUROLOGY Year: 2010 Reference: Ann Neurol. 2010 Aug;68(2):184-92. Impact factor: Publication type: Paper in international publication Authors: Bove, Jordi; Dehay, Benjamin; Jackson-Lewis, Vernice; Perier, Celine; Przedborski, Serge; Rabinovitch, Peter S; Vila, Miquel et al. DOI: 10.1002/ana.22034
PMID: 19616617 Journal: FREE RADICAL BIOLOGY AND MEDICINE Year: 2009 Reference: Free Radic Biol Med. 2009 Oct 1;47(7):1049-56. Impact factor: Publication type: Paper in international publication Authors: Chesselet, Marie-Francoise; Choi, Dong-Kug; Dawson, Ted M; Dawson, Valina L; Hoang, Tuan; Jackson-Lewis, Vernice; Nagai, Makiko; Nagata, Tetsuya; Prou, Delphine; Przedborski, Serge et al. DOI: 10.1016/j.freeradbiomed.2009.07.013
PMID: 17483459 Journal: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME Year: 2007 Reference: Proc Natl Acad Sci U S A. 2007 May 8;104(19):8161-6. Epub 2007 May 2. Impact factor: Publication type: Paper in international publication Authors: Bouillet, Philippe; Bove, Jordi; Choi, Dong-Kug; Dehay, Benjamin; Jackson-Lewis, Vernice; Perier, Celine; Przedborski, Serge; Rathke-Hartlieb, Silvia; Schulz, Jorg B; Strasser, Andreas et al. DOI: 10.1073/pnas.0609874104
PhD student: Núria Peñuelas Peñarroya Director/s: Miquel Vila Bover, Ariadna Laguna Tuset University: Year: 2023
PhD student: Jordi Galiano Landeira Director/s: Jordi Bove Badell University: Universidad Autònoma de Barcelona Year: 2021
PhD student: Albert Torra i Talavera Director/s: Jordi Bove Badell, Miquel Vila Bover University: Universidad Autònoma de Barcelona Year: 2019
PhD student: Sandra Franco Iborra Director/s: Miquel Vila Bover University: Universidad Autònoma de Barcelona Year: 2018
PhD student: Oriol de Fabregues-Boixar Nebot Director/s: Francesc Miquel Rodriguez, Miquel Vila Bover University: Universidad Autònoma de Barcelona Year: 2016
The initiative seeks to raise awareness of the disease and promote the well-being of those affected, while fostering empathy and scientific vocations among young people.
On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.
Vall d'Hebron has participated in a phase III clinical trial which confirmed the efficacy and safety of subcutaneous infusion of levodopa therapy.
Vall d'Hebron Iniciativa per al Parkinson (VHIP) is a research project aimed at the development of biochemical markers for the early detection of Parkinson's disease. This study is carried out in people at high risk of having this disease, because they carry genetic mutations that predispose to the development of Parkinson's or because they present non-motor symptoms that manifest themselves years before motor symptoms.
