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Neurodegenerative Diseases

The research conducted in our group is geared toward elucidating the cause and molecular mechanisms of neurodegeneration in Parkinson's disease (PD), a disabling, currently incurable common neurodegenerative disorder. To this end, we perform clinical and pre-clinical translational research in both PD patients and in human-relevant experimental in vitro and in vivo PD-related models. 

Elucidating the molecular mechanisms underlying neurodegeneration in PD should allow to: 

  • Identify biomarkers for PD diagnosis, early detection, patient stratification, disease progression, prognosis or response to treatment. This is the objective of the VHIP Project that the team is carrying out.
  • Identify new molecular targets for potential therapeutic intervention and prevention.
  • Develop novel therapeutic strategies with disease-modifying potential.
  • Unravel molecular pathways common to other neurodegenerative diseases and, in a broader sense, brain aging.
     

Publications

Implementation of programmes for the transition of adolescents to adult care.

PMID: 38016858
Journal: Anales de pediatria
Year: 2023
Reference: An Pediatr (Engl Ed). 2023 Nov 27:S2341-2879(23)00255-7. doi: 10.1016/j.anpede.2023.09.014.
Impact factor:
Publication type: Paper in international publication
Authors: Aceituno-Lopez, Maria Angeles; Asmarats, Luis; Avvedimento, Marisa; Belahnech, Yassin; Bonnet, Guillaume; Camprodon-Gomez, Maria; Cheema, Asim N; De La Torre Hernandez, Jose M; Del-Toro-Riera, Mireia; Esposito, Giovanni et al.
DOI: 10.1016/j.anpede.2023.09.014

Addressing the unmet needs in patients with type 2 inflammatory diseases: when quality of life can make a difference.

PMID: 38026127
Journal:
Year: 2023
Reference: Front Allergy. 2023 Nov 9;4:1296894. doi: 10.3389/falgy.2023.1296894. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Aceituno-Lopez, Maria Angeles; Alobid, Isam; Camprodon-Gomez, Maria; Del-Toro-Riera, Mireia; Espinosa, Miriam; Gomez de la Fuente, Enrique; Lara-Fernandez, Roser; Luca de Tena, Africa; Marti-Beltran, Sergi; Moreno-Galdo, Antonio et al.
DOI: 10.3389/falgy.2023.1296894

Survival and Long-Term Functional Status of COVID-19 Patients Requiring Prolonged ECMO Support.

PMID: 38134435
Journal:
Year: 2023
Reference: Ann Am Thorac Soc. 2023 Dec 22. doi: 10.1513/AnnalsATS.202306-572OC.
Impact factor:
Publication type: Paper in international publication
Authors: Argudo, Eduard; Broman, Lars Mikael; Campos, Isabel; Combes, Alain; Domenech Vila, Josep Maria; Ferrer, Ricard; Gallart, Elisabet; Langouet, Elise; Martin Sastre, Sara; Martinez Martinez, Maria et al.
DOI: 10.1513/AnnalsATS.202306-572OC

Blog

News

Vall d'Hebron has participated in a phase III clinical trial which confirmed the efficacy and safety of subcutaneous infusion of levodopa therapy.

This initiative is part of a pioneering study that seeks to assess how the relationship between different age groups can influence the quality of life and mental health of patients.

Dr. Miquel Vila, head of the Neurodegenerative Diseases research group at VHIR, is the co-chair of the local organising committee. And Dr. Ariadna Laguna, principal investigator of the same group, is a scientific ambassador.

Job offers

Licensed Research Technician - Neurodegenerative Diseases Research Group.
Start date:
12/04/2022
End date:
26/04/2022
Document: Download
Research Technician-Study Coordinator
Start date:
17/02/2022
End date:
03/03/2022
Document: Download
International Project Manager - Neurodegenerative Diseases Research Group
Start date:
16/02/2022
End date:
03/03/2022
Document: Download

Coneix i participa al projecte VHIP

Vall d'Hebron Iniciativa per al Parkinson (VHIP) is a research project aimed at the development of biochemical markers for the early detection of Parkinson's disease. This study is carried out in people at high risk of having this disease, because they carry genetic mutations that predispose to the development of Parkinson's or because they present non-motor symptoms that manifest themselves years before motor symptoms.

Access the project and study