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Physiology and Pathophysiology of the Digestive Tract

The group of Physiology and Pathophysiology of the Digestive Tract focuses its research activity on the functioning of the digestive tract as a whole, including the functions of secretion, motility, absorption and barrier both in healthy individuals and in the presence of disease. The application of knowledge to clinical practice is a priority for the group.

Research in digestive motility encompasses disorders of visceral sensitivity, the brain-gut axis and intestinal allergy. Research on inflammation also includes the pancreas.

We have also launched a cross-sectional research program that focuses on the role of the gut microbiota in inflammation and gut function. 

 

Team

Teodora Pribic

Teodora Pribic

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Alejandro  Henao  Paez

Alejandro Henao Paez

Physiology and Pathophysiology of the Digestive Tract
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Ariadna Aguilar Cayuelas

Ariadna Aguilar Cayuelas

Research technician
Physiology and Pathophysiology of the Digestive Tract
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Beatriz Lobo Alvarez

Beatriz Lobo Alvarez

Main researcher
Physiology and Pathophysiology of the Digestive Tract
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Blanca Grases Pintó

Blanca Grases Pintó

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Claudia Maria Herrera de Guise

Claudia Maria Herrera de Guise

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Teodora Pribic

Teodora Pribic

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Alejandro  Henao  Paez

Alejandro Henao Paez

Physiology and Pathophysiology of the Digestive Tract
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Ariadna Aguilar Cayuelas

Ariadna Aguilar Cayuelas

Research technician
Physiology and Pathophysiology of the Digestive Tract
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Beatriz Lobo Alvarez

Beatriz Lobo Alvarez

Main researcher
Physiology and Pathophysiology of the Digestive Tract
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Blanca Grases Pintó

Blanca Grases Pintó

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Claudia Maria Herrera de Guise

Claudia Maria Herrera de Guise

Postdoctoral researcher
Physiology and Pathophysiology of the Digestive Tract
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Projects

Contribución diferencial del epitelio intestinal a la fisiopatología de la diarrea crónica en el síndrome del intestino irritable y la colitis microscópica. Perfil clínico-biológico para el diagnóstico diferencial.

IP: -
Collaborators: Beatriz Lobo Alvarez, Merce Albert Bayo, Inés de Torres Ramirez, Ana Maria Gonzalez Castro, Marc Pigrau Pastor, Xavier Serra Ruiz
Funding agency: Instituto de Salud Carlos III
Funding: 183920
Reference: PI19/01643
Duration: 01/01/2020 - 30/06/2024

Inflammatory Bowel Disease and Microbiome: Diagnosis and prediction of disease activity from the lab to the patients

IP: Chaysavanh Manichanh
Collaborators: Claudia Maria Herrera de Guise, Natalia Borruel Sainz, Francesc Casellas Jordá, Francisca Yañez Araya
Funding agency: Instituto de Salud Carlos III
Funding: 135520
Reference: PI20/00130
Duration: 01/01/2021 - 31/12/2024

H2O Health Outcomes Observatory

IP: Yolima Cossio Gil
Collaborators: Cristina Hernández Pascual, Natalia Borruel Sainz, Xavier Serra Ruiz, Gemma Galán Martinez
Funding agency: The Innovative Medicines Initiative
Funding: 1097257.5
Reference: H2O_IMI2-2020
Duration: 01/10/2020 - 30/09/2025

Publications

An integral approach to the molecular diagnosis of tuberous sclerosis complex: the role of mosaicism and splicing variants.

PMID: 37356622
Journal: JOURNAL OF MOLECULAR DIAGNOSTICS
Year: 2023
Reference: J Mol Diagn. 2023 Jun 23:S1525-1578(23)00134-4. doi: 10.1016/j.jmoldx.2023.06.006.
Impact factor:
Publication type: Paper in international publication
Authors: Antolin, Maria; Blasco-Perez, Laura; Camprodon-Gomez, Maria; Garcia-Arumi, Elena; Iranzo-Nuez, Leticia; Lopez-Ortega, Ricard; Martinez-Cruz, Desiree; Tenes, Anna; Tizzano, Eduardo F et al.
DOI: 10.1016/j.jmoldx.2023.06.006

Methods for Evaluating the Efficacy of Medical Castration: A Systematic Review.

PMID: 37444589
Journal: Cancers
Year: 2023
Reference: Cancers (Basel). 2023 Jul 3;15(13):3479. doi: 10.3390/cancers15133479.
Impact factor:
Publication type: Review in international publication
Authors: Aguilar, Adriana; Morote, Juan; Planas, Jacques; Trilla, Enrique et al.
DOI: 10.3390/cancers15133479

Distinctive gastrointestinal motor dysfunction in patients with MNGIE.

PMID: 37448106
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2023
Reference: Neurogastroenterol Motil. 2023 Jul 13:e14643. doi: 10.1111/nmo.14643.
Impact factor:
Publication type: Paper in international publication
Authors: Accarino, Anna; Alcala-Gonzalez, Luis G; Azpiroz, Fernando; Llaurado, Arnau; Malagelada, Carolina; Ramon, Ramon; Sanchez-Tejerina, Daniel et al.
DOI: 10.1111/nmo.14643

Metabolic response of intestinal microbiota to guar gum consumption.

PMID: 37457982
Journal: Frontiers in Nutrition
Year: 2023
Reference: Front Nutr. 2023 Jun 30;10:1160694. doi: 10.3389/fnut.2023.1160694. eCollection 2023.
Impact factor:
Publication type: Paper in international publication
Authors: Azpiroz, Fernando; Barber, Claudia; Guarner, Francisco; Margolles, Abelardo; Sabater, Carlos et al.
DOI: 10.3389/fnut.2023.1160694

Elevated Serum Triglyceride Levels in Acute Pancreatitis: A Parameter to be Measured and Considered Early.

PMID: 35355100
Journal: WORLD JOURNAL OF SURGERY
Year: 2022
Reference: World J Surg. 2022 Jul;46(7):1758-1767. doi: 10.1007/s00268-022-06533-w. Epub 2022 Mar 30.
Impact factor: 3.352
Publication type: Paper in international publication
Authors: Charco, Ramon, Balsells, Joaquim, Molero, Xavier, Tasayco, Stephanie, Blanco, Laia, Hidalgo, Nils Jimmy, Pando, Elizabeth, Alberti, Piero, Vidal, Laura, Mata, Rodrigo et al.
DOI: 10.1007/s00268-022-06533-w

Effect of colonic distension on small bowel motility measured by jejunal high-resolution manometry.

PMID: 35318777
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2022
Reference: Neurogastroenterol Motil. 2022 Mar 22:e14351. doi: 10.1111/nmo.14351.
Impact factor: 3.598
Publication type: Paper in international publication
Authors: Alcala, Luis G, Malagelada, Carolina, Livovsky, Dan M, Azpiroz, Fernando et al.
DOI: 10.1111/nmo.14351

Health-related quality of life decline in clinically stable inflammatory bowel disease patients during the COVID-19 outbreak.

PMID: 35297257
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2022
Reference: Rev Esp Enferm Dig. 2022 Mar 17. doi: 10.17235/reed.2022.8668/2022.
Impact factor: 2.086
Publication type: Paper in international publication
Authors: Perez Martinez, Zahira, Casellas, Francesc, Ibarz, Arantxa, Borruel Sainz, Natalia, Serra Ruiz, Xavier, Herrera-de Guise, Claudia, Mayorga Ayala, Luis Fernando, Robles Alonso, Virginia et al.
DOI: 10.17235/reed.2022.8668/2022

Pancreatitis crónica para el clínico. Parte 2: Tratamiento y seguimiento. Documento de posicionamiento interdisciplinar de la Societat Catalana de Digestologia y la Societat Catalana de Pàncrees (versión castellana)

PMID: 34171422
Journal: Gastroenterologia y Hepatologia
Year: 2022
Reference: Gastroenterol Hepatol. 2022 Apr;45(4):304-314. doi: 10.1016/j.gastrohep.2021.05.016. Epub 2021 Jun 23.
Impact factor: 2.102
Publication type: Paper in national publication
Authors: Molero, Xavier, Ayuso, Juan Ramon, Balsells, Joaquim, Boadas, Jaume, Busquets, Juli, Casteras, Anna, Concepcion, Mar, Cuatrecasas, Miriam, Esparrach, Gloria Fernandez, Fort, Esther et al.
DOI: 10.1016/j.gastrohep.2021.05.016

Normalization of long-term quality of life in Crohn's disease patients receiving ustekinumab.

PMID: 33213168
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2021
Reference: Rev Esp Enferm Dig. 2021 May;113(5):313-317. doi: 10.17235/reed.2020.6941/2020.
Impact factor: 2.086
Publication type: Paper in national publication
Authors: Marques Cami, Miquel, Robles Alonso, Virginia, Borruel Sainz, Natalia, Herrera de Guise, Claudia, Mayorga Ayala, Luis, Casellas Jorda, Francesc et al.
DOI: 10.17235/reed.2020.6941/2020

Gastrointestinal Contributions to the Postprandial Experience.

PMID: 33801924
Journal: Nutrients
Year: 2021
Reference: Nutrients. 2021 Mar 10;13(3). pii: nu13030893. doi: 10.3390/nu13030893.
Impact factor: 5.719
Publication type: Review in international publication
Authors: Livovsky, Dan M, Azpiroz, Fernando et al.
DOI: 10.3390/nu13030893

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): Position paper on diagnosis, prognosis, and treatment by the MNGIE International Network.

PMID: 32898308
Journal: JOURNAL OF INHERITED METABOLIC DISEASE
Year: 2021
Reference: J Inherit Metab Dis. 2021 Mar;44(2):376-387. doi: 10.1002/jimd.12300. Epub 2020 Sep 8.
Impact factor: 4.982
Publication type: Review in international publication
Authors: Hirano, Michio, Carelli, Valerio, De Giorgio, Roberto, Pironi, Loris, Accarino, Anna, Cenacchi, Giovanna, D'Alessandro, Roberto, Filosto, Massimiliano, Marti, Ramon, Nonino, Francesco et al.
DOI: 10.1002/jimd.12300

Fungal and Bacterial Loads: Noninvasive Inflammatory Bowel Disease Biomarkers for the Clinical Setting.

PMID: 33758031
Journal: mSystems
Year: 2021
Reference: mSystems. 2021 Mar 23;6(2). pii: 6/2/e01277-20. doi: 10.1128/mSystems.01277-20.
Impact factor: 6.496
Publication type: Paper in international publication
Authors: Sarrabayrouse, G, Elias, A, Yanez, F, Mayorga, L, Varela, E, Bartoli, C, Casellas, F, Borruel, N, Herrera de Guise, C, Machiels, K et al.
DOI: 10.1128/mSystems.01277-20

Endoscopic stenting for gastroduodenal outlet obstruction of a malignant origin, real life experience in a single center.

PMID: 32496109
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2020
Reference: Rev Esp Enferm Dig. 2020 Sep;112(9):712-715. doi: 10.17235/reed.2020.6600/2019.
Impact factor: 1.591
Publication type: Paper in international publication
Authors: Armengol Bertroli, Jordi, Pascasio-Hernandez, Mario Jose, Benages Curell, Anna, Castillo Cejas, Maria Dolores, Pigrau Pastor, Marc, Sihuay Diburga, Denisse, Guevara Cubas, Jorge, Castro-Reyes, Luz Maria, Jimenez Hernandez, Cesar, Tasayco Huaman, Stephanie et al.
DOI: 10.17235/reed.2020.6600/2019

Motor dysfunction of the gut in cystic fibrosis.

PMID: 32475007
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2020
Reference: Neurogastroenterol Motil. 2020 Sep;32(9):e13883. doi: 10.1111/nmo.13883. Epub 2020 May 31.
Impact factor: 2.946
Publication type: Paper in international publication
Authors: Malagelada, Carolina, Bendezu, R-Alvaro, Segui, Santi, Vitria, Jordi, Merino, Xavier, Nieto, Adoracion, Sihuay, Denisse, Accarino, Anna, Molero, Xavier, Azpiroz, Fernando et al.
DOI: 10.1111/nmo.13883

Leishmania infantum asymptomatic infection in inflammatory bowel disease patients under anti-TNF therapy.

PMID: 32420499
Journal: Heliyon
Year: 2020
Reference: Heliyon. 2020 May 8;6(5):e03940. doi: 10.1016/j.heliyon.2020.e03940. eCollection 2020 May.
Impact factor: 0
Publication type: Paper in international publication
Authors: Guillen, M Carmen, Alcover, M Magdalena, Borruel, Natalia, Sulleiro, Elena, Salvador, Fernando, Berenguer, Diana, Herrera-de Guise, Claudia, Rodriguez, Veronica, Moure, Zaira, Sanchez-Montalva, Adrian et al.
DOI: 10.1016/j.heliyon.2020.e03940

International Consensus Guidelines for Risk Factors in Chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club.

PMID: 32376198
Journal: PANCREATOLOGY
Year: 2020
Reference: Pancreatology. 2020 Jun;20(4):579-585. doi: 10.1016/j.pan.2020.03.014. Epub 2020 Apr 8.
Impact factor: 3.629
Publication type: Review in international publication
Authors: Hegyi, Peter, Parniczky, Andrea, Lerch, Markus M, Sheel, Andrea R G, Rebours, Vinciane, Forsmark, Chris E, Del Chiaro, Marco, Rosendahl, Jonas, de-Madaria, Enrique, Szucs, Akos et al.
DOI: 10.1016/j.pan.2020.03.014

Antibiotic therapy in acute pancreatitis: From global overuse to evidence based recommendations.

PMID: 31068256
Journal: PANCREATOLOGY
Year: 2019
Reference: Pancreatology. 2019 Jun;19(4):488-499. doi: 10.1016/j.pan.2019.04.003. Epub 2019 Apr 19.
Impact factor: 3.241
Publication type: Paper in international publication
Authors: Szepes, Zoltan, Miko, Alexandra, Mosztbacher, Dora, Nemeth, Balazs Csaba, Pecsi, Daniel, Szabo, Aniko, Szucs, Akos, Varju, Peter, Szentesi, Andrea, Darvasi, Erika et al.
DOI: 10.1016/j.pan.2019.04.003

The experience of inflammatory bowel disease patients with healthcare: A survey with the IEXPAC instrument.

PMID: 30946348
Journal: MEDICINE
Year: 2019
Reference: Medicine (Baltimore). 2019 Apr;98(14):e15044. doi: 10.1097/MD.0000000000015044.
Impact factor: 1.87
Publication type: Paper in international publication
Authors: Marin-Jimenez, Ignacio, Casellas, Francesc, Cortes, Xavier, Garcia-Sepulcre, Mariana F, Julia, Berta, Cea-Calvo, Luis, Soto, Nadia, Navarro-Correal, Ester, Saldana, Roberto, de Toro, Javier et al.
DOI: 10.1097/MD.0000000000015044

Biological Response to Meal Ingestion: Gender Differences.

PMID: 30917512
Journal: Nutrients
Year: 2019
Reference: Nutrients. 2019 Mar 26;11(3). pii: nu11030702. doi: 10.3390/nu11030702.
Impact factor: 4.171
Publication type: Paper in international publication
Authors: Amigo, Nuria, Accarino, Anna, Correig, Xavier, Azpiroz, Fernando, Nieto, Adoracion, Galan, Carmen, Borghi, Giulio, Monrroy, Hugo, Pribic, Teodora et al.
DOI: 10.3390/nu11030702

Non-invasive Prediction of High-risk Varices in Patients with Primary Biliary Cholangitis and Primary Sclerosing Cholangitis.

PMID: 30315285
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2019
Reference: Am J Gastroenterol. 2019 Mar;114(3):446-452. doi: 10.1038/s41395-018-0265-7.
Impact factor: 10.241
Publication type: Paper in international publication
Authors: Tasayco-Huaman, Stephanie, Moctezuma-Velazquez, Carlos, Saffioti, Francesca, Roccarina, Davide, Vargas, Victor, Nilsson, Jan-Erick, Tsochatzis, Emmanuel, Augustin, Salvador, Montano-Loza, Aldo J, Berzigotti, Annalisa et al.
DOI: 10.1038/s41395-018-0265-7

Functional neuromuscular impairment in severe intestinal dysmotility.

PMID: 30178519
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2018
Reference: Neurogastroenterol Motil. 2018 Dec;30(12):e13458. doi: 10.1111/nmo.13458. Epub 2018 Sep 3.
Impact factor: 3.842
Publication type: Paper in international publication
Authors: Gallego, Diana, Malagelada, Carolina, Accarino, Anna, Gori, Alessandra, Malagelada, Juan Ramon, Azpiroz, Fernando, De Giorgio, Roberto, Jimenez, Marcel et al.
DOI: 10.1111/nmo.13458

Metabolomic signature of the postprandial experience.

PMID: 30101554
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2018
Reference: Neurogastroenterol Motil. 2018 Dec;30(12):e13447. doi: 10.1111/nmo.13447. Epub 2018 Aug 13.
Impact factor: 3.842
Publication type: Paper in international publication
Authors: Gomez, Josep, Amigo, Nuria, Accarino, Anna, Correig, Xavier, Azpiroz, Fernando, Canellas, Nicolau, Ciccantelli, Barbara, Malagelada, Carolina, Pribic, Teodora et al.
DOI: 10.1111/nmo.13447

Th1-skewed profile and excessive production of proinflammatory cytokines in a NFKB1-deficient patient with CVID and severe gastrointestinal manifestations.

PMID: 30063981
Journal: CLINICAL IMMUNOLOGY
Year: 2018
Reference: Clin Immunol. 2018 Oct;195:49-58. doi: 10.1016/j.clim.2018.07.015. Epub 2018 Jul 29.
Impact factor: 3.557
Publication type: Paper in international publication
Authors: Dieli-Crimi, Romina, Martinez-Gallo, Monica, Franco-Jarava, Clara, Antolin, Maria, Blasco, Laura, Paramonov, Ida, Semidey, Maria E, Fernandez, Antoni Alvarez, Velasquez, Julio, Martin-Nalda, Andrea et al.
DOI: 10.1016/j.clim.2018.07.015

Effects of Prebiotics vs a Diet Low in Fodmaps in Patients with Functional Gut Disorder.

PMID: 29964041
Journal: GASTROENTEROLOGY
Year: 2018
Reference: Gastroenterology. 2018 Oct;155(4):1004-1007. doi: 10.1053/j.gastro.2018.06.045. Epub 2018 Jun 30.
Impact factor: 20.773
Publication type: Paper in international publication
Authors: Huaman, Jose-Walter, Mego, Marianela, Manichanh, Chaysavanh, Canellas, Nicolau, Canueto, Daniel, Segurola, Hegoi, Jansana, Marta, Malagelada, Carolina, Accarino, Anna, Vulevic, Jelena et al.
DOI: 10.1053/j.gastro.2018.06.045

Bloating and Abdominal Distension: Old Misconceptions and Current Knowledge.

PMID: 28508867
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2017
Reference: Am J Gastroenterol. 2017 Aug;112(8):1221-1231. doi: 10.1038/ajg.2017.129. Epub 2017 May 16.
Impact factor: 9.566
Publication type: Review in national publication
Authors: Malagelada, Juan R, Accarino, Anna, Azpiroz, Fernando et al.
DOI: 10.1038/ajg.2017.129

Small Bowel Motility.

PMID: 28429202
Journal: Current gastroenterology reports
Year: 2017
Reference: Curr Gastroenterol Rep. 2017 Jun;19(6):26. doi: 10.1007/s11894-017-0565-x.
Impact factor: 0
Publication type: Review in national publication
Authors: Malagelada, Carolina, Malagelada, Juan R et al.
DOI: 10.1007/s11894-017-0565-x

Colonic gas homeostasis: Mechanisms of adaptation following HOST-G904 galactooligosaccharide use in humans.

PMID: 28418214
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2017
Reference: Neurogastroenterol Motil. 2017 Sep;29(9). doi: 10.1111/nmo.13080. Epub 2017 Apr 18.
Impact factor: 3.617
Publication type: Paper in international publication
Authors: Mego, M, Accarino, A, Tzortzis, G, Vulevic, J, Gibson, G, Guarner, F, Azpiroz, F et al.
DOI: 10.1111/nmo.13080

A systems approach identifies time-dependent associations of multimorbidities with pancreatic cancer risk.

PMID: 28383714
Journal: ANNALS OF ONCOLOGY
Year: 2017
Reference: Ann Oncol. 2017 Jul 1;28(7):1618-1624. doi: 10.1093/annonc/mdx167.
Impact factor: 11.855
Publication type: Paper in international publication
Authors: Barbera, V M, Gomez-Rubio, P, Rosato, V, Marquez, M, Bosetti, C, Molina-Montes, E, Rava, M, Pinero, J, Michalski, C W, Farre, A et al.
DOI: 10.1093/annonc/mdx167

Evidence-based Guidelines for the Management of Exocrine Pancreatic Insufficiency After Pancreatic Surgery.

PMID: 27045859
Journal: ANNALS OF SURGERY
Year: 2016
Reference: Ann Surg. 2016 Dec;264(6):949-958.
Impact factor: 8.569
Publication type: Paper in international publication
Authors: Marra-Lopez, Carlos, Sabater, Luis, Ausania, Fabio, Bakker, Olaf J, Boadas, Jaume, Dominguez-Munoz, J Enrique, Falconi, Massimo, Fernandez-Cruz, Laureano, Frulloni, Luca, Gonzalez-Sanchez, Victor et al.
DOI: 10.1097/SLA.0000000000001732

Perception of lactose intolerance impairs health-related quality of life.

PMID: 27188918
Journal: EUROPEAN JOURNAL OF CLINICAL NUTRITION
Year: 2016
Reference: Eur J Clin Nutr. 2016 Sep;70(9):1068-72. doi: 10.1038/ejcn.2016.80. Epub 2016 May 18.
Impact factor: 2.935
Publication type: Paper in international publication
Authors: Casellas, F, Aparici, A, Perez, M J, Rodriguez, P et al.
DOI: 10.1038/ejcn.2016.80

Colonic content in health and its relation to functional gut symptoms.

PMID: 26871593
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2016
Reference: Neurogastroenterol Motil. 2016 Jun;28(6):849-54. doi: 10.1111/nmo.12782. Epub 2016 Feb 12.
Impact factor: 3.31
Publication type: Paper in international publication
Authors: Bendezu, R A, Barba, E, Burri, E, Cisternas, D, Accarino, A, Quiroga, S, Monclus, E, Navazo, I, Malagelada, J-R, Azpiroz, F et al.
DOI: 10.1111/nmo.12782

Health-related quality of life and determinant factors in celiac disease. A population-based analysis of adult patients in Spain.

PMID: 26901502
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2016
Reference: Rev Esp Enferm Dig. 2016 Apr;108(4):181-9. doi: 10.17235/reed.2016.4094/2015.
Impact factor: 1.455
Publication type: Paper in international publication
Authors: Rodriguez Almagro, Julian, Hernandez Martinez, Antonio, Lucendo, Alfredo Jose, Casellas, Francesc, Solano Ruiz, Maria Carmen, Siles Gonzalez, Jose et al.
DOI: 10.17235/reed.2016.4094/2015

Intestinal gas content and distribution in health and in patients with functional gut symptoms.

PMID: 26095329
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2015
Reference: Neurogastroenterol Motil. 2015 Sep;27(9):1249-57. doi: 10.1111/nmo.12618. Epub 2015 Jun 21.
Impact factor: 3.587
Publication type: Paper in international publication
Authors: Malagelada, C, Segui, S, Accarino, A, Quiroga, S, Monclus, E, Navazo, I, Malagelada, J-R, Azpiroz, F, Cisternas, D, Burri, E et al.
DOI: 10.1111/nmo.12618

Intestinal gas homeostasis: disposal pathways.

PMID: 25581042
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2015
Reference: Neurogastroenterol Motil. 2015 Mar;27(3):363-369. doi: 10.1111/nmo.12498. Epub 2015 Jan 4.
Impact factor: 3.587
Publication type: Paper in international publication
Authors: Mego, M, Bendezu, A, Accarino, A, Malagelada, J-R, Azpiroz, F et al.
DOI: 10.1111/nmo.12498

Safety of probiotics and synbiotics in children under 18 years of age.

PMID: 25809217
Journal: Beneficial Microbes
Year: 2015
Reference: Benef Microbes. 2015 Oct 15;6(5):615-30. doi: 10.3920/BM2014.0157. Epub 2015 Apr 22.
Impact factor: 2.614
Publication type: Paper in international publication
Authors: van den Nieuwboer, M, Brummer, R J, Guarner, F, Morelli, L, Cabana, M, Claassen, E et al.
DOI: 10.3920/BM2014.0157

Accumulative effect of food residues on intestinal gas production.

PMID: 26303858
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2015
Reference: Neurogastroenterol Motil. 2015 Nov;27(11):1621-8. doi: 10.1111/nmo.12662. Epub 2015 Aug 25.
Impact factor: 3.587
Publication type: Paper in international publication
Authors: Mego, M, Accarino, A, Malagelada, J-R, Guarner, F, Azpiroz, F et al.
DOI: 10.1111/nmo.12662

From basic to applied research: lessons from the human microbiome projects.

PMID: 25291122
Journal: J CLIN GASTROENTEROL
Year: 2014
Reference: J Clin Gastroenterol. 2014 Nov-Dec;48 Suppl 1:S3-4. doi: 10.1097/MCG.0000000000000242.
Impact factor: 3.186
Publication type: Paper in international publication
Authors: Guarner, Francisco, Robles-Alonso, Virginia et al.
DOI: 10.1097/MCG.0000000000000242

Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes.

PMID: 24997787
Journal: NAT BIOTECHNOL
Year: 2014
Reference: Nat Biotechnol. 2014 Aug;32(8):822-8. doi: 10.1038/nbt.2939. Epub 2014 Jul 6.
Impact factor: 39.08
Publication type: Paper in international publication
Authors: Levenez, Florence, Nielsen, Trine, Manichanh, Chaysavanh, Arumugam, Manimozhiyan, Batto, Jean-Michel, Quintanilha Dos Santos, Marcelo B, Blom, Nikolaj, Borruel, Natalia, Burgdorf, Kristoffer S, Boumezbeur, Fouad et al.
DOI: 10.1038/nbt.2939

Microbiome Composition by Pyrosequencing in Mesenteric Lymph Nodes of Rats with CCl-Induced Cirrhosis.

PMID: 24296725
Journal: J INNATE IMMUN
Year: 2014
Reference: J Innate Immun. 2014;6(3):263-71. doi: 10.1159/000356454. Epub 2013 Nov 29.
Impact factor: 4.557
Publication type: Paper in international publication
Authors: Manichanh, Chaysavanh, Guarner, Carlos, Soriano, German, Sancho, Francesc, Cuenca, Silvia, Sanchez, Elisabet, Santiago, Alba, El Khader, Ismail, Panda, Suchita, Vidal, Silvia et al.
DOI: 10.1159/000356454

Transcultural adaptation and validation of the Celiac Disease Quality of Life (CD-QOL) survey, a specific questionnaire to measure quality of life in patients with celiac disease.

PMID: 24641455
Journal: REV ESP ENFERM DIG
Year: 2014
Reference: Rev Esp Enferm Dig. 2014 Dec;105(10):585-593.
Impact factor: 1.317
Publication type: Paper in national publication
Authors: Lopez-Vivancos, J, Duenas, C, Casellas, F, Rodrigo, L, Molina-Infante, J, Vivas, S, Lucendo, A J, Rosinach, M, Fernandez-Banares, F et al.
DOI:

Adaptable image cuts for motility inspection using WCE.

PMID: 23098835
Journal: COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
Year: 2013
Reference: Comput Med Imaging Graph. 2013 Jan;37(1):72-80. doi: 10.1016/j.compmedimag.2012.09.002. Epub 2012 Oct 23.
Impact factor: 1.664
Publication type: Paper in international publication
Authors: Drozdzal, Michal, Vitria, Jordi, Malagelada, Carolina, Azpiroz, Fernando, Radeva, Petia, Segui, Santi et al.
DOI: 10.1016/j.compmedimag.2012.09.002

The Spanish Pancreatic Club's recommendations for the diagnosis and treatment of chronic pancreatitis: part 2 (treatment).

PMID: 23395565
Journal: PANCREATOLOGY
Year: 2013
Reference: Pancreatology. 2013 Jan-Feb;13(1):18-28. doi: 10.1016/j.pan.2012.11.310. Epub 2012 Nov 27.
Impact factor: 2.043
Publication type: Paper in international publication
Authors: Farre, A, de-Madaria, E, Abad-Gonzalez, A, Aparicio, J R, Aparisi, L, Boadas, J, Boix, E, de-Las-Heras, G, Dominguez-Munoz, E, Iglesias-Garcia, J et al.
DOI: 10.1016/j.pan.2012.11.310

Impact of orocecal transit time on patient s perception of lactose intolerance.

PMID: 23548006
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2013
Reference: Rev Esp Enferm Dig. 2013 Jan;105(1):13-18.
Impact factor: 1.652
Publication type: Paper in national publication
Authors: Casellas, F, Aparici, A, Casaus, M, Rodriguez, P, Malagelada, J R et al.
DOI:

Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier.

PMID: 22637702
Journal: GUT
Year: 2013
Reference: Gut. 2013 Aug;62(8):1160-8. doi: 10.1136/gutjnl-2012-302093. Epub 2012 May 25.
Impact factor: 10.732
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1136/gutjnl-2012-302093

Functional gut disorders or disordered gut function? Small bowel dysmotility evidenced by an original technique.

PMID: 22129212
Journal: NEUROGASTROENTEROLOGY AND MOTILITY
Year: 2012
Reference: Neurogastroenterol Motil. 2012 Mar;24(3):223-8, e104-5. doi: 10.1111/j.1365-2982.2011.01823.x. Epub 2011 Nov 30.
Impact factor: 3.414
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1111/j.1365-2982.2011.01823.x

The Jejunum of Diarrhea-Predominant Irritable Bowel Syndrome Shows Molecular Alterations in the Tight Junction Signaling Pathway That Are Associated With Mucosal Pathobiology and Clinical Manifestations.

PMID: 22415197
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2012
Reference: Am J Gastroenterol. 2012 May;107(5):736-46. doi: 10.1038/ajg.2011.472. Epub 2012 Mar 13.
Impact factor: 7.282
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1038/ajg.2011.472

Restoration of quality of life of patients with inflammatory bowel disease after one year with antiTNFalpha treatment.

PMID: 22398074
Journal: Journal of Crohns & Colitis
Year: 2012
Reference: J Crohns Colitis. 2012 Oct;6(9):881-6. doi: 10.1016/j.crohns.2012.01.019. Epub 2012 Feb 14.
Impact factor: 2.566
Publication type: Paper in international publication
Authors: , , , , , , et al.
DOI: 10.1016/j.crohns.2012.01.019

Chronic psychosocial stress induces reversible mitochondrial damage and corticotropin-releasing factor receptor type-1 upregulation in the rat intestine and IBS-like gut dysfunction.

PMID: 21641728
Journal: PSYCHONEUROENDOCRINOLOGY
Year: 2012
Reference: Psychoneuroendocrinology. 2012 Jan;37(1):65-77. Epub 2011 Jun 8.
Impact factor: 5.809
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1016/j.psyneuen.2011.05.005

Abdomino-phrenic dyssynergia in patients with abdominal bloating and distension.

PMID: 21540894
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2011
Reference: Am J Gastroenterol. 2011 May;106(5):815-9.
Impact factor: 6.882
Publication type: Paper in international publication
Authors: Villoria, Albert, Azpiroz, Fernando, Burri, Emanuel, Cisternas, Daniel, Soldevilla, Alfredo, Malagelada, Juan-R et al.
DOI: 10.1038/ajg.2010.408

Enterotypes of the human gut microbiome.

PMID: 21508958
Journal: NATURE
Year: 2011
Reference: Nature. 2011 May 12;473(7346):174-80. Epub 2011 Apr 20.
Impact factor: 36.101
Publication type: Paper in international publication
Authors: , , , , , , , , , et al.
DOI: 10.1038/nature09944

Transforming growth factor-beta type 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis.

PMID: 21465486
Journal: JOURNAL OF PATHOLOGY
Year: 2011
Reference: J Pathol. 2011 Aug;224(4):461-72. doi: 10.1002/path.2870. Epub 2011 Apr 4.
Impact factor: 7.274
Publication type: Paper in international publication
Authors: , , , , , , , et al.
DOI: 10.1002/path.2870

A novel nonstop mutation in TYMP does not induce nonstop mRNA decay in a MNGIE patient with severe neuropathy.

PMID: 21412940
Journal: HUMAN MUTATION
Year: 2011
Reference: Hum Mutat. 2011 Apr;32(4):E2061-8. doi: 10.1002/humu.21447. Epub 2011 Jan 18.
Impact factor: 5.956
Publication type: Paper in international publication
Authors: Pinos, Tomas, Accarino, Anna, Andreu, Antoni L, Pintos-Morell, Guillem, Martii, Ramon, Rodriguez-Palmero, Agusti, Torres-Torronteras, Javier et al.
DOI: 10.1002/humu.21447

Normal values in ambulatory oesophageal pH monitoring at two levels in Spain.

PMID: 20617860
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2010
Reference: Rev Esp Enferm Dig. 2010 Jul;102(7):406-12.
Impact factor: 0.994
Publication type: Paper in national publication
Authors: Mearin, F, Minguez, M, Mones, J, Mora, F, Munoz, C, Perez de la Serna, J, Ponce, J, Rodriguez-Tellez, M, Romero, M J, Ruiz de Leon, A et al.
DOI:

Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress.

PMID: 20600818
Journal: BRAIN BEHAVIOR AND IMMUNITY
Year: 2010
Reference: Brain Behav Immun. 2010 Oct;24(7):1166-75. Epub 2010 Jun 25.
Impact factor: 5.061
Publication type: Paper in international publication
Authors: Vicario, Maria, Guilarte, Mar, Alonso, Carmen, Yang, Pinchang, Martinez, Cristina, Gonzalez, Ana, Guila, Meritxell, Pigrau, Marc, Saperas, Esteban, Azpiroz, Fernando et al.
DOI: 10.1016/j.bbi.2010.06.002

Influence of colectomy on hydrogen excretion in breath.

PMID: 19902224
Journal: INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
Year: 2010
Reference: Int J Colorectal Dis. 2010 Apr;25(4):485-9. Epub 2009 Nov 10.
Impact factor: 2.102
Publication type: Paper in international publication
Authors: Guarner, F, Casaus, M, Casellas, Francesc, Torrejon, A, Vilaseca, J, Aparici, A, Rodriguez, P et al.
DOI: 10.1007/s00384-009-0832-x

Intestinal motility assessment with video capsule endoscopy: automatic annotation of phasic intestinal contractions.

PMID: 19423434
Journal: IEEE TRANSACTIONS ON MEDICAL IMAGING
Year: 2010
Reference: IEEE Trans Med Imaging. 2010 Feb;29(2):246-59. Epub 2009 May 5.
Impact factor: 3.54
Publication type: Paper in international publication
Authors: Vilarino, Fernando, Spyridonos, Panagiota, Deiorio, Fosca, Vitria, Jordi, Azpiroz, Fernando, Radeva, Petia et al.
DOI: 10.1109/TMI.2009.2020753

Non-anatomical intestinal transplantation.

PMID: 19335051
Journal: REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
Year: 2009
Reference: Rev Esp Enferm Dig. 2009 Feb;101(2):139-41, 141-3.
Impact factor: 1.263
Publication type: Paper in national publication
Authors: Armengol-Miro, J R, Azpiroz, F, Accarino, A, Planas, M, Dot, J, Charco, R, Malagelada, C, Llopart, L, Bueno, J, Bilbao, I et al.
DOI:

Adhesion properties of Lactobacillus casei strains to resected intestinal fragments and components of the extracellular matrix.

PMID: 18974977
Journal: ARCHIVES OF MICROBIOLOGY
Year: 2009
Reference: Arch Microbiol. 2009 Feb;191(2):153-61.
Impact factor: 1.975
Publication type: Paper in international publication
Authors: Munoz-Provencio, Diego, Llopis, Marta, Antolin, Maria, de Torres, Ines, Guarner, Francisco, Perez-Martinez, Gaspar, Monedero, Vicente et al.
DOI: 10.1007/s00203-008-0436-9

Abdominal distention results from caudo-ventral redistribution of contents.

PMID: 19208364
Journal: GASTROENTEROLOGY
Year: 2009
Reference: Gastroenterology. 2009 May;136(5):1544-51.
Impact factor: 12.591
Publication type: Paper in international publication
Authors: Accarino, Anna, Perez, Frederic, Azpiroz, Fernando, Quiroga, Sergi, Malagelada, Juan-R et al.
DOI: 10.1053/j.gastro.2009.01.067

Management of painful chronic pancreatitis with single-dose radiotherapy.

PMID: 19190609
Journal: AMERICAN JOURNAL OF GASTROENTEROLOGY
Year: 2009
Reference: Am J Gastroenterol. 2009 Feb;104(2):349-55.
Impact factor: 6.444
Publication type: Paper in international publication
Authors: Malagelada, J-R, Molero, Xavier, Guarner, Luisa, Navalpotro, Begona, Giralt, Jordi et al.
DOI: 10.1038/ajg.2008.128

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Among the genes described, there are some related to digestive system functions, which reinforces the biological entity of irritable bowel syndrome as a digestive disease.

The international study, in which Vall d'Hebron participated, monitored patients who were hospitalized for COVID-19 for 12 months and compared their gastrointestinal symptoms with another group of patients diagnosed with other medical pathologies.

Els estudis avançaran en els camps de les malalties digestives, el VIH, la fatiga crònica, les patologies cardíaques, l’hepatitis, la diabetis i l’oftalmologia.