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The science produced by our scientists is very important. In 2022, 1,629 papers were published in scientific journals with a global impact factor of over 15,000 points.

Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study.

PMID: 25877855
Journal: LANCET ONCOLOGY
Year: 2015
Reference: Lancet Oncol. 2015 May;16(5):499-508. doi: 10.1016/S1470-2045(15)70127-0. Epub 2015 Apr 12.
Impact factor: 24.69
Publication type: Paper in international publication
Authors: Laplaige, Philippe, Tabernero, Josep, Yoshino, Takayuki, Cohn, Allen Lee, Obermannova, Radka, Bodoky, Gyorgy, Garcia-Carbonero, Rocio, Ciuleanu, Tudor-Eliade, Portnoy, David C, Van Cutsem, Eric et al.
DOI: 10.1016/S1470-2045(15)70127-0

Randomized trial of TAS-102 for refractory metastatic colorectal cancer.

PMID: 25970050
Journal: NEW ENGLAND JOURNAL OF MEDICINE
Year: 2015
Reference: N Engl J Med. 2015 May 14;372(20):1909-19. doi: 10.1056/NEJMoa1414325.
Impact factor: 55.873
Publication type: Paper in international publication
Authors: Tabernero, Josep, Mayer, Robert J, Van Cutsem, Eric, Falcone, Alfredo, Yoshino, Takayuki, Garcia-Carbonero, Rocio, Mizunuma, Nobuyuki, Yamazaki, Kentaro, Shimada, Yasuhiro, Scheithauer, Werner et al.
DOI: 10.1056/NEJMoa1414325

Rapid resolution of brain ischemic hypoxia after cerebral revascularization in moyamoya disease.

PMID: 25584958
Journal: NEUROSURGERY
Year: 2015
Reference: Neurosurgery. 2015 Mar;76(3):302-12; discussion 312. doi: 10.1227/NEU.0000000000000609.
Impact factor: 3.62
Publication type: Paper in international publication
Authors: Noguer, Montserrat, Arikan, Fuat, Vilalta, Jordi, Torne, Ramon, Sahuquillo, Juan, Lorenzo-Bosquet, Carles et al.
DOI: 10.1227/NEU.0000000000000609

Rates of faecal colonization by carbapenemase-producing Enterobacteriaceae among patients admitted to ICUs in Spain.

PMID: 26163400
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2015
Reference: J Antimicrob Chemother. 2015 Oct;70(10):2916-8. doi: 10.1093/jac/dkv187. Epub 2015 Jul 9.
Impact factor: 5.313
Publication type: Paper in international publication
Authors: Diaz-Lamas, Ana Maria, Fernandez-Martinez, Marta, Fontanals, Dionisia, Gonzalez-Lopez, Juan Jose, Lopez-Contreras, Joaquin, Martinez-Martinez, Luis, Mora-Rillo, Marta, Munoz, Maria, Navarro, Ferran, Oliver, Antonio et al.
DOI: 10.1093/jac/dkv187

Rationale and design of the Cyclosporine to ImpRove Clinical oUtcome in ST-elevation myocardial infarction patients (the CIRCUS trial).

PMID: 26027612
Journal: AMERICAN HEART JOURNAL
Year: 2015
Reference: Am Heart J. 2015 Jun;169(6):758-766.e6. doi: 10.1016/j.ahj.2015.02.020. Epub 2015 Mar 13.
Impact factor: 4.463
Publication type: Clinical Trials
Authors: Aupetit, Jean-Francois, Jouve, Bernard, Motreff, Pascal, Tron, Christophe, Labeque, Jean-Noel, Steg, Pierre G, Cottin, Yves, Range, Gregoire, Clerc, Jerome, Coussement, Patrick et al.
DOI: 10.1016/j.ahj.2015.02.020

Rationale and design of the RIBS IV randomised clinical trial (drug-eluting balloons versus everolimus-eluting stents for patients with drug-eluting stent restenosis).

PMID: 25244700
Journal: EuroIntervention
Year: 2015
Reference: EuroIntervention. 2015 Jul;11(3):336-42. doi: 10.4244/EIJY14M09_07.
Impact factor: 3.758
Publication type: Paper in international publication
Authors: Alfonso, Fernando, Perez-Vizcayno, Maria Jose, Cardenas, Alberto, Garcia Del Blanco, Bruno, Garcia-Touchard, Arturo, Lopez-Minguez, Jose Ramon, Rivero, Fernando, Masotti, Monica, Cequier, Angel, Moris, Cesar et al.
DOI: 10.4244/EIJY14M09_07

Rationale, design and objectives of ARegPKD, a European ARPKD registry study.

PMID: 25886171
Journal: BMC Nephrology
Year: 2015
Reference: BMC Nephrol. 2015 Feb 18;16:22. doi: 10.1186/s12882-015-0002-z.
Impact factor: 1.69
Publication type: Paper in international publication
Authors: Duzova, Ali, Goebel, Heike, Haffner, Dieter, Hero, Barbara, Hoppe, Bernd, Illig, Thomas, Jankauskiene, Augustina, Klopp, Norman, Konig, Jens, Litwin, Mieczyslaw et al.
DOI: 10.1186/s12882-015-0002-z

Real-time assessment of (1)(3)C metabolism reveals an early lactate increase in the brain of rats with acute liver failure.

PMID: 25303736
Journal: NMR IN BIOMEDICINE
Year: 2015
Reference: NMR Biomed. 2015 Jan;28(1):17-23. doi: 10.1002/nbm.3226. Epub 2014 Oct 10.
Impact factor: 3.044
Publication type: Paper in international publication
Authors: Chavarria, Laia, Romero-Gimenez, Jordi, Monteagudo, Eva, Lope-Piedrafita, Silvia, Cordoba, Juan et al.
DOI: 10.1002/nbm.3226

Recent advances in the treatment of melanoma with BRAF and MEK inhibitors.

PMID: 26488003
Journal: Annals of translational medicine
Year: 2015
Reference: Ann Transl Med. 2015 Sep;3(15):207. doi: 10.3978/j.issn.2305-5839.2015.05.13.
Impact factor: 0
Publication type: Review in international publication
Authors: Munoz-Couselo, Eva, Garcia, Jesus Soberino, Perez-Garcia, Jose Manuel, Cebrian, Vanesa Ortega, Castan, Javier Cortes et al.
DOI: 10.3978/j.issn.2305-5839.2015.05.13

Recognizing the place of trials with treatment of physician's choice as the control arm.

PMID: 25732168
Journal: JOURNAL OF CLINICAL ONCOLOGY
Year: 2015
Reference: J Clin Oncol. 2015 Apr 10;33(11):1300-1. doi: 10.1200/JCO.2014.59.3228. Epub 2015 Mar 2.
Impact factor: 18.428
Publication type: Letter whit IF
Authors: Twelves, Chris, Jove, Maria, Cortes, Javier et al.
DOI: 10.1200/JCO.2014.59.3228

Recomendaciones para el uso clínico del microarray genómico en diagnóstico prenatal

PMID: 0003nopmid
Journal: Prog Obstet Ginecol
Year: 2015
Reference: Progresos de Obstetricia y Ginecología, 2015-12-01, Volumen 58, Número 10, Páginas 470-473
Impact factor: 0
Publication type: Paper in national publication
Authors: Plaja Rustein, Alberto, Campo Casanelles, Miguel del, Casals, Elena, Figueras, Francesc, Chica, Rosana de la, Armengol, Lluis, Cirigliano , Vincenzo, Borrell, Antoni et al.
DOI: 10.1016/j.pog.2015.05.003

[Recommendations for bacillus Calmette-Guerin vaccination in children with latent tuberculosis infection].

PMID: 26169597
Journal: ANALES DE PEDIATRIA
Year: 2015
Reference: An Pediatr (Barc). 2015 Oct;83(4):291-2. doi: 10.1016/j.anpedi.2015.06.003. Epub 2015 Jul 11.
Impact factor: 0.833
Publication type: Paper in national publication
Authors: Guarch Ibanez, B, Bruguera Riera, A, Gonzalez Antelo, A, Rodrigo Pendas, J A et al.
DOI: 10.1016/j.anpedi.2015.06.003

[Recommendations for respiratory support in the newborn (iii). Surfactant and nitric oxide].

PMID: 25840706
Journal: ANALES DE PEDIATRIA
Year: 2015
Reference: An Pediatr (Barc). 2015 Nov;83(5):354.e1-6. doi: 10.1016/j.anpedi.2015.02.012. Epub 2015 Apr 1.
Impact factor: 0.833
Publication type: Paper in national publication
Authors: Elorza Fernandez, D, Castillo Salinas, F, Bustos Lozano, G, Gresa Munoz, M, Lopez de Heredia Goya, J, Aguar Carrascosa, M, Miracle Echegoyen, X, Fernandez Lorenzo, J R, Serrano, M M, Concheiro Guisan, A et al.
DOI: 10.1016/j.anpedi.2015.02.012

Recommendations for somatic and germline genetic testing of single pheochromocytoma and paraganglioma based on findings from a series of 329 patients.

PMID: 26269449
Journal: JOURNAL OF MEDICAL GENETICS
Year: 2015
Reference: J Med Genet. 2015 Oct;52(10):647-56. doi: 10.1136/jmedgenet-2015-103218. Epub 2015 Aug 12.
Impact factor: 6.335
Publication type: Paper in international publication
Authors: Diez-Hernandez, Alberto, Curras-Freixes, Maria, Inglada-Perez, Lucia, Mancikova, Veronika, Montero-Conde, Cristina, Leton, Rocio, Comino-Mendez, Inaki, Apellaniz-Ruiz, Maria, Sanchez-Barroso, Lara, Aguirre Sanchez-Covisa, Miguel et al.
DOI: 10.1136/jmedgenet-2015-103218

Recommendations for the clinical application of aneuploidy detection in cell-free fetal DNA in maternal blood

PMID: 0004nopmid
Journal: Prog Obstet Ginecol
Year: 2015
Reference: 0004nopmid
Impact factor: 0
Publication type: Paper in national publication
Authors: Plaja, Alberto, , , , , , , et al.
DOI: 10.1016/j.pog.2014.12.003

Recommendations for the use of methotrexate in rheumatoid arthritis: up and down scaling of the dose and administration routes.

PMID: 24746914
Journal: Reumatologia clinica
Year: 2015
Reference: Reumatol Clin. 2015 Jan-Feb;11(1):3-8. doi: 10.1016/j.reuma.2014.02.012. Epub 2014 Apr 18.
Impact factor: 0
Publication type: Paper in national publication
Authors: Zea Mendoza, Antonio, Quijada Carrera, Jesus, Tornero Molina, Jesus, Ballina Garcia, Francisco Javier, Calvo Alen, Jaime, Caracuel Ruiz, Miguel Angel, Carbonell Abello, Jordi, Lopez Meseguer, Antonio, Moreno Muelas, Jose Vicente, Perez Sandoval, Trinidad et al.
DOI: 10.1016/j.reuma.2014.02.012

Recommendations on hematopoietic stem cell transplantation for inherited bone marrow failure syndromes.

PMID: 26052913
Journal: BONE MARROW TRANSPLANTATION
Year: 2015
Reference: Bone Marrow Transplant. 2015 Sep;50(9):1168-72. doi: 10.1038/bmt.2015.117. Epub 2015 Jun 8.
Impact factor: 3.57
Publication type: Review in international publication
Authors: Leblanc, T, Dufour, C, Dalle, J-H, Samarasinghe, S, Bonanomi, S, Corbacioglu, S, Wlodarski, M, Peffault de Latour, R, Peters, C, Gibson, B et al.
DOI: 10.1038/bmt.2015.117

[Recurrent meningitis due to anatomical defects: The bacteria indicates its origin.]

PMID: 25446794
Journal: ANALES DE PEDIATRIA
Year: 2015
Reference: An Pediatr (Barc). 2015 Jun;82(6):388-96. doi: 10.1016/j.anpedi.2014.09.008. Epub 2014 Oct 29.
Impact factor: 0.722
Publication type: Paper in national publication
Authors: Morgenstern Isaak, A, Bach Faig, A, Martinez, S, Martin-Nalda, A, Vazquez Mendez, E, Pumarola Segura, F, Soler-Palacin, P et al.
DOI: 10.1016/j.anpedi.2014.09.008

Recurrent miscarriage: causes, evaluation and management.

PMID: 25681385
Journal: POSTGRADUATE MEDICAL JOURNAL
Year: 2015
Reference: Postgrad Med J. 2015 Mar;91(1073):151-62. doi: 10.1136/postgradmedj-2014-132672. Epub 2015 Feb 13.
Impact factor: 1.448
Publication type: Review in international publication
Authors: Garrido-Gimenez, Carmen, Alijotas-Reig, Jaume et al.
DOI: 10.1136/postgradmedj-2014-132672

Reduced darunavir dose is as effective in maintaining HIV suppression as the standard dose in virologically suppressed HIV-infected patients: a randomized clinical trial.

PMID: 25525195
Journal: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Year: 2015
Reference: J Antimicrob Chemother. 2015 Apr;70(4):1139-45. doi: 10.1093/jac/dku516. Epub 2014 Dec 18.
Impact factor: 5.313
Publication type: Paper in international publication
Authors: Molto, Jose, Valle, Marta, Ferrer, Elena, Domingo, Pere, Curran, Adrian, Santos, Jose Ramon, Mateo, Maria Gracia, Di Yacovo, Maria Silvana, Miranda, Cristina, Podzamczer, Daniel et al.
DOI: 10.1093/jac/dku516

Reduction of butyrate- and methane-producing microorganisms in patients with Irritable Bowel Syndrome.

PMID: 26239401
Journal: Scientific Reports
Year: 2015
Reference: Sci Rep. 2015 Aug 4;5:12693. doi: 10.1038/srep12693.
Impact factor: 5.578
Publication type: Paper in international publication
Authors: Pozuelo, Marta, Panda, Suchita, Santiago, Alba, Mendez, Sara, Accarino, Anna, Santos, Javier, Guarner, Francisco, Azpiroz, Fernando, Manichanh, Chaysavanh et al.
DOI: 10.1038/srep12693

Reexamining treatment of high-grade T1 bladder cancer according to depth of lamina propria invasion: a prospective trial of 200 patients.

PMID: 25535728
Journal: BRITISH JOURNAL OF CANCER
Year: 2015
Reference: Br J Cancer. 2015 Feb 3;112(3):468-74. doi: 10.1038/bjc.2014.633. Epub 2014 Dec 23.
Impact factor: 4.836
Publication type: Paper in international publication
Authors: Martin-Doyle, W, Raventos, C X, Lozano, F, Mullane, S A, Leow, J J, Barletta, J A, Bellmunt, J, Morote, J, de Torres, I, Werner, L et al.
DOI: 10.1038/bjc.2014.633

Reflex seizures triggered by cutaneous stimuli.

PMID: 26590698
Journal: SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
Year: 2015
Reference: Seizure. 2015 Dec;33:72-5. doi: 10.1016/j.seizure.2015.10.013. Epub 2015 Oct 25.
Impact factor: 1.822
Publication type: Paper in international publication
Authors: Toledo, M, Sarria, S, Santamarina, E, Gonzalez-Cuevas, M, Sueiras-Gil, M, Salas-Puig, J, Sala-Padro, J et al.
DOI: 10.1016/j.seizure.2015.10.013

Regional analysis of health service utilisation by persons with borderline personality disorders: implications for evidence-informed policy.

PMID: 25862205
Journal: Journal of Mental Health Policy and Economics
Year: 2015
Reference: J Ment Health Policy Econ. 2015 Mar;18(1):17-25.
Impact factor:
Publication type: Letter or abstract
Authors: Ferrer, Marc, Andion, Oscar, Bendeck, Murielle, Calvo, Natalia, Prat, Monica, Aragones, Enric, Barral, Carmen, Casas, Miguel, Salvador-Carulla, Luis et al.
DOI: