About the VHIR
Here at the Vall d'Hebron Research Institute (VHIR) we promote biomedical research, innovation and teaching. Over 1,800 people are seeking to understand diseases today so the treatment can be improved tomorrow.
Research
We are working to understand diseases, to find out how they operate and to create better treatments for patients. Get to know about our groups and their lines of research.
People
People are the centre of the Vall d'Hebron Research Institute (VHIR). This is why we are bound by the principles of freedom of research, gender equality and professional attitudes that HRS4R promotes.
Clinical trials
Our work is not just basic or translational; we are leaders in clinical research. Enter and find about the clinical trials we are conducting and why we are a world reference in this field.
Progress
Our aim is to make the research carried out at the Vall d’Hebron Research Institute (VHIR) a driving force for transformation. How? By identifying new channels and solutions for the promotion of people's health and well-being.
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The research conducted in our group is geared toward elucidating the cause and molecular mechanisms of neurodegeneration in Parkinson's disease (PD), a disabling, currently incurable common neurodegenerative disorder. To this end, we perform clinical and pre-clinical translational research in both PD patients and in human-relevant experimental in vitro and in vivo PD-related models.
Elucidating the molecular mechanisms underlying neurodegeneration in PD should allow to:
IP: Jordi Bove Badell
Autophagy is the degradation of intracellular components inside the lysosomes and it is essential for the maintenance of cellular homeostasis and neuronal viability. Alterations in the autophagy process have been associated with neurodegenerative diseases including Parkinson’s, Huntington’s and Alzheimer’s disease and has been shown to be one of the main causes that contribute to neuronal death in these pathologies.
Our efforts are currently directed to:
- Development of new therapies for Parkinson’s disease based in the restoration of lysosomal glucocerebrosidase (GBA) activity.
- Development of new autophagy pharmacological modulators (mTOR-independent) as a therapeutic strategy in neurodegenerative diseases.
IP: Marta Martínez Vicente, Miquel Vila Bover
Co-PI: Pia Cosma, CRG.
Given the current lack of disease-modifying therapies for Parkinson’s disease (PD), we are exploring whether cell-fusion-mediated regeneration of dopaminergic neurons can be achieved, for therapeutic purposes, in experimental animal models of PD after transplantation of Wnt-activated haematopoietic stem and progenitor cells (HSPCs).
IP: Miquel Vila Bover
The main focus of our research is to study the role of autophagy in neurodegeneration.
Autophagy is the degradation of intracellular components inside the lysosomes and it is essential for the maintenance of cellular homeostasis and neuronal viability. Alterations in the autophagy process have been associated with neurodegenerative diseases including Parkinson’s, Huntington’s and Alzheimer’s disease, and has been shown to be one of the main causes that contribute to neuronal death in these pathologies.
- Study the pathogenic role of autophagic/lysosomal dysfunction in Parkinson's disease
- Development of new therapies for Parkinson’s disease based in the restoration of lysosomal glucocerebrosidase (GBA) activity through nanoencapsulation.
- Study selective autophagy in Huntington’s disease: charaterization of mitophagy impairment in Huntington’s disease.
IP: Marta Martínez Vicente
IP: Ariadna Laguna Tuset Collaborators: Anna Santamaria Margalef, Maria Mar Hernandez Guillamon, Sara Mas Assens Funding agency: Fundación Española Ciencia y Tecnología (FECYT) Funding: 15000 Reference: FCT-2023-19804 Duration: 01/12/2024 - 30/11/2025
IP: Ariadna Laguna Tuset Collaborators: - Funding agency: EUROPEAN COMMISSION Funding: 20000 Reference: EC/IMPETUS/2024/LAGUNA Duration: 07/06/2024 - 31/12/2025
IP: Ariadna Laguna Tuset Collaborators: Laia Perez Lasarte Funding agency: Agència Gestió Ajuts Universitaris i de Recerca Funding: 74452.89 Reference: 2024 FI-1 00557 Duration: 01/05/2024 - 30/04/2025
IP: Ariadna Laguna Tuset Collaborators: - Funding agency: Ministerio de Ciencia e Innovación-MICINN Funding: 199998.14 Reference: CNS2023-145555 Duration: 01/04/2024 - 31/03/2026
PMID: 39998751 Journal: Annals of Intensive Care Year: 2025 Reference: Ann Intensive Care. 2025 Feb 25;15(1):27. doi: 10.1186/s13613-025-01430-6. Impact factor: Publication type: Paper in international publication Authors: Albaiceta, Guillermo M; Amaya-Villar, Rosario; Anon, Jose Manuel; Balan, Ana; Barbe, Ferran; Barbera, Carme; Barberan, Jose; Barbeta, Enric; Barreiros, Claudia; Blandino, Aaron et al. DOI: 10.1186/s13613-025-01430-6
PMID: 40009712 Journal: PERFUSION-UK Year: 2025 Reference: Perfusion. 2025 Feb 26:2676591251324136. doi: 10.1177/02676591251324136. Impact factor: Publication type: Paper in international publication Authors: Aftab, Muhammad; Alexander, Peta M A; Bassi, Gianluigi Li; Buscher, Hergen; Cespedes, Marcela; Ciullo, Anna; Fraser, John F; Heinsar, Silver; Jacobs, Jeffrey P; Labib, Ahmed et al. DOI: 10.1177/02676591251324136
PMID: 40010369 Journal: Lancet Respiratory Medicine Year: 2025 Reference: Lancet Respir Med. 2025 Feb 21:S2213-2600(24)00369-2. doi: 10.1016/S2213-2600(24)00369-2. Impact factor: Publication type: Paper in international publication Authors: Alessandri, Francesco; Barrett, Nicholas; Belohlavek, Jan; Boeken, Udo; Bolotin, Gil; Broman, Lars Mikael; Carelli, Simone; de la Sota, Enrique Perez; De Piero, Maria Elena; Filip, Bursa et al. DOI: 10.1016/S2213-2600(24)00369-2
PMID: 38515193 Journal: CRITICAL CARE Year: 2024 Reference: Crit Care. 2024 Mar 21;28(1):91. doi: 10.1186/s13054-024-04876-5. Impact factor: Publication type: Paper in international publication Authors: Amaya-Villar, Rosario; Anon, Jose M; Areny-Balaguero, Aina; Artigas, Antonio; Balan-Marino, Ana; Barbe, Ferran; Barbera, Carme; Barberan, Jose; Bermejo, Jesus; Blandino-Ortiz, Aaron et al. DOI: 10.1186/s13054-024-04876-5
PMID: 38527130 Journal: CIRCULATION Year: 2024 Reference: Circulation. 2024 Mar 26;149(13):1033-1052. doi: 10.1161/CIRCULATIONAHA.123.067087. Epub 2024 Mar 25. Impact factor: Publication type: Paper in international publication Authors: Binzenhofer, Leonhard; Combes, Alain; De Roeck, Frederic; Erglis, Andrejs; Hagl, Christian; Hausleiter, Jorg; Hering, Daniel; Luedike, Peter; Lusebrink, Enzo; Massberg, Steffen et al. DOI: 10.1161/CIRCULATIONAHA.123.067087
PMID: 38576081 Journal: MOVEMENT DISORDERS Year: 2024 Reference: Mov Disord. 2024 Apr 4. doi: 10.1002/mds.29802. Impact factor: Publication type: Paper in international publication Authors: Bezard, Erwan; Ferrario, Juan; Kalia, Lorraine V; Lin, Chin-Hsien; Mollenhauer, Brit; Outeiro, Tiago F; Salama, Mohamed; Standaert, David G; Svenningsson, Per; Taiwo, Lolade et al. DOI: 10.1002/mds.29802
PMID: 38591764 Journal: Clinical and Translational Medicine Year: 2024 Reference: Clin Transl Med. 2024 Apr;14(4):e1654. doi: 10.1002/ctm2.1654. Impact factor: Publication type: Other (letters to the editor, abstracts, corrigendum, etc.) Authors: Comabella, Manuel; Fernandez Velasco, Jose Ignacio; Fissolo, Nicolas; Goicoechea, Carlos; Malhotra, Sunny; Martinez-Vicente, Marta; Miguez, Andres; Monreal, Enric; Montalban, Xavier; Montpeyo, Marta et al. DOI: 10.1002/ctm2.1654
PMID: 36683517 Journal: Journal of Parkinsons Disease Year: 2023 Reference: J Parkinsons Dis. 2023;13(2):219-231. doi: 10.3233/JPD-225014. Impact factor: Publication type: Paper in international publication Authors: Alonso Losada, Maria G; Alonso Redondo, Ruben; Alvarez Sauco, Maria; Avila Rivera, Maria A; Borrue, Carmen; Buongiorno, Maria Teresa; Caballol, Nuria; Cabo, Iria; Carrillo Padilla, Francisco; Cores Bartolome, Carlos et al. DOI: 10.3233/JPD-225014
PMID: 36647231 Journal: Journal of Clinical Neurology Year: 2023 Reference: J Clin Neurol. 2023 Jul;19(4):344-357. doi: 10.3988/jcn.2022.0186. Epub 2023 Jan 2. Impact factor: Publication type: Paper in international publication Authors: Aguilar, Miquel; Alonso Losada, Maria G; Alonso Redondo, Ruben; Alvarez Sauco, Maria; Avila Rivera, Maria A; Blazquez Estrada, Marta; Borrue, Carmen; Caballol, Nuria; Cabo, Iria; Carrillo Padilla, Francisco et al. DOI:
PMID: 36717986 Journal: BRAIN Year: 2023 Reference: Brain. 2023 Jan 30:awac445. doi: 10.1093/brain/awac445. Impact factor: Publication type: Paper in international publication Authors: Cladera-Sastre, Joana M; Cladera-Sastre, Joana M; Compte, Joan; Cuadros, Thais; Gonzalez-Sepulveda, Marta; Guillard-Sirieix, Camille; Laguna, Ariadna; Lorente-Picon, Marina; Lorente-Picon, Marina; Nicolau, Alba et al. DOI: 10.1093/brain/awac445
PMID: 36753892 Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES Year: 2023 Reference: J Neurol Sci. 2023 Mar 15;446:120565. doi: 10.1016/j.jns.2023.120565. Epub 2023 Jan 28. Impact factor: Publication type: Paper in international publication Authors: Alvarez, Paula Fernandez; Arumi, Elena Garcia; Gratacos, Margarida; Hernandez-Vara, Jorge; Juntas, Raul; Lainez, Elena; Llaurado, Arnau; Martinez, Victoria Gonzalez; Raguer, Nuria; Salvado, Maria et al. DOI: 10.1016/j.jns.2023.120565
PMID: 35852918 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2022 Reference: Eur J Neurol. 2022 Dec;29(12):3720-3727. doi: 10.1111/ene.15513. Epub 2022 Jul 30. Impact factor: Publication type: Paper in international publication Authors: Adarmes-Gomez, Astrid; Aguilar-Barbera, Miquel; Arroyo, Sonia Escalante; Avila, Asuncion; Bejr-Kasem, Helena; Campolongo, Antonia; Carrillo, Fatima; Carrillo-Padilla, Francisco; Cots-Foraster, Anna; de Deus Fonticoba, Teresa et al. DOI: 10.1111/ene.15513
PMID: 35906684 Journal: Orphanet Journal of Rare Diseases Year: 2022 Reference: Orphanet J Rare Dis. 2022 Jul 29;17(1):298. doi: 10.1186/s13023-022-02452-0. Impact factor: Publication type: Paper in international publication Authors: Arborio-Pinel, R; Ariceta, G; Broseta, J J; Calleja, M A; Diaz-Curiel, M; Espin, J; Espinosa, L; Hernandez, J; Marin, S; Martinez, V et al. DOI: 10.1186/s13023-022-02452-0
PMID: 35883596 Journal: Cells Year: 2022 Reference: Cells. 2022 Jul 8;11(14). pii: cells11142153. doi: 10.3390/cells11142153. Impact factor: Publication type: Paper in international publication Authors: Cabrera-Perez, Raquel; Coll-Bonet, Ruth; Garcia-Lopez, Joan; Jaramillo, Jessica; Jorge Hernández Vara; Kumru, Hatice; Marmolejo-Martinez-Artesero, Sara; Mirabel, Clementine; Navarro, Xavier; Puigdomenech-Poch, Maria et al. DOI: 10.3390/cells11142153
PMID: 35805133 Journal: Cells Year: 2022 Reference: Cells. 2022 Jun 28;11(13). pii: cells11132046. doi: 10.3390/cells11132046. Impact factor: Publication type: Paper in international publication Authors: Albert-Bayo, Merce; Alonso-Cotoner, Carmen; Azpiroz, Fernando; Exposito, Elba; Fortea, Marina; Ganda Mall, John-Peter; Gonzalez-Castro, Ana M; Guagnozzi, Danila; Lobo, Beatriz; Martinez, Cristina et al. DOI: 10.3390/cells11132046
PMID: 34879838 Journal: BMC Neurology Year: 2021 Reference: BMC Neurol. 2021 Dec 8;21(1):477. doi: 10.1186/s12883-021-02485-1. Impact factor: Publication type: Paper in international publication Authors: Aguilar, Miquel; Alonso-Losada, Maria Gema; Alvarez-Sauco, Maria; Avila-Rivera, Maria Asuncion; Bejr-Kasem, Helena; Blazquez-Estrada, Marta; Borrue, Carmen; Caballol, Nuria; Cabo-Lopez, Iria; Carrillo-Padilla, Francisco et al. DOI: 10.1186/s12883-021-02485-1
PMID: 34852293 Journal: EBioMedicine Year: 2021 Reference: EBioMedicine. 2021 Nov 28;74:103731. doi: 10.1016/j.ebiom.2021.103731. Impact factor: Publication type: Letter or abstract Authors: Alarcon-Aris, Diana; Artigas, Francesc; Bortolozzi, Analia; Campa, Leticia; Coppola-Segovia, Valentin; Ferres-Coy, Albert; Galofre, Mireia; Kordower, Jeffrey H; Miquel-Rio, Lluis; Montefeltro, Andres et al. DOI: 10.1016/j.ebiom.2021.103731
PMID: 34778332 Journal: Frontiers in Nutrition Year: 2021 Reference: Front Nutr. 2021 Oct 28;8:718093. doi: 10.3389/fnut.2021.718093. eCollection 2021. Impact factor: Publication type: Review in international publication Authors: Abril-Gil, Mar; Albert-Bayo, Merce; Alonso-Cotoner, Carmen; Exposito, Elba; Fortea, Marina; Ganda Mall, John-Peter; Gonzalez-Castro, Ana Maria; Guagnozzi, Danila; Henao-Paez, Alejandro; Lobo, Beatriz et al. DOI: 10.3389/fnut.2021.718093
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PMID: 32867153 Journal: Nutrients Year: 2020 Reference: Nutrients. 2020 Aug 27;12(9). pii: nu12092610. doi: 10.3390/nu12092610. Impact factor: Publication type: Paper in international publication Authors: Brummer, Robert J; Fart, Frida; Ganda-Mall, John Peter; Lindqvist, Carl Marten; Rajan, Sukithar Kochappi; Rangel, Ignacio; Repsilber, Dirk; Schoultz, Ida; Tingo, Lina; Wall, Rebecca et al. DOI: 10.3390/nu12092610
PMID: 32587362 Journal: Scientific Reports Year: 2020 Reference: Sci Rep. 2020 Jun 25;10(1):10310. doi: 10.1038/s41598-020-66221-4. Impact factor: Publication type: Paper in international publication Authors: Arnal Segura, Magdalena; Avila, Asuncion; Botta-Orfila, Teresa; Caballol, Nuria; Calopa, Matilde; Camara, Ana; Classen, Serge Jauma; Compta, Yaroslau; de Fabregues, Oriol; Ezquerra, Mario et al. DOI: 10.1038/s41598-020-66221-4
PMID: 32786306 Journal: ACS Chemical Neuroscience Year: 2020 Reference: ACS Chem Neurosci. 2020 Sep 2;11(17):2679-2687. doi: 10.1021/acschemneuro.0c00336. Epub 2020 Aug 24. Impact factor: Publication type: Paper in international publication Authors: Carballo-Carbajal, Iria; Compte, Joan; Cuadros, Thais; Galiano-Landeira, Jordi; Gonzalez-Sepulveda, Marta; Guillard-Sirieix, Camille; Kobayashi, Jumpei; Laguna, Ariadna; Nicolau, Alba; Parent, Annabelle et al. DOI: 10.1021/acschemneuro.0c00336
PMID: 32810825 Journal: EBioMedicine Year: 2020 Reference: EBioMedicine. 2020 Sep;59:102944. doi: 10.1016/j.ebiom.2020.102944. Epub 2020 Aug 15. Impact factor: Publication type: Paper in international publication Authors: Alarcon-Aris, Diana; Artigas, Francesc; Bortolozzi, Analia; Campa, Leticia; Coppola-Segovia, Valentin; Ferres-Coy, Albert; Galofre, Mireia; Kordower, Jeffrey H; Miquel-Rio, Lluis; Montefeltro, Andres et al. DOI: 10.1016/j.ebiom.2020.102944
PMID: 31480882 Journal: Autophagy Year: 2019 Reference: Autophagy. 2019 Nov;15(11):2028-2030. doi: 10.1080/15548627.2019.1659621. Epub 2019 Sep 3. Impact factor: Publication type: Paper in international publication Authors: Carballo-Carbajal, Iria; Laguna, Ariadna; Vila, Miquel et al. DOI: 10.1080/15548627.2019.1659621
PMID: 31251435 Journal: MOVEMENT DISORDERS Year: 2019 Reference: Mov Disord. 2019 Oct;34(10):1440-1451. doi: 10.1002/mds.27776. Epub 2019 Jun 28. Impact factor: Publication type: Paper in international publication Authors: Vila, Miquel et al. DOI: 10.1002/mds.27776
PMID: 31179586 Journal: EUROPEAN JOURNAL OF NEUROLOGY Year: 2019 Reference: Eur J Neurol. 2019 Nov;26(11):1399-1407. doi: 10.1111/ene.14008. Epub 2019 Jul 4. Impact factor: Publication type: Paper in international publication Authors: Aguilar, M; Alonso, P Sanchez; Aramburu, I Gonzalez; Ardura, J Gonzalez; Ariztegui, N Lopez; Borrue, C; Caballol, N; Cabo, I; Caldentey, J Garcia; Castrillo, J C Martinez et al. DOI: 10.1111/ene.14008
PMID: 31077261 Journal: Alzheimers Research & Therapy Year: 2019 Reference: Alzheimers Res Ther. 2019 May 10;11(1):42. doi: 10.1186/s13195-019-0498-8. Impact factor: Publication type: Paper in international publication Authors: Bonaterra, Anna; Cano-Sarabia, Mary; Colell, Guillem; de Retana, Sofia Fernandez; Hernandez-Guillamon, Mar; Marazuela, Paula; Maspoch, Daniel; Montaner, Joan; Sanchez-Quesada, Jose Luis; Sole, Montse et al. DOI: 10.1186/s13195-019-0498-8
PMID: 30485814 Journal: Cell Reports Year: 2018 Reference: Cell Rep. 2018 Nov 27;25(9):2484-2496.e9. doi: 10.1016/j.celrep.2018.11.002. Impact factor: Publication type: Paper in international publication Authors: Bossowski, Jozef Piotr; Brice, Alexis; Carballo-Carbajal, Iria; Condroyer, Christel; Coque, Emmanuelle; Desagher, Solange; Laguna, Ariadna; Lassot, Irena; Lesage, Suzanne; Mangone, Graziella et al. DOI: 10.1016/j.celrep.2018.11.002
PMID: 30405116 Journal: Cell Death & Disease Year: 2018 Reference: Cell Death Dis. 2018 Nov 7;9(11):1122. doi: 10.1038/s41419-018-1154-0. Impact factor: Publication type: Paper in international publication Authors: Cuadros, Thais; Franco-Iborra, Sandra; Parent, Annabelle; Perier, Celine; Romero-Gimenez, Jordi; Vila, Miquel et al. DOI: 10.1038/s41419-018-1154-0
PMID: 30048013 Journal: ANNALS OF NEUROLOGY Year: 2018 Reference: Ann Neurol. 2018 Sep;84(3):347-360. doi: 10.1002/ana.25300. Epub 2018 Aug 31. Impact factor: Publication type: Paper in international publication Authors: Abu-Rumeileh, Samir; Baiardi, Simone; Belotti, Alessia; Capellari, Sabina; Cortelli, Pietro; Didato, Giuseppe; Gelpi, Ellen; Giaccone, Giorgio; Hernandez-Vara, Jorge; Imperiale, Daniele et al. DOI: 10.1002/ana.25300
PMID: 29875626 Journal: Frontiers in Neuroscience Year: 2018 Reference: Front Neurosci. 2018 May 23;12:342. doi: 10.3389/fnins.2018.00342. eCollection 2018. Impact factor: Publication type: Review in international publication Authors: Franco-Iborra, Sandra; Perier, Celine; Vila, Miquel et al. DOI: 10.3389/fnins.2018.00342
PMID: 28520872 Journal: HUMAN MOLECULAR GENETICS Year: 2017 Reference: Hum Mol Genet. 2017 Jul 15;26(14):2603-2615. doi: 10.1093/hmg/ddx120. Impact factor: Publication type: Paper in international publication Authors: Bezard, Erwan; Dehay, Benjamin; Dovero, Sandra; Engeln, Michel; Favereaux, Alexandre; Fernagut, Pierre-Olivier; Georges, Francois; Glangetas, Christelle; Lo Bianco, Christophe; Lopez-Gonzalez, Maria Jose et al. DOI: 10.1093/hmg/ddx120
PMID: 28337125 Journal: Frontiers in Molecular Neuroscience Year: 2017 Reference: Front Mol Neurosci. 2017 Mar 8;10:64. doi: 10.3389/fnmol.2017.00064. eCollection 2017. Impact factor: Publication type: Review in international publication Authors: Martinez-Vicente, Marta et al. DOI: 10.3389/fnmol.2017.00064
PMID: 28247355 Journal: Methods in molecular biology (Clifton, N.J.) Year: 2017 Reference: Methods Mol Biol. 2017;1556:255-280. doi: 10.1007/978-1-4939-6771-1_14. Impact factor: Publication type: Paper in international publication Authors: Garcia-Prat, Laura; Martinez-Vicente, Marta; Munoz-Canoves, Pura et al. DOI: 10.1007/978-1-4939-6771-1_14
PMID: 27154504 Journal: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM Year: 2017 Reference: J Cereb Blood Flow Metab. 2017 Mar;37(3):927-937. doi: 10.1177/0271678X16649196. Epub 2016 Jul 20. Impact factor: Publication type: Paper in international publication Authors: Bove, Jordi; Chavarria, Laia; Cordoba, Juan; Garcia-Lezana, Teresa; Genesca, Joan; Oria, Marc; Romero-Gimenez, Jordi; Vila, Miquel et al. DOI: 10.1177/0271678X16649196
PMID: 27492176 Journal: Methods in molecular biology (Clifton, N.J.) Year: 2016 Reference: Methods Mol Biol. 2016;1460:223-40. doi: 10.1007/978-1-4939-3810-0_16. Impact factor: Publication type: Paper in international publication Authors: Garcia-Prat, Laura; Martinez-Vicente, Marta; Munoz-Canoves, Pura et al. DOI: 10.1007/978-1-4939-3810-0_16
PMID: 27428421 Journal: EBioMedicine Year: 2016 Reference: EBioMedicine. 2016 Jun;8:83-95. doi: 10.1016/j.ebiom.2016.04.016. Epub 2016 Apr 19. Impact factor: Publication type: Paper in international publication Authors: Altarche-Xifro, Wassim; Bortolozzi, Analia; Bove, Jordi; Cosma, Maria Pia; di Vicino, Umberto; Munoz-Martin, Maria Isabel; Vila, Miquel et al. DOI: 10.1016/j.ebiom.2016.04.016
PMID: 26738589 Journal: NATURE Year: 2016 Reference: Nature. 2016 Jan 7;529(7584):37-42. doi: 10.1038/nature16187. Impact factor: Publication type: Paper in international publication Authors: Ballestar, Esteban; Garcia-Prat, Laura; Gutarra, Susana; Martinez-Vicente, Marta; Munoz-Canoves, Pura; Ortet, Laura; Perdiguero, Eusebio; Rebollo, Elena; Rodriguez-Ubreva, Javier; Ruiz-Bonilla, Vanessa et al. DOI: 10.1038/nature16187
PMID: 26934325 Journal: Oncotarget Year: 2016 Reference: Oncotarget. 2016 Mar 15;7(11):12286-8. doi: 10.18632/oncotarget.7766. Impact factor: Publication type: Review in national publication Authors: Garcia-Prat, Laura; Martinez-Vicente, Marta; Munoz-Canoves, Pura et al. DOI: 10.18632/oncotarget.7766
PMID: 26394101 Journal: CURR BIOL Year: 2015 Reference: Curr Biol. 2015 Sep 21;25(18):R797-800. doi: 10.1016/j.cub.2015.07.062. Impact factor: Publication type: Paper in international publication Authors: Franco-Iborra, Sandra; Perier, Celine et al. DOI: 10.1016/j.cub.2015.07.062
PMID: 25997864 Journal: PARKINSONISM RELAT D Year: 2015 Reference: Parkinsonism Relat Disord. 2015 Aug;21(8):996-8. doi: 10.1016/j.parkreldis.2015.04.030. Epub 2015 May 6. Impact factor: Publication type: Letter whit IF Authors: Alvarez, R; Bregman, J; de Fabregues, O; Galvez-Barron, C; Hernandez-Vara, J; Martinez-Castrillo, J C; Perez-Lopez, C; Perez-Martinez, D A; Rodriguez-Molinero, A; Romagosa, J et al. DOI: 10.1016/j.parkreldis.2015.04.030
PMID: 25915474 Journal: NAT NEUROSCI Year: 2015 Reference: Nat Neurosci. 2015 Jun;18(6):826-35. doi: 10.1038/nn.4004. Epub 2015 Apr 27. Impact factor: Publication type: Paper in international publication Authors: Alvarsson, Alexandra; Deng, Qiaolin; Ericson, Johan; Gomez-Galan, Marta; Jacobsen, Jesper Kjaer; Joodmardi, Eliza; Kehr, Jan; Laguna, Ariadna; Nobre, Andre; Perlmann, Thomas et al. DOI: 10.1038/nn.4004
PMID: 26343462 Journal: COMPR PSYCHIAT Year: 2015 Reference: Compr Psychiatry. 2015 Oct;62:13-9. doi: 10.1016/j.comppsych.2015.06.010. Epub 2015 Jun 17. Impact factor: Publication type: Paper in international publication Authors: Alegre, Jose; Calvo, Natalia; Casas, Miguel; Castro-Marrero, Jesus; Hernandez-Vara, Jorge; Ramirez, Nicolas; Saez-Francas, Naia et al. DOI: 10.1016/j.comppsych.2015.06.010
PMID: 24243558 Journal: ANNALS OF NEUROLOGY Year: 2014 Reference: Ann Neurol. 2014 Mar;75(3):351-62. doi: 10.1002/ana.24066. Epub 2014 Feb 18. Impact factor: Publication type: Paper in international publication Authors: Bezard, E; Blesa, J; Bove, J; Carballo-Carbajal, I; Dehay, B; Dovero, S; Farinas, I; Fernagut, P O; Obeso, J A; Parent, A et al. DOI: 10.1002/ana.24066
PMID: 24351900 Journal: JOURNAL OF THE NEUROLOGICAL SCIENCES Year: 2014 Reference: J Neurol Sci. 2014 Feb 15;337(1-2):167-72. doi: 10.1016/j.jns.2013.12.003. Epub 2013 Dec 7. Impact factor: Publication type: Paper in international publication Authors: Alegre, Jose; Casas, Miguel; Corominas-Roso, Margarita; Hernandez-Vara, Jorge; Jacas, Carlos; Saez-Francas, Naia et al. DOI: 10.1016/j.jns.2013.12.003
PMID: 24012443 Journal: MEDICINA CLINICA Year: 2014 Reference: Med Clin (Barc). 2014 Feb 20;142(4):186. doi: 10.1016/j.medcli.2013.06.022. Epub 2013 Sep 6. Impact factor: Publication type: Paper in national publication Authors: Hernandez-Vara, Jorge; Salvado, Maria et al. DOI: 10.1016/j.medcli.2013.06.022
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The initiative seeks to raise awareness of the disease and promote the well-being of those affected, while fostering empathy and scientific vocations among young people.
On World Clinical Trials Day, we highlight some of the studies we have participated in that confirm the efficacy of new drugs, allowing their approval by regulatory agencies.
Vall d'Hebron has participated in a phase III clinical trial which confirmed the efficacy and safety of subcutaneous infusion of levodopa therapy.
Vall d'Hebron Iniciativa per al Parkinson (VHIP) is a research project aimed at the development of biochemical markers for the early detection of Parkinson's disease. This study is carried out in people at high risk of having this disease, because they carry genetic mutations that predispose to the development of Parkinson's or because they present non-motor symptoms that manifest themselves years before motor symptoms.
