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Neurodegenerative Diseases

The research conducted in our group is geared toward elucidating the cause and molecular mechanisms of neurodegeneration in Parkinson's disease (PD), a disabling, currently incurable common neurodegenerative disorder. To this end, we perform clinical and pre-clinical translational research in both PD patients and in human-relevant experimental in vitro and in vivo PD-related models. 

Elucidating the molecular mechanisms underlying neurodegeneration in PD should allow to: 

  • Identify biomarkers for PD diagnosis, early detection, patient stratification, disease progression, prognosis or response to treatment. This is the objective of the VHIP Project that the team is carrying out.
  • Identify new molecular targets for potential therapeutic intervention and prevention.
  • Develop novel therapeutic strategies with disease-modifying potential.
  • Unravel molecular pathways common to other neurodegenerative diseases and, in a broader sense, brain aging.
     

Publications

Time to start testing KRAS and BRAF V600E mutations in stage III colon cancer? Not in routine care, yet in clinical trials.

PMID: 37996169
Journal: ANNALS OF ONCOLOGY
Year: 2023
Reference: Ann Oncol. 2023 Nov;34(11):962-963. doi: 10.1016/j.annonc.2023.10.002.
Impact factor:
Publication type: Editorail in international publication
Authors: Avellanet, Merce; Baldellou, Laura; Deus, Claudia Maria; Dienstmann, R; Enriquez-Calzada, Silvia; Enriquez-Calzada, Silvia; Gea-Rodriguez, Elvira; Gine-Garriga, Maria; Hernandez-Vara, Jorge; Laguna, Ariadna et al.
DOI: 10.1016/j.annonc.2023.10.002

Implementation of programmes for the transition of adolescents to adult care.

PMID: 38016858
Journal: Anales de pediatria
Year: 2023
Reference: An Pediatr (Engl Ed). 2023 Nov 27:S2341-2879(23)00255-7. doi: 10.1016/j.anpede.2023.09.014.
Impact factor:
Publication type: Paper in international publication
Authors: Aceituno-Lopez, Maria Angeles; Asmarats, Luis; Avvedimento, Marisa; Belahnech, Yassin; Bonnet, Guillaume; Camprodon-Gomez, Maria; Cheema, Asim N; De La Torre Hernandez, Jose M; Del-Toro-Riera, Mireia; Esposito, Giovanni et al.
DOI: 10.1016/j.anpede.2023.09.014

Addressing the unmet needs in patients with type 2 inflammatory diseases: when quality of life can make a difference.

PMID: 38026127
Journal:
Year: 2023
Reference: Front Allergy. 2023 Nov 9;4:1296894. doi: 10.3389/falgy.2023.1296894. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Aceituno-Lopez, Maria Angeles; Aceituno-Lopez, Maria Angeles; Alobid, Isam; Camprodon-Gomez, Maria; Del-Toro-Riera, Mireia; Espinosa, Miriam; Gomez de la Fuente, Enrique; Lara-Fernandez, Roser; Lara-Fernandez, Roser; Luca de Tena, Africa et al.
DOI: 10.3389/falgy.2023.1296894

Survival and Long-Term Functional Status of COVID-19 Patients Requiring Prolonged ECMO Support.

PMID: 38134435
Journal:
Year: 2023
Reference: Ann Am Thorac Soc. 2023 Dec 22. doi: 10.1513/AnnalsATS.202306-572OC.
Impact factor:
Publication type: Paper in international publication
Authors: Argudo, Eduard; Broman, Lars Mikael; Campos, Isabel; Combes, Alain; Domenech Vila, Josep Maria; Ferrer, Ricard; Gallart, Elisabet; Langouet, Elise; Martin Sastre, Sara; Martinez Martinez, Maria et al.
DOI: 10.1513/AnnalsATS.202306-572OC

Blog

News

The initiative seeks to raise awareness of the disease and promote the well-being of those affected, while fostering empathy and scientific vocations among young people.

On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.

Vall d'Hebron has participated in a phase III clinical trial which confirmed the efficacy and safety of subcutaneous infusion of levodopa therapy.

Coneix i participa al projecte VHIP

Vall d'Hebron Iniciativa per al Parkinson (VHIP) is a research project aimed at the development of biochemical markers for the early detection of Parkinson's disease. This study is carried out in people at high risk of having this disease, because they carry genetic mutations that predispose to the development of Parkinson's or because they present non-motor symptoms that manifest themselves years before motor symptoms.

Access the project and study