Ophtalmology
The clinical and basic research activity of the Ophthalmology Research Group is dedicated to finding new treatments for blindness through the development of new therapies for macular and retinal degenerative diseases, as well as for retinal vascular diseases (diabetic retinopathy and retinal vascular occlusions). Our group consists of core researchers and clinical researchers, so there is a clear clinical translation of the ongoing research in the research group.
We have a research program for the development of new therapeutic strategies based on:
- Cell therapies
- Formulations of ocular solutions (LUCIA PI18 and CELLUX EuroNanoMed/AC19)
- Biological matrices
- Gene therapy
- Animal models
- Retinal cell models based on stem cell-derived organoids.
In the clinical part, the research group bases its activity on clinical trials to develop new treatments for retinal diseases as well as on the ophthalmic involvement of systemic treatments, an example is the phase II trial to test mesenchymal cells (MSV) intravitreal in non-arteritic ischemic optic neuropathy (NAION), the RECOGNISED study or the PULSAR study with aflibercept.
Publications
[Not Available].
PMID: 37923065
Journal: Actas dermo-sifiliograficas
Year: 2023
Reference: Actas Dermosifiliogr. 2023 Nov 1:S0001-7310(23)00866-9. doi: 10.1016/j.ad.2023.10.032.
Impact factor:
Publication type: Paper in international publication
Authors: Abraldes Lopez-Veiga, Maximino Jose; Abraldes, Maximino; Aldazabal-Echeveste, Maialen; Alforja, Socorro; Alforja, Socorro; Alonso, Elena; Arias-Barquet, Lluis; Arruabarrena, Carolina; Arruabarrena, Carolina; Ascaso Puyuelo, Francisco Javier et al.
DOI: 10.1016/j.ad.2023.10.032
Retinal microvascular abnormalities in patients after COVID-19 depending on disease severity.
PMID: 33328184
Journal: BRITISH JOURNAL OF OPHTHALMOLOGY
Year: 2022
Reference: Br J Ophthalmol. 2022 Apr;106(4):559-563. doi: 10.1136/bjophthalmol-2020-317953. Epub 2020 Dec 16.
Impact factor: 4.638
Publication type: Paper in international publication
Authors: Sanchez, Adrian, Zapata, Miguel Angel, Banderas Garcia, Sandra, Arcos, Gabriel, Velazquez-Villoria, Daniel, Garcia-Arumi, Jose, Otero-Romero, Susana, Falco, Anna et al.
DOI: 10.1136/bjophthalmol-2020-317953
Orbital filariasis.
PMID: 35282899
Journal: MEDICINA CLINICA
Year: 2022
Reference: Med Clin (Barc). 2022 Jul 8;159(1):56. doi: 10.1016/j.medcli.2022.02.004. Epub 2022 Mar 10.
Impact factor: 1.725
Publication type: Paper in national publication
Authors: Sanchez-Vela, Laura, Garrido-Marin, Marta, Sanchez-Dalmau, Bernardo F et al.
DOI: 10.1016/j.medcli.2022.02.004
Pseudomonas aeruginosa keratitis after penetrating keratoplasty: Donor with bilateral positive corneoscleral rim culture.
PMID: 35277282
Journal: JOURNAL FRANCAIS D OPHTALMOLOGIE
Year: 2022
Reference: J Fr Ophtalmol. 2022 Mar 8. pii: S0181-5512(22)00088-2. doi: 10.1016/j.jfo.2021.10.018.
Impact factor: 0.818
Publication type: Letter or abstract
Authors: Sabater-Cruz, N, Martin, S, Guell, J L, Calatayud, M, Casaroli-Marano, R P et al.
DOI: 10.1016/j.jfo.2021.10.018
Obstruction of an EX-PRESS(R) glaucoma device after suture lysis: Treatment with Nd:YAG laser.
PMID: 34952720
Journal: JOURNAL FRANCAIS D OPHTALMOLOGIE
Year: 2022
Reference: J Fr Ophtalmol. 2022 Mar;45(3):e119-e121. doi: 10.1016/j.jfo.2021.08.018. Epub 2021 Dec 21.
Impact factor: 0.818
Publication type: Letter or abstract
Authors: Garrell-Salat, X, Rigo, J, Castany, M, Trejo-Velasco, F, Garcia-Arumi, J et al.
DOI: 10.1016/j.jfo.2021.08.018
Transcriptomics analysis of Ccl2/Cx3cr1/Crb1rd8 deficient mice provides new insights into the pathophysiology of progressive retinal degeneration.
PMID: 33373623
Journal: EXPERIMENTAL EYE RESEARCH
Year: 2021
Reference: Exp Eye Res. 2021 Feb;203:108424. doi: 10.1016/j.exer.2020.108424. Epub 2020 Dec 26.
Impact factor:
Publication type: Paper in international publication
Authors: Arumi, Jose Garcia; Badia, Anna; Duarri, Anna; Ferreira-de-Souza, Barbara; Fontrodona, Laura; Salas, Anna; Zapata, Miguel Angel et al.
DOI: 10.1016/j.exer.2020.108424
Palytoxin-Related Keratoconjunctivitis Assessed by High-Resolution Anterior Segment Optical Coherence Tomography.
PMID: 34963267
Journal: Turkish journal of ophthalmology
Year: 2021
Reference: Turk J Ophthalmol. 2021 Dec 28;51(6):393-397. doi: 10.4274/tjo.galenos.2021.93384.
Impact factor: 0
Publication type: Letter whit IF
Authors: Nalda, Sara Martin, Oliveres, Joan, Garrido-Marin, Marta, Marti, Monica Berges, Aragon-Roca, David, Trejo-Velasco, Fernando et al.
DOI: 10.4274/tjo.galenos.2021.93384
Multiocular organoids from human induced pluripotent stem cells displayed retinal, corneal, and retinal pigment epithelium lineages.
PMID: 34809716
Journal: Stem Cell Research & Therapy
Year: 2021
Reference: Stem Cell Res Ther. 2021 Nov 22;12(1):581. doi: 10.1186/s13287-021-02651-9.
Impact factor: 6.832
Publication type: Paper in international publication
Authors: Isla-Magrane, Helena, Veiga, Anna, Garcia-Arumi, Jose, Duarri, Anna et al.
DOI: 10.1186/s13287-021-02651-9
Ex-Press P50 device filtering failure due to non-visible intraluminal blockages.
PMID: 32838551
Journal: EUROPEAN JOURNAL OF OPHTHALMOLOGY
Year: 2021
Reference: Eur J Ophthalmol. 2021 Jul;31(4):1822-1828. doi: 10.1177/1120672120952032. Epub 2020 Aug 24.
Impact factor: 2.597
Publication type: Paper in international publication
Authors: Dou Saenz De Vizmanos, Antonio, Azarfane, Brahim, Castany Aregall, Marta, Rigo Quera, Jaume, Banderas Garcia, Sandra, Garcia Arumi, Josep et al.
DOI: 10.1177/1120672120952032
[Ocular leprosy: A case report].
PMID: 32778351
Journal: JOURNAL FRANCAIS D OPHTALMOLOGIE
Year: 2020
Reference: J Fr Ophtalmol. 2020 Nov;43(9):963-966. doi: 10.1016/j.jfo.2020.03.004. Epub 2020 Aug 7.
Impact factor: 0.636
Publication type: Letter or abstract
Authors: Berges, M, Cilveti, E, Kirkegaard, E, Azarfane, B, Bisbe, L et al.
DOI: 10.1016/j.jfo.2020.03.004
Delay in diagnosis resulting in corneal perforation: nucleic acid amplification tests for a rapid identification of ocular Neisseria gonorrhoeae infection.
PMID: 32703844
Journal: SEXUALLY TRANSMITTED INFECTIONS
Year: 2020
Reference: Sex Transm Infect. 2020 Dec;96(8):562. doi: 10.1136/sextrans-2020-054549. Epub 2020 Jul 23.
Impact factor: 3.396
Publication type: Letter or abstract
Authors: Sevilla, Nerea, Martin, Sara, Serra-Pladevall, Judit, Kirkegaard, Eric, Bisbe, Laia, Puig, Javier Jose et al.
DOI: 10.1136/sextrans-2020-054549
Author Correction: The LRRC8-mediated volume-regulated anion channel is altered in glaucoma.
PMID: 32632252
Journal: Scientific Reports
Year: 2020
Reference: Sci Rep. 2020 Jul 7;10(1):11443. doi: 10.1038/s41598-020-68525-x.
Impact factor: 3.998
Publication type: Letter or abstract
Authors: Gasull, Xavier, Castany, Marta, Castellanos, Aida, Rezola, Mikel, Andres-Bilbe, Alba, Canut, Maria Isabel, Estevez, Raul, Borras, Teresa, Comes, Nuria et al.
DOI: 10.1038/s41598-020-68525-x
Is optical coherence tomography angiography helpful in the differential diagnosis of choroidal nevus versus melanoma?
PMID: 31210061
Journal: EUROPEAN JOURNAL OF OPHTHALMOLOGY
Year: 2020
Reference: Eur J Ophthalmol. 2020 Jul;30(4):723-729. doi: 10.1177/1120672119851768. Epub 2019 Jun 18.
Impact factor: 1.642
Publication type: Paper in international publication
Authors: Garcia-Arumi Fuste, Claudia, Peralta Iturburu, Federico, Garcia-Arumi, Jose et al.
DOI: 10.1177/1120672119851768
The EX-PRESS glaucoma shunt versus nonpenetrating deep sclerectomy with Esnoper implant in combined surgery for open-angle glaucoma: a prospective randomized study.
PMID: 30714336
Journal: ACTA OPHTHALMOLOGICA
Year: 2019
Reference: Acta Ophthalmol. 2019 Nov;97(7):e952-e961. doi: 10.1111/aos.14023. Epub 2019 Feb 3.
Impact factor:
Publication type: Paper in international publication
Authors: Anton, Alfonso; Castany, Marta; Gil, Alfonso; Martinez, Alberto; Moreno-Montanes, Javier; Munoz, Marcos; Munoz-Negrete, Francisco J; Urcelay, Jose et al.
DOI: 10.1111/aos.14023
Effects of Topically Administered Neuroprotective Drugs in Early Stages of Diabetic Retinopathy. Results of the EUROCONDOR Clinical Trial.
PMID: 30389750
Journal: DIABETES
Year: 2019
Reference: Diabetes. 2019 Feb;68(2):457-463. doi: 10.2337/db18-0682. Epub 2018 Nov 2.
Impact factor:
Publication type: Paper in international publication
Authors: Aldington, Stephen J; Bandello, Francesco; Costa, Miguel Angelo; Cunha-Vaz, Jose; Egan, Catherine; Frydkjaer-Olsen, Ulrik; Garcia-Arumi, Jose; Gibson, Jonathan; Grauslund, Jakob; Harding, Simon P et al.
DOI: 10.2337/db18-0682
Long-term probability of intraocular pressure elevation with the intravitreal dexamethasone implant in the real-world.
PMID: 30608950
Journal: PLoS One
Year: 2019
Reference: PLoS One. 2019 Jan 4;14(1):e0209997. doi: 10.1371/journal.pone.0209997. eCollection 2019.
Impact factor:
Publication type: Paper in international publication
Authors: Adan, Alfredo; Boixadera, Anna; Copete, Sergio; Distefano, Laura; Figueras-Roca, Marc; Garcia-Arumi, Jose; Sala-Puigdollers, Anna; Velazquez-Villoria, Daniel; Zarranz-Ventura, Javier et al.
DOI: 10.1371/journal.pone.0209997
Diabetic retinopathy as an independent predictor of subclinical cardiovascular disease: baseline results of the PRECISED study.
PMID: 31908800
Journal: BMJ Open Diabetes Research & Care
Year: 2019
Reference: BMJ Open Diabetes Res Care. 2019 Dec 29;7(1):e000845. doi: 10.1136/bmjdrc-2019-000845. eCollection 2019.
Impact factor: 5.067
Publication type: Paper in international publication
Authors: Simo, Rafael, Baneras, Jordi, Hernandez, Cristina, Rodriguez-Palomares, Jose, Valente, Filipa, Gutierrez, Laura, Gonzalez-Alujas, Teresa, Ferreira, Ignacio, Aguade-Bruix, Santiago, Seron, Daniel et al.
DOI: 10.1136/bmjdrc-2019-000845
Guidelines for the Management of Diabetic Macular Edema by the European Society of Retina Specialists (EURETINA).
PMID: 28423385
Journal: OPHTHALMOLOGICA
Year: 2017
Reference: Ophthalmologica. 2017;237(4):185-222. doi: 10.1159/000458539. Epub 2017 Apr 20.
Impact factor: 1.742
Publication type: Clinical guide
Authors: Chakravarthy, Usha, Schmidt-Erfurth, Ursula, Garcia-Arumi, Jose, Bandello, Francesco, Berg, Karina, Larsen, Michael, Tadayoni, Ramin, Loewenstein, Anat, Jonas, Jost, Gerendas, Bianca S et al.
DOI: 10.1159/000458539
Combination of Anti-VEGF and Laser Photocoagulation for Diabetic Macular Edema: A Review.
PMID: 28348882
Journal: Journal of Ophthalmology
Year: 2017
Reference: J Ophthalmol. 2017;2017:2407037. doi: 10.1155/2017/2407037. Epub 2017 Feb 27.
Impact factor: 1.712
Publication type: Review in international publication
Authors: Distefano, Laura N, Garcia-Arumi, Jose, Martinez-Castillo, Vicente, Boixadera, Anna et al.
DOI: 10.1155/2017/2407037
Efficacy of immunomodulatory therapy with interferon-beta or glatiramer acetate on multiple sclerosis-associated uveitis.
PMID: 28188020
Journal: Archivos de la Sociedad Espanola de Oftalmologia
Year: 2017
Reference: Arch Soc Esp Oftalmol. 2017 Jun;92(6):273-279. doi: 10.1016/j.oftal.2016.11.018. Epub 2017 Feb 8.
Impact factor: 0
Publication type: Paper in national publication
Authors: Velazquez-Villoria, D, Macia-Badia, C, Segura-Garcia, A, Pastor Idoate, S, Arcos-Algaba, G, Velez-Escola, L, Garcia-Arumi, J et al.
DOI: 10.1016/j.oftal.2016.11.018
Telemedicine for a General Screening of Retinal Disease Using Nonmydriatic Fundus Cameras in Optometry Centers: Three-Year Results.
PMID: 27228051
Journal: Telemedicine and e-Health
Year: 2017
Reference: Telemed J E Health. 2017 Jan;23(1):30-36. doi: 10.1089/tmj.2016.0020. Epub 2016 May 26.
Impact factor: 2.031
Publication type: Paper in international publication
Authors: Zapata, Miguel A, Arcos, Gabriel, Fonollosa, Alex, Abraldes, Maximino, Olenik, Andrea, Gutierrez, Estanislao, Garcia-Arumi, Jose et al.
DOI: 10.1089/tmj.2016.0020
ENDORESECTION TECHNIQUE WITH/WITHOUT BRACHYTHERAPY FOR MANAGEMENT OF HIGH POSTERIOR CHOROIDAL MELANOMA: Extended Follow-up Results.
PMID: 25462434
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2015
Reference: Retina. 2015 Apr;35(4):628-37. doi: 10.1097/IAE.0000000000000379.
Impact factor: 3.177
Publication type: Paper in international publication
Authors: Velazquez, Daniel, Dinares-Fernandez, M Carme, Tresserra, Francesc, Corcostegui, Borja, Zapata, Miguel Angel, Leila, Mahmoud, Garcia-Arumi, Jose et al.
DOI: 10.1097/IAE.0000000000000379
A review of current management of vitreomacular traction and macular hole.
PMID: 25821592
Journal: Journal of Ophthalmology
Year: 2015
Reference: J Ophthalmol. 2015;2015:809640. doi: 10.1155/2015/809640. Epub 2015 Mar 3.
Impact factor: 1.425
Publication type: Paper in international publication
Authors: Garcia-Layana, Alfredo, Garcia-Arumi, Jose, Ruiz-Moreno, Jose M, Arias-Barquet, Lluis, Cabrera-Lopez, Francisco, Figueroa, Marta S et al.
DOI: 10.1155/2015/809640
Comparative study between fundus autofluorescence and red reflectance imaging of choroidal nevi using ultra-wide-field scanning laser ophthalmoscopy.
PMID: 25650707
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2015
Reference: Retina. 2015 Jun;35(6):1202-10. doi: 10.1097/IAE.0000000000000463.
Impact factor: 3.243
Publication type: Paper in international publication
Authors: Zapata, Miguel Angel, Leila, Mahmoud, Teixidor, Teresa, Garcia-Arumi, Jose et al.
DOI: 10.1097/IAE.0000000000000463
Endoresection of a high equatorial choroidal melanoma.
PMID: 25383839
Journal: Retinal cases & brief reports
Year: 2015
Reference: Retin Cases Brief Rep. 2015 Winter;9(1):30-2. doi: 10.1097/ICB.0000000000000081.
Impact factor:
Publication type: Letter or abstract
Authors: Garcia-Arumi, Jose, Distefano, Laura N, Quijano, Claudia et al.
DOI: 10.1097/ICB.0000000000000081
Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives.
PMID: 24183659
Journal: TRENDS ENDOCRIN MET
Year: 2014
Reference: Trends Endocrinol Metab. 2014 Jan;25(1):23-33. doi: 10.1016/j.tem.2013.09.005. Epub 2013 Nov 1.
Impact factor: 8.868
Publication type: Paper in international publication
Authors: Simo, Rafael, Hernandez, Cristina, Bandello, F, Burks, D, Cunha-Vaz, J, Egan, C, Garcia-Arumi, J, Gibson, J, Harding, S, Karadeniz, S et al.
DOI: 10.1016/j.tem.2013.09.005
Photodynamic therapy for symptomatic subretinal fluid related to choroidal nevus.
PMID: 22366902
Journal: RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
Year: 2012
Reference: Retina. 2012 May;32(5):936-41. doi: 10.1097/IAE.0b013e318232c366.
Impact factor: 2.812
Publication type: Paper in international publication
Authors: , , , , , , , , et al.
DOI: 10.1097/IAE.0b013e318232c366
Prospective clinical trial evaluating the efficacy of photodynamic therapy for symptomatic circumscribed choroidal hemangioma.
PMID: 18973950
Journal: OPHTHALMOLOGY
Year: 2009
Reference: Ophthalmology. 2009 Jan;116(1):100-105.e1.
Impact factor: 5.296
Publication type: Paper in international publication
Authors: Boixadera, Anna, Garcia-Arumi, Jose, Martinez-Castillo, Vicente, Encinas, Jose Luis, Elizalde, Javier, Blanco-Mateos, Gonzalo, Caminal, Jose, Capeans, Carmela, Armada, Felix, Navea, Amaparo et al.
DOI: 10.1016/j.ophtha.2008.08.029
Ocular syphilis--back again: understanding recent increases in the incidence of ocular syphilitic disease.
PMID: 19585365
Journal: OCULAR IMMUNOLOGY AND INFLAMMATION
Year: 2009
Reference: Ocul Immunol Inflamm. 2009 May-Jun;17(3):207-12.
Impact factor: 0.919
Publication type: Paper in international publication
Authors: Fonollosa, Alex, Giralt, Joan, Pelegrin, Laura, Sanchez-Dalmau, Bernat, Segura, Antonio, Garcia-Arumi, Jose, Adan, Alfredo et al.
DOI: 10.1080/09273940902741709
Pars plana vitrectomy alone with diffuse illumination and vitreous dissection to manage primary retinal detachment with unseen breaks.
PMID: 19822846
Journal: ARCHIVES OF OPHTHALMOLOGY
Year: 2009
Reference: Arch Ophthalmol. 2009 Oct;127(10):1297-304.
Impact factor: 3.242
Publication type: Paper in international publication
Authors: Martinez-Castillo, Vicente, Boixadera, Anna, Garcia-Arumi, Jose et al.
DOI: 10.1001/archophthalmol.2009.254
Interphotoreceptor retinoid-binding protein (IRBP) is downregulated at early stages of diabetic retinopathy.
PMID: 19823802
Journal: DIABETOLOGIA
Year: 2009
Reference: Diabetologia. 2009 Dec;52(12):2633-41.
Impact factor: 6.418
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1007/s00125-009-1548-8
News
On January 24, a session was held to explain what these three-dimensional models are and what advantages they have, as well as to review some of their applications in research.
Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.
Dr. José García Arumi and Dr. Anna Duarri from the Ophthalmology research group at Vall Hebron Recerca lead the project.