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Neurovascular Diseases

Stroke is a medical emergency and a leading cause of death and disability worldwide affecting millions of subjects. In this context the Neurovascular Research Laboratory was created in 2001 focused in stroke research from a basic and translational perspective, covering all stages of the disease: from prevention and treatment, to recovery.

Nowadays our team is composed by a highly motivated group of researchers including clinical and basic scientists, with group leaders involved in National and International projects with public or private research funding on biomarkers for clinical decision making in stroke, the presence of silent infarctions, the assessment of cognition and cognitive decline, developing experimental models of cerebral ischemia testing new treatments complementary to reperfusion, and developing studies on cerebral amyloid angiopathy, tissue neurorepair or post-stroke rehabilitation.

Complementary studies on vascular dementia and Alzheimer disease related to amyloid-beta protein have also been encompassed as part of our research in the last years.

Team

Marcel Lamana Vallverdu

Marcel Lamana Vallverdu

Research technician
Neurovascular Diseases
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Maria Pilar Delgado Martínez

Maria Pilar Delgado Martínez

Main researcher
Neurovascular Diseases
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Marta Sofia Machado Pereira

Marta Sofia Machado Pereira

Predoctoral researcher
Neurovascular Diseases
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Miguel García Gabilondo

Miguel García Gabilondo

Research technician
Neurovascular Diseases
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Nicolas Garcia Rodriguez

Nicolas Garcia Rodriguez

Predoctoral researcher
Neurovascular Diseases
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Nuria Paz Torres Aguila

Nuria Paz Torres Aguila

Predoctoral researcher
Neurovascular Diseases
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Marcel Lamana Vallverdu

Marcel Lamana Vallverdu

Research technician
Neurovascular Diseases
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Maria Pilar Delgado Martínez

Maria Pilar Delgado Martínez

Main researcher
Neurovascular Diseases
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Marta Sofia Machado Pereira

Marta Sofia Machado Pereira

Predoctoral researcher
Neurovascular Diseases
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Miguel García Gabilondo

Miguel García Gabilondo

Research technician
Neurovascular Diseases
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Nicolas Garcia Rodriguez

Nicolas Garcia Rodriguez

Predoctoral researcher
Neurovascular Diseases
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Nuria Paz Torres Aguila

Nuria Paz Torres Aguila

Predoctoral researcher
Neurovascular Diseases
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Projects

Implicaction of proteins associated with vascular beta-amyloid in Cerebral Amyloid Angiopathy

IP: Maria Mar Hernandez Guillamon
Collaborators: Marcel Lamana Vallverdu, Anna Bonaterra Pastra, Jessica Camacho Soriano, Olga Maisterra Santos, Olalla Pancorbo Rosal
Funding agency: Instituto de Salud Carlos III
Funding: 169400
Reference: PI20/00465
Duration: 01/01/2021 - 30/06/2025

Characterization of the CD8 T cell response in Parkinson’s disease for the development of preventive and therapeutic strategies that halt the progression of the disease: SARS-Cov-2-induced long term-hyposmia as a possible prodromal stage

IP: Jordi Bove Badell
Collaborators: Miquel Vila Bover, Alejandro Ferré Masó, Oriol de Fabregues-Boixar Nebot, Carles Lorenzo Bosquet, Thais Cuadros Arasa, Antonio Palasi Franco, David Ramos Vicente, Mariona Marchena Herrera
Funding agency: Instituto de Salud Carlos III
Funding: 165770
Reference: PI21/01358
Duration: 01/01/2022 - 31/12/2024

Publications

Ceruletide and Alpha-1 Antitrypsin as a Novel Combination Therapy for Ischemic Stroke.

PMID: 35226340
Journal: Neurotherapeutics
Year: 2022
Reference: Neurotherapeutics. 2022 Mar;19(2):513-527. doi: 10.1007/s13311-022-01203-0. Epub 2022 Feb 28.
Impact factor: 7.62
Publication type: Paper in international publication
Authors: Valls, Raquel, de Ramon, Helena, Garcia-Rodriguez, Paula, Orset, Cyrille, Artigas, Laura, Sardon, Teresa, Rosell, Anna, Montaner, Joan, Ramiro, Laura, Simats, Alba et al.
DOI: 10.1007/s13311-022-01203-0

Mortality and bleeding complications of COVID-19 critically ill patients with venous thromboembolism.

PMID: 34751541
Journal: INTERNATIONAL ANGIOLOGY
Year: 2022
Reference: Int Angiol. 2022 Feb;41(1):1-8. doi: 10.23736/S0392-9590.21.04704-0. Epub 2021 Nov 9.
Impact factor: 2.789
Publication type: Paper in international publication
Authors: Ruiz-Rodriguez, Juan Carlos, Ferrer, Ricard, DE Nadal, Miriam, Suito-Alcantara, Milagros A, Llagostera, Secundino, Bellmunt, Sergi, Gil, Miquel, Martinez, Lucia, Rodriguez, Manuela, Gil-Sala, Daniel et al.
DOI: 10.23736/S0392-9590.21.04704-0

Comparative analysis between 1-D, 2-D and 3-D carotid web quantification.

PMID: 35172982
Journal: Journal of NeuroInterventional Surgery
Year: 2022
Reference: J Neurointerv Surg. 2022 Feb 16. pii: neurintsurg-2021-018192. doi: 10.1136/neurintsurg-2021-018192.
Impact factor: 5.836
Publication type: Paper in international publication
Authors: Perry da Camara, Catarina, Nogueira, Raul G, Al-Bayati, Alhamza R, Pisani, Leonardo, Mohammaden, Mahmoud, Allen, Jason W, Nahab, Fadi, Olive Gadea, Marta, Frankel, Michael R, Haussen, Diogo C et al.
DOI: 10.1136/neurintsurg-2021-018192

Endovascular administration of magnetized nanocarriers targeting brain delivery after stroke.

PMID: 34229512
Journal: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Year: 2022
Reference: J Cereb Blood Flow Metab. 2022 Feb;42(2):237-252. doi: 10.1177/0271678X211028816. Epub 2021 Jul 6.
Impact factor: 6.2
Publication type: Paper in international publication
Authors: Grayston, Alba, Zhang, Yajie, Garcia-Gabilondo, Miguel, Arrue, Mercedes, Martin, Abraham, Kopcansky, Peter, Timko, Milan, Kovac, Jozef, Strbak, Oliver, Castellote, Laura et al.
DOI: 10.1177/0271678X211028816

Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage.

PMID: 33801197
Journal: Journal of Clinical Medicine
Year: 2021
Reference: J Clin Med. 2021 Mar 2;10(5). pii: jcm10050989. doi: 10.3390/jcm10050989.
Impact factor: 4.242
Publication type: Paper in international publication
Authors: Marazuela, Paula, Bonaterra-Pastra, Anna, Faura, Julia, Penalba, Anna, Pizarro, Jesus, Pancorbo, Olalla, Rodriguez-Luna, David, Vert, Carla, Rovira, Alex, Pujadas, Francesc et al.
DOI: 10.3390/jcm10050989

SSAO/VAP-1 in Cerebrovascular Disorders: A Potential Therapeutic Target for Stroke and Alzheimer's Disease.

PMID: 33805974
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Year: 2021
Reference: Int J Mol Sci. 2021 Mar 25;22(7). pii: ijms22073365. doi: 10.3390/ijms22073365.
Impact factor: 5.924
Publication type: Review in international publication
Authors: Unzeta, Mercedes, Hernandez-Guillamon, Mar, Sun, Ping, Sole, Montse et al.
DOI: 10.3390/ijms22073365

Extracellular vesicles from recombinant cell factories improve the activity and efficacy of enzymes defective in lysosomal storage disorders.

PMID: 33738082
Journal: Journal of Extracellular Vesicles
Year: 2021
Reference: J Extracell Vesicles. 2021 Mar;10(5):e12058. doi: 10.1002/jev2.12058. Epub 2021 Mar 12.
Impact factor: 25.841
Publication type: Paper in international publication
Authors: Seras-Franzoso, Joaquin, Diaz-Riascos, Zamira V, Corchero, Jose Luis, Gonzalez, Patricia, Garcia-Aranda, Natalia, Mandana, Monica, Riera, Roger, Boullosa, Ana, Mancilla, Sandra, Grayston, Alba et al.
DOI: 10.1002/jev2.12058

[Quality of life in adult patients with idiopathic generalised epilepsy. The EPILAK study].

PMID: 33710609
Journal: REVISTA DE NEUROLOGIA
Year: 2021
Reference: Rev Neurol. 2021 Mar 16;72(6):195-202. doi: 10.33588/rn.7206.2020518.
Impact factor: 0.87
Publication type: Paper in national publication
Authors: Salas-Puig, J, Sopelana, D, Quintana, M, Seijo-Raposo, I, Abraira, L, Fonseca, E, Santamarina, E, Toledo, M et al.
DOI: 10.33588/rn.7206.2020518

Circulating TIMP-1 is associated with hematoma volume in patients with spontaneous intracranial hemorrhage.

PMID: 32587306
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Jun 25;10(1):10329. doi: 10.1038/s41598-020-67250-9.
Impact factor: 3.998
Publication type: Paper in international publication
Authors: Navarro-Oviedo, Manuel, Munoz-Arrondo, Roberto, Zandio, Beatriz, Marta-Enguita, Juan, Bonaterra-Pastra, Anna, Rodriguez, Jose Antonio, Roncal, Carmen, Paramo, Jose A, Toledo, Estefania, Montaner, Joan et al.
DOI: 10.1038/s41598-020-67250-9

Screening of Embolic Sources by Point-of-Care Ultrasound in the Acute Phase of Ischemic Stroke.

PMID: 32532655
Journal: ULTRASOUND IN MEDICINE AND BIOLOGY
Year: 2020
Reference: Ultrasound Med Biol. 2020 Sep;46(9):2173-2180. doi: 10.1016/j.ultrasmedbio.2020.05.009. Epub 2020 Jun 10.
Impact factor: 2.514
Publication type: Paper in international publication
Authors: Juega, Jesus, Pagola, Jorge, Gonzalez-Alujas, Teresa, Rodriguez-Luna, David, Rubiera, Marta, Rodriguez-Villatoro, Noelia, Garcia-Tornel, Alvaro, Requena, Manuel, Deck, Matias, Sero, Laia et al.
DOI: 10.1016/j.ultrasmedbio.2020.05.009

Ambulatory Blood Pressure Levels in the Prediction of Progression of Cerebral Small Vessel Disease.

PMID: 32511756
Journal: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
Year: 2020
Reference: J Am Geriatr Soc. 2020 Oct;68(10):2232-2239. doi: 10.1111/jgs.16568. Epub 2020 Jun 8.
Impact factor: 4.18
Publication type: Paper in international publication
Authors: Palasi, Antoni, Pujadas, Francesc, Mundet, Xavier, Vinyoles, Ernest, Delgado, Pilar, Pizarro, Jesus, Maisterra, Olga, Riba-Llena, Iolanda, Jimenez-Balado, Joan et al.
DOI: 10.1111/jgs.16568

Cardioembolic Ischemic Stroke Gene Expression Fingerprint in Blood: a Systematic Review and Verification Analysis.

PMID: 31475302
Journal: Translational Stroke Research
Year: 2020
Reference: Transl Stroke Res. 2020 Jun;11(3):326-336. doi: 10.1007/s12975-019-00730-x. Epub 2019 Sep 2.
Impact factor: 5.78
Publication type: Review in international publication
Authors: Clua-Espuny, Josep Lluis, Pedrote, Alonso, Pagola, Jorge, Juega, Jesus, Bustamante, Alejandro, Montaner, Joan, Munoz, Miguel Angel, Jickling, Glen C, Meisel, Christian, Meisel, Andreas et al.
DOI: 10.1007/s12975-019-00730-x

Long-term epilepsy after early post-stroke status epilepticus.

PMID: 31077960
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2019
Reference: Seizure. 2019 Jul;69:193-197. doi: 10.1016/j.seizure.2019.04.022. Epub 2019 May 1.
Impact factor: 2.765
Publication type: Paper in international publication
Authors: Abraira, Laura, Toledo, Manuel, Guzman, Lorena, Sueiras, Maria, Quintana, Manuel, Fonseca, Elena, Salas-Puig, Javier, Alvarez-Sabin, Jose, Santamarina, Estevo et al.
DOI: 10.1016/j.seizure.2019.04.022

Brain ApoA-I, ApoJ and ApoE Immunodetection in Cerebral Amyloid Angiopathy.

PMID: 30918495
Journal: Frontiers in Neurology
Year: 2019
Reference: Front Neurol. 2019 Mar 13;10:187. doi: 10.3389/fneur.2019.00187. eCollection 2019.
Impact factor: 2.635
Publication type: Paper in international publication
Authors: Camacho, Jessica, Moline, Teresa, Bonaterra-Pastra, Anna, Ramon Y Cajal, Santiago, Martinez-Saez, Elena, Hernandez-Guillamon, Mar et al.
DOI: 10.3389/fneur.2019.00187

Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome.

PMID: 30834194
Journal: Epilepsy & behavior case reports
Year: 2019
Reference: Epilepsy Behav Case Rep. 2019 Feb 7;11:92-95. doi: 10.1016/j.ebcr.2019.01.008. eCollection 2019.
Impact factor: 0
Publication type: Paper in international publication
Authors: Santamarina, Estevo, Alpuente, Alicia, Maisterra, Olga, Sueiras, Maria, Sarria, Silvana, Guzman, Lorena, Abraira, Laura, Salas-Puig, Javier, Toledo, Manuel et al.
DOI: 10.1016/j.ebcr.2019.01.008

Update in status epilepticus.

PMID: 30803796
Journal: MEDICINA CLINICA
Year: 2019
Reference: Med Clin (Barc). 2019 Jul 19;153(2):70-77. doi: 10.1016/j.medcli.2019.01.013. Epub 2019 Feb 23.
Impact factor: 1.277
Publication type: Review in national publication
Authors: Santamarina, Estevo, Abraira, Laura, Toledo, Manuel et al.
DOI: 10.1016/j.medcli.2019.01.013

Prevalence of hippocampal enlarged perivascular spaces in a sample of patients with hypertension and their relation with vascular risk factors and cognitive function.

PMID: 29326289
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
Year: 2018
Reference: J Neurol Neurosurg Psychiatry. 2018 Jun;89(6):651-656. doi: 10.1136/jnnp-2017-316724. Epub 2018 Jan 11.
Impact factor: 7.144
Publication type: Paper in international publication
Authors: Jimenez-Balado, Joan, Riba-Llena, Iolanda, Garde, Edurne, Valor, Marta, Gutierrez, Belen, Pujadas, Francesc, Delgado, Pilar et al.
DOI: 10.1136/jnnp-2017-316724

Single Cell Immuno-laser Microdissection Coupled to Label-free Proteomics to Reveal the Proteotypes of Human Brain Cells After Ischemia.

PMID: 29133510
Journal: MOLECULAR & CELLULAR PROTEOMICS
Year: 2018
Reference: Mol Cell Proteomics. 2018 Jan;17(1):175-189. doi: 10.1074/mcp.RA117.000419. Epub 2017 Nov 13.
Impact factor: 5.232
Publication type: Paper in international publication
Authors: Garcia-Berrocoso, Teresa, Llombart, Victor, Colas-Campas, Laura, Hainard, Alexandre, Licker, Virginie, Penalba, Anna, Ramiro, Laura, Simats, Alba, Martinez-Saez, Elena, Canals, Francesc et al.
DOI: 10.1074/mcp.RA117.000419

Blog

News

The Cardiovascular Diseases and Neurovascular Diseases groups at VHIR will investigate new therapeutic strategies for heart failure, nanomedicine in stroke and the prevention of cardiovascular toxicity in the case of oncological treatments.

La recerca és fonamental per contrarestar els efectes de la pol·lució, que segons l’AEMPS, va ser la causa de més de 300.000 morts prematures a la UE el 2020.

The international study has identified 89 genes involved in the risk of developing a stroke, 61 of which had not been previously described.

Job offers

PHd Candidate Neurovascular Research Laboratory
Start date:
25/10/2022
End date:
09/11/2022
Document: Download
Research technician Neurovascular Research Laboratory
Start date:
29/09/2022
End date:
12/10/2022
Document: Download
Clinical Researcher-Neurovascular diseases group.
Start date:
28/03/2022
End date:
11/04/2022
Document: Download